IP Library › Granted Patent US 12,194,078
Granted Patent B2
US 12,194,078 · App. 17/869,863 · Granted Jan 14, 2025

Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant

Inventor: Lloyd Johnston (Belmont, MA)
Assignee: Cartesian Therapeutics, Inc.
A61K38/44A61K9/51A61K9/5153A61K38/43A61K45/00A61P29/00A61P37/06A61K31/165A61K31/192A61K31/436A61K31/445A61K31/573A61K45/06A61K2300/00C12Y107/03003
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,194,078
App. No.
17/869,863
Granted
Jan 14, 2025
Kind
B2
Abstract

Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.

Claims (22)

1. A method, comprising:

concomitantly administering to a subject in need thereof 1) a composition comprising synthetic nanocarriers comprising an immunosuppressant and 2) a composition comprising an uricase; and

further comprising administering 3) a composition comprising an anti-inflammatory therapeutic,

wherein the composition comprising an anti-inflammatory therapeutic is administered concomitantly with the composition comprising synthetic nanocarriers comprising an immunosuppressant and the composition comprising an uricase, and wherein the concomitant administration of 1), 2), and 3) is repeated on a monthly basis.

2. The method of claim 1 , wherein the composition comprising an anti-inflammatory therapeutic is administered prior to the composition comprising synthetic nanocarriers comprising an immunosuppressant and the composition comprising an uricase.

3. The method of claim 1 , wherein the anti-inflammatory therapeutic is administered at least once prior.

4. The method of claim 1 , wherein the anti-inflammatory therapeutic is administered a week prior.

5. The method of claim 1 , wherein the anti-inflammatory therapeutic is a nonsteroidal anti-inflammatory drug (NSAID).

6. The method of claim 1 , wherein the anti-inflammatory therapeutic is colchicine or ibuprofen.

7. The method of claim 1 , wherein the method further comprises administering to the subject one or more compositions comprising an infusion reaction therapeutic.

8. The method of claim 7 , wherein the one or more compositions comprising an infusion reaction therapeutic comprises an antihistamine and/or a corticosteroid.

9. The method of claim 8 , wherein the antihistamine is fexofenadine.

10. The method of claim 8 , wherein the corticosteroid is methylprednisolone, prednisone or dexamethasone.

11. The method of claim 7 , wherein the one or more compositions comprising an infusion reaction therapeutic is/are administered at least once prior to the composition comprising synthetic nanocarriers comprising an immunosuppressant and the composition comprising an uricase.

12. The method of claim 11 , wherein the composition(s) comprising an infusion reaction therapeutic is administered at least twice prior to the composition comprising synthetic nanocarriers comprising an immunosuppressant and the composition comprising an uricase.

13. The method of claim 7 , wherein the composition(s) comprising an infusion reaction therapeutic is administered within 24 hours of the composition comprising synthetic nanocarriers comprising an immunosuppressant and the composition comprising an uricase.

