IP Library › Granted Patent US 12,208,106
Granted Patent B2
US 12,208,106 · App. 17/498,496 · Granted Jan 28, 2025

Methods of vitamin D treatment

Inventors: Joel Z. Melnick (Evanston, IL); Charles W. Bishop (Miami, FL); P. Martin Petkovich (Kingston, CA); Stephen A. Strugnell (Madison, WI)
Assignee: EIRGEN PHARMA LTD.
A61K31/593A61K9/0053A61K31/592A61P3/02A61P13/12
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,208,106
App. No.
17/498,496
Granted
Jan 28, 2025
Kind
B2
Abstract

Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng/ml and/or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D to less than 20.

Claims (15)

1. A method of treating a patient with Chronic Kidney Disease Stage 5 and having secondary hyperparathyroidism and vitamin D insufficiency, wherein the patient is undergoing hemodialysis three times per week, comprising administering to the patient an extended release formulation of 25-hydroxyvitamin D 3 at a dose of 300-900 mcg per week divided into two or three doses per week.

2. The method of claim 1 , wherein the patient has a serum iPTH level ≥150 pg/mL and <600 pg/mL.

3. The method of claim 1 , wherein the patient has a serum iPTH level ≥400 pg/mL and <900 pg/mL.

4. The method of claim 1 , comprising administering to the patient the extended release formulation of 25-hydroxyvitamin D 3 at a dose of 600 mcg per week.

5. The method of claim 1 , comprising administering to the patient the extended release formulation of 25-hydroxyvitamin D 3 at a dose of 900 mcg per week.

6. The method of claim 1 , comprising administering to the patient the extended release formulation of 25-hydroxyvitamin D 3 to raise the patient's serum 25-hydroxyvitamin D 3 level to at least 50 ng/mL.

7. The method of claim 6 , comprising administering to the patient the extended release formulation of 25-hydroxyvitamin D 3 to raise the patient's serum 25-hydroxyvitamin D 3 level to in a range of 50 ng/mL to 200 ng/mL.

8. The method of claim 1 , wherein the treatment reduces the patient's serum iPTH level.

9. The method of claim 8 , wherein the treatment reduces the patient's serum iPTH level by at least 30%.

10. The method of claim 1 , wherein the 25-hydroxyvitamin D 3 is administered orally in capsule form.

11. The method of claim 1 , wherein the extended release 25-hydroxyvitamin D 3 therapy does not increase the patient's serum calcium level.

12. The method of claim 1 , wherein the extended release 25-hydroxyvitamin D 3 therapy does not increase the patient's serum phosphorous level.

13. A method of treating a patient with Chronic Kidney Disease Stage 5 and having secondary hyperparathyroidism and vitamin D insufficiency, wherein the patient is undergoing hemodialysis three times per week, comprising administering to the patient an extended release formulation of 25-hydroxyvitamin D 3 at a dose of 600 mcg to 900 mcg per week, divided into three doses per week.

14. The method of claim 13 , wherein the patient's serum 25-hydroxyvitamin D 3 level is raised to in a range of 50 ng/mL to 200 ng/mL and the therapy does not increase the patient's serum calcium level and does not increase the patient's serum phosphorous level.

