IP Library › Granted Patent US 12,558,466
Granted Patent B2
US 12,558,466 · App. 18/079,278 · Granted Feb 24, 2026

Hemodiafiltration system with disposable pumping unit

Inventors: Ying-Cheng Lo (Green Oaks, IL); Robert W. Childers (New Port Richey, FL); Thomas D. Kelly (Highland Park, IL); Justin Rohde (Des Plaines, IL)
Assignees: Vantive US Healthcare LLC; Vantive Health GmbH
A61M1/1639A61M1/1522A61M1/153A61M1/154A61M1/155A61M1/1561A61M1/15625A61M1/1563A61M1/1565A61M1/159A61M1/16A61M1/1603A61M1/1605A61M1/1635A61M1/166A61M1/28A61M1/284A61M1/34A61M1/36224A61M1/36225A61M1/362261A61M1/362262A61M1/362265A61M1/3627A61M1/3401A61M1/36222A61M2205/127A61M2205/3331A61M2205/3368A61M2205/502Y10T29/49826
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Quick Facts
Patent No.
US 12,558,466
App. No.
18/079,278
Granted
Feb 24, 2026
Kind
B2
Abstract

A hemodiafiltration system with a disposable pumping unit is disclosed. An example system includes a medical fluid pump actuator, a medical fluid heater, a blood filter and a disposable unit. The example disposable unit includes a medical fluid cassette portion including a medical fluid cassette housing configured to be operatively connected to the medical fluid pump actuator to pump medical fluid through the medical fluid cassette portion when the medical fluid cassette portion is in fluid communication with a medical fluid source. The example medical fluid cassette portion is also configured to be placed in fluid communication with the blood filter and with an extracorporeal circuit communicating with the blood filter, the fluid communication enabling hemodiafiltration to be performed. The example disposable unit also includes a heater bag configured to be placed in operable communication with the medical fluid heater and in fluid communication with the medical fluid cassette portion.

Claims (47)

1 . A hemodiafiltration system comprising:

a medical fluid pump actuator;

a medical fluid heater that is spaced away from the medical fluid pump actuator;

a blood filter;

a peristaltic blood pump actuator; and

a disposable unit including

a medical fluid cassette portion including a medical fluid cassette housing configured to be operatively connected to the medical fluid pump actuator to pump medical fluid through the medical fluid cassette portion when the medical fluid cassette portion is in fluid communication with a medical fluid source, the medical fluid cassette portion configured to be placed in fluid communication with the blood filter and with an extracorporeal circuit communicating with the blood filter, the fluid communication enabling hemodiafiltration to be performed,

a heater bag configured to be placed in operable communication with the medical fluid heater and in fluid communication with the medical fluid cassette portion via a to-heater tube and a from-heater tube, wherein the heater bag is spaceable away from the medical fluid cassette portion, and wherein the spacing of the medical fluid heater away from the medical fluid pump actuator enables the heater bag to be placeable in operable communication with the medical fluid heater while the medical fluid cassette portion is operably connected to the medical fluid pump actuator, and

a blood cassette portion having a blood cassette housing holding at least a portion of the extracorporeal circuit, the blood cassette portion configured to be operatively connected to the peristaltic blood pump actuator to pump blood through the blood cassette portion when the blood cassette portion is in fluid communication with a blood source, the blood cassette portion in fluid communication with the blood filter,

wherein the medical fluid cassette housing is separate from the blood cassette housing.

2 . The hemodiafiltration system of claim 1 , wherein the medical fluid pump actuator is a peristaltic medical fluid pump actuator.

3 . The hemodiafiltration system of claim 1 , further comprising a hemodiafiltration machine including (i) the peristaltic blood pump actuator located at a blood pump portion of the machine operable with the blood cassette portion of the disposable unit, (ii) the medical fluid pump actuator located at a medical fluid pump portion of the machine operable with the medical fluid cassette portion of the disposable unit, and (iii) the medical fluid heater located at a heater portion of the machine operable with the heater bag of the disposable unit.

4 . The hemodiafiltration system of claim 3 , wherein the heater portion of the machine is located between the medical fluid pump portion of the machine and the blood pump portion of the machine.

5 . The hemodiafiltration system of claim 3 , wherein the medical fluid pump portion of the machine is located between the heater portion of the machine and the blood pump portion of the machine.

6 . The hemodiafiltration system of claim 3 , wherein the heater bag in operation is placed between the heater portion of the machine and a door hinged to the machine.

7 . The hemodiafiltration system of claim 6 , wherein the heater bag is positioned vertically between the heater portion of the machine and the door.

8 . The hemodiafiltration system of claim 1 , wherein the blood cassette housing is located at a first side of the disposable unit and the medical fluid cassette housing is located at a second side of the disposable unit.

