IP Library › Granted Patent US 12,246,011
Granted Patent B2
US 12,246,011 · App. 18/207,447 · Granted Mar 11, 2025

Radiation mitigator and method of use thereof

Inventors: Milton L. Brown (Brookeville, MD); Yali Kong (Fairfax, VA); Courtney Houchen (Edmond, OK); Sripathi M. Sureban (Oklahoma City, OK); Parthasarathy Chandrakesan (Edmond, OK)
Assignees: Georgetown University; The Board of Regents of the University of Oklahoma
A61K31/454A61K31/4184A61P39/00
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Quick Facts
Patent No.
US 12,246,011
App. No.
18/207,447
Granted
Mar 11, 2025
Kind
B2
Abstract

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

Claims (19)

1. A method for treating or preventing radiation-induced tissue injury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by formula II

or a pharmaceutically acceptable salt thereof, thereby treating or preventing radiation-induced tissue injury in the subject.

2. The method of claim 1 , wherein the compound is administered prior to exposure of the subject to radiation.

3. The method of claim 1 , wherein the compound is administered after exposure of the subject to radiation.

4. The method of claim 1 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

5. The method of claim 1 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

6. The method of claim 1 , wherein the tissue comprises gastrointestinal tissue.

7. The method of claim 1 , wherein the tissue comprises hematopoietic tissue.

8. The method of claim 1 , wherein the tissue comprises neural tissue.

9. The method of claim 1 , wherein the compound is administered orally.

10. The method of claim 1 , wherein the compound is administered parenterally.

11. The method of claim 1 , wherein the subject is a mammal.

12. The method of claim 1 , wherein the subject is a human.

13. The method of claim 1 , wherein the radiation-induced tissue injury is prevented.

14. The method of claim 1 , wherein the radiation-induced tissue injury is treated.

15. The method of claim 2 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

16. The method of claim 2 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

17. The method of claim 3 , wherein the radiation-induced tissue injury is acute radiation-induced tissue injury.

18. The method of claim 3 , wherein the radiation-induced tissue injury is chronic radiation-induced tissue injury.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2024
From: HOUCHEN, COURTNEY; SUREBAN, SRIPATHI M.; CHANDRAKESAN, PARTHASARATHY
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Reel/Frame 068900/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2024
From: BROWN, MILTON L.; KONG, YALI
To: GEORGETOWN UNIVERSITY
Reel/Frame 068900/0347 →
Continuity (4)
Division 17728485 · Apr 25, 2022
Continuation 16089794
Provisional Application 62316121 · Mar 31, 2016
Related Publication 20230310407A1 · Oct 5, 2023
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