Granted Patent
B2
US 12,201,838 · App. 18/085,270 · Granted Jan 21, 2025
Pain management based on emotional expression measurements
Inventors:
Kyle Harish Srivastava (Saint Paul, MN); Bryan Allen Clark (Forest Lake, MN); Elizabeth Mary Annoni (White Bear Lake, MN); Sandra Nagale (Bolton, MA); Pramodsingh Hirasingh Thakur (Woodbury, MN); Jianwen Gu (Valencia, CA); David L. Perschbacher (Blaine, MN)
A61N1/36139A61B5/0077A61B5/1104A61B5/165A61B5/4803A61B5/4824A61B5/4836A61B5/4848A61N1/0534A61N1/0551A61N1/36062A61N1/36071G16H20/70G16H40/63G16H50/30
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Abstract
This document discusses, among other things, systems and methods for managing pain in a subject. A system may include one or more sensors configured to sense from the subject information corresponding to emotional reaction to pain, such as emotional expression. The emotional expression includes facial or vocal expression. A pain analyzer circuit may generate a pain score using signal metrics of facial or vocal expression extracted from the sensed information. The pain score may be output to a user or a process. The system may additionally include a neurostimulator that can adaptively control the delivery of pain therapy by automatically adjusting stimulation parameters based on the pain score.
Claims (50)
1. A method of providing neuromodulation therapy to a patient via a medical-device system, the method comprising:
receiving information about emotional reaction of the patient to pain;
generating a plurality of signal metrics from the received information;
calculating a score indicative of patient emotional reaction to pain using the generated plurality of signal metrics; and
initiating or adjusting a neuromodulation therapy based at least in part on the calculated score.
2. The method of claim 1 , wherein the neuromodulation therapy includes at least one of a spinal cord stimulation therapy, a deep brain stimulation therapy, a peripheral nerve stimulation therapy, a functional electrical stimulation therapy, a motor cortex stimulation therapy, a sacral nerve stimulation therapy, a radiofrequency ablation therapy, or a vagus nerve stimulation therapy.
3. The method of claim 1 , wherein the received information about emotional reaction to pain includes information about facial, vocal, or behavioral expressions of the patient related to pain,
wherein the neuromodulation therapy is delivered to a neural target for pain management.
4. The method of claim 3 , comprising:
trending at least one of the plurality of signal metrics over time;
determining a rate of change in the trended at least one signal metric; and
generating a diagnostic of a chronic pain or an abrupt pain based at least in part on the rate of change in the trended at least one signal metric.
5. The method of claim 4 , wherein initiating or adjusting the neuromodulation therapy is further based on the generated diagnostic.
6. The method of claim 1 , wherein the received information about emotional reaction to pain includes motor activity information indicative of or correlated to an emotional or psychological state of the patient.
7. The method of claim 6 , wherein the received motor activity information is indicative of or correlated to an emotional or psychological reaction to pain.
8. The method of claim 6 , wherein the motor activity information includes a speech motor control signal, and wherein the plurality of signal metrics generated from the received motor activity information includes one or more of speed, volume, pitch, inclination, regularity, or a degree of coordination during speech.
9. The method of claim 1 , wherein the received information about emotional reaction to pain includes a facial image or video of the patient, and wherein the plurality of signal metrics include one or more facial image features.
10. The method of claim 9 , wherein the one or more facial image features include at least one of a spatial or temporal change or a rate of change of a facial landmark.
11. The method of claim 1 , wherein calculating the score indicative of patient emotional reaction to pain includes:
calculating metric-specific scores respectively for each of the plurality of signal metrics; and
determining a composite score using a weighted combination of the plurality of signal metrics each scaled by respective weight factors.
12. A non-transitory machine-readable storage medium that includes instructions that, when executed by one or more processors of a machine, cause the machine to perform operations comprising:
receiving information about emotional reaction of a patient to pain;
generating a plurality of signal metrics from the received information;
calculating a score indicative of patient emotional reaction to pain using the generated plurality of signal metrics; and
generating a control signal to initiate or adjust a neuromodulation therapy based at least in part on the calculated score.
13. The non-transitory machine-readable storage medium of claim 12 , wherein the control signal to initiate or adjust the neuromodulation therapy includes directing the neuromodulation therapy to a neural target for pain management.
14. The non-transitory machine-readable storage medium of claim 12 , wherein the instructions cause the machine to perform operations further comprising:
trending at least one of the plurality of signal metrics over time;
determining a rate of change in the trended at least one signal metric; and
generating a diagnostic of a chronic pain or an abrupt pain based at least in part on the rate of change in the trended at least one signal metric.
15. The non-transitory machine-readable storage medium of claim 12 , wherein the received information about emotional reaction to pain includes information about facial, vocal, or behavioral expressions of the patient related to pain,
wherein the operation of calculating the score indicative of patient emotional reaction to pain includes calculating metric-specific scores respectively for each of the plurality of signal metrics, and determining a composite emotional reaction score using a weighted combination of the plurality of signal metrics each scaled by respective weight factors.
16. A medical-device system, comprising:
a therapy circuit configured to provide a neuromodulation therapy to a patient;
a receiver circuit configured to receive information about emotional reaction of the patient to pain; and
a controller circuit configured to:
generate a plurality of signal metrics from the received information;
calculate a score indicative of patient emotional reaction to pain using the generated plurality of signal metrics; and
generate a control signal to the therapy circuit to initiate or adjust the neuromodulation therapy based at least in part on the calculated score.