9 . A hemodiafiltration system comprising:

a medical fluid pump actuator;

a medical fluid heater that is spaced away from the medical fluid pump actuator;

a blood filter;

a peristaltic blood pump actuator; and

a disposable unit including

a medical fluid cassette portion including a medical fluid cassette housing configured to be operatively connected to the medical fluid pump actuator to pump medical fluid through the medical fluid cassette portion when the medical fluid cassette portion is in fluid communication with a medical fluid source, the medical fluid cassette portion configured to be placed in fluid communication with the blood filter and with an extracorporeal circuit communicating with the blood filter, the fluid communication enabling hemodiafiltration to be performed,

a heater bag configured to be placed in operable communication with the medical fluid heater and in fluid communication with the medical fluid cassette portion via a to-heater tube and a from-heater tube, wherein the heater bag is spaceable away from the medical fluid cassette portion, and wherein the spacing of the medical fluid heater away from the medical fluid pump actuator enables the heater bag to be placeable in operable communication with the medical fluid heater while the medical fluid cassette portion is operably connected to the medical fluid pump actuator, and

a blood cassette portion having a blood cassette housing holding at least a portion of the extracorporeal circuit, the blood cassette portion configured to be operatively connected to the peristaltic blood pump actuator to pump blood through the blood cassette portion when the blood cassette portion is in fluid communication with a blood source, the blood cassette portion in fluid communication with the blood filter,

wherein the blood cassette portion of the disposable unit includes an air separation chamber for separating air from pumped blood, the air separation chamber in fluid communication with a to-patient line of the extracorporeal circuit.

10 . The hemodiafiltration system of claim 9 , wherein the blood cassette housing is integrated with the medical fluid cassette housing.

11 . The hemodiafiltration system of claim 9 , wherein the medical fluid cassette housing holds a medical fluid line leading to an inlet of the blood filter.

12 . The hemodiafiltration system of claim 11 , wherein the medical fluid line is additionally directly connected to the extracorporeal circuit.

13 . A hemodiafiltration system comprising:

a medical fluid pump actuator;

a medical fluid heater;

a blood filter;

a blood pump actuator; and

a disposable unit including

a medical fluid cassette portion including a medical fluid cassette housing configured to be operatively connected to the medical fluid pump actuator to pump medical fluid through the medical fluid cassette portion when the medical fluid cassette portion is in fluid communication with a medical fluid source, the medical fluid cassette portion configured to be placed in fluid communication with the blood filter, the fluid communication enabling hemodiafiltration to be performed,

a heater bag configured to be placed in operable communication with the medical fluid heater and in fluid communication with the medical fluid cassette portion via a to-heater tube and a from-heater tube, wherein the heater bag is spaceable away from the medical fluid cassette portion, and

a blood cassette portion having a blood cassette housing holding at least a portion of an extracorporeal circuit, the blood cassette portion configured to be operatively connected to the blood pump actuator to pump blood through the blood cassette portion when the blood cassette portion is in fluid communication with a blood source, the blood cassette portion in fluid communication with the blood filter,

wherein the medical fluid cassette housing is separate from the blood cassette housing.

14 . The hemodiafiltration system of claim 13 , wherein the medical fluid pump actuator is a peristaltic medical fluid pump actuator and the blood pump actuator is a peristaltic blood pump actuator.

15 . The hemodiafiltration system of claim 13 , further comprising a hemodiafiltration machine including (i) the blood pump actuator located at a blood pump portion of the machine operable with the blood cassette portion of the disposable unit, (ii) the medical fluid pump actuator located at a medical fluid pump portion of the machine operable with the medical fluid cassette portion of the disposable unit, and (iii) the medical fluid heater located at a heater portion of the machine operable with the heater bag of the disposable unit.

16 . The hemodiafiltration system of claim 15 , wherein the heater portion of the machine is located between the medical fluid pump portion of the machine and the blood pump portion of the machine.

17 . The hemodiafiltration system of claim 15 , wherein the medical fluid pump portion of the machine is located between the heater portion of the machine and the blood pump portion of the machine.

18 . The hemodiafiltration system of claim 15 , wherein the heater bag in operation is placed between the heater portion of the machine and a door hinged to the machine.

19 . The hemodiafiltration system of claim 18 , wherein the heater bag is positioned vertically between the heater portion of the machine and the door.

20 . The hemodiafiltration system of claim 13 , wherein the blood cassette housing is located at a first side of the disposable unit and the medical fluid cassette housing is located at a second side of the disposable unit.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2025
From: BAXTER INTERNATIONAL INC.
To: VANTIVE US HEALTHCARE LLC
Reel/Frame 073413/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2025
From: BAXTER HEALTHCARE SA
To: VANTIVE HEALTH GMBH
Reel/Frame 073438/0790 →
SECURITY INTEREST Recorded Jan 31, 2025
From: VANTIVE US HEALTHCARE LLC; GAMBRO RENAL PRODUCTS, INC.
To: ARES CAPITAL CORPORATION
Reel/Frame 070076/0701 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 22, 2022
From: LO, YING-CHENG; CHILDERS, ROBERT W.; KELLY, THOMAS D.; ROHDE, JUSTIN
To: BAXTER INTERNATIONAL INC.; BAXTER HEALTHCARE SA
Reel/Frame 062181/0520 →
Continuity (6)
Continuation 16160511 · Oct 15, 2018
Continuation 15888566 · Feb 5, 2018
Continuation 14708614 · May 11, 2015
Continuation 13213692 · Aug 19, 2011
Continuation 11530842 · Sep 11, 2006
Related Publication 20230116321A1 · Apr 13, 2023
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