14. The method of claim 1 , wherein the uricase is pegylated uricase.

15. The method of claim 14 , wherein the pegylated uricase is pegadricase or pegloticase.

16. The method of claim 1 , wherein the immunosuppressant is a mammalian target of rapamycin (mTOR) inhibitor.

17. The method of claim 16 , wherein the mTOR inhibitor is a rapalog.

18. The method of claim 17 , wherein the rapalog is rapamycin.

19. The method of claim 1 , wherein the subject is human.

Assignments (2)
CHANGE OF NAME Recorded Dec 2, 2024
From: SELECTA BIOSCIENCES, INC.
To: CARTESIAN THERAPEUTICS, INC.
Reel/Frame 069469/0723 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 14, 2022
From: JOHNSTON, LLOYD
To: SELECTA BIOSCIENCES, INC.
Reel/Frame 061423/0294 →
Continuity (3)
Continuation 15917742 · Mar 11, 2018
Provisional Application 62470250 · Mar 11, 2017
Related Publication 20230119226A1 · Apr 20, 2023
References Cited (400)
US 5100669A · Hyon et al. · 1992 [cited by applicant]
US 5268455A · Cianciolo · 1993 [cited by applicant]
US 5543158A · Gref et al. · 1996 [cited by applicant]
US 5578325A · Domb et al. · 1996 [cited by applicant]
US 5679347A · Porcelli et al. · 1997 [cited by applicant]
US 5700674A · Koyama et al. · 1997 [cited by applicant]
US 5762904A · Okada et al. · 1998 [cited by applicant]
US 5814617A · Hoffman et al. · 1998 [cited by applicant]
US 5843452A · Wiedmann et al. · 1998 [cited by applicant]
US 5912017A · Mathiowitz et al. · 1999 [cited by applicant]
US 5928647A · Rock · 1999 [cited by applicant]
US 6007845A · Domb et al. · 1999 [cited by applicant]
US 6009548A · Chen et al. · 1999 [cited by applicant]
US 6060082A · Chen et al. · 2000 [cited by applicant]
US 6197229B1 · Ando et al. · 2001 [cited by applicant]
US 6251957B1 · Wilson · 2001 [cited by applicant]
US 6306640B1 · Nicolette · 2001 [cited by applicant]
US 6387397B1 · Chen et al. · 2002 [cited by applicant]
US 6468771B1 · Einerhand et al. · 2002 [cited by applicant]
US 6800296B1 · Langer et al. · 2004 [cited by applicant]
US 6835809B1 · Liu et al. · 2004 [cited by applicant]
US 6838089B1 · Carlsson et al. · 2005 [cited by applicant]
US 6881421B1 · da Silveira et al. · 2005 [cited by applicant]
US 6913915B2 · Ensor et al. · 2005 [cited by applicant]
US 7045508B2 · Scaria · 2006 [cited by applicant]
US 7186699B2 · Harding et al. · 2007 [cited by applicant]
US 7465583B2 · Samulski et al. · 2008 [cited by applicant]
US 7550441B2 · Farokhzad et al. · 2009 [cited by applicant]
US 7727969B2 · Farokhzad et al. · 2010 [cited by applicant]
US 7790449B2 · Gao et al. · 2010 [cited by applicant]
US 7803622B2 · Engelhardt et al. · 2010 [cited by applicant]
US 7884109B2 · Ohlmeyer et al. · 2011 [cited by applicant]
US 8063022B1 · High et al. · 2011 [cited by applicant]
US 8343497B2 · Shi et al. · 2013 [cited by applicant]
US 8367113B2 · Gu et al. · 2013 [cited by applicant]
US 8409842B2 · Clark et al. · 2013 [cited by applicant]
US 8455510B2 · Nan et al. · 2013 [cited by applicant]
US 8568487B2 · Witt et al. · 2013 [cited by applicant]
US 8629151B2 · Zepp et al. · 2014 [cited by applicant]
US 8637255B2 · Wilson et al. · 2014 [cited by applicant]
US 8652487B2 · Maldonado et al. · 2014 [cited by applicant]
US 8654487B2 · Mikani et al. · 2014 [cited by applicant]
US 8679837B2 · Zolotukhin et al. · 2014 [cited by applicant]