17. The medical-device system of claim 16 , wherein the therapy circuit is configured to provide the neuromodulation therapy including at least one of a spinal cord stimulation therapy, a deep brain stimulation therapy, a peripheral nerve stimulation therapy, a functional electrical stimulation therapy, a motor cortex stimulation therapy, a sacral nerve stimulation therapy, a radiofrequency ablation therapy, or a vagus nerve stimulation therapy.
18. The medical-device system of claim 16 , wherein the therapy circuit is configured to deliver the neuromodulation therapy to a neural target for pain management.
19. The medical-device system of claim 16 , wherein the control circuit is configured to:
trend at least one of the plurality of signal metrics over time;
determine a rate of change in the trended at least one signal metric; and
generate a diagnostic of a chronic pain or an abrupt pain based at least in part on the rate of change in the trended at least one signal metric.
20. The medical-device system of claim 16 , wherein the received information about emotional reaction to pain includes information about facial, vocal, or behavioral expressions of the patient related to pain,
wherein to calculate the score indicative of patient emotional reaction to pain, the controller circuit is configured to:
calculate metric-specific scores respectively for each of the plurality of signal metrics; and
determining a composite score using a weighted combination of the plurality of signal metrics each scaled by respective weight factors.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 11, 2023
From: SRIVASTAVA, KYLE HARISH; CLARK, BRYAN ALLEN; ANNONI, ELIZABETH MARY; NAGALE, SANDRA; THAKUR, PRAMODSINGH HIRASINGH; GU, JIANWEN; PERSCHBACHER, DAVID L.
To: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
Reel/Frame 065186/0480 →
Continuity (4)
Provisional Application
62445082
· Jan 11, 2017
References Cited (400)
US 4297685A
· Brainard, II
· 1981
[cited by applicant]
US 5187675A
· Dent et al.
· 1993
[cited by applicant]
US 5774591A
· Black et al.
· 1998
[cited by applicant]
US 6016103A
· Leavitt
· 2000
[cited by applicant]
US 6076011A
· Hoover
· 2000
[cited by applicant]
US 6088040A
· Oda et al.
· 2000
[cited by applicant]
US 6173260B1
· Slaney
· 2001
[cited by applicant]
US 6480734B1
· Zhang et al.
· 2002
[cited by applicant]
US 6497658B2
· Roizen et al.
· 2002
[cited by applicant]
US 6654632B2
· Lange et al.
· 2003
[cited by applicant]
US 6659968B1
· McClure
· 2003
[cited by applicant]
US 6731984B2
· Cho et al.
· 2004
[cited by applicant]
US 6871099B1
· Whitehurst et al.
· 2005
[cited by applicant]
US 7001337B2
· Dekker
· 2006
[cited by applicant]
US 7004907B2
· Banet et al.
· 2006
[cited by applicant]
US 7177686B1
· Turcott
· 2007
[cited by applicant]
US 7189204B2
· Ni et al.
· 2007
[cited by applicant]
US 7222075B2
· Petrushin
· 2007
[cited by applicant]
US 7299086B2
· McCabe et al.
· 2007
[cited by applicant]
US 7376457B2
· Ross
· 2008
[cited by applicant]
US 7407485B2
· Huiku
· 2008
[cited by applicant]
US 7463927B1
· Chaouat
· 2008
[cited by applicant]
US 7566308B2
· Stahmann
· 2009
[cited by applicant]
US 7627475B2
· Petrushin
· 2009
[cited by applicant]
US 7636602B2
· Baru Fassio et al.
· 2009
[cited by applicant]
US 7650184B2
· Walter
· 2010
[cited by applicant]
US 7678061B2
· Lee et al.
· 2010
[cited by applicant]
US 7775993B2
· Heruth et al.
· 2010
[cited by applicant]
US 7957809B2
· Bourget et al.
· 2011
[cited by applicant]
US 7986991B2
· Prichep
· 2011
[cited by applicant]
US 8019439B2
· Kuzma et al.
· 2011
[cited by applicant]
US 8055348B2
· Heruth et al.
· 2011
[cited by applicant]
US 8083682B2
· Dalal et al.
· 2011
[cited by applicant]
US 8192376B2
· Lovett et al.
· 2012
[cited by applicant]
US 8209182B2
· Narayanan
· 2012
[cited by applicant]
US 8290596B2
· Wei et al.
· 2012
[cited by applicant]
US 8332038B2
· Heruth et al.
· 2012
[cited by applicant]
US 8398556B2
· Sethi et al.
· 2013
[cited by applicant]
US 8447401B2
· Miesel et al.
· 2013
[cited by applicant]
US 8475370B2
· McCombie et al.
· 2013
[cited by applicant]
US 8529459B2
· Malker et al.
· 2013
[cited by applicant]
US 8606356B2
· Lee et al.
· 2013
[cited by applicant]
US 8688221B2
· Miesel
· 2014
[cited by applicant]
US 8744587B2
· Miesel et al.
· 2014
[cited by applicant]
US 8805518B2
· King et al.
· 2014
[cited by applicant]
US 9066659B2
· Thakur et al.
· 2015
[cited by applicant]
US 9072870B2
· Wu et al.
· 2015
[cited by applicant]
US 9119965B2
· Xi et al.
· 2015
[cited by applicant]
US 9314168B2
· Watson et al.
· 2016
[cited by applicant]
US 9395792B1
· Kahn et al.
· 2016
[cited by applicant]
US 9517344B1
· Bradley
· 2016
[cited by applicant]
US 20010037222A1
· Platt et al.
· 2001
[cited by applicant]
US 20040015091A1
· Greenwald et al.
· 2004
[cited by applicant]
US 20050010262A1
· Sharan et al.