15. A method of treating a patient with Chronic Kidney Disease Stage 5 and having secondary hyperparathyroidism and vitamin D insufficiency, wherein the patient is undergoing hemodialysis three times per week, comprising orally administering to the patient an extended release formulation of 25-hydroxyvitamin D 3 at a dose of 600 mcg to 900 mcg per week, divided into three doses per week, and raise the patient's serum 25-hydroxyvitamin D 3 level to in a range of 50 ng/mL to 200 ng/mL wherein the therapy does not increase the patient's serum calcium level and does not increase the patient's serum phosphorous level.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2022
From: MELNICK, JOEL Z.; BISHOP, CHARLES W.; PETKOVICH, P. MARTIN; STRUGNELL, STEPHEN A.
To: OPKO IRELAND GLOBAL HOLDINGS, LIMITED
Reel/Frame 059259/0226 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2022
From: OPKO IRELAND GLOBAL HOLDINGS, LTD.
To: EIRGEN PHARMA LTD.
Reel/Frame 059259/0244 →
Continuity (3)
Continuation 16089235
Provisional Application 62314359 · Mar 28, 2016
Related Publication 20220062304A1 · Mar 3, 2022
References Cited (400)
US 3565924A · DeLuca et al. · 1971 [cited by applicant]
US 3833622A · Babcock et al. · 1974 [cited by applicant]
US 3880894A · De Luca et al. · 1975 [cited by applicant]
US 3974272A · Polli et al. · 1976 [cited by applicant]
US 4004003A · Babcock et al. · 1977 [cited by applicant]
US 4230701A · Holick et al. · 1980 [cited by applicant]
US 4335120A · Holick et al. · 1982 [cited by applicant]
US 4442093A · Maeda et al. · 1984 [cited by applicant]
US 4448721A · DeLuca et al. · 1984 [cited by applicant]
US 4555364A · DeLuca et al. · 1985 [cited by applicant]
US 4668517A · Weber et al. · 1987 [cited by applicant]
US 4684524A · Eckenhoff et al. · 1987 [cited by applicant]
US 4695591A · Hanna et al. · 1987 [cited by applicant]
US 4721613A · Urquhart et al. · 1988 [cited by applicant]
US 4729895A · Makino et al. · 1988 [cited by applicant]
US 4755544A · Makino et al. · 1988 [cited by applicant]
US 4892821A · Omura et al. · 1990 [cited by applicant]
US 4997824A · Popovtzer et al. · 1991 [cited by applicant]
US 5026559A · Eichel et al. · 1991 [cited by applicant]
US 5160742A · Mazer et al. · 1992 [cited by applicant]
US 5167965A · Schulz · 1992 [cited by applicant]
US 5328903A · Ishii et al. · 1994 [cited by applicant]
US 5342626A · Winston, Jr. et al. · 1994 [cited by applicant]
US 5354743A · Thys-Jacobs · 1994 [cited by applicant]
US 5403831A · DeLuca et al. · 1995 [cited by applicant]
US 5431917A · Yamamoto et al. · 1995 [cited by applicant]
US 5472712A · Oshlack et al. · 1995 [cited by applicant]
US 5487900A · Itoh et al. · 1996 [cited by applicant]
US 5529991A · Knutson et al. · 1996 [cited by applicant]
US 5593690A · Akiyama et al. · 1997 [cited by applicant]
US 5602116A · Knutson et al. · 1997 [cited by applicant]
US 5614513A · Knutson et al. · 1997 [cited by applicant]
US 5622941A · Knutson et al. · 1997 [cited by applicant]
US 5693615A · Stone · 1997 [cited by applicant]
US 5707980A · Knutson et al. · 1998 [cited by applicant]
US 5756123A · Yamamoto et al. · 1998 [cited by applicant]
US 5783215A · Arwidsson et al. · 1998 [cited by applicant]
US 5795882A · Bishop et al. · 1998 [cited by applicant]
US 5861386A · Knutson et al. · 1999 [cited by applicant]
US 5869473A · Knutson et al. · 1999 [cited by applicant]