US 8865487B2 · Kostka et al. · 2014 [cited by applicant]
US 9005665B2 · Gourapura · 2015 [cited by applicant]
US 9006254B2 · Zepp et al. · 2015 [cited by applicant]
US 9017697B2 · Thomas · 2015 [cited by applicant]
US 9066978B2 · Ilyinskii et al. · 2015 [cited by applicant]
US 9265815B2 · Fraser et al. · 2016 [cited by applicant]
US 9289476B2 · Fraser et al. · 2016 [cited by applicant]
US 9289477B2 · Fraser et al. · 2016 [cited by applicant]
US 9295718B2 · Fraser et al. · 2016 [cited by applicant]
US 9377454B2 · Rosario-Jansen et al. · 2016 [cited by applicant]
US 9636309B2 · Carlyle et al. · 2017 [cited by applicant]
US 9764031B2 · Ilyinskii et al. · 2017 [cited by applicant]
US 9884112B2 · Zepp et al. · 2018 [cited by applicant]
US 9987354B2 · Fraser et al. · 2018 [cited by applicant]
US 9993548B2 · Maldonado et al. · 2018 [cited by applicant]
US 9994443B2 · Zepp et al. · 2018 [cited by applicant]
US 10004802B2 · Kishimoto et al. · 2018 [cited by applicant]
US 10039822B2 · Altreuter et al. · 2018 [cited by applicant]
US 10046064B2 · Kishimoto · 2018 [cited by applicant]
US 10071114B2 · Kishimoto · 2018 [cited by applicant]
US 10335395B2 · Kishimoto · 2019 [cited by applicant]
US 10357482B2 · Maldonado · 2019 [cited by applicant]
US 10357483B2 · Maldonado et al. · 2019 [cited by applicant]
US 10420835B2 · Fraser et al. · 2019 [cited by applicant]
US 10434088B2 · Maldonado et al. · 2019 [cited by applicant]
US 10441651B2 · Kishimoto et al. · 2019 [cited by applicant]
US 10668053B2 · Maldonado · 2020 [cited by applicant]
US 11235057B2 · Altreuter et al. · 2022 [cited by applicant]
US 11298342B2 · Maldonado · 2022 [cited by applicant]
US 11334422B2 · Cai et al. · 2022 [cited by applicant]
US 11426451B2 · Johnston · 2022 [cited by applicant]
US 11633422B2 · Kishimoto · 2023 [cited by applicant]
US 11717569B2 · Fraser et al. · 2023 [cited by applicant]
US 20020014242A1 · Scaria et al. · 2002 [cited by applicant]
US 20020019361A1 · Scaria · 2002 [cited by applicant]
US 20020086049A1 · Bolton et al. · 2002 [cited by applicant]
US 20020095135A1 · Meeker · 2002 [cited by applicant]
US 20040005315A1 · Siemionow · 2004 [cited by applicant]
US 20040204379A1 · Cheng et al. · 2004 [cited by applicant]
US 20040029106A1 · Samulski et al. · 2004 [cited by applicant]
US 20040038406A1 · Unger et al. · 2004 [cited by applicant]
US 20040043483A1 · Qian et al. · 2004 [cited by applicant]
US 20040097463A1 · Oh et al. · 2004 [cited by applicant]
US 20040141958A1 · Steinaa et al. · 2004 [cited by applicant]
US 20040247680A1 · Farokhzad et al. · 2004 [cited by applicant]
US 20050037075A1 · Farokhzad et al. · 2005 [cited by applicant]
US 20060002852A1 · Saltzman et al. · 2006 [cited by applicant]
US 20060002971A1 · Saltzman et al. · 2006 [cited by applicant]
US 20060147432A1 · Moore et al. · 2006 [cited by applicant]
US 20060159766A1 · Jenkins et al. · 2006 [cited by applicant]
US 20060210638A1 · Liversidge et al. · 2006 [cited by applicant]
US 20060222652A1 · Sebbel et al. · 2006 [cited by applicant]
US 20060251677A1 · Bachmann et al. · 2006 [cited by applicant]
US 20060251710A1 · Kwon et al. · 2006 [cited by applicant]
US 20060251711A1 · Konduri et al. · 2006 [cited by applicant]
US 20060269540A1 · Robert et al. · 2006 [cited by applicant]
US 20070014804A1 · Burkhard · 2007 [cited by applicant]