· 2005
[cited by applicant]
US 20080015659A1
· Zhang et al.
· 2008
[cited by applicant]
US 20080077192A1
· Harry et al.
· 2008
[cited by applicant]
US 20090124863A1
· Liu et al.
· 2009
[cited by applicant]
US 20090312663A1
· John et al.
· 2009
[cited by applicant]
US 20090318986A1
· Alo et al.
· 2009
[cited by applicant]
US 20100016913A1
· Arcot-Krishnamurthy et al.
· 2010
[cited by applicant]
US 20100105997A1
· Ecker et al.
· 2010
[cited by applicant]
US 20100286549A1
· John et al.
· 2010
[cited by applicant]
US 20110021928A1
· Giovangrandi et al.
· 2011
[cited by applicant]
US 20110034760A1
· Brynelsen et al.
· 2011
[cited by applicant]
US 20110137134A1
· Hemmerling et al.
· 2011
[cited by applicant]
US 20130165994A1
· Ternes et al.
· 2013
[cited by applicant]
US 20140276188A1
· Jardin
· 2014
[cited by applicant]
US 20150025335A1
· Jain et al.
· 2015
[cited by applicant]
US 20150289803A1
· Wu et al.
· 2015
[cited by applicant]
US 20160144194A1
· Roothans et al.
· 2016
[cited by applicant]
US 20160158551A1
· Kent et al.
· 2016
[cited by applicant]
US 20170165485A1
· Sullivan et al.
· 2017
[cited by applicant]
US 20180078768A1
· Thakur et al.
· 2018
[cited by applicant]
US 20180193650A1
· Srivastava et al.
· 2018
[cited by applicant]
AU 2017335497B2
· 2020
[cited by applicant]
AU 2017334841B2
· 2020
[cited by applicant]
EP 1059064A2
· 2000
[cited by applicant]
EP 1897586A1
· 2008
[cited by applicant]
EP 3519037B1
· 2020
[cited by applicant]
EP 3568069B1
· 2021
[cited by applicant]
EP 3518736B1
· 2021
[cited by applicant]
KR 20050053824A
· 2005
[cited by applicant]
KR 1020050053824A
· 2005
[cited by applicant]
RU 2559783C1
· 2015
[cited by applicant]
WO WO2007007058A1
· 2007
[cited by applicant]
WO WO2009055127A1
· 2009
[cited by applicant]
WO WO2010051406A1
· 2010
[cited by applicant]
WO WO2011008747A2
· 2011
[cited by applicant]
WO WO2011053607A1
· 2011
[cited by applicant]
WO WO2013134479A1
· 2013
[cited by applicant]
WO WO2014151860A1
· 2014
[cited by applicant]
WO WO2015060888A1
· 2015
[cited by applicant]
WO WO2015128567
· 2015
[cited by applicant]
WO WO2016025989A1
· 2016
[cited by applicant]
WO WO2016077786A1
· 2016
[cited by applicant]
WO WO2018052695A1
· 2018
[cited by applicant]
WO WO2018063637A1
· 2018
[cited by applicant]
WO WO2018063912A1
· 2018
[cited by applicant]
WO WO2018080887A1
· 2018
[cited by applicant]
WO WO2019018206A1
· 2019
[cited by applicant]
“2015 Sleep in America® Poll Sleep and Pain—Summary of Findings”, National Sleep Foundation, (2015), 1-54.
[cited by applicant]
“U.S. Appl. No. 15/687,925, Final Office Action mailed Feb. 14, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/687,925, Non Final Office Action mailed Jun. 11, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/687,925, Non Final Office Action mailed Oct. 9, 2018”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 15/687,925, Response filed Jan. 9, 2019 to Non Final Office Action mailed Oct. 9, 2018”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 15/687,925, Response filed May 13, 2019 to Final Office Action mailed Feb. 14, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Examiner Interview Summary mailed Sep. 25, 2019”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Final Office Action mailed Jul. 29, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Non Final Office Action mailed Jan. 11, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Non Final Office Action mailed Oct. 30, 2019”, 6 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Notice of Allowance mailed Apr. 14, 2020”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Response filed Jan. 7, 2020 to Non Final Office Action mailed Oct. 30, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Response filed Sep. 25, 2019 to Final Office Action mailed Jul. 29, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/688,676, Response filed Apr. 9, 2019 to Non Final Office Action mailed Jan. 11, 2019”, 12 pgs.
[cited by applicant]
“U.S. Appl. No. 15/711,578, Examiner Interview Summary mailed Aug. 28, 2019”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/711,578, Non Final Office Action mailed May 23, 2019”, 6 pgs.