US 5872113A · Nestor, Jr. et al. · 1999 [cited by applicant]
US 5888994A · Hennessy et al. · 1999 [cited by applicant]
US 5919986A · Barbier et al. · 1999 [cited by applicant]
US 5939408A · Batcho et al. · 1999 [cited by applicant]
US 5958451A · Chen · 1999 [cited by applicant]
US 5976784A · DeLuca et al. · 1999 [cited by applicant]
US 6001884A · Nemeth et al. · 1999 [cited by applicant]
US 6011068A · Nemeth et al. · 2000 [cited by applicant]
US 6031003A · Nemeth et al. · 2000 [cited by applicant]
US 6034075A · Thys-Jacobs · 2000 [cited by applicant]
US 6051567A · Abrahamson et al. · 2000 [cited by applicant]
US 6096876A · St-Arnaud et al. · 2000 [cited by applicant]
US 6121469A · Norman et al. · 2000 [cited by applicant]
US 6133250A · Knutson et al. · 2000 [cited by applicant]
US 6139875A · Adams et al. · 2000 [cited by applicant]
US 6147064A · Knutson et al. · 2000 [cited by applicant]
US 6150346A · Knutson et al. · 2000 [cited by applicant]
US 6190591B1 · van Lengerich · 2001 [cited by applicant]
US 6190695B1 · Hoshino et al. · 2001 [cited by applicant]
US 6211244B1 · Van Wagenen et al. · 2001 [cited by applicant]
US 6214376B1 · Gennadios · 2001 [cited by applicant]
US 6228849B1 · Thys-Jacobs · 2001 [cited by applicant]
US 6242434B1 · Bishop et al. · 2001 [cited by applicant]
US 6265392B1 · Abrahamson et al. · 2001 [cited by applicant]
US 6274169B1 · Abrahamson et al. · 2001 [cited by applicant]
US 6288849B1 · Teramoto · 2001 [cited by applicant]
US 6313146B1 · Van Wagenen et al. · 2001 [cited by applicant]
US 6340473B1 · Tanner et al. · 2002 [cited by applicant]
US 6342249B1 · Wong et al. · 2002 [cited by applicant]
US 6375981B1 · Gilleland et al. · 2002 [cited by applicant]
US 6376479B1 · Knutson et al. · 2002 [cited by applicant]
US 6380408B1 · Posner et al. · 2002 [cited by applicant]
US 6413463B1 · Yamamoto et al. · 2002 [cited by applicant]
US 6432936B1 · DeLuca et al. · 2002 [cited by applicant]
US 6491950B1 · Gutierrez-Rocca et al. · 2002 [cited by applicant]
US 6503893B2 · Bishop et al. · 2003 [cited by applicant]
US 6521608B1 · Henner et al. · 2003 [cited by applicant]
US 6524788B1 · Cantor · 2003 [cited by applicant]
US 6569463B2 · Patel et al. · 2003 [cited by applicant]
US 6572888B2 · Byrd · 2003 [cited by applicant]
US 6582727B2 · Tanner et al. · 2003 [cited by applicant]
US 6596314B2 · Wong et al. · 2003 [cited by applicant]
US 6627622B2 · DeLuca et al. · 2003 [cited by applicant]
US 6645527B2 · Oshlack et al. · 2003 [cited by applicant]
US 6770295B1 · Kreilg et al. · 2004 [cited by applicant]
US 6887493B2 · Shefer et al. · 2005 [cited by applicant]
US 6893658B1 · Iida et al. · 2005 [cited by applicant]
US 6903083B2 · Knutson et al. · 2005 [cited by applicant]
US 6911217B1 · Gren et al. · 2005 [cited by applicant]
US 6923988B2 · Patel et al. · 2005 [cited by applicant]
US 6929803B2 · Wong et al. · 2005 [cited by applicant]
US 6949256B2 · Fonkwe et al. · 2005 [cited by applicant]
US 6982258B2 · Posner et al. · 2006 [cited by applicant]
US RE39079E · Tanner et al. · 2006 [cited by applicant]
US 7033996B2 · Christakos · 2006 [cited by applicant]
US 7056655B2 · Cantor · 2006 [cited by applicant]
US 7101865B2 · Posner et al. · 2006 [cited by applicant]
US 7122530B2 · Bishop et al. · 2006 [cited by applicant]
US 7166585B2 · Posner et al. · 2007 [cited by applicant]
US 7189843B2 · Tsai et al. · 2007 [cited by applicant]
US 7226932B2 · Gokhale et al. · 2007 [cited by applicant]
