Granted Patent B2

US 12,454,515 · App. 18/106,273 · Granted Oct 28, 2025

Inventor: Matthew Baggott (Redwood City, CA)

Assignee: Tactogen Inc

C07D307/79

Abstract

Claims (66)

1. A compound of formula:

or a pharmaceutically acceptable salt or salt mixture thereof;

wherein:

R 1 is hydrogen, methyl, —CH 2 F, —CF 3 , ethyl, —CH 2 CH 2 F, —CH 2 CF 2 H, —CH 2 CF 3 , or —CF 2 CF 3 .

2. The compound of claim 1 wherein the compound is of formula:

or a pharmaceutically acceptable salt or salt mixture thereof.

3. The compound of claim 1 wherein the compound is of formula:

or a pharmaceutically acceptable salt or salt mixture thereof.

4. The compound of claim 1 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

5. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

6. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

7. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

8. The compound of claim 5 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

9. The compound of claim 6 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

10. The compound of claim 7 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

11. The compound of claim 5 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

12. The compound of claim 6 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

13. The compound of claim 7 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

14. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

15. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

16. The compound of claim 4 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

17. The compound of claim 14 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

18. The compound of claim 15 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

19. The compound of claim 16 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

20. The compound of claim 14 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

21. The compound of claim 15 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

22. The compound of claim 16 wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

23. The compound of claim 1 , wherein the pharmaceutically acceptable salt(s) is hydrochloric acid, sulfate, aspartate, saccharate, phosphate, oxalate, acetate, amino acid anion, gluconate, maleate, malate, citrate, mesylate, nitrate or tartrate, or a mixture thereof.

24. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt or salt mixture thereof and a pharmaceutically acceptable carrier or excipient.

25. The pharmaceutical composition of claim 24 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

26. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

27. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

28. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

29. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

30. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

31. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

32. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

33. The pharmaceutical composition of claim 25 , wherein the compound is:

or a pharmaceutically acceptable salt or salt mixture thereof.

Assignments (1)

Continuity (3)

References Cited (73)