Antimicrobial solutions and methods of using the same in the treatment or prevention of infections
Antimicrobial compositions include a therapeutically effective amount of neem oil, extract of the plant Hypericum spp., polyunsaturated fatty acids (PUFAs), carrageenans, and/or chlorhexidine; and (optionally) in combination with one or more pharmaceutically acceptable carriers, additives, and/or diluents. The antimicrobial compositions are effective in treating or preventing upper respiratory tract infections, preferably upper respiratory tract infections caused by human Coronaviruses and are included within methods of treating or preventing infection of the upper respiratory tract of humans by a microbial pathogen.
1 . An antimicrobial solution, comprising:
an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
Neem oil;
one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject; and
polyunsaturated fatty acids (PUFAs).
2 . The antimicrobial solution of claim 1 , wherein the Neem oil includes between 6-16% of linoleic acid, 25-54% of oleic acid, 16-33% of palmitic acid, and 9-24% of stearic acid.
3 . The antimicrobial solution of claim 1 , wherein the extract of the plant Hypericum spp. comprises extract from Hypericum perforatum.
4 . The antimicrobial solution of claim 1 , wherein the extract of the plant Hypericum spp. comprises hypericin as a main active ingredient.
5 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the Neem oil in a volumetric proportion of at most 10% (v/v) of the total volume of the antimicrobial solution.
6 . The antimicrobial solution of claim 1 , wherein the extract of the plant Hypericum spp. and the Neem oil are provided in a volume ratio of greater than 100:1.
7 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of at most 5% (v/v) of the total volume of the antimicrobial solution.
8 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of at most 10% (v/v) of the total volume of the antimicrobial solution.
9 . An antimicrobial solution, comprising:
an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
Neem oil;
one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject; and
carrageenan.
10 . The antimicrobial solution of claim 1 , further comprising a chlorhexidine.
11 . An antimicrobial solution, comprising:
an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
Neem oil; and
one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject,
wherein the pharmaceutically acceptable carrier comprises glycerol.
12 . The antimicrobial solution of claim 1 , wherein the one or more pharmaceutically acceptable additives includes a flavor-enhancing additive.
13 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the one or more pharmaceutically acceptable carriers, additives, and/or diluents in a volumetric proportion of at least 10% (v/v) of the total volume of the antimicrobial solution.
14 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the one or more pharmaceutically acceptable carriers, additives, and/or diluents in a volumetric proportion of at least 33% (v/v) of the total volume of the antimicrobial solution.
15 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution is in the form of a lotion, a hydrogel, a mouth spray, and/or a nasal spray.
16 . The antimicrobial solution of claim 15 , wherein the antimicrobial solution is in the form of a mouth spray, and/or a nasal spray, and wherein the antimicrobial solution is delivered in 50 μL-200 μL doses per actuation of the mouth spray and/or the nasal spray.
17 . A method of treatment or prophylaxis, comprising:
providing an antimicrobial solution that includes
an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution,
Neem oil,
one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject, and
polyunsaturated fatty acids (PUFAs); and
administering the antimicrobial solution to a mouth and/or nose of a subject.
18 . An antimicrobial solution, comprising:
an extract of the plant Hypericum spp. in a volumetric proportion of 2.5% to 60% (v/v) of a total volume of the antimicrobial solution;
Neem oil; and
one or more pharmaceutically acceptable carriers, additives, and/or diluents that configure the antimicrobial solution to form a barrier film in a nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of a subject;
wherein the one or more pharmaceutically acceptable additives includes a flavor-enhancing additive, and
wherein the flavor-enhancing additive includes menthol.
19 . The antimicrobial solution of claim 1 , wherein the one or more pharmaceutically acceptable carriers, additives, and/or diluents configure the antimicrobial solution to form a non-water soluble barrier film in the nasal mucosa, oral mucosa, and/or oropharyngeal mucosa of the subject.
20 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution is in the form of a mouth spray and/or a nasal spray.
21 . The antimicrobial solution of claim 1 , wherein the one or more pharmaceutically acceptable carriers, additives, and/or diluents include glycerol, water, and an emulsifier.
22 . The method of claim 17 , comprising administering the antimicrobial solution to the nose of the subject.
23 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of 5% to 60% (v/v) of a total volume of the antimicrobial solution.
24 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of 5% to 50% (v/v) of a total volume of the antimicrobial solution.
25 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of 10% to 50% (v/v) of a total volume of the antimicrobial solution.
26 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of 5% to 30% (v/v) of a total volume of the antimicrobial solution.
27 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the extract of the plant Hypericum spp. in a volumetric proportion of 5% to 25% (v/v) of the total volume of the antimicrobial solution.
28 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the polyunsaturated fatty acids (PUFAs) in a volumetric proportion of 5% to 80% (v/v) of the total volume of the antimicrobial solution.
29 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the polyunsaturated fatty acids (PUFAs) in a volumetric proportion of 5% to 50% (v/v) of the total volume of the antimicrobial solution.
30 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises the polyunsaturated fatty acids (PUFAs) in a volumetric proportion of 10% to 50% (v/v) of the total volume of the antimicrobial solution.
31 . The antimicrobial solution of claim 2 , wherein the extract of the plant Hypericum spp. and the Neem oil are provided in a volume ratio of greater than 10:1.
32 . The antimicrobial solution of claim 2 , wherein the extract of the plant Hypericum spp. and the Neem oil are provided in a volume ratio of greater than 1000:1.
33 . The antimicrobial solution of claim 1 , wherein the antimicrobial solution comprises chlorhexidine in an amount of 0.05% to 0.2% (w/v) of the antimicrobial solution.
34 . The antimicrobial solution of claim 9 , wherein the antimicrobial solution comprises the carrageenan in an amount of 5% to 20% (w/v) of the antimicrobial solution.