[cited by applicant]
“U.S. Appl. No. 15/711,578, Notice of Allowance mailed Nov. 25, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/711,578, Repsonse filed Aug. 23, 2019 to Non Final Office Action mailed May 23, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/711,578, Supplemental Response filed Aug. 28, 2019 to Non Final Office Action mailed May 23, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, 312 Amendment filed Apr. 22, 2020”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, Corrected Notice of Allowability mailed Mar. 18, 2020”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, Non Final Office Action mailed Jul. 23, 2019”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, Notice of Allowance mailed Jan. 23, 2020”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, PTO Response to Rule 312 Communication mailed Apr. 30, 2020”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 15/788,403, Response filed Oct. 8, 2019 to Non Final Office Action mailed Jul. 23, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,756, Examiner Interview Summary mailed Aug. 28, 2019”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,756, Non Final Office Action mailed Jul. 1, 2019”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,756, Notice of Allowance mailed Dec. 19, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,756, Response filed Aug. 29, 2019 to Non Final Office Action mailed Jul. 1, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,760, Examiner Interview Summary mailed Aug. 28, 2019”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,760, Non Final Office Action mailed Jul. 1, 2019”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,760, Notice of Allowance mailed Dec. 19, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,760, Response filed Aug. 29, 2019 to Non-Final Office Action mailed Jul. 1, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,767, Non Final Office Action mailed Dec. 17, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,767, Notice of Allowance mailed Apr. 6, 2020”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,767, Response filed Mar. 4, 2020 to Non Final Office Action mailed Dec. 17, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Advisory Action mailed Dec. 22, 2020”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Examiner Interview Summary mailed Apr. 29, 2021”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Examiner Interview Summary mailed Dec. 11, 2020”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Final Office Action mailed Oct. 22, 2020”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Non Final Office Action mailed Apr. 2, 2020”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Notice of Allowance mailed Apr. 23, 2021”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, PTO Response to Rule 312 Communication mailed Dec. 22, 2020”, 4 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Response filed Jun. 30, 2020 to Non Final Office Action mailed Apr. 2, 2020”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,772, Response filed Dec. 15, 2020 to Final Office Action mailed Oct. 22, 2020”, 12 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,789, Non Final Office Action mailed Apr. 2, 2020”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,801, Non Final Office Action mailed Sep. 30, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,801, Notice of Allowance mailed Feb. 5, 2020”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,801, Response filed Dec. 18, 2019 to Non Final Office Action mailed Sep. 30, 2019”, 12 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,873, Non Final Office Action mailed Apr. 3, 2020”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,873, Notice of Allowance mailed Oct. 22, 2020”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 15/867,873, Response filed Jun. 30, 2020 to Non Final Office Action mailed Apr. 1, 2020”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Advisory Action mailed Feb. 10, 2020”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Examiner Interview Summary mailed Aug. 3, 2020”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Examiner Interview Summary mailed Nov. 21, 2019”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Final Office Action mailed Dec. 16, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Non Final Office Action mailed Jul. 2, 2020”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Non Final Office Action mailed Sep. 11, 2019”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Notice of Allowance mailed Nov. 30, 2020”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Response filed Jan. 31, 2020 to Final Office Action mailed Dec. 16, 2019”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Response filed Mar. 16, 2020 to Advisory Action mailed Feb. 10, 2020”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Response filed Sep. 29, 2020 to Non Final Office Action mailed Jul. 2, 2020”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 15/888,808, Response filed Nov. 19, 2019 to Non Final Office Action mailed Sep. 11, 2019”, 10 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Examiner Interview Summary mailed Sep. 15, 2020”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Final Office Action mailed Jul. 27, 2020”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Non Final Office Action mailed Apr. 3, 2020”, 15 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Notice of Allowance mailed Sep. 29, 2020”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Response filed Jun. 30, 2020 to Non Final Office Action mailed Apr. 3, 2020”, 13 pgs.
[cited by applicant]
“U.S. Appl. No. 16/034,304, Response filed Sep. 16, 2020 to Final Office Action mailed Jul. 27, 2020”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 16/800,822, Non Final Office Action mailed Nov. 29, 2021”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 16/800,822, Notice of Allowance mailed May 18, 2022”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 16/800,822, Response filed Feb. 3, 2022 to Non Final Office Action mailed Nov. 29, 2021”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 16/820,474, Corrected Notice of Allowability mailed Feb. 9, 2022”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 16/820,474, Non Final Office Action mailed Oct. 12, 2021”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 16/820,474, Notice of Allowance mailed Jan. 25, 2022”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 16/820,474, Response filed Dec. 16, 2021 to Non Final Office Action mailed Oct. 12, 2021”, 9 pgs.
[cited by applicant]
“U.S. Appl. No. 16/821,161, Non Final Office Action mailed Jan. 3, 2022”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 16/821,161, Notice of Allowance mailed Apr. 4, 2022”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 16/821,161, Response filed Jan. 27, 2022 to Non Final Office Action mailed Jan. 3, 2022”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Examiner Interview Summary mailed Feb. 4, 2022”, 3 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Examiner Interview Summary mailed Jun. 29, 2022”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Final Office Action mailed May 10, 2022”, 17 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Non Final Office Action mailed Jan. 4, 2022”, 14 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Notice of Allowance mailed Aug. 31, 2022”, 8 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Response filed Feb. 2, 2022 to Non Final Office Action mailed Jan. 4, 2022”, 11 pgs.
[cited by applicant]
“U.S. Appl. No. 16/848,580, Response filed Jun. 27, 2022 to Final Office Action mailed May 10, 2022”, 12 pgs.
[cited by applicant]
“U.S. Appl. No. 17/145,514, Examiner Interview Summary mailed Sep. 14, 2022”, 2 pgs.
[cited by applicant]
“U.S. Appl. No. 17/145,514, Non Final Office Action mailed Aug. 4, 2022”, 7 pgs.
[cited by applicant]
“U.S. Appl. No. 17/145,514, Notice of Allowance mailed Oct. 5, 2022”, 5 pgs.
[cited by applicant]
“U.S. Appl. No. 17/145,514, Response filed Sep. 26, 2022 to Non Final Office Action mailed Aug. 4, 2022”, 8 pgs.
[cited by applicant]
“Australian Application Serial No. 2017325823, First Examination Report mailed Jun. 19, 2019”, 3 pgs.
[cited by applicant]
“Australian Application Serial No. 2017334841, First Examination Report mailed Jun. 24, 2019”, 3 pgs.
