IP Library › Granted Patent US 12,404,329
Granted Patent B2
US 12,404,329 · App. 18/415,608 · Granted Sep 2, 2025

Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3

Inventors: John R. Desjarlais (Pasadena, CA); Alex Nisthal (Monrovia, CA); Michael Hedvat (Encino, CA); Matthew Adam Dragovich (Monrovia, CA)
Assignee: Xencor, Inc.
C07K16/2809A61P35/00C07K16/3069C07K16/468C12N15/63A61K2039/505C07K2317/31C07K2317/33C07K2317/52C07K2317/56C07K2317/73
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Quick Facts
Patent No.
US 12,404,329
App. No.
18/415,608
Granted
Sep 2, 2025
Kind
B2
Abstract

Provided herein are novel antigen binding domains and antibodies (e.g., heterodimeric antibodies) that bind Prostate Specific Membrane Antigen (PSMA). In exemplary embodiments, the anti-PSMA antibodies also bind CD3. Such antibodies that bind PSMA and CD3 are useful, for example in the treatment of PSMA-related cancer.

Claims (14)

1. A composition comprising a Prostate Specific Membrane Antigen (PSMA) binding domain comprising:

a) a variable heavy domain comprising the variable heavy complementarity determining regions vhCDR1, vhCDR2, and vhCDR3 of a variable heavy domain having an amino acid sequence of SEQ ID NO: 217; and

b) a variable light domain comprising the variable light complementarity determining regions vlCDR1, vlCDR2, and vlCDR3 of a variable light domain having an amino acid sequence of one of the following: SEQ ID NO: 252, SEQ ID NO: 257, and SEQ ID NO: 286.

2. A composition comprising a Prostate Specific Membrane Antigen (PSMA) binding domain comprising:

a) a variable heavy domain having an amino acid sequence of SEQ ID NO: 217; and

b) a variable light domain having an amino acid sequence of one of the following: SEQ ID NO: 252, SEQ ID NO: 257, and SEQ ID NO: 286.

3. A nucleic acid composition comprising:

a) a first nucleic acid encoding the variable heavy domain according claim 2 ; and

b) a second nucleic acid encoding the variable light domain according to claim 2 .

4. An expression vector composition comprising:

a) a first expression vector comprising the first nucleic acid of claim 3 ; and

b) a second expression vector comprising the second nucleic of claim 3 .

5. A host cell comprising the expression vector composition according to claim 4 .

6. A method of making a Prostate Specific Membrane Antigen (PSMA) binding domain comprising culturing the host cell according to claim 5 under conditions wherein the PSMA binding domain is expressed, and recovering the PSMA binding domain.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2024
From: DESJARLAIS, JOHN R.; NISTHAL, ALEX; HEDVAT, MICHAEL; DRAGOVICH, MATTHEW ADAM
To: XENCOR, INC.
Reel/Frame 068730/0205 →
Continuity (4)
Continuation 17321325 · May 14, 2021
Provisional Application 63042315 · Jun 22, 2020
Provisional Application 63025082 · May 14, 2020
Related Publication 20240417466A1 · Dec 19, 2024
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