IP Library › Granted Patent US 12,558,377
Granted Patent B2
US 12,558,377 · App. 17/969,461 · Granted Feb 24, 2026

Immunocompatible chorionic membrane products

Inventors: Samson Tom (Baltimore, MD); Alla Danilkovitch (Columbia, MD); Dana Yoo (Falls Church, VA); Timothy Jansen (Baltimore, MD); Jin-Qiang Kuang (Woodstock, MD); Jennifer Michelle Marconi (Glen Burnie, MD)
Assignee: OSIRIS THERAPEUTICS, INC.
A61K35/28A01N1/125A61K35/50A61K38/1825A61K38/1841A61K38/39A61K38/57C12N5/0605C12N2500/02C12N2501/115C12N2502/025
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Quick Facts
Patent No.
US 12,558,377
App. No.
17/969,461
Granted
Feb 24, 2026
Kind
B2
Abstract

Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

Claims (15)

1 . A method of treating a skin wound, the method comprising topically applying to the skin wound a placental product comprising a chorionic membrane,

wherein the chorionic membrane is substantially free of trophoblasts, and

wherein the chorionic membrane comprises:

one or more matrix metalloproteases (MMPs) comprising MMP-9 and TIMP-1, wherein a ratio of MMP-9 to TIMP-1 is from about 7-10 to 1; and

viable cells native to the chorionic membrane,

wherein at least 70% of the cells native to the chorionic membrane are viable, and

wherein the viable cells comprise mesenchymal stem cells (MSCs) and fibroblasts wherein the placental product is cryopreserved, and wherein the method further comprises thawing the placental product prior to applying the placental product to the skin wound.

2 . The method of claim 1 , wherein the skin wound is selected from a chronic wound, an ulcer, a diabetic ulcer, a foot ulcer, a diabetic foot ulcer, a venous ulcer, a venous leg ulcer, a leg ulcer, a pressure ulcer, a burn, a thermal burn, a chemical burn, a partial thickness burn, or a full thickness burn.

3 . The method of claim 1 , wherein the skin wound is selected from a laceration, a scrape, an incision, a puncture, a wound caused by a projectile, an epidermal wound, a dermal wound, a surgical wound, an acute wound, a congenital wound, a toxic epidermal necrolysis, an epidermolysis bullosa, or a pyoderma gangrenosum.

4 . The method of claim 1 , wherein less than 5% of cells of the chorionic membrane are CD14+ macrophages.

5 . The method of claim 1 , wherein the chorionic membrane comprises one or more therapeutic factors native to the chorionic membrane.

6 . The method of claim 1 , wherein the chorionic membrane comprises extracellular matrix native to the chorionic membrane.

7 . The method of claim 1 , wherein the chorionic membrane is immunocompatible.

8 . The method of claim 1 , wherein the placental product further comprises a cryopreservation medium.

9 . The method of claim 1 , wherein the placental product further comprises an amniotic membrane wherein the amniotic membrane comprises a layer of amniotic epithelial cells.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2022
From: TOM, SAMSON; DANILKOVITCH, ALLA; YOO, DANA; JANSEN, TIMOTHY; KUANG, JIN-QIANG; MARCONI, JENNIFER MICHELLE
To: OSIRIS THERAPEUTICS, INC.
Reel/Frame 061473/0753 →
Continuity (7)
Continuation 16296463 · Mar 8, 2019
Continuation 14291256 · May 30, 2014
Continuation 13030507 · Feb 18, 2011
Provisional Application 61369562 · Jul 30, 2010
Provisional Application 61338464 · Feb 18, 2010
Provisional Application 61338489 · Feb 18, 2010
Related Publication 20230113145A1 · Apr 13, 2023
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