US 7255921B2 · Kamaguchi et al. · 2007 [cited by applicant]
US 7422758B2 · Block et al. · 2008 [cited by applicant]
US 7528122B2 · DeLuca et al. · 2009 [cited by applicant]
US 7632518B2 · Tritsch et al. · 2009 [cited by applicant]
US 7648826B1 · Albertson et al. · 2010 [cited by applicant]
US 7807194B2 · Modliszewski et al. · 2010 [cited by applicant]
US 7816341B2 · Sewall et al. · 2010 [cited by applicant]
US 7829595B2 · Lawrence et al. · 2010 [cited by applicant]
US 7846475B2 · Shiraishi et al. · 2010 [cited by applicant]
US 7973024B2 · Posner et al. · 2011 [cited by applicant]
US 8088410B2 · Tritsch et al. · 2012 [cited by applicant]
US 8101203B2 · Cao · 2012 [cited by applicant]
US 8101204B2 · Cao · 2012 [cited by applicant]
US 8142811B2 · Oshlack et al. · 2012 [cited by applicant]
US 8207149B2 · Tabash et al. · 2012 [cited by applicant]
US 8231896B2 · Tanner et al. · 2012 [cited by applicant]
US 8268352B2 · Vaya et al. · 2012 [cited by applicant]
US 8293270B2 · Sukuru · 2012 [cited by applicant]
US 8329677B2 · Bishop et al. · 2012 [cited by applicant]
US 8361488B2 · Bishop et al. · 2013 [cited by applicant]
US 8377470B2 · Tanner et al. · 2013 [cited by applicant]
US 8426391B2 · Bishop et al. · 2013 [cited by applicant]
US 8592401B2 · Petkovich et al. · 2013 [cited by applicant]
US 8759328B2 · Deluca et al. · 2014 [cited by applicant]
US 8778373B2 · Bishop et al. · 2014 [cited by applicant]
US 8906410B2 · Bishop et al. · 2014 [cited by applicant]
US 8962239B2 · Petkovich et al. · 2015 [cited by applicant]
US 8992971B2 · Yang · 2015 [cited by applicant]
US 9017720B2 · Andersen et al. · 2015 [cited by applicant]
US 9125823B2 · Selva et al. · 2015 [cited by applicant]
US 9402855B2 · Bishop et al. · 2016 [cited by applicant]
US 9408858B2 · Bishop et al. · 2016 [cited by applicant]
US 9498486B1 · Bishop et al. · 2016 [cited by applicant]
US 9500661B2 · Petkovich et al. · 2016 [cited by applicant]
US 9861644B2 · White et al. · 2018 [cited by applicant]
US 9913852B2 · Bishop et al. · 2018 [cited by applicant]
US 9918940B2 · Bishop et al. · 2018 [cited by applicant]
US 9943530B2 · Bishop et al. · 2018 [cited by applicant]
US 10220047B2 · Petkovich et al. · 2019 [cited by applicant]
US 10300078B2 · White et al. · 2019 [cited by applicant]
US 10350224B2 · White et al. · 2019 [cited by applicant]
US 10357502B2 · White et al. · 2019 [cited by applicant]
US 10493084B2 · Petkovich et al. · 2019 [cited by applicant]
US 11173168B2 · Melnick et al. · 2021 [cited by applicant]
US 20010028896A1 · Byrd · 2001 [cited by applicant]
US 20010036472A1 · Wong et al. · 2001 [cited by applicant]
US 20020018810A1 · Oshlack et al. · 2002 [cited by applicant]
US 20020031798A1 · Anazawa et al. · 2002 [cited by applicant]
US 20020044968A1 · van Lengerich · 2002 [cited by applicant]
US 20020081331A1 · Tanner et al. · 2002 [cited by applicant]
US 20020128240A1 · Mazess · 2002 [cited by applicant]
US 20020155154A1 · Wong et al. · 2002 [cited by applicant]
US 20020183288A1 · Mazess et al. · 2002 [cited by applicant]
US 20030059471A1 · Compton et al. · 2003 [cited by applicant]
US 20030083360A1 · Crotts et al. · 2003 [cited by applicant]
US 20030129194A1 · Mazess et al. · 2003 [cited by applicant]
US 20030138482A1 · Fonkwe et al. · 2003 [cited by applicant]
US 20030152629A1 · Shefer et al. · 2003 [cited by applicant]
US 20030157560A1 · Cantor · 2003 [cited by applicant]