US 20070036757A1 · Kleinschmidt et al. · 2007 [cited by applicant]
US 20070110685A1 · Auspitz et al. · 2007 [cited by applicant]
US 20070110724A1 · Samulski et al. · 2007 [cited by applicant]
US 20070190032A1 · Coffey et al. · 2007 [cited by applicant]
US 20070254897A1 · Gjorstrup · 2007 [cited by applicant]
US 20080031899A1 · Reddy et al. · 2008 [cited by applicant]
US 20080044484A1 · Minev · 2008 [cited by applicant]
US 20080064859A1 · Vandenbark et al. · 2008 [cited by applicant]
US 20080081074A1 · Gu et al. · 2008 [cited by applicant]
US 20080145441A1 · Penades et al. · 2008 [cited by applicant]
US 20080160089A1 · Vitiello et al. · 2008 [cited by applicant]
US 20080254045A1 · Donda et al. · 2008 [cited by applicant]
US 20080268063A1 · Jon et al. · 2008 [cited by applicant]
US 20080311140A1 · Lee et al. · 2008 [cited by applicant]
US 20090004259A1 · Rabinovich et al. · 2009 [cited by applicant]
US 20090028910A1 · DeSimone et al. · 2009 [cited by applicant]
US 20090028948A1 · Cammarano et al. · 2009 [cited by applicant]
US 20090074828A1 · Alexis et al. · 2009 [cited by applicant]
US 20090082260A1 · Lamb et al. · 2009 [cited by applicant]
US 20090142318A1 · Eck et al. · 2009 [cited by applicant]
US 20090155292A1 · Santamaria et al. · 2009 [cited by applicant]
US 20090226525A1 · de Los Rios et al. · 2009 [cited by applicant]
US 20090298710A1 · Farokhzad et al. · 2009 [cited by applicant]
US 20100008932A1 · Bensussan et al. · 2010 [cited by applicant]
US 20100028450A1 · Vasu et al. · 2010 [cited by applicant]
US 20100055076A1 · Lim et al. · 2010 [cited by applicant]
US 20100055189A1 · Hubbell et al. · 2010 [cited by applicant]
US 20100062968A1 · Pulendran et al. · 2010 [cited by applicant]
US 20100068261A1 · Tamarkin et al. · 2010 [cited by applicant]
US 20100068286A1 · Troiano et al. · 2010 [cited by applicant]
US 20100069426A1 · Zale et al. · 2010 [cited by applicant]
US 20100080816A1 · Hadeiba et al. · 2010 [cited by applicant]
US 20100099613A1 · Buyse et al. · 2010 [cited by applicant]
US 20100111993A1 · Tureci et al. · 2010 [cited by applicant]
US 20100112077A1 · Desai et al. · 2010 [cited by applicant]
US 20100129392A1 · Shi et al. · 2010 [cited by applicant]
US 20100129439A1 · Alexis et al. · 2010 [cited by applicant]
US 20100151000A1 · Thomas et al. · 2010 [cited by applicant]
US 20100172994A1 · Sigmund et al. · 2010 [cited by applicant]
US 20100183602A1 · Carballido Herrera et al. · 2010 [cited by applicant]
US 20100183727A1 · Iannacone et al. · 2010 [cited by applicant]
US 20100189742A1 · Van Der Burg et al. · 2010 [cited by applicant]
US 20100196401A1 · Scaria · 2010 [cited by applicant]
US 20100203142A1 · Zhang et al. · 2010 [cited by applicant]
US 20100233197A1 · Wakatsuki Pedersen et al. · 2010 [cited by applicant]
US 20100233251A1 · Von Andrian et al. · 2010 [cited by applicant]
US 20100273220A1 · Yanik et al. · 2010 [cited by applicant]
US 20100303850A1 · Lipford et al. · 2010 [cited by applicant]
US 20100323019A1 · Lim et al. · 2010 [cited by applicant]
US 20100323199A1 · Gu et al. · 2010 [cited by applicant]
US 20110004148A1 · Ishii et al. · 2011 [cited by applicant]
US 20110020388A1 · Zepp et al. · 2011 [cited by applicant]
US 20110027217A1 · Zepp et al. · 2011 [cited by applicant]
