IP Library › Granted Patent US 12,201,584
Granted Patent B2
US 12,201,584 · App. 17/072,250 · Granted Jan 21, 2025

Anaerobic blood storage containers

Inventors: Tatsuro Yoshida (West Newton, MA); Rafael Cordero (Bedford, MA); Jancarlo Sarita (Lynn, MA); Michael Zocchi (Arlington, VA); Michael Wolf (Brookline, MA); Philip Michael Keegan (Newton, MA); Narendran Renganathan (Plano, TX); Jeffrey Karl Sutton (Medway, MA)
Assignee: Hemanext Inc.
A61J1/10A01N1/0263A61J1/1462A61J1/1468A61J1/1475A61J1/1487A61J1/18B32B1/00B32B3/06B32B3/08B32B7/12B32B27/08B32B27/18B32B27/205B32B27/286B32B27/306B32B27/32B32B27/34B32B27/36B65D81/268A61M1/0209B32B2250/24B32B2307/308B32B2307/412B32B2307/414B32B2307/514B32B2307/7242B32B2307/7244B32B2307/7246B32B2307/7265B32B2439/80B32B2535/00B65D81/266
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Quick Facts
Patent No.
US 12,201,584
App. No.
17/072,250
Granted
Jan 21, 2025
Kind
B2
Abstract

A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.

Claims (25)

1. A blood storage device 20 for storing oxygen depleted blood comprising:

an outer receptacle 201 substantially impermeable to oxygen;

an inner collapsible blood container 202 comprising polyvinyl chloride (PVC) doped with a plasticizer;

at least one inlet/outlet 30 that is substantially impermeable to oxygen passing through said outer receptacle 201 and that is in fluid communication with said inner collapsible container 202 ; and

an oxygen sorbent 207 situated within said outer receptacle 201 ,

wherein said at least one inlet/outlet 30 comprises a unitary tube that is substantially impermeable to oxygen comprising tubing 304 , a bond 302 , and tubing 205 , wherein said unitary tube is a barrier traversing tube 305 comprising an outer layer 308 , an inner layer 306 , and an intermediate oxygen barrier layer 307 .

2. The blood storage device of claim 1 , wherein said plasticizer is citrate.

3. The blood storage device of claim 1 , wherein said plasticizer is bis (7-methyloctyl) cyclohexane-1,2-dicarboxylate (DINCH).

4. The blood storage device of claim 1 , wherein said outer receptacle 201 consists of a heat sealable polyethylene (PE) inner layer, an alumina barrier middle layer, and a polyethylene terephthalate (PET) outer layer.

5. The blood storage device of claim 1 , wherein said outer receptacle 201 comprises polyethylene terephthalate (PET).

6. The blood storage device of claim 4 , wherein said PET further comprises a barrier coating of silica or alumina.

7. The blood storage device of claim 1 , wherein said outer receptacle further comprises a polyolefin inner layer.

8. The blood storage device of claim 1 , wherein said inner collapsible blood container 202 comprises PVC doped with diethylhexyl phthalate (DEHP).

9. The blood storage device of claim 1 , wherein said inner collapsible blood container 202 has a moisture vapor transmission rate (MVTR) of 10 g/m 2 /24 hrs or less when tested at a temperature of 23±2° C.

10. The blood storage device of claim 1 , wherein said oxygen sorbent 207 further comprises a carbon dioxide sorbent.

11. The blood storage device of claim 10 , wherein said oxygen sorbent 207 is provided as a single sachet comprising 8 grams of sorbent, situated outside of said inner collapsible blood container 202 .

12. The blood storage device of claim 1 , wherein said oxygen sorbent 207 has a capacity of at least 100 cc oxygen.

13. The blood storage device of claim 1 , wherein said blood storage device 20 includes from 0.5 to 150 grams of said oxygen sorbent 207 in one or more sachets.

14. The blood storage device of claim 1 , wherein said tubing 205 comprises PVC having a Barrer value of less than 3 Barrer.

15. The blood storage device of claim 1 , wherein said outer layer 308 consists of polyethylene (PE), said inner layer 306 consists of PVC, and said intermediate oxygen barrier layer 307 consists of ethylene-vinyl acetate (EVA).

16. The blood storage device of claim 1 , further comprising a spacer 213 and a headspace comprising a volume between said outer receptacle 201 and said inner collapsible blood container 202 , wherein the headspace is maintained at a partial pressure of oxygen (PO 2 ) of less than 15 millimeters of mercury (mmHg) during a storage period of at least 64 days.

17. The blood storage device of claim 16 , wherein said spacer 213 is selected from the group consisting of a mesh, a molded mat, a woven mat, a non-woven mat, an open cell foam, a strand veil, and a strand mat.

18. The blood storage device of claim 1 , further comprising an oxygen indicator.

19. The blood storage device of claim 1 , wherein said oxygen depleted blood stored in said inner collapsible blood container 202 maintains an oxygen saturation level (SO 2 ) during a storage period that increases by less than 5% over said oxygen saturation level at the beginning of storage.

20. The blood storage device of claim 1 , wherein said inner collapsible blood container 202 has an oxygen permeability of between 3 and 350 Barrer.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2021
From: YOSHIDA, TATSURO; CORDERO, RAFAEL; SARITA, JANCARLO; ZOCCHI, MICHAEL; WOLF, MICHAEL; KEEGAN, PHILIP MICHAEL; RENGANATHAN, NARANDRAN; SUTTON, JEFFREY KARL
To: NEW HEALTH SCIENCES, INC.
Reel/Frame 056085/0866 →
CHANGE OF NAME Recorded Apr 29, 2021
From: NEW HEALTH SCIENCES, INC.
To: HEMANEXT INC.
Reel/Frame 056097/0264 →
Continuity (6)
Continuation 15708925 · Sep 19, 2017
Continuation 15475898 · Mar 31, 2017
Continuation PCTUS2016029069 · Apr 22, 2016
Provisional Application 62151957 · Apr 23, 2015
Provisional Application 62151839 · Apr 23, 2015
Related Publication 20210100721A1 · Apr 8, 2021
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