US 20030191093A1 · Chen et al. · 2003 [cited by applicant]
US 20030195171A1 · Daifotis et al. · 2003 [cited by applicant]
US 20040043971A1 · Mazess et al. · 2004 [cited by applicant]
US 20040092534A1 · Yam et al. · 2004 [cited by applicant]
US 20040101554A1 · Kirschner et al. · 2004 [cited by applicant]
US 20040132695A1 · Posner et al. · 2004 [cited by applicant]
US 20040197407A1 · Subramanian et al. · 2004 [cited by applicant]
US 20040224930A1 · Posner et al. · 2004 [cited by applicant]
US 20040258749A1 · Guldner et al. · 2004 [cited by applicant]
US 20050014211A1 · Armbruster et al. · 2005 [cited by applicant]
US 20050019374A1 · Modliszewski et al. · 2005 [cited by applicant]
US 20050037064A1 · Basquin et al. · 2005 [cited by applicant]
US 20050069579A1 · Kamaguchi et al. · 2005 [cited by applicant]
US 20050101576A1 · Whitehouse et al. · 2005 [cited by applicant]
US 20050106233A1 · Andersen et al. · 2005 [cited by applicant]
US 20050124591A1 · Tian et al. · 2005 [cited by applicant]
US 20050143358A1 · DeLuca et al. · 2005 [cited by applicant]
US 20050147669A1 · Lawrence et al. · 2005 [cited by applicant]
US 20050148557A1 · Tian et al. · 2005 [cited by applicant]
US 20050148558A1 · Knutson et al. · 2005 [cited by applicant]
US 20050186268A1 · Hoshi et al. · 2005 [cited by applicant]
US 20050208055A1 · Chuang et al. · 2005 [cited by applicant]
US 20050287213A1 · Wong et al. · 2005 [cited by applicant]
US 20060009425A1 · Delgado-Herrera et al. · 2006 [cited by applicant]
US 20060019933A1 · Boardman et al. · 2006 [cited by applicant]
US 20060029660A1 · Fonkwe et al. · 2006 [cited by applicant]
US 20060034937A1 · Patel · 2006 [cited by applicant]
US 20060057201A1 · Bonney et al. · 2006 [cited by applicant]
US 20060193877A1 · Tengler et al. · 2006 [cited by applicant]
US 20060210610A1 · Davidson et al. · 2006 [cited by applicant]
US 20060223119A1 · Cantor · 2006 [cited by applicant]
US 20060228808A1 · Clarke et al. · 2006 [cited by applicant]
US 20060257481A1 · Gurney et al. · 2006 [cited by applicant]
US 20070026067A1 · Yam et al. · 2007 [cited by applicant]
US 20070027120A1 · Whitehouse et al. · 2007 [cited by applicant]
US 20070032461A1 · Adorini et al. · 2007 [cited by applicant]
US 20070122477A1 · Bishop et al. · 2007 [cited by applicant]
US 20070155664A1 · Ranklove et al. · 2007 [cited by applicant]
US 20070190146A1 · Roger et al. · 2007 [cited by applicant]
US 20070207488A1 · Trump et al. · 2007 [cited by applicant]
US 20080109983A1 · Davis · 2008 [cited by applicant]
US 20080134937A1 · Yang · 2008 [cited by applicant]
US 20080199534A1 · Goldberg et al. · 2008 [cited by applicant]
US 20080317764A1 · Huber et al. · 2008 [cited by applicant]
US 20090004284A1 · Cheng et al. · 2009 [cited by applicant]
US 20090069389A1 · Choi et al. · 2009 [cited by applicant]
US 20090137536A1 · Mazess et al. · 2009 [cited by applicant]
US 20090155355A1 · Heuer et al. · 2009 [cited by applicant]
US 20090176748A1 · Tabash et al. · 2009 [cited by applicant]
US 20090209501A1 · Bishop et al. · 2009 [cited by applicant]
US 20090262685A1 · Schuringa et al. · 2009 [cited by applicant]
US 20090311316A1 · Bishop et al. · 2009 [cited by applicant]
US 20100120728A1 · Petkovich et al. · 2010 [cited by applicant]
US 20100144679A1 · Lyles · 2010 [cited by applicant]
US 20100144684A1 · Bishop · 2010 [cited by applicant]
US 20100204189A1 · Petkovich et al. · 2010 [cited by applicant]