US 20110052697A1 · Farokhzad et al. · 2011 [cited by applicant]
US 20110070153A1 · Hyde et al. · 2011 [cited by applicant]
US 20110070154A1 · Hyde et al. · 2011 [cited by applicant]
US 20110076273A1 · Adler et al. · 2011 [cited by applicant]
US 20110110965A1 · Fraser et al. · 2011 [cited by applicant]
US 20110166172A1 · Nan et al. · 2011 [cited by applicant]
US 20110171248A1 · Pittet et al. · 2011 [cited by applicant]
US 20110223201A1 · Lipford et al. · 2011 [cited by applicant]
US 20110243976A1 · Bagnoli et al. · 2011 [cited by applicant]
US 20110262491A1 · Keegan et al. · 2011 [cited by applicant]
US 20110272836A1 · Keegan et al. · 2011 [cited by applicant]
US 20110293700A1 · Bratzler et al. · 2011 [cited by applicant]
US 20110293701A1 · Bratzler et al. · 2011 [cited by applicant]
US 20110293723A1 · Bratzler et al. · 2011 [cited by applicant]
US 20120014966A1 · Solinger et al. · 2012 [cited by applicant]
US 20120027806A1 · Ilyinskii et al. · 2012 [cited by applicant]
US 20120027808A1 · Iannacone et al. · 2012 [cited by applicant]
US 20120039989A1 · Hubbell et al. · 2012 [cited by applicant]
US 20120058153A1 · Ilyinskii et al. · 2012 [cited by applicant]
US 20120058154A1 · Ilyinskii et al. · 2012 [cited by applicant]
US 20120064110A1 · Ilyinskii et al. · 2012 [cited by applicant]
US 20120070493A1 · Fraser et al. · 2012 [cited by applicant]
US 20120076831A1 · Miller et al. · 2012 [cited by applicant]
US 20120077860A1 · Garcia · 2012 [cited by applicant]
US 20120100606A1 · Zolotukhin et al. · 2012 [cited by applicant]
US 20120114677A1 · Zepp et al. · 2012 [cited by applicant]
US 20120148612A1 · Hafner et al. · 2012 [cited by applicant]
US 20120171229A1 · Zepp et al. · 2012 [cited by applicant]
US 20120244222A1 · Altreuter et al. · 2012 [cited by applicant]
US 20120276109A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276133A1 · Maldonado et al. · 2012 [cited by applicant]
US 20120276134A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276155A1 · Kishimoto et al. · 2012 [cited by applicant]
US 20120276156A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276157A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276158A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276159A1 · Fraser et al. · 2012 [cited by applicant]
US 20120276160A1 · Maldonado et al. · 2012 [cited by applicant]
US 20120294888A1 · Kishimoto et al. · 2012 [cited by applicant]
US 20120301454A1 · Rosario-Jansen et al. · 2012 [cited by applicant]
US 20120301498A1 · Altreuter et al. · 2012 [cited by applicant]
US 20120301510A1 · Kishimoto et al. · 2012 [cited by applicant]
US 20120308563A1 · Arya et al. · 2012 [cited by applicant]
US 20130028857A1 · Gao et al. · 2013 [cited by applicant]
US 20130028941A1 · Altreuter et al. · 2013 [cited by applicant]
US 20130039954A1 · Pittet et al. · 2013 [cited by applicant]
US 20130058894A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058901A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058902A1 · Kishimoto et al. · 2013 [cited by applicant]
US 20130058963A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058970A1 · Kishimoto et al. · 2013 [cited by applicant]
US 20130058974A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058975A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058976A1 · Kishimoto et al. · 2013 [cited by applicant]
