IP Library › Granted Patent US 12,226,632
Granted Patent B2
US 12,226,632 · App. 18/175,963 · Granted Feb 18, 2025

Method and apparatus for transdermal stimulation over the palmar and plantar surfaces

Inventors: Amit Rajguru (Lafayette, CA); Daniel R. Burnett (San Francisco, CA); Alexander Vergara (San Francisco, CA); Michael Hemati (San Francisco, CA)
Assignee: EMKinetics, Inc.
A61N1/36021A61B5/388A61N1/0456A61N1/36007A61N1/36057A61N2/02A61B5/4047A61N1/0551A61N1/36017A61N1/3787A61N2/004
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Quick Facts
Patent No.
US 12,226,632
App. No.
18/175,963
Granted
Feb 18, 2025
Kind
B2
Abstract

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Claims (68)

1. A method of treating overactive bladder or incontinence, comprising:

non-invasively positioning a first portion of a subject's body near an ankle relative to an electrical stimulator such that a tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;

passing a current through the electrical stimulator;

delivering an electrical stimulus from the electrical stimulator to the tibial nerve such that the tibial nerve directly receives the electrical stimulation to treat overactive bladder or incontinence;

detecting for an electrical conduction in the tibial nerve via a sensor in communication with a controller by detecting for a lack of presence of the electrical conduction at a second portion of the subject's body distant from the first portion as an indicator of electrode migration from the first portion; and

adjusting the electrical stimulus via the controller in response to the electrical conduction detected in the tibial nerve.

2. The method of claim 1 wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator near an ankle of the patient.

3. The method of claim 1 wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the subject.

4. The method of claim 1 further comprising displaying physiological parameters detected from the subject.

5. The method of claim 1 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

6. The method of claim 1 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of electrode malfunction from the first portion.

7. The method of claim 6 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

8. The method of claim 1 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of proper electrode placement upon the first portion.

9. The method of claim 8 wherein detecting for the lack of the presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

10. The method of claim 1 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction through tissue at the second portion of the subject's body distant from the first portion as an indicator of electrode placement upon the first portion.

11. The method of claim 10 wherein detecting for the lack of the presence of the electrical conduction through tissue comprises detecting via an electrode patch positioned upon the second portion.

12. The method of claim 1 wherein the sensor comprises an EMG electrode.

13. A method of treating overactive bladder or incontinence, comprising:

non-invasively positioning a first portion of a subject's body near an ankle relative to an electrical stimulator such that a tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;

passing a current through the electrical stimulator;

delivering an electrical stimulus from the electrical stimulator to the tibial nerve such that the tibial nerve directly receives the electrical stimulation to treat overactive bladder or incontinence;

detecting for an electrical conduction in the tibial nerve via a sensor in communication with a controller by detecting for a lack of presence of the electrical conduction at a second portion of the subject's body distant from the first portion as an indicator of electrode malfunction from the first portion; and

adjusting the electrical stimulus via the controller in response to the electrical conduction detected in the tibial nerve.

14. The method of claim 13 wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator near an ankle of the patient.

15. The method of claim 13 wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the subject.

16. The method of claim 13 further comprising displaying physiological parameters detected from the subject.

17. The method of claim 13 wherein detecting for the electrical conduction further comprises detecting for a lack of presence of the electrical conduction at a second portion of the subject's body distant from the first portion as an indicator of electrode migration from the first portion.

18. The method of claim 17 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

19. The method of claim 13 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

20. The method of claim 13 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of proper electrode placement upon the first portion.

21. The method of claim 20 wherein detecting for the lack of the presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

22. The method of claim 13 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction through tissue at the second portion of the subject's body distant from the first portion as an indicator of electrode placement upon the first portion.

23. The method of claim 22 wherein detecting for the lack of the presence of the electrical conduction through tissue comprises detecting via an electrode patch positioned upon the second portion.

