Granted Patent B2

US 12,350,355 · App. 18/322,979 · Granted Jul 8, 2025

Inventors: Arif Ali Baig (Mason, OH); Tammy Baker (Cincinnati, OH); Aaron Reed Biesbrock (Maineville, OH); Samuel James St. John (Cincinnati, OH)

Assignee: The Procter & Gamble Company

A61K8/27A61K8/20A61K8/21A61K8/24A61K8/35A61K8/362A61K8/365A61K8/44A61K8/731A61K8/8147A61K8/97A61K8/9789A61Q11/00A61K2800/28A61K2800/30A61K2800/48A61K2800/74A61K2800/92

Abstract

Claims (31)

1. An oral care composition comprising:

(a) hops extract comprising hops beta acid and hops oils, wherein the hops extract comprises from greater than 0% to less than 2.5%, by weight of the hops extract, of the hops oils, wherein the oral care composition comprises from about 0.01% to about 10%, by weight of the composition, of the hops beta acid, and wherein the hops beta acid comprises only non-hydrogenated hops beta acids; and

(b) from about 0.01% to about 10%, by weight of the composition, of fluoride,

wherein the oral care composition has a pH of greater than 7.

2. The oral care composition of claim 1 , wherein the composition is free of stannous fluoride.

3. The oral care composition of claim 1 , further comprising from about 10% to about 50%, by weight of the composition, of calcium, and wherein the composition is free of silica.

4. The oral care composition of claim 3 , further comprising from about 1% to about 20%, by weight of the composition, of a buffering agent, wherein the buffering agent comprises a conjugate acid of the calcium.

5. The oral care composition of claim 4 , wherein the buffering agent comprises a bicarbonate ion source and the calcium comprises calcium carbonate.

6. The oral care composition of claim 1 , wherein the hops beta acid comprises lupulone, colupulone, adlupulone, or combinations thereof.

7. The oral composition of claim 1 , wherein the fluoride is selected from the group consisting of sodium fluoride, sodium monofluorophosphate, amine fluoride, indium fluoride, and combinations thereof.

8. The oral care composition of claim 1 , further comprising from about 0.01% to about 10%, by weight of the composition, of an antibacterial agent comprising a metal ion source.

9. The oral care composition of claim 8 , wherein the metal ion source comprises a tin ion source, a zinc ion source, or combinations thereof.

10. The oral care composition of claim 9 , wherein the metal ion source comprises the tin ion source, and the tin ion source comprises stannous chloride.

11. The oral care composition of claim 1 , further comprising potassium nitrate.

12. The oral care composition of claim 1 , further comprising an amino acid, wherein the amino acid comprises a basic amino acid, an acidic amino acid, a neutral amino acid, or combinations thereof.

13. The oral care compositions claim 12 , wherein the amino acid comprises glycine, alanine, valine, isoleucine, tryptophan, phenylalanine, proline, methionine, leucine, serine, threonine, tyrosine, asparagine, glutamine, cysteine, citrulline, aspartic acid, glutamic acid, lysine, arginine, histidine, or combinations thereof.

14. An oral care composition comprising:

(a) from about 0.01% to about 10%, by weight of the composition, of hops beta acid, wherein the hops beta acid comprises only non-hydrogenated hops beta acids;

(b) from about 0.01% to about 10%, by weight of the composition, of stannous fluoride; and

(c) citrate,

wherein the oral care composition has a pH of greater than 7.

15. The oral care composition of claim 14 , wherein the hops beta acid comprises lupulone, colupulone, adlupulone, or combinations thereof.

16. The oral care composition of claims 14 , further comprising from about 10% to about 50% of calcium.

17. The oral care composition of claim 16 , wherein the calcium comprises calcium abrasive.

18. The oral care composition of claim 17 , wherein the calcium abrasive comprises calcium carbonate.

19. The oral care composition of claim 16 , wherein the oral care composition comprises from about 1% to about 20%, by weight of the composition, of buffering agent, wherein the buffering agent comprises a conjugate acid of the calcium.

20. The oral care composition of claim 14 , further comprising from about 0.01% to about 20%, by weight of the composition, of a thickening system, wherein the thickening system comprises polyacrylic acid, cellulose, a cellulose derivative, xanthan gum, a carrageenan, or combinations thereof.

21. The oral care composition of claim 20 , wherein the thickening system is free of a copolymer of maleic anhydride and methyl vinyl ether.

22. The oral care composition of claim 14 , further comprising potassium nitrate.

23. The oral care composition of claim 14 , further comprising an amino acid, wherein the amino acid comprises a basic amino acid, an acidic amino acid, a neutral amino acid, or combinations thereof.

24. The oral care composition of claim 23 , wherein the amino acid comprises glycine, alanine, valine, isoleucine, tryptophan, phenylalanine, proline, methionine, leucine, serine, threonine, tyrosine, asparagine, glutamine, cysteine, citrulline, aspartic acid, glutamic acid, lysine, arginine, histidine, or combinations thereof.

Continuity (10)

References Cited (232)