US 20130058977A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130058978A1 · Maldonado et al. · 2013 [cited by applicant]
US 20130059009A1 · Kishimoto et al. · 2013 [cited by applicant]
US 20130096182A1 · Chatterjee et al. · 2013 [cited by applicant]
US 20140030344A1 · Zepp et al. · 2014 [cited by applicant]
US 20140031418A1 · Wilson et al. · 2014 [cited by applicant]
US 20140037585A1 · Wright et al. · 2014 [cited by applicant]
US 20140155469A1 · Bahou et al. · 2014 [cited by applicant]
US 20140193453A1 · Zepp et al. · 2014 [cited by applicant]
US 20140199340A1 · Maldonado · 2014 [cited by applicant]
US 20140212462A1 · Kang et al. · 2014 [cited by applicant]
US 20140242173A1 · Zepp et al. · 2014 [cited by applicant]
US 20140294982A1 · Freund et al. · 2014 [cited by applicant]
US 20140328854A1 · Maldonado et al. · 2014 [cited by applicant]
US 20140328921A1 · Maldonado · 2014 [cited by applicant]
US 20140328922A1 · Maldonado · 2014 [cited by applicant]
US 20140328923A1 · Maldonado et al. · 2014 [cited by applicant]
US 20140328924A1 · Kishimoto · 2014 [cited by applicant]
US 20140335186A1 · Kishimoto et al. · 2014 [cited by applicant]
US 20140336245A1 · Mingozzi et al. · 2014 [cited by applicant]
US 20140356361A1 · Maldonado et al. · 2014 [cited by applicant]
US 20150024007A1 · Hessel et al. · 2015 [cited by applicant]
US 20150065562A1 · Yazicioglu et al. · 2015 [cited by applicant]
US 20150099707A1 · Pastan et al. · 2015 [cited by applicant]
US 20150111955A1 · High et al. · 2015 [cited by applicant]
US 20150320728A1 · Fraser et al. · 2015 [cited by applicant]
US 20150320856A1 · Altreuter et al. · 2015 [cited by applicant]
US 20150320870A1 · Maldonado · 2015 [cited by applicant]
US 20150320884A1 · Fraser et al. · 2015 [cited by applicant]
US 20150328300A1 · Zepp et al. · 2015 [cited by applicant]
US 20150328309A1 · Ilyinskii et al. · 2015 [cited by applicant]
US 20150328333A1 · Fraser et al. · 2015 [cited by applicant]
US 20150335762A1 · Fraser et al. · 2015 [cited by applicant]
US 20150359865A1 · Kishimoto · 2015 [cited by applicant]
US 20150374815A1 · Kishimoto et al. · 2015 [cited by applicant]
US 20160022650A1 · Fraser et al. · 2016 [cited by applicant]
US 20160030554A1 · Kishimoto et al. · 2016 [cited by applicant]
US 20160030555A1 · Kishimoto et al. · 2016 [cited by applicant]
US 20160067228A1 · Kishimoto et al. · 2016 [cited by applicant]
US 20160074372A1 · Kishimoto · 2016 [cited by applicant]
US 20160074427A1 · Kishimoto · 2016 [cited by applicant]
US 20160074531A1 · Kishimoto · 2016 [cited by applicant]
US 20160074532A1 · Kishimoto · 2016 [cited by applicant]
US 20160128986A1 · O'Neil et al. · 2016 [cited by applicant]
US 20160128987A1 · Griset et al. · 2016 [cited by applicant]
US 20160220501A1 · Fraser et al. · 2016 [cited by applicant]
US 20160243253A1 · Fraser et al. · 2016 [cited by applicant]
US 20160256401A1 · Fraser et al. · 2016 [cited by applicant]
US 20160279234A1 · Kishimoto et al. · 2016 [cited by applicant]
US 20170021037A1 · Wang et al. · 2017 [cited by applicant]
US 20170067042A1 · Venditti et al. · 2017 [cited by applicant]
US 20170224620A1 · Zale et al. · 2017 [cited by applicant]
US 20170258927A1 · Johnston · 2017 [cited by applicant]
US 20170349433A1 · Lipford et al. · 2017 [cited by applicant]
US 20180043023A1 · Ilyinski et al. · 2018 [cited by applicant]
