Granted Patent
B2
US 12,453,688 · App. 17/972,186 · Granted Oct 28, 2025
Cosmetic compositions comprising dragline spider silk
Inventors:
Konstantin Press (Rishon Le-Zion, IL); Gregory Idelson (Maale Adumim, IL); Ariel Givant (Jerusalem, IL); Alon Meir (Jerusalem, IL); Noa Hadar (Givat Brenner, IL)
Assignee:
SEEVIX MATERIAL SCIENCES LTD.
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Abstract
Cosmeceutical compositions comprising a major ampullate spidroin protein (MaSp)-based fiber are disclosed. Articles comprising the compositions are further disclosed.
Claims (12)
1. A cosmeceutical composition comprising a cosmeceutical effective amount of a composite, wherein the composite comprises a derivatized porous major ampullate spidroin protein (MaSp)-based fiber bound to a metal oxide particle, wherein:
said metal oxide particle is characterized by a particle size between 10 and 900 nm;
said derivatized porous MaSp-based fiber is insoluble in an aqueous solution;
said derivatized porous MaSp-based fiber is in a form of particles having an average particle size between 0.5 μm and 1.5 μm and is characterized by a BET surface area of at least 10 m 2 /g;
said derivatized porous MaSp-based fiber comprises a functional moiety covalently bound to a tyrosine of the derivatized porous MaSp-based fiber via a diazo bond;
said functional moiety comprises a polymer bound to a plurality of metal oxide chelating groups;
said metal oxide particle is bound to the derivatized porous MaSp-based fiber via said metal oxide chelating groups.
2. The cosmeceutical composition of claim 1 , further comprising a cosmetically acceptable carrier; wherein said metal oxide particle is characterized by a particle size between 100 and 500 nm; and wherein said metal oxide particle is a titania particle.
3. The cosmeceutical composition of claim 1 , characterized as a sunscreen composition.
4. The cosmeceutical composition of claim 1 , wherein said cosmeceutical effective amount is between 10% w/w and 50% w/w of the composite within the composition.
5. The cosmeceutical composition of claim 1 , wherein a w/w ratio of said derivatized porous MaSp-based fiber to said metal oxide particle within said composition is between 0.01:1 and 2:1.
6. The cosmeceutical composition of claim 1 , wherein said polymer comprises polyglutaraldehyde (PGA), and wherein a w/w ratio of said polymer to said derivatized porous MaSp-based fiber is between 0.001 and 5.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 24, 2022
From: PRESS, KONSTANTIN; IDELSON, GREGORY; GIVANT, ARIEL; MEIR, ALON; HADAR, NOA
To: SEEVIX MATERIAL SCIENCES LTD.
Reel/Frame 061517/0786 →
Continuity (7)
Continuation
PCTIL2021050476
· Apr 25, 2021
Provisional Application
63144089
· Feb 1, 2021
Provisional Application
63134343
· Jan 6, 2021
Provisional Application
63079621
· Sep 17, 2020
Provisional Application
63048135
· Jul 5, 2020
Provisional Application
63014444
· Apr 23, 2020
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