IP Library › Granted Patent US 12,484,903
Granted Patent B2
US 12,484,903 · App. 17/375,746 · Granted Dec 2, 2025

Blood oxygenation treatment methods and devices

Inventors: Stanton J. Rowe (Irvine, CA); Robert S. Schwartz (Irvine, CA); Glen Rabito (Irvine, CA); Robert C. Taft (Irvine, CA); Elliot Howard (Irvine, CA); Alexander Siegel (Irvine, CA); Joseph Passman (Irvine, CA)
Assignee: NXT Biomedical, LLC
A61B17/11A61B5/14542A61B5/686A61B17/00234A61B17/12022A61B2017/00252A61B2017/1139
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Quick Facts
Patent No.
US 12,484,903
App. No.
17/375,746
Granted
Dec 2, 2025
Kind
B2
Abstract

Methods and devices for increasing oxygenation levels in the blood supply and thereby treating the condition of hypoxemia. Multiple approaches such as pressure reduction in the pulmonary circulatory system, reducing triggering mechanisms in the main pulmonary artery and restricting flow in the pulmonary circulatory system are disclosed. Interventions associated with those approaches can including shunting, restrictors, compliance devices, pharmacologic substances, etc.

Claims (54)

1 . A method of improving oxygen levels in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention;

wherein the intervening comprises pressure reduction in the pulmonary circulation;

wherein the pressure reduction in the pulmonary circulation comprises shunting of said pulmonary circulation; and,

wherein shunting of said pulmonary circulation comprises right-to-right shunting of blood vessels in said pulmonary system.

2 . A method according to claim 1 , wherein said right-to-right shunting comprises shunting flow from the right pulmonary artery to the superior vena cava.

3 . A method according to claim 1 , further comprising iterating said intervening based on the comparing of said post-intervention oxygen measurement with said baseline oxygen measurement.

4 . A method according to claim 3 , wherein the iterating of said intervening is repeated until target oxygen measurement is obtained.

5 . A method of improving oxygen levels in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention;

wherein the intervening comprises restriction of flow in the pulmonary system;

wherein the restriction of flow comprises restricting flow in one or more blood vessels of said pulmonary system; and,

wherein restricting flow in one or more blood vessels comprises placing a flow restriction element into the main pulmonary artery of said patient.

6 . A method of improving oxygen levels in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention;

wherein the intervening comprises introducing compliance into said pulmonary circulation; and,

wherein the introduction of compliance comprises placing a gas-filled balloon into the pulmonary circulation.

7 . A method according to claim 6 , wherein said balloon is disposed in the SVC.

8 . A method of improving oxygen levels in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

intervening invasively in the native oxygenation process of said patient so as to increase the oxygen present in said patient's blood;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention;

wherein the intervening comprises draining the lymphatic system; and,

wherein draining the lymphatic system includes draining the interstitial spaces of said lymphatic system.

9 . A system for improving oxygen levels in a patient comprising:

a device for measuring oxygen levels in a patient;

a device for intervening invasively in the native pulmonary oxygenation process of a patient;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient;

wherein said device for intervening in the native pulmonary oxygenation process is a shunting device; and,

wherein said shunting device is an implantable shunt configured for right-to-right shunting.

10 . A system according to claim 9 , wherein said implantable shunt is configured for placement in the right pulmonary artery and the superior vena cava of said patient.

11 . A method of improving oxygen levels in a patient comprising:

conducting oxygen measurements of a patient's blood to establish a baseline oxygen measurement for said patient;

shunting flow from the right pulmonary artery to the superior vena cava so as to increase the oxygen present in said patient's blood;

conducting post-intervention oxygen measurement of said patient's blood after said intervention;

comparing said post-intervention oxygen measurement with said baseline oxygen measurement to evaluate the efficacy of the intervention.

12 . A method according to claim 11 , wherein shunting flow from the right pulmonary artery to the superior vena cava includes placing a rivet stent between said right pulmonary artery and said superior vena cava.