US 20180071394A1 · O'Neil et al. · 2018 [cited by applicant]
US 20180085319A1 · Kishimoto · 2018 [cited by applicant]
US 20180193482A1 · Ilyinski et al. · 2018 [cited by applicant]
US 20180256709A1 · Zepp et al. · 2018 [cited by applicant]
US 20180289776A1 · Johnston et al. · 2018 [cited by applicant]
US 20190076458A1 · Kishimoto et al. · 2019 [cited by applicant]
US 20190076522A1 · Altreuter et al. · 2019 [cited by applicant]
US 20190142974A1 · Ilyinskii et al. · 2019 [cited by applicant]
US 20190262434A1 · Brown · 2019 [cited by applicant]
US 20200038462A1 · Keller et al. · 2020 [cited by applicant]
US 20200038463A1 · Keller et al. · 2020 [cited by applicant]
US 20200069659A1 · Kishimoto · 2020 [cited by applicant]
US 20200069660A1 · Maldonado et al. · 2020 [cited by applicant]
US 20200078341A1 · Maldonado · 2020 [cited by applicant]
US 20200101154A1 · Fraser et al. · 2020 [cited by applicant]
US 20200101155A1 · Kishimoto et al. · 2020 [cited by applicant]
US 20200113874A1 · Maldonado et al. · 2020 [cited by applicant]
US 20200360350A1 · Maldonado · 2020 [cited by applicant]
US 20200360453A1 · Kishimoto et al. · 2020 [cited by applicant]
US 20200390718A1 · Kishimoto et al. · 2020 [cited by applicant]
US 20200399628A1 · Johnston et al. · 2020 [cited by applicant]
US 20210154324A1 · Ilyinskii et al. · 2021 [cited by applicant]
US 20210187081A1 · Johnston et al. · 2021 [cited by applicant]
US 20210290601A1 · Ilyinskii et al. · 2021 [cited by applicant]
US 20210308058A1 · Johnston · 2021 [cited by applicant]
US 20220071968A1 · Kishimoto · 2022 [cited by applicant]
US 20220133864A1 · Kishimoto · 2022 [cited by applicant]
US 20220323607A1 · Kishimoto et al. · 2022 [cited by applicant]
US 20230032226A1 · Maldonado · 2023 [cited by applicant]
US 20230107561A1 · Johnston · 2023 [cited by applicant]
US 20230140196A1 · Kishimoto · 2023 [cited by applicant]
US 20230141563A1 · Ilyinskii et al. · 2023 [cited by applicant]
US 20230310593A1 · Kishimoto et al. · 2023 [cited by applicant]
US 20230321224A1 · Fraser et al. · 2023 [cited by applicant]
US 20230321225A1 · Fraser et al. · 2023 [cited by applicant]
US 20230357437A1 · Ilyinskii et al. · 2023 [cited by applicant]
US 20230364124A1 · Kishimoto · 2023 [cited by applicant]
US 20240024517A1 · Kishimoto · 2024 [cited by applicant]
US 20240148841A1 · Li et al. · 2024 [cited by applicant]
US 20240156955A1 · Fraser et al. · 2024 [cited by applicant]
BR PI0808635A2 · 2014 [cited by applicant]
BR 112013027500A2 · 2017 [cited by applicant]
BR 112013027514A2 · 2017 [cited by applicant]
BR 112015023793A2 · 2017 [cited by applicant]
BR 112015027279A2 · 2017 [cited by applicant]
CA 2834514A1 · 2012 [cited by applicant]
CA 2957808A1 · 2016 [cited by applicant]
CN 1335398 · 2002 [cited by applicant]
CN 1391479 · 2003 [cited by applicant]
CN 1678188A · 2005 [cited by applicant]
CN 1777621A · 2006 [cited by applicant]
CN 1979166A · 2007 [cited by applicant]
CN 101175481A · 2008 [cited by applicant]
CN 101437491A · 2009 [cited by applicant]
CN 101484461A · 2009 [cited by applicant]
CN 101646418A · 2010 [cited by applicant]
CN 101703781A · 2010 [cited by applicant]
CN 101861165A · 2010 [cited by applicant]
CN 101990429A · 2011 [cited by applicant]
CN 102016814A · 2011 [cited by applicant]
CN 102803954A · 2012 [cited by applicant]
