Granted Patent B2

US 12,446,965 · App. 18/821,934 · Granted Oct 21, 2025

Inventors: Ifat Lavi (Moshav Mishmeret, IL); Moran Shalhon Livne (Rosh Haayin, IL)

Assignee: Cathworks Ltd.

A61B34/10A61B34/25G16H50/30G16H50/50A61B2034/105

Abstract

Claims (43)

1. A method implemented by a system of one or more processors, the method comprising:

accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels;

obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and

causing presentation of a user interface, wherein the user interface:

presents a graph mapping individual positions along the length of the at least one of the vessels on a first axis and values of the index indicative of vascular function on a second axis,

presents individual user interface elements enabling nulling of individual lesions, and

updates the graph in response to received user input to one or more of the user interface elements, wherein the user input nulls effects of one or more lesions, wherein the user input triggers the update, by the system, based on the cardiac model and the update is configured to address crosstalk effects associated with remaining lesions;

wherein nulling a lesion causes updating diameters at the positions along the length which are associated with the nulled lesion, and wherein the updated diameters cause the index drop associated with the nulled lesion to be reduced.

2. The method of claim 1 , wherein the user interface elements are toggles proximate to respective positions associated with the index drops on the graph.

3. The method of claim 1 , wherein the plurality of lesions comprises at least one user-identified lesion.

4. The method of claim 1 , wherein the plurality of lesions further comprises at least one automatically-identified lesion that meets an index drop threshold.

5. The method of claim 1 , wherein the cardiac model includes a three-dimensional model generated based on angiographic images.

6. The method of claim 1 , wherein the values of the index indicative of vascular function are fractional flow reserve values.

7. The method of claim 1 , wherein the graph is a line.

8. The method of claim 1 , wherein the updated diameters cause the index drops associated with lesion to be reduced less than a threshold.

9. The method of claim 1 , wherein the user interface updates the graph to include a mapping of updated index indicative of vascular function associated with nulling the effects of the one or more lesions.

10. The method of claim 9 , wherein the update to the graph indicates whether the at least one of the vessel is healthy based on values of the updated index indicative of vascular function being above a threshold index.

11. The method of claim 10 , wherein the graph presented by the user interface comprises a mapping of the threshold index along the length of the at least one of the vessels, and wherein the graph indicates the at least one of the vessels is healthy when the mapping of the updated index indicative of vascular function is above the mapping of the threshold index across the first axis.

12. The method of claim 1 , wherein the index drops are with respect to reductions in fractional flow reserve value, and wherein updating the index indicative of vascular function includes updating the index drops along the length of the at least one of the vessels.

13. The method of claim 1 , wherein the updating of the index indicative of vascular function includes identifying a change in a distal value of the index indicative of vascular function at a threshold distance from a distal end of the at least one vessel.

14. The method of claim 1 , wherein the user interface presents the graph mapping individual positions along the length of the vessel and the values of the index indicative of vascular function prior to the update simultaneously with the update to the graph.

15. The method of claim 1 , further comprising:

determining the values of the index indicative of vascular function along the length based on diameters of the at least one of the vessels that are determined from the cardiac model; and

in response to receiving the user input, determining updated values of the index indicative of vascular function along the length based on the diameters determined from the cardiac model and the user input, the user input nulling the effects of the one or more lesions by adjusting diameters of the positions associated with the one or more lesions to be above a threshold diameter.

16. The method of claim 1 , wherein the user interface further presents a three-dimensional representation of the cardiac model simultaneously with the graph.

17. Non-transitory computer storage media storing instructions that when executed by a system of one or more computers, cause the one or more computers to:

access a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels;

obtain, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and

cause presentation of a user interface, wherein the user interface:

presents a graph mapping individual positions along the length of the at least one of the vessels on a first axis and values of the index indicative of vascular function on a second axis,

presents individual user interface elements enabling nulling of individual lesions, and

updates the graph in response to received user input to one or more of the user interface elements, wherein the user input nulls effects of one or more lesions,

wherein the user input triggers the update, by the system, based on the cardiac model and the update is configured to address crosstalk effects associated with remaining lesions;

wherein nulling a lesion causes updating diameters at the positions along the length which are associated with the nulled lesion, and wherein the updated diameters cause the index drop associated with the nulled lesion to be reduced.

18. The computer storage media of claim 17 , wherein the index drops are with respect to reductions in fractional flow reserve value, and wherein updating the graph includes updating the index drops along the length of the at least one of the vessels.

19. A system comprising one or more processors and non-transitory computer storage media storing instructions that when executed by the one or more processors, cause the one or more processors to:

access a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels;

obtain, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and

cause presentation of a user interface, wherein the user interface:

presents a graph mapping individual positions along the length of the at least one of the vessels on a first axis and values of the index indicative of vascular function on a second axis,

presents individual user interface elements enabling nulling of individual lesions, and

updates the graph in response to received user input to one or more of the user interface elements, wherein the user input nulls effects of one or more lesions, wherein the user input triggers the update, by the system, based on the cardiac model and the update is configured to address crosstalk effects associated with remaining lesions;

wherein nulling a lesion causes updating diameters at the positions along the length which are associated with the nulled lesion, and wherein the updated diameters cause the index drop associated with the nulled lesion to be reduced.

Assignments (1)

Continuity (3)

References Cited (400)