Aspirin derivatives and uses thereof
View Patent ↗The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.
1. A method of treating colorectal cancer in a subject in need thereof, comprising:
administering to said subject a therapeutically effective amount of a compound having the following structure:
or a pharmaceutically acceptable salt or prodrug thereof,
wherein:
E is —O—;
each of R A and R C is independently —H or —OH;
each of R D and R B is independently —H, —OH or —O—C 1-6 alkyl; and
R E is —O—C 1-6 acyl.
2. The method of claim 1 , wherein R A is —OH.
3. The