US 20100227889A1 · Gerspacher et al. · 2010 [cited by applicant]
US 20100291191A1 · Shoichet et al. · 2010 [cited by applicant]
US 20100291197A1 · Schwab · 2010 [cited by applicant]
US 20110039809A1 · Buck et al. · 2011 [cited by applicant]
US 20110039810A1 · Buck et al. · 2011 [cited by applicant]
US 20110039811A1 · Buck et al. · 2011 [cited by applicant]
US 20110105444A1 · Deluca et al. · 2011 [cited by applicant]
US 20110118218A1 · Buck et al. · 2011 [cited by applicant]
US 20110130370A1 · Briault et al. · 2011 [cited by applicant]
US 20110171298A1 · Cao · 2011 [cited by applicant]
US 20110182986A1 · Speirs et al. · 2011 [cited by applicant]
US 20110256230A1 · Haeusler et al. · 2011 [cited by applicant]
US 20110300210A1 · Swanson et al. · 2011 [cited by applicant]
US 20110318321A1 · Selva et al. · 2011 [cited by applicant]
US 20110319503A1 · Muller et al. · 2011 [cited by applicant]
US 20120015916A1 · Tabash et al. · 2012 [cited by applicant]
US 20120135103A1 · Walsh et al. · 2012 [cited by applicant]
US 20130085121A1 · Wang et al. · 2013 [cited by applicant]
US 20130137663A1 · Messner et al. · 2013 [cited by applicant]
US 20130178451A1 · Bishop et al. · 2013 [cited by applicant]
US 20130189522A1 · Fujii et al. · 2013 [cited by applicant]
US 20130216618A1 · Muller et al. · 2013 [cited by applicant]
US 20130302309A1 · Yang · 2013 [cited by applicant]
US 20140088202A1 · Cade et al. · 2014 [cited by applicant]
US 20140248400A1 · Phonchareon et al. · 2014 [cited by applicant]
US 20140274977A1 · Bishop et al. · 2014 [cited by applicant]
US 20140349979A1 · White et al. · 2014 [cited by applicant]
US 20140357603A1 · Bishop et al. · 2014 [cited by applicant]
US 20150079165A1 · Bishop et al. · 2015 [cited by applicant]
US 20150119472A1 · Shuai et al. · 2015 [cited by applicant]
US 20150119473A1 · Shuai et al. · 2015 [cited by applicant]
US 20170119677A1 · Bishop et al. · 2017 [cited by applicant]
US 20180021354A1 · Petkovich et al. · 2018 [cited by applicant]
CA 2241205A1 · 1997 [cited by applicant]
CN 101668517A · 2010 [cited by applicant]
DE 20321698U1 · 2008 [cited by applicant]
EP 227836A1 · 1987 [cited by applicant]
EP 0413828A1 · 1991 [cited by applicant]
EP 0508756A1 · 1992 [cited by applicant]
EP 0387808B1 · 1993 [cited by applicant]
EP 0629405A1 · 1994 [cited by applicant]
EP 1080055A2 · 2001 [cited by applicant]
EP 1208843A1 · 2002 [cited by applicant]
EP 1165061B1 · 2005 [cited by applicant]
EP 1980255A1 · 2008 [cited by applicant]
EP 2148661B1 · 2012 [cited by applicant]
EP 2591354A1 · 2013 [cited by applicant]
EP 2037936B1 · 2014 [cited by applicant]
JP 55139320 · 1980 [cited by applicant]
JP 57188520 · 1982 [cited by applicant]
JP 58032823 · 1983 [cited by applicant]
JP 58206524A · 1983 [cited by applicant]
JP 64031722 · 1989 [cited by applicant]
JP 02229115 · 1990 [cited by applicant]
JP H02229115A · 1990 [cited by applicant]
JP 04198129 · 1992 [cited by applicant]
JP 04208225A · 1992 [cited by applicant]
JP H04288016A · 1992 [cited by applicant]
JP 07242550A · 1995 [cited by applicant]
JP 08092098A · 1996 [cited by applicant]
JP 10158171A · 1998 [cited by applicant]
JP 11158074 · 1999 [cited by applicant]
JP 2001512418A · 2001 [cited by applicant]
JP 2002302447A · 2002 [cited by applicant]
JP 2004175750A · 2004 [cited by applicant]
JP 2004531548A · 2004 [cited by applicant]
JP 2005505589A · 2005 [cited by applicant]