13 . A method according to claim 11 , wherein shunting flow from the right pulmonary artery to the superior vena cava includes placing a star-shaped shunt between said right pulmonary artery and said superior vena cava.

14 . A system for improving oxygen levels in a patient comprising:

a device for measuring oxygen levels in a patient;

an implantable shunt configured for placement in the right pulmonary artery and the superior vena cava of said patient for intervening invasively in the native pulmonary oxygenation process of a patient;

a device for measuring the oxygen levels of said patient post intervention in the native pulmonary oxygenation process of said patient.

15 . A system according to claim 14 , wherein said implantable shunt is a rivet stent.

16 . A system according to claim 14 , wherein said implantable shunt is a star-shaped stent.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2026
From: NXT BIOMEDICAL, LLC
To: EDWARDS LIFESCIENCES CORPORATION
Reel/Frame 074374/0978 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2026
From: ROWE, STANTON J.; SCHWARTZ, ROBERT S.; RABITO, GLEN; TAFT, ROBERT C.; HOWARD, ELLIOT; SIEGEL, ALEXANDER; PASSMAN, JOSEPH
To: NXT BIOMEDICAL, LLC
Reel/Frame 074154/0959 →
Continuity (6)
Continuation 16714611 · Dec 13, 2019
Provisional Application 62942631 · Dec 2, 2019
Provisional Application 62896144 · Sep 5, 2019
Provisional Application 62802656 · Feb 7, 2019
Provisional Application 62779380 · Dec 13, 2018
Related Publication 20210338240A1 · Nov 4, 2021
References Cited (28)
US 5113862A · Mortazavi · 1992 [cited by applicant]
US 5662711A · Douglas · 1997 [cited by applicant]
US 5743259A · Kruse · 1998 [cited by examiner]
US 5797879A · DeCampli · 1998 [cited by applicant]
US 20020179098A1 · Makower et al. · 2002 [cited by applicant]
US 20040193231A1 · David · 2004 [cited by examiner]
US 20040249335A1 · Faul · 2004 [cited by examiner]
US 20050021092A1 · Yun · 2005 [cited by examiner]
US 20140018649A1 · Jespersen · 2014 [cited by examiner]
US 20160031903A1 · Nakai · 2016 [cited by examiner]
US 20170182277A1 · Niklewski · 2017 [cited by examiner]
US 20170232241A1 · Brenneman et al. · 2017 [cited by applicant]
US 20180153440A1 · Lee et al. · 2018 [cited by applicant]
US 20190153440A1 · Kantardzhieva · 2019 [cited by examiner]
US 20190343579A1 · Tandri · 2019 [cited by examiner]
JP H04261647A · 1992 [cited by applicant]
JP 2001500033A · 2001 [cited by applicant]
JP 2003503125A · 2003 [cited by applicant]
JP 2017521214A · 2017 [cited by applicant]
WO WO1998007399A1 · 1998 [cited by applicant]
WO WO1999039633A1 · 1999 [cited by applicant]
WO WO2016007851A1 · 2016 [cited by applicant]
WO WO2018125822A2 · 2018 [cited by applicant]
Japanese Patent Office, Office Action dated Oct. 3, 2023 with English translation in Japanese Patent Application No. 2021-533658, 6 pages. [cited by applicant]
WIPO, U.S. International Search Authority, International Search Report and Written Opinion mailed Feb. 25, 2020 in International Patent Application No. PCT/US2019/066399, 8 pages. [cited by applicant]
WIPO, U.S. International Preliminary Examining Authority, International Preliminary Report on Patentability mailed Sep. 4, 2020 in International Patent Application No. PCT/US2019/066399, 22 pages. [cited by applicant]
European Patent Office, Extended European Search Report dated Jan. 3, 2023 in European Patent Application No. 19894407.6, 9 pages. [cited by applicant]
Canadian Intellectual Property Office, Office Action dated Jan. 14, 2025 in Canadian Patent Application No. 3,123,011, 10 pages. [cited by applicant]