[cited by applicant]
“Australian Application Serial No. 2017334841, Response filed Feb. 6, 2020 to First Examination Report mailed Jun. 24, 2019”, 14 pgs.
[cited by applicant]
“Australian Application Serial No. 2017335497, First Examination Report mailed Jun. 26, 2019”, 13 pgs.
[cited by applicant]
“Australian Application Serial No. 2017335497, Response filed Nov. 27, 2019 to First Examination Report mailed Jun. 26, 2019”, 18 pgs.
[cited by applicant]
“European Application Serial No. 17762308.9, Response to Communication pursuant to Rules 161 & 162 filed Nov. 26, 2019”, 23 pgs.
[cited by applicant]
“European Application Serial No. 17778108.5, Response to Communication Pursuant to Rules 161 and 162 filed Dec. 2, 2019”, 3 pgs.
[cited by applicant]
“European Application Serial No. 17794503.7, Response to Communication Pursuant to Rules 161 and 162 filed Dec. 30, 2019”, 11 pgs.
[cited by applicant]
“European Application Serial No. 18701908.8, Communication Pursuant to Article 94(3) EPC mailed May 20, 2020”, 6 pgs.
[cited by applicant]
“European Application Serial No. 18701908.8, Response filed Sep. 29, 2020 to Communication Pursuant to Article 94(3) EPC mailed May 20, 2020”, 29 pgs.
[cited by applicant]
“European Application Serial No. 18701908.8, Response to Communication Pursuant to Rules 161 and 162 filed Mar. 16, 2020”, 8 pgs.
[cited by applicant]
“European Application Serial No. 18702012.8, Response to Communication Pursuant to Rules 161 and 162 filed Mar. 11, 2020”, 12 pgs.
[cited by applicant]
“European Application Serial No. 18704105.8, Communication Pursuant to Article 94(3) EPC mailed Jan. 5, 2022”, 9 pgs.
[cited by applicant]
“European Application Serial No. 18704105.8, Response filed May 6, 2022 to Communication Pursuant to Article 94(3) EPC mailed Jan. 5, 2022”, 35 pgs.
[cited by applicant]
“European Application Serial No. 18704105.8, Response to Communication Pursuant to Rules 161 and 162 filed Feb. 27, 2020”, 10 pgs.
[cited by applicant]
“European Application Serial No. 21188652.8, Extended European Search Report mailed Nov. 24, 2021”, 9 pgs.
[cited by applicant]
“European Application Serial No. 21188652.8, Response filed Jul. 4, 2022 to Extended European Search Report mailed Nov. 24, 2021”, 10 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048867, International Preliminary Report on Patentability mailed Mar. 28, 2019”, 8 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048867, International Search Report mailed Nov. 13, 2017”, 5 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048867, Written Opinion mailed Nov. 13, 2017”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048896, International Preliminary Report on Patentability mailed Apr. 11, 2019”, 8 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048896, International Search Report mailed Nov. 27, 2017”, 5 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/048896, Written Opinion mailed Nov. 27, 2017”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/052685, International Preliminary Report on Patentability mailed Apr. 11, 2019”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/052685, International Search Report mailed Jan. 4, 2018”, 5 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/052685, Written Opinion mailed Jan. 4, 2018”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/057367, International Preliminary Report on Patentability mailed May 9, 2019”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/057367, International Search Report mailed Jan. 19, 2018”, 4 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2017/057367, Written Opinion mailed Jan. 19, 2018”, 4 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013251, International Preliminary Report on Patentability mailed Jul. 25, 2019”, 7 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013251, International Search Report mailed Apr. 12, 2018”, 4 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013251, Written Opinion mailed Apr. 20, 2018”, 5 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013257, International Preliminary Report on Patentability mailed Jul. 25, 2019”, 8 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013257, International Search Report mailed Apr. 19, 2018”, 4 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013257, Written Opinion mailed Apr. 19, 2018”, 6 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013268, International Preliminary Report on Patentability mailed Jul. 25, 2019”, 13 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013268, International Search Report mailed Apr. 30, 2018”, 5 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/013268, Written Opinion mailed Apr. 30, 2018”, 11 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/041860, International Preliminary Report on Patentability mailed Jan. 30, 2020”, 7 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/041860, International Search Report mailed Oct. 17, 2018”, 4 pgs.
[cited by applicant]
“International Application Serial No. PCT/US2018/041860, Written Opinion mailed Oct. 17, 2018”, 5 pgs.
[cited by applicant]
Ahern, David K., et al., “Comparison of lumbar paravertebral EMG patterns in chronic low back pain patients and non-patient controls”, Pain, 34, (1988), 153-160.
[cited by applicant]
Allum, John H.J., et al., “A speedy solution for balance and gait analysis: angular velocity measured at the centre of body mass”, Current Opinion in Neurology 18, (2005), 15-21.
[cited by applicant]
Alo, Kenneth M., et al., “Effect of Spinal Cord Stimulation on Sensory Nerve Conduction Threshold Functional Measures”, Neuromodulation, vol. 3, No. 3, (2000), 145-154.
[cited by applicant]
Ambady, Nalini, et al., “Thin Slices of Expressive Behavior as Predictors of Interpersonal Consequences: A Meta-Analysis”, Psychological Bulletin, 1992, vol. 111, No. 2, 256-274.
[cited by applicant]
Annoni, Elizabeth M., et al., “Method and Apparatus for Pain Management Using Objective Pain Measure”, U.S. Appl. No. 62/400,336, filed Sep. 27, 2016.