JP 2005513419A · 2005 [cited by applicant]
JP 2005528383A · 2005 [cited by applicant]
JP 2005531532A · 2005 [cited by applicant]
JP 2005535682A · 2005 [cited by applicant]
JP 2005538189A · 2005 [cited by applicant]
JP 2006517593A · 2006 [cited by applicant]
JP 2006523221A · 2006 [cited by applicant]
JP 2007525472A · 2007 [cited by applicant]
JP 2010506520A · 2010 [cited by applicant]
JP 2010525079A · 2010 [cited by applicant]
JP 2011512343A · 2011 [cited by applicant]
JP 2012515738A · 2012 [cited by applicant]
KR 1020120005228A · 2012 [cited by applicant]
WO WO9112807A1 · 1991 [cited by applicant]
WO WO91016899A1 · 1991 [cited by applicant]
WO WO9209271A1 · 1992 [cited by applicant]
WO WO94000128A1 · 1994 [cited by applicant]
WO WO96000074A1 · 1996 [cited by applicant]
WO WO96001621A1 · 1996 [cited by applicant]
WO WO96031215A1 · 1996 [cited by applicant]
WO WO97011053A1 · 1997 [cited by applicant]
WO WO98018610A1 · 1998 [cited by applicant]
WO WO98029105A2 · 1998 [cited by applicant]
WO WO99011272A1 · 1999 [cited by applicant]
WO WO9949027A1 · 1999 [cited by applicant]
WO WO9961398A2 · 1999 [cited by applicant]
WO WO00021504A1 · 2000 [cited by applicant]
WO WO00035419A2 · 2000 [cited by applicant]
WO WO0060109A1 · 2000 [cited by applicant]
WO WO00061123A2 · 2000 [cited by applicant]
WO WO01037808A1 · 2001 [cited by applicant]
WO WO0172286A1 · 2001 [cited by applicant]
WO WO0292056A1 · 2002 [cited by applicant]
WO WO0309572A1 · 2003 [cited by applicant]
WO WO0330869A1 · 2003 [cited by applicant]
WO WO03039521A1 · 2003 [cited by applicant]
WO WO03039572A1 · 2003 [cited by applicant]
WO WO03045381A1 · 2003 [cited by applicant]
WO WO03047595A1 · 2003 [cited by applicant]
WO WO0386267A2 · 2003 [cited by applicant]
WO WO03086415A1 · 2003 [cited by applicant]
WO WO03088976A1 · 2003 [cited by applicant]
WO WO03093459A1 · 2003 [cited by applicant]
WO WO03106411A1 · 2003 [cited by applicant]
WO WO2004010981A1 · 2004 [cited by applicant]
WO WO2004028515A1 · 2004 [cited by applicant]
WO WO2004054968A2 · 2004 [cited by applicant]
WO WO2004058235A2 · 2004 [cited by applicant]
WO WO2004071497A1 · 2004 [cited by applicant]
WO WO2004080467A2 · 2004 [cited by applicant]
WO WO2004098617A2 · 2004 [cited by applicant]
WO WO2004101554A1 · 2004 [cited by applicant]
WO WO2004110381A2 · 2004 [cited by applicant]
WO WO2004110391A2 · 2004 [cited by applicant]
WO WO2005000268A2 · 2005 [cited by applicant]
WO WO2005003358A1 · 2005 [cited by applicant]
WO WO2005011652A2 · 2005 [cited by applicant]
WO WO2005123120A1 · 2005 [cited by applicant]
WO WO2006052452A1 · 2006 [cited by applicant]
WO WO2006059180A2 · 2006 [cited by applicant]
WO WO2006113505A2 · 2006 [cited by applicant]
WO WO2007039193A1 · 2007 [cited by applicant]
WO WO2007039569A2 · 2007 [cited by applicant]
WO WO2007047327A2 · 2007 [cited by applicant]
WO WO2007050724A2 · 2007 [cited by applicant]
WO WO2007050975A2 · 2007 [cited by applicant]
WO WO2007053608A2 · 2007 [cited by applicant]
WO WO2007068287A1 · 2007 [cited by applicant]
WO WO2007092221A2 · 2007 [cited by applicant]
WO WO2007092755A2 · 2007 [cited by applicant]
WO WO2007146004A1 · 2007 [cited by applicant]
WO WO2008008608A2 · 2008 [cited by applicant]
WO WO2008043449A1 · 2008 [cited by applicant]
WO WO2008097646A1 · 2008 [cited by applicant]
WO WO2008116113 · 2008 [cited by applicant]
WO WO2008116133A1 · 2008 [cited by applicant]
WO WO2008134512A1 · 2008 [cited by applicant]
