Granted Patent B2

US 12,558,427 · App. 17/597,638 · Granted Feb 24, 2026

Inventors: Nan Ji (Arlington, MA); Michael D. Sintchak (Winchester, MA); Yi Zhang (Belmont, MA); Xiaozhang Zheng (Lexington, MA)

Assignee: Kymera Therapeutics, Inc.

A61K47/55C07D401/14C07D413/14

Abstract

Claims (23)

1 . A compound of formula I′:

or a pharmaceutically acceptable salt thereof, wherein:

X 1 is —C(R) 2 or —C(O);

X 2 and X 3 are —C(O)—;

Z 1 and Z 2 are a carbon atom;

Ring A x is benzo;

L x is —O—;

each R is independently selected from hydrogen or C 1-6 alkyl;

R y is

Ring B x is phenyl;

is a single or double bond;

w is 0;

x is 0; and

y is 1;

L is

IRAK is

2 . The compound of claim 1 , wherein said compound is selected from any of the following formulae:

or a pharmaceutically acceptable salt thereof.

3 . The compound claim 1 , wherein said compound is selected from:

or a pharmaceutically acceptable salt thereof.

4 . A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

5 . The pharmaceutical composition according to claim 4 , further comprising an additional therapeutic agent.

6 . The compound of claim 1 , wherein L is

Assignments (1)

Continuity (5)

References Cited (400)