[cited by applicant]
Annoni, Elizabeth M., et al., “Pain Management Based on Brain Activity Monitoring”, U.S. Appl. No. 62/445,061, filed Jan. 11, 2017.
[cited by applicant]
Annoni, Elizabeth M., et al., “Pain Management Based on Muscle Tension Measurements”, U.S. Appl. No. 62/445,092, filed Jan. 11, 2017.
[cited by applicant]
Annoni, Elizabeth M., et al., “Pain Management Based on Respiration-Mediated Heart Rates”, U.S. Appl. No. 62/445,069, filed Jan. 11, 2017.
[cited by applicant]
Annoni, Elizabeth M., et al., “Patient-Specific Calibration of Pain Quantification”, U.S. Appl. No. 62/445,095, filed Jan. 11, 2017.
[cited by applicant]
Arsenault, Marianne, et al., “Pain Modulation Induced by Respiration: Phase and Frequency Effects”, Neuroscience 252, (2013), 501-511.
[cited by applicant]
Artner, Juraj, et al., “Prevalence of sleep deprivation in patients with chronic neck and back pain: a retrospective evaluation of 1016 patients”, Journal of Pain Research: 6, (2013), 1-6.
[cited by applicant]
Ashraf, A B, et al., “The painful face—Pain expression recognition using active appearance models”, Image and Vision Computing Elsevier Guildford, GB, vol. 27, No. 12, (Nov. 1, 2009), 1788-1796.
[cited by applicant]
Bakker, Jorn, et al., “What's your current stress level? Detection of stress patterns from GSR sensor data”, Eindhoven University of Technology—The Netherlands, (2011), 1-8.
[cited by applicant]
Baliki, Marwan N., et al., “Beyond Feeling: Chronic Pain hurts the Brain, Disrupting the Default-Mode Network Dynamics”, The Journal of Neuroscience, 28 (6), (Feb. 6, 2008), 1398-1403.
[cited by applicant]
Banos, Oresti, et al., “PhysioDroid: Combining Wearable Health Sensors and Mobile Devices for a Ubiquitous, Continuous, and Personal Monitoring”, The Scientific World Journal, vol. 2014 Article ID 190824, (2014), 11 pgs.
[cited by applicant]
Bansevicius, Dalius, et al., “Mental stress of long duration: EMG activity, perceived tension, fatigue, and pain development in pain-free subjects”, Headache: The Journal of Head and Face Pain; 37.8, (1997), 499-510.
[cited by applicant]
Barad, Meredith J., et al., “Complex Regional Pain Syndrome Is Associated With Structural Abnormalities in Pain-Related Regions of the Human Brain”, The Journal of Pain, vol. 15, No. 2, (Feb. 2014), 197-203.
[cited by applicant]
Barkley, Jacob E., et al., “The effect of spinal cord stimulation unit revision on perceived pain, anxiety, mobility and physical activity in individuals with low back/lower extremity pain”, Kent State University —The S…
[cited by applicant]
Bartlett, Marian Stewart, et al., “Automatic Decoding of Facial Movements Reveals Deceptive Pain Expressions”, Current Biology 24, 738-743, Mar. 31, 2014.
[cited by applicant]
Beneck, George J., et al., “Spectral analysis of EMG using intramuscular electrodes reveals non-linear fatigability characteristics in persons with chronic low back pain”, Journal of Electromyography and Kinesiology 23,…
[cited by applicant]
Ben-Israel, Nir, et al., “Monitoring the nociception level: a multi-parameter approach”, J Clin Monit Comput, (Jul. 2012), 10 pgs.
[cited by applicant]
Ben-Israel, Nir, et al., “Monitoring the nociception level: a multi-parameter approach”, J Clin Monit Comput 27, (2013), 659-668.
[cited by applicant]
Berthomier, Christian, et al., “Automatic analysis of single-channel sleep EEG: validation in healthy individuals”, Sleep-New York Then Westchester-30.11, (2007), 1587-1595.
[cited by applicant]
Boselli, E., et al., “Prediction of immediate postoperative pain using the analgesia/nociception index: a prospective observational study”, British Journal of Anaesthesia 112 (4):, (2014), 715-721.
[cited by applicant]
Boselli, E., et al., “Prospective observational study of the non-invasive assessment of immediate postoperative pain using the analgesia/nociception index (ANI)”, British Journal of Anaesthesia 111, (2013), 453-459.
[cited by applicant]
Broucqsault-Dédrie, Celine, et al., “Measurement of Heart Rate Variability to Assess Pain in Sedated Critically Ill Patients: A Prospective Observational Study”, PLOS One, (Jan. 25, 2016), 1-11.
[cited by applicant]
Bunde, Armin, et al., “Correlated and uncorrelated regions in heart-rate fluctuations during sleep”, Physical Review Letters 85.17, (2000), 3736-3739.
[cited by applicant]
Chan, C. W.Y., et al., “Subjective pain sensation is linearly correlated with the Flexion reflex in man”, Brain Research, 479, (1989), 145-150.
[cited by applicant]
Chapman, C. Richard, et al., “Phasic pupil dilation response to noxious stimulation in normal volunteers: relationship to brain evoked potentials and pain report”, (1999), 44-52.
[cited by applicant]
Chen, Shuzhen, et al., “The role of the autonomic nervous system in hypertension: a bond graph model study”, Physiological measurement 29.4 (2008): 473, (2008), 473-495.