WO WO2008134518A2 · 2008 [cited by applicant]
WO WO2008134523A1 · 2008 [cited by applicant]
WO WO2009047644A2 · 2009 [cited by applicant]
WO WO2009092755A1 · 2009 [cited by applicant]
WO WO2009101132A1 · 2009 [cited by applicant]
WO WO2009101135A1 · 2009 [cited by applicant]
WO WO2009101137A1 · 2009 [cited by applicant]
WO WO2009124210A1 · 2009 [cited by applicant]
WO WO2010011906A1 · 2010 [cited by applicant]
WO WO2010034342A1 · 2010 [cited by applicant]
WO WO2011031621A2 · 2011 [cited by applicant]
WO WO2011063952A1 · 2011 [cited by applicant]
WO WO2011095388A1 · 2011 [cited by applicant]
WO WO2011123476A1 · 2011 [cited by applicant]
WO WO2012006475A1 · 2012 [cited by applicant]
WO WO2012018329A1 · 2012 [cited by applicant]
WO WO2012076429A1 · 2012 [cited by applicant]
WO WO2012091569A1 · 2012 [cited by applicant]
WO WO2012117236A1 · 2012 [cited by applicant]
WO WO2012145491A2 · 2012 [cited by applicant]
WO WO2014029953A1 · 2014 [cited by applicant]
WO WO2014143941A1 · 2014 [cited by applicant]
WO WO2014193255A1 · 2014 [cited by applicant]
WO WO2014202754A1 · 2014 [cited by applicant]
WO WO2016020508A2 · 2016 [cited by applicant]
Rhee et al. Semin. Dial., Nov. 2013, vol. 26, No. 6, pp. 1-14 (Year: 2013). [cited by examiner]
Hidroferol® (calcifediol): Casos de Hipercalcemia e Hipervitaminosis D, Butlletí de Farmacovigilància de Catalunya, 9(5):17-20 (2011). [cited by applicant]
K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease, National Kidney Foundation, Am. J. Kidney Dis., 42 (Supplement 3):1-202 (2003). [cited by applicant]
9 Things That Can Undermine Your Vitamin D Level: Don't Let Your Vitamin D Absorption Slip Away, Harvard Health Publishing, downloaded from the Internet at: <https://www.health.harvard.edu/healthbeat/9-things-that-can-u… [cited by applicant]
ACP Formulary and Pocket Guide to Psychopharmacology, Virginia DMHMRSAS, vol. 1, Iss. 1, (2004-2005). [cited by applicant]
Al-Aly, Z., Changes in Serum 25-Hydroxyvitamin D and Plasma Intact PTH Levels Following Treatment with Ergocalciferol in Patients With CKD, Am. J. Kid. Dis., 50(1):59-68 (2007). [cited by applicant]
Albertson et al., Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene, Nat. Genet., 25(2):144-6 (2000). [cited by applicant]
AlfaD3® 0.25, 0.5 or 1 microgram Capsules (Alfacalcidol, Package Leaflet, Apr. 2010). [cited by applicant]
Alfarol® Capsules 3ug (Package Leaflet, Mar. 2011). [cited by applicant]
Alvarez et al., Vitamin D Supplementation in Pre-Dialysis Chronic Kidney Disease, Dermato-Endocrinology, 4(2):118-127 (2012). [cited by applicant]
Amin, The impact of improved phosphorus control: use of sevelamer hydrochloride in patients with chronic renal failure, Nephrol Dial Transplant, 17:340-345 (2002). [cited by applicant]
Anderson et al., Expression of VDR and CYP24A1 mRNA in human tumors, Cancer Chemother. Pharmacol., 57(2):234-40 (2006). [cited by applicant]
Anderson et al., Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase-polymerase chain reaction, 2003. J. Mol. Endoc 31:1… [cited by applicant]
Andress, Vitamin D in chronic kidney disease: A systematic role for selective vitamin D receptor activation, Kidney Int., 69:33-43 (2006). [cited by applicant]
Arekat et al., Dramatic improvement of BMD following vitamin D therapy in a bone marrow transplant recipient, J. Clin. Densitometry, 5(3):297-71 (2002). [cited by applicant]