IP Library › Granted Patent US 12,624,089
Granted Patent B2
US 12,624,089 · App. 17/854,023 · Granted May 12, 2026

Antigen-binding molecule for promoting disappearance of antigen via FcγRIIB

Inventors: Tomoyuki Igawa (Shizuoka, JP); Atsuhiko Maeda (Shizuoka, JP); Yuki Iwayanagi (Shizuoka, JP); Kenta Haraya (Shizuoka, JP); Hitoshi Katada (Shizuoka, JP); Shojiro Kadono (Kanagawa, JP); Futa Mimoto (Shizuoka, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha
C07K16/00C07K16/2866C07K16/303A61K2039/505C07K2317/41C07K2317/52C07K2317/524C07K2317/526C07K2317/71C07K2317/72C07K2317/76C07K2317/92C07K2317/94
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Quick Facts
Patent No.
US 12,624,089
App. No.
17/854,023
Granted
May 12, 2026
Kind
B2
Abstract

The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an FcγR-binding domain having Fcγ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.

Claims (12)

1 . A pharmaceutical composition comprising an antibody comprising a heavy chain constant region comprising SEQ ID NO: 14 with at least the following substitutions: L234Y/P238D/A330K, wherein all position numbers are by EU numbering.

2 . The pharmaceutical composition of claim 1 , wherein the heavy chain constant region further comprises a V264I substitution, by EU numbering.

3 . The pharmaceutical composition of claim 1 , wherein the heavy chain constant region further comprises a K439E substitution, by EU numbering.

4 . The pharmaceutical composition of claim 2 , wherein the heavy chain constant region further comprises a K439E substitution, by EU numbering.

5 . The pharmaceutical composition of claim 1 , wherein the antibody further comprises a human or humanized heavy chain variable domain, a human or humanized light chain variable domain, and a human light chain constant region.

6 . The pharmaceutical composition of claim 2 , wherein the antibody further comprises a human or humanized heavy chain variable domain, a human or humanized light chain variable domain, and a human light chain constant region.

7 . A pharmaceutical composition comprising an antibody comprising a heavy chain constant region comprising SEQ ID NO: 14 with at least the following substitutions: L234Y/P238D/A330K, and with a deletion of the two carboxy-terminal amino acids, wherein all position numbers are by EU numbering.

8 . The pharmaceutical composition of claim 7 , wherein the heavy chain constant region further comprises a V264I substitution, by EU numbering.

9 . The pharmaceutical composition of claim 7 , wherein the heavy chain constant region further comprises a K439E substitution, by EU numbering.

10 . The pharmaceutical composition of claim 8 , wherein the heavy chain constant region further comprises a K439E substitution, by EU numbering.

11 . The pharmaceutical composition of claim 7 , wherein the antibody further comprises a human or humanized heavy chain variable domain, a human or humanized light chain variable domain, and a human light chain constant region.

12 . The pharmaceutical composition of claim 8 , wherein the antibody further comprises a human or humanized heavy chain variable domain, a human or humanized light chain variable domain, and a human light chain constant region.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 5, 2022
From: IGAWA, TOMOYUKI; MAEDA, ATSUHIKO; IWAYANAGI, YUKI; HARAYA, KENTA; KATADA, HITOSHI; KADONO, SHOJIRO; MIMOTO, FUTA
To: CHUGAI SEIYAKU KABUSHIKI KAISHA
Reel/Frame 061316/0678 →
Priority Claims (3)
WO PCT/JP2012/054624 · Feb 24, 2012 · international
JP 2012-185866 · Aug 24, 2012 · national
WO PCT/JP2012/075092 · Sep 28, 2012 · international
Continuity (2)
Division 14379825
Related Publication 20230140797A1 · May 4, 2023
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