Antimicrobial compositions and methods of use thereof
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
1. A method of treating a gram positive or gram negative bacterial infection, comprising:
administering to a subject in need thereof an effective amount of an antimicrobial peptide comprising the amino acid sequence of SEQ ID NO: 3 and a cell penetrating peptide (CPP) domain.
2. The method of claim 1 , wherein said antimicrobial peptide comprises the amino acid sequence of SEQ ID NO: 5.
3. The method of claim 1 , wherein said antimicrobial peptide further comprises a second antimicrobial domain, wherein said second antimicrobial domain is different from said first antimicrobial domain.
4. The method of claim 1 , wherein said antimicrobial peptide is administered in combination with another antimicrobial agent.
5. The method of claim 4 , wherein said another antimicrobial agent is another antimicrobial peptide.
6. The method of claim 4 , wherein said antimicrobial peptide is a PEGylated peptide.
7. A method of treating a gram positive or gram negative bacterial infection, comprising:
administering to a subject in need of such treatment an effective amount of an in vivo expression vector that encodes an antimicrobial peptide comprising the amino sequence of SEQ ID NO: 3 and a cell penetrating peptide (CPP) domain,
wherein said in vivo expression vector expresses said antimicrobial peptide in said subject.
8. The method of claim 7 , wherein said antimicrobial peptide comprises the amino acid sequence of SEQ ID NO: 5.