[cited by applicant]
Cheng, Qian, et al., “GaitTrack: Health Monitoring of Body Motion from Spatio-Temporal Parameters of Simple Smart Phones”, The ACM Conference on Bioinformatics, Computational Biology, Biomed Biomedical Informatics (BCB)…
[cited by applicant]
Chuang, Chiung-Cheng, et al., “Photoplethysmography variability as an alternative approach to obtain heart rate variability information in chronic pain patient”, J Clin Monit Comput—Published online, (Feb. 24, 2015), 1-…
[cited by applicant]
Chung, OK Y., “Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain”, Pain 138, (2008), 87-97.
[cited by applicant]
Ciampi De Andrade, Daniel, et al., “Neurophysiological assessment of spinal cord stimulation in failed back surgery syndrome”, Pain 150, (2010), 485-491.
[cited by applicant]
Cinaz, Burcu, et al., “Monitoring of mental workload levels during an everyday life office-work scenario”, Pers Ubiquit Comput 17, (2013), 229-239.
[cited by applicant]
Clark, Bryan Allen, et al., “Pain Management Based on Functional Measurements”, U.S. Appl. No. 62/445,075, filed Jan. 11, 2017.
[cited by applicant]
Culic, Ognjen, et al., “Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia:diagnostic implications”, Clin Rheumatol 35, (2016), 2565-2571.
[cited by applicant]
Dansie, Elizabeth J., et al., “Activity in Adults with Chronic Widespread Pain”, The Journal of Pain—Accepted Manuscript, (2014), 33 pgs.
[cited by applicant]
Davydov, Dmitry M., et al., “Cardiovascular activity and chronic pain severity”, Physiology & Behavior 152, 203-216 (2015).
[cited by applicant]
De-La-Herran, Alvaro M., et al., “Gait Analysis Methods: An Overview of Wearable and Non-Wearable Systems, Highlighting Clinical Applications”, Sensors 14, (2014), 3362-3394.
[cited by applicant]
Denk, Franziska, et al., “Chronic Pain: Emerging Evidence for the Involvement of Epigenetics”. Neuron 73 (3), (2012), 435-444.
[cited by applicant]
Duschek, S., “Relationship between baroreceptor cardiac reflex sensitivity and pain experience in normotensive individuals”, International Journal of Psychophysiology 65, (2007), 193-200.
[cited by applicant]
Eisenberg, Elon, et al., “Quantitative Sensory Testing for Spinal Cord Stimulation in Patients With Chronic Neuropathic Pain”, (2006), 161-165.
[cited by applicant]
Elgendi, Mohamed, “On the analysis of fingertip photoplethysmogram signals”, Current cardiology reviews 8.1, (2012), 14-25.
[cited by applicant]
Evans, Subhadr, et al., “Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children”, Journal of Pain Research 3.6, (2013), 44…
[cited by applicant]
Fagius, J., et al., “The cold pressor test: effects on sympathetic nerve activity in human muscle and skin nerve fascicles”, Acta physiologica Scandinavica 137.3, (1989), 325-334.
[cited by applicant]
Fazalbhoy, Azharuddin, et al., “Individual differences in the cardiovascular responses to tonic muscle pain: parallel increases or decreases in muscle sympathetic nerve activity, blood pressure and heart rate”, Exp Phys…
[cited by applicant]
Foo, H., et al., “Brainstem modulation of pain during sleep and waking”, Sleep medicine reviews 7.2, (2003), 145-154.
[cited by applicant]
Frederiks, Joost, et al., “Within-subject electrocardiogramences at equal heart rates: role of the autonomic nervous system”, Pflügers Archiv 441.5, (2001), 717-724.
[cited by applicant]
Geisser, Michael E., et al., “Pain-Related Fear, Lumbar Flexion, and Dynamic EMG Among Persons With Chronic Musculoskeletal Low Back Pain”, Clin J Pain, vol. 20, No. 2, (Apr. 2004).
[cited by applicant]
Generaal, Ellen, et al., “Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders”, BMC Musculoskeletal Disorders, 15:227, (2014…
[cited by applicant]
Gesche, Heiko, et al., “Continuous blood pressure measurement by using the pulse transit time: comparison to a cuff-based method”, European journal of applied physiology 112.1, (2012), 309-315.
[cited by applicant]
Godfrey, A., et al., “Direct measurement of human movement by accelerometry”, Medical Engineering & Physics 30 (2008) 1364-1386.
[cited by applicant]
Godfrey, A., et al., “Instrumenting gait with an accelerometer: a system and algorithm examination”, Medical Engineering & Physics, Mar. 2015, doi:10.1016/j.medengphy.2015.02.003, 24 pgs.
[cited by applicant]
Gouveia, S., et al., “Assessing Baroreflex Sensitivity in the Sequences Technique: Local versus Global Approach”, Computers in Cardiology, 32, (2005), 279-282.
[cited by applicant]
Granovsky, Yelena, et al., “Objective Correlate of Subjective Pain Perception by Contact Heat-Evoked Potentials”, The Journal of Pain, vol. 9, No. 1, (Jan. 2008), 53-63.
[cited by applicant]
Green, Alexande L., “Measurement of muscle sympathetic nerve activity reveals true sympathetic changes in chronic pain”, Exp Physiol 97.10, (2012), 1083.
[cited by applicant]
Hallman, David, et al., “Autonomic regulation, physical activity and perceived stress in subjects with musculoskeletal pain: 24-hour ambulatory monitoring”, International Journal of Psychophysiology 86, (2012), 276-282.
[cited by applicant]
Hallman, David M., et al., “Changes in physical activity and heart rate variability in chronic neck-shoulder pain: monitoring during work and leisure time”, Int Arch Occup Environ Health 87, (2014), 735-744.
