IP Library › Granted Patent US 12,606,600
Granted Patent B2
US 12,606,600 · App. 17/310,582 · Granted Apr 21, 2026

Antimicrobial NCR2 peptides

Inventors: Dilip M. Shah (St. Louis, MO); Siva L. S. Velivelli (St. Louis, MO)
Assignee: Donald Danforth Plant Science Center
C07K14/415A01N63/60C12N15/8282
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Quick Facts
Patent No.
US 12,606,600
App. No.
17/310,582
Granted
Apr 21, 2026
Kind
B2
Abstract

Antimicrobial nodule specific cysteine rich (NCR2) peptides and proteins are disclosed along with compositions comprising the NCR2 peptides or NCR2 proteins and transgenic or genetically edited plants or microorganisms that express the NCR2 peptides or proteins to inhibit growth of pathogenic microbes. Such NCR2 peptides, proteins, compositions, plants, and microorganisms can provide for inhibition of fungal and oomycete growth.

Claims (9)

1 . A composition comprising an antimicrobial peptide comprising the amino acid sequence of SEQ ID NO: 1 or the amino acid sequence of SEQ ID NO: 1 and a C-terminal cysteine residue

and an agriculturally, pharmaceutically, or veterinarily acceptable carrier, diluent, or excipient.

2 . The composition of claim 1 , wherein the antimicrobial peptide further comprises an operably linked second antimicrobial peptide and wherein the second antimicrobial peptide is a defensin or nodule specific cysteine rich (NCR) peptide.

3 . The composition of claim 1 , wherein the antimicrobial peptide and the second antimicrobial peptide are operably linked by a spacer peptide.

4 . A medical device comprising the device and the composition of claim 1 , wherein the device comprises at least one surface that is topically coated and/or impregnated with the composition.

5 . The medical device of claim 4 , wherein said device is a stent, a catheter, a contact lens, a condom, a patch, or a diaphragm.

6 . The composition of claim 2 , wherein the second antimicrobial peptide is a defensin and wherein the defensin comprises an antimicrobial peptide having at least 99% or 100% sequence identity across the entire length of SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, or SEQ ID NO: 17.

7 . The composition of claim 1 , wherein the antimicrobial peptide comprises the amino acid sequence of SEQ ID NO: 1 and a C-terminal cysteine residue.

8 . The composition of claim 1 , wherein the antimicrobial peptide comprises SEQ ID NO: 1 and does not have a C-terminal cysteine residue.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 31, 2021
From: SHAH, DILIP M.; VELIVELLI, SIVA L.S.
To: DONALD DANFORTH PLANT SCIENCE CENTER
Reel/Frame 057337/0561 →
Continuity (2)
Provisional Application 62811297 · Feb 27, 2019
Related Publication 20220098249A1 · Mar 31, 2022
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