CN 103079589A · 2013 [cited by applicant]
CN 103282380A · 2013 [cited by applicant]
CN 102871966B · 2013 [cited by applicant]
CN 103491957A · 2014 [cited by applicant]
CN 103501793 · 2014 [cited by applicant]
CN 103501820A · 2014 [cited by applicant]
CN 103517707A · 2014 [cited by applicant]
CN 104822370A · 2015 [cited by applicant]
CN 105283175 · 2016 [cited by applicant]
CN 105307641A · 2016 [cited by applicant]
CN 105339012A · 2016 [cited by applicant]
CN 106714826A · 2017 [cited by applicant]
CN 106715699A · 2017 [cited by applicant]
CN 107072964A · 2017 [cited by applicant]
CN 107073050A · 2017 [cited by applicant]
CN 107073091A · 2017 [cited by applicant]
CN 107075499A · 2017 [cited by applicant]
CN 109069643A · 2018 [cited by applicant]
CN 109152819A · 2019 [cited by applicant]
EP 0759941B1 · 2000 [cited by applicant]
EP 1795185A2 · 2007 [cited by applicant]
EP 1932538A1 · 2008 [cited by applicant]
EP 2073848A2 · 2009 [cited by applicant]
EP 2345412A1 · 2011 [cited by applicant]
EP 2522338A2 · 2012 [cited by applicant]
EP 2217269B1 · 2017 [cited by applicant]
EP 3426285A1 · 2019 [cited by applicant]
JP H01502909A · 1989 [cited by applicant]
JP H10507758A · 1998 [cited by applicant]
JP 2005516893A · 2005 [cited by applicant]
JP 2006257095 · 2006 [cited by applicant]
JP 2007532517A · 2007 [cited by applicant]
JP 2008515806A · 2008 [cited by applicant]
JP 2008532953A · 2008 [cited by applicant]
JP 2009531068 · 2009 [cited by applicant]
JP 2010100578A · 2010 [cited by applicant]
JP 2010514805 · 2010 [cited by applicant]
JP 2010533160A · 2010 [cited by applicant]
JP 2010535025 · 2010 [cited by applicant]
JP 2011512326A · 2011 [cited by applicant]
JP 2012502930A · 2012 [cited by applicant]
JP 2012512175A · 2012 [cited by applicant]
JP 2012515722A · 2012 [cited by applicant]
JP 2012516691A · 2012 [cited by applicant]
JP 2013541504A · 2013 [cited by applicant]
JP 2014513092A · 2014 [cited by applicant]
JP 2014513102A · 2014 [cited by applicant]
JP 2014513722A · 2014 [cited by applicant]
JP 2014514331A · 2014 [cited by applicant]
JP 2014514332A · 2014 [cited by applicant]
JP 2014514333A · 2014 [cited by applicant]
JP 2016517889A · 2016 [cited by applicant]
JP 2016526048A · 2016 [cited by applicant]
JP 2017038592A · 2017 [cited by applicant]
JP 2017512466A · 2017 [cited by applicant]
JP 2017513048 · 2017 [cited by applicant]
JP 2017122113A · 2017 [cited by applicant]
JP 2017527565A · 2017 [cited by applicant]
JP 2017527571A · 2017 [cited by applicant]
JP 2017529342A · 2017 [cited by applicant]
KR 1020100099849A · 2010 [cited by applicant]
KR 1020170045344A · 2017 [cited by applicant]
KR 1020230053709A · 2023 [cited by applicant]
RU 2246318C2 · 2005 [cited by applicant]
WO WO8806451A1 · 1988 [cited by applicant]
WO WO199511696A1 · 1995 [cited by applicant]
WO WO1996012406A1 · 1996 [cited by applicant]
WO WO199620698A2 · 1996 [cited by applicant]
WO WO1998002441A2 · 1998 [cited by applicant]
WO WO1998010056A1 · 1998 [cited by applicant]
WO WO199922762A1 · 1999 [cited by applicant]
WO WO199934826A1 · 1999 [cited by applicant]
WO WO0032773A1 · 2000 [cited by applicant]
WO WO200042989A2 · 2000 [cited by applicant]
WO WO2001068133A1 · 2001 [cited by applicant]
WO WO2001091802A1 · 2001 [cited by applicant]
WO WO200209770A1 · 2002 [cited by applicant]