IP Library › Granted Patent US 12,533,312
Granted Patent B2
US 12,533,312 · App. 17/836,079 · Granted Jan 27, 2026

Method and system for preventing sore throat in humans

Inventor: Joseph E. Kovarik (Englewood, CO)
Assignee: Seed Health, Inc.
A61K9/006A61F5/566A61K9/7007A61K31/047A61K35/74A61K35/741A61K35/744A61K45/06A61K49/0045A61K49/0069
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Quick Facts
Patent No.
US 12,533,312
App. No.
17/836,079
Granted
Jan 27, 2026
Kind
B2
Abstract

A method and system to prevent sore throat infections in humans includes the administration of an active ingredient to a site on the mucus membranes of the throat of a human that inhibits adherence and promotes desorption of S. pyogenes to soft tissue surfaces, such as the pharyngeal and oral mucosa of a human. A mucoadhesive strip having a surface topography that resists bioadhesion of undesired bacteria that are typically present in a human's mouth is preferably employed and that has one or more encapsulated agents selected from the group consisting of an antibiotic; lactic acid bacteria; S. pyogenes modified by a CRISPR-Cas system to reduce one or more virulence factors; and a breath mint solution.

Claims (11)

1 . A system for reducing the likelihood of Streptococcus pyogenes infections in a human being, comprising, a solid strip having a first and second side, said first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person's mouth, and wherein said strip includes one of an analgesic, and a lactic acid bacteria that coaggregates with Streptococcus pyogenes , said lactic acid bacteria selected from the group consisting of Lactobacillus lactis, Lactobacillus helveticus, Lactobacillus jensenii, Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus amylovorus, Lactobacillus delbrueckii, Lactobacillus casei, Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus pentosus, Lactobacillus rhamnosus, Lactobacillus curvatus, Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus fructivorans, Lactobacillus hilgardii, Lactobacillus fermentum, Lactobacillus viridescens, Bifidobacterium bifidum , and Lactobacillus ingluviei , wherein said strip has an analgesic encapsulated inside a frangible encapsulation structure that is broken by a person pressing against said strip with the person's tongue and wherein said encapsulation structure is devoid of liposomes.

2 . The system of claim 1 , wherein said strip comprises at least one of Lactobacillus crispatus, Lactobacillus plantarum , and Lactobacillus brevis.

3 . The system of claim 1 , wherein said strip includes at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof.

4 . The system of claim 1 wherein said strip is dissolvable in a person's mouth within a period of 3 hours.

5 . The system of claim 1 , wherein said strip further includes at least 200 mg of xylitol.

6 . The system of claim 1 , wherein the strip comprises lactic acid bacteria comprising Lactobacillus crispatus.

7 . A system for reducing the likelihood of Streptococcus pyogenes infections in a human being, comprising, a solid strip having a first and second side, said first side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person's mouth, and wherein said strip includes a lactic acid bacteria that coaggregates with Streptococcus pyogenes , wherein said lactic acid bacteria comprises Lactobacillus crispatus , and wherein said lactic acid bacteria is encapsulated inside a frangible encapsulation structure that is broken by a person pressing against said strip with the person's tongue and wherein said encapsulation structure is devoid of liposomes.

8 . The system of claim 7 , wherein said strip further includes at least 200 mg of xylitol.

9 . The system of claim 1 , wherein said strip reduces the adhesion of S. pyogenes to an epithelial tissue of a person.

10 . The system of claim 7 , wherein the strip further comprises an analgesic encapsulated inside a frangible encapsulation structure that is broken by a person pressing against said strip with the person's tongue and wherein said encapsulation structure is devoid of liposomes.

11 . The system of claim 7 , wherein said strip includes at least one polymer selected from the group consisting of pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, tragacanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl polymer, amylose, high amylose starch, hydroxypropylated high amylose starch, dextrin, pectin, chitin, chitosan, levan, elsinan, collagen, gelatin, zein, gluten, soy protein isolate, whey protein isolate, casein and mixtures thereof.

Assignments (2)
SECURITY INTEREST Recorded Jul 21, 2026
From: SEED HEALTH, INC.
To: JPMORGAN CHASE BANK, N.A., AS LENDER
Reel/Frame 076028/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2022
From: KOVARIK, JOSEPH E.
To: SEED HEALTH, INC.
Reel/Frame 060316/0182 →
Continuity (27)
Continuation In Part 16884772 · May 27, 2020
Continuation In Part 16136950 · Sep 20, 2018
Continuation 15385278 · Dec 20, 2016
Continuation In Part 15270034 · Sep 20, 2016
Continuation In Part 15228454 · Aug 4, 2016
Continuation In Part 14954074 · Nov 30, 2015
Continuation In Part 14752192 · Jun 26, 2015
Continuation In Part 14611458 · Feb 2, 2015
Continuation In Part 14574517 · Dec 18, 2014
Continuation In Part 14502097 · Sep 30, 2014
Continuation 14307651 · Jun 18, 2014
Continuation In Part 14225503 · Mar 26, 2014
Continuation In Part 14079054 · Nov 13, 2013
Continuation 13425913 · Mar 21, 2012
Continuation 13367052 · Feb 6, 2012
Provisional Application 62275341 · Jan 6, 2016
Provisional Application 62274550 · Jan 4, 2016
Provisional Application 62387405 · Dec 24, 2015
Provisional Application 62387404 · Dec 24, 2015
Provisional Application 62072476 · Oct 30, 2014
Provisional Application 62053926 · Sep 23, 2014
Provisional Application 62014855 · Jun 20, 2014
Provisional Application 61919297 · Dec 20, 2013
Provisional Application 61556023 · Nov 4, 2011
Provisional Application 61467767 · Mar 25, 2011
Provisional Application 61439652 · Feb 4, 2011
Related Publication 20220296500A1 · Sep 22, 2022
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