[cited by applicant]
Hallman, David M., et al., “Long-Term Monitoring of Physical Behavior Reveals Different Cardiac Responses to Physical Activity among Subjects with and without Chronic Neck Pain”, BioMed Research International, vol. 2015…
[cited by applicant]
Hartwich, Doreen, et al., “Effect of muscle metaboreflex activation on spontaneous cardiac baroreflex sensitivity during exercise in humans”, J Physiol 589.24, (2011), 6157-6171.
[cited by applicant]
Jensen, MP, et al., “Brain EEG activity correlates of chronic pain in persons with spinal cord injury: clinical implications”, Nature; Spinal Cord; 51, (Jul. 17, 2012), 55-58.
[cited by applicant]
Jess, Gunnar, et al., “Monitoring heart rate variability to assess experimentally induced pain using the analgesia nociception index—A randomised volunteer study”, Eur J Anaesthesiol 32, (2015), 1-8.
[cited by applicant]
Kang, Jon-Eun, et al., “Pulse transit time shows vascular changes caused by propofol in children”, J Clin Monit Comput 29, (2015), 533-537.
[cited by applicant]
Keefe, Francis J,, et al., “An Objective Approach to Quantifing Pain Behavior and Gait Patterns in Low Back Pain Patients”, Pain, 21, (1985), 153-161.
[cited by applicant]
Kemler, Marius A., et al., “Impact of Spinal Cord Stimulation on Sensory Characteristics in Complex Regional Pain Syndrome Type 1—A Randomized Trial”, Anesthesiology, 95, (2001), 72-80.
[cited by applicant]
Keshari, Kayvan R., et al., “Lactic Acid and Proteoglycans as Metabolic Markers dor Discogenic Back Pain”, SPINE, vol. 13, No. 3, (2008), 312-317.
[cited by applicant]
Kim, Young Uk, et al., “Pulse Transit Time as a Predictor of the Efficacy of a Celiac Plexus Block in Patients With Chronic Intractable Abdominal Pain”, Clin J Pain, vol. 32, No. 6, (Jun. 2015), 522-526.
[cited by applicant]
Kodituwakku, Sandun, et al., “Point Process Respiratory Sinus Arrhythmia Analysis during Deep Tissue Pain Stimulation”, Computing in Cardiology 38, (2011), 193-196.
[cited by applicant]
Koenig, J., et al., “Heart rate variability and experimentally induced pain in healthy adults: A systematic review”, European Journal of Pain 18, (2014), 301-314.
[cited by applicant]
Koenig, Julian, et al., “Chronic Pain and Heart Rate Variability in a Cross-Sectional Occupational Sample Evidence for Impaired Vagal Control”, The Clinical Journal of Pain, Publish Ahead of Print, (2015), 31 pgs.
[cited by applicant]
La Rovere, Maria Teresa, et al., “Baroreflex Sensitivity: Measurement and Clinical Implications”, Ann Noninvasive Electrodardiol, 13(2):191-207, 2008.
[cited by applicant]
Lamoth, Claudine J.C., et al., “How do persons with chronic low back pain speed up and slow down? Trunk-pelvis coordination and erector spinae activity during gait”, Gait & Posture 23, (2006), 230-239.
[cited by applicant]
Lamoth, Claudine J.C., et al., “Pelvis-Thorax Coordination in the Transverse Plane During Walking in Persons With Nonspecific Low Back Pain”, SPINE, vol. 27, No. 4, (2002), E92-E99.
[cited by applicant]
Lane, James D., et al., “Respiratory Sinus Arrhythmia and Cardiovascular Responses to Stress”, Psychophysiology, vol. 29, No. 4, (1992), 461-470.
[cited by applicant]
Latremoliere, Alban, et al., “Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway”, Neuron, 86 (6), (2015), 1393-1406.
[cited by applicant]
Ledowski, Thomas, et al., “The influence of age and sex on the relationship between heart rate variability, haemodynamic variables and subjective measures of acute post-operative pain”, European Journal of Anesthesiolog…
[cited by applicant]
Lee, Jihyoung, et al., “Validation of normalized pulse volume in the outer ear as a simple measure of sympathetic activity using warm and cold pressor tests: towards applications in ambulatory monitoring”, Physiol. Meas…
[cited by applicant]
Lidberg, Lars, et al., “Sympathetic Skin Nerve Dischai gcs in Relation lo Anipliliule ol Skin Resistance Responses”, Psychophysiology, vol. 18, No. 3, (May 1981), 268-270.
[cited by applicant]
Littlewort, Gwen C., et al., “Automatic Coding of Facial Expressions Displayed During Posed and Genuine Pain”, Image and Vision Computing, 27(12) p. 1741-1844.
[cited by applicant]
Logier, R., et al., “PhysioDoloris: a monitoring device for Analgesia / Nociception balance evaluation using Heart Rate Variability analysis”, 32nd Annual International Conference of the IEEE EMBS, (2010), 1194-1197.
[cited by applicant]
Looney, David, et al., “The In-the-Ear Recording Concept”, IEEE Pulse Nov./Dec. 2012, 32-42.
[cited by applicant]
Marchi, Antonio, et al., “Pain Biomarkers”, Clin Drug Invest, 29 Suppl 1, (2009), 41-46.
[cited by applicant]
Martini, Chris H., et al., “Ability of the Nociception Level, a Multiparameter Composite of Autonomic Signals, to Detect Noxious Stimuli during Propofol-Remifentanil Anesthesia”, Anesthesiology, vol. 123, No. 3, (2015),…
[cited by applicant]
Mauer, C,, et al., “Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes”, Pain 150, (2010), 439-…
[cited by applicant]