IP Library › Granted Patent US 12,590,266
Granted Patent B2
US 12,590,266 · App. 18/635,139 · Granted Mar 31, 2026

Free polyunsaturated fatty acid-containing compositions and manufacturing method therefor

Inventors: Yuhei Kosuge (Tokyo, JP); Hideaki Yamaguchi (Tokyo, JP); Nobushige Doisaki (Tokyo, JP)
Assignee: NISSUI CORPORATION
C11C1/04A23D9/007A23L33/12A61K31/201A61K31/202C07C51/087C07C57/12C07C69/58C11C3/00A23V2002/00
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Quick Facts
Patent No.
US 12,590,266
App. No.
18/635,139
Granted
Mar 31, 2026
Kind
B2
Abstract

The present disclosure is: a free polyunsaturated fatty acid-containing composition, which comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, the content being at least 80.0% of the fatty acids in the composition, and satisfies at least one selected from a group consisting of conditions (1) and (2): (1) the content of conjugated unsaturated fatty acid is 1.0% or less of the fatty acids in the composition, and (2) the Gardner color is less than 3+; and a manufacturing method for the free polyunsaturated fatty acid-containing composition comprising the preparation of a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms, and hydrolysis of a reaction solution containing the prepared raw material composition, a lower alcohol, water and an alkali catalyst at a temperature of 10° C. or lower.

Claims (14)

1 . A manufacturing method of a free polyunsaturated fatty acid-containing composition, the method comprising:

providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbons in a form of an alkyl ester, wherein a content of polyunsaturated fatty acid alkyl ester in the raw material is 80.0% or greater of fatty acid alkyl esters in the raw material; and

performing hydrolysis treatment on a reaction solution containing the provided raw material composition, a lower alcohol, water, and an alkali catalyst at −20° C. to 10° C. to obtain the free polyunsaturated fatty acid-containing composition,

wherein the free polyunsaturated fatty acid-containing composition comprises at least one polyunsaturated fatty acid having 20 or more carbons.

2 . The manufacturing method according to claim 1 , the method further comprising adding an acid to the reaction solution to terminate the hydrolysis reaction, wherein a pH of the reaction solution after the acid addition is from pH 1.0 to 6.0.

3 . The manufacturing method according to claim 1 , wherein an amount of the lower alcohol in the reaction solution is from 0.9 equivalents to 32.0 equivalents relative to an amount of total fatty acids in the raw material composition.

4 . The manufacturing method according to claim 1 , wherein an amount of the lower alcohol in the reaction solution is from 0.20 to 8.20 in terms of weight content ratio relative to the water.

5 . The manufacturing method according to claim 1 , wherein the water in the reaction solution is from 6.0 equivalents to 13.0 equivalents relative to an amount of total fatty acids in the raw material composition.

6 . The manufacturing method according to claim 1 , wherein the alkali catalyst in the reaction solution is from 1.0 equivalent to 2.3 equivalents relative to an amount of total fatty acids in the raw material composition.

7 . The manufacturing method according to claim 1 , wherein the alkali catalyst is at least one selected from the group consisting of sodium hydroxide and potassium hydroxide.

8 . The manufacturing method according to claim 1 , wherein the hydrolysis treatment is performed at 2° C. to 10° C.

9 . The manufacturing method according to claim 1 , wherein the raw material composition is derived from a microbial raw material.

10 . The manufacturing method according to claim 9 , wherein the microbial raw material is a microbial oil derived from a microorganism of the genus Labyrinthula , the genus Yarrowia , the genus Pichia , or the genus Mortierella.

11 . The manufacturing method according to claim 9 , wherein the microbial raw material is a microbial oil derived from Mortierella elongata, Mortierella exigua, Mortierella hygrophila , or Mortierella alpina.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2024
From: KOSUGE, YUHEI; YAMAGUCHI, HIDEAKI; DOISAKI, NOBUSHIGE
To: NIPPON SUISAN KAISHA, LTD.
Reel/Frame 067107/0304 →
CHANGE OF NAME Recorded Apr 15, 2024
From: NIPPON SUISAN KAISHA, LTD.
To: NISSUI CORPORATION
Reel/Frame 067123/0429 →
Priority Claims (1)
JP 2015-170856 · Aug 31, 2015 · national
Continuity (6)
Continuation 17860234 · Jul 8, 2022
Division 17124636 · Dec 17, 2020
Continuation 16752048 · Jan 24, 2020
Continuation 15906602 · Feb 27, 2018
Continuation PCTJP2016075444 · Aug 31, 2016
Related Publication 20240254407A1 · Aug 1, 2024
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