24. The method of claim 13 wherein the sensor comprises an EMG electrode.

25. A method of treating overactive bladder or incontinence, comprising:

non-invasively positioning a first portion of a subject's body near an ankle relative to an electrical stimulator such that a tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;

passing a current through the electrical stimulator;

delivering an electrical stimulus from the electrical stimulator to the tibial nerve such that the tibial nerve directly receives the electrical stimulation to treat overactive bladder or incontinence;

detecting for an electrical conduction in the tibial nerve via a sensor in communication with a controller by detecting for a lack of presence of the electrical conduction at a second portion of the subject's body distant from the first portion as an indicator of proper electrode placement upon the first portion; and

adjusting the electrical stimulus via the controller in response to the electrical conduction detected in the tibial nerve.

26. The method of claim 25 wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator near an ankle of the patient.

27. The method of claim 25 wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the subject.

28. The method of claim 25 further comprising displaying physiological parameters detected from the subject.

29. The method of claim 25 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of electrode migration from the first portion.

30. The method of claim 29 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

31. The method of claim 25 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of electrode malfunction from the first portion.

32. The method of claim 31 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

33. The method of claim 25 wherein detecting for the lack of the presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

34. The method of claim 25 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction through tissue at the second portion of the subject's body distant from the first portion as an indicator of electrode placement upon the first portion.

35. The method of claim 34 wherein detecting for the lack of the presence of the electrical conduction through tissue comprises detecting via an electrode patch positioned upon the second portion.

36. The method of claim 25 wherein the sensor comprises an EMG electrode.

37. A method of treating overactive bladder or incontinence, comprising:

non-invasively positioning a first portion of a subject's body near an ankle relative to an electrical stimulator such that a tibial nerve within the first portion of the body is directly targeted by the electrical stimulator;

passing a current through the electrical stimulator;

delivering an electrical stimulus from the electrical stimulator to the tibial nerve such that the tibial nerve directly receives the electrical stimulation to treat overactive bladder or incontinence;

detecting for an electrical conduction in the tibial nerve via a sensor in communication with a controller by detecting for a lack of presence of the electrical conduction through tissue at a second portion of the subject's body distant from the first portion as an indicator of electrode placement upon the first portion; and

adjusting the electrical stimulus via the controller in response to the electrical conduction detected in the tibial nerve.

38. The method of claim 37 wherein non-invasively positioning comprises positioning an electrode patch in communication with the electrical stimulator near an ankle of the patient.

39. The method of claim 37 wherein delivering the electrical stimulus comprises activating the electrical stimulator for a duration of about 30 minutes per week to treat the subject.

40. The method of claim 37 further comprising displaying physiological parameters detected from the subject.

41. The method of claim 37 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of electrode migration from the first portion.

42. The method of claim 41 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

43. The method of claim 37 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of electrode malfunction from the first portion.

44. The method of claim 43 wherein detecting for the lack of presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

45. The method of claim 37 wherein detecting for the electrical conduction further comprises detecting for the lack of presence of the electrical conduction at the second portion of the subject's body distant from the first portion as an indicator of proper electrode placement upon the first portion.

46. The method of claim 45 wherein detecting for the lack of the presence of the electrical conduction comprises detecting via an electrode patch positioned upon the second portion.

47. The method of claim 37 wherein detecting for the lack of the presence of the electrical conduction through tissue comprises detecting via an electrode patch positioned upon the second portion.

48. The method of claim 37 wherein the sensor comprises an EMG electrode.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2023
From: RAJGURU, AMIT
To: EMKINETICS, INC.
Reel/Frame 062828/0884 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2023
From: BURNETT, DANIEL R.; VERGARA, ALEXANDER; HEMATI, MICHAEL
To: EMKINETICS, INC.
Reel/Frame 062829/0140 →
Continuity (12)
Continuation 17346084 · Jun 11, 2021
Continuation 16732706 · Jan 2, 2020
Continuation 15474875 · Mar 30, 2017
Continuation In Part 15084356 · Mar 29, 2016
Continuation 13840936 · Mar 15, 2013
Continuation In Part PCTUS2011052415 · Sep 20, 2011
Continuation In Part 12508529 · Jul 23, 2009
Continuation In Part 11866329 · Oct 2, 2007
Provisional Application 62350610 · Jun 15, 2016
Provisional Application 61403680 · Sep 20, 2010
Provisional Application 60848720 · Oct 2, 2006
Related Publication 20230201584A1 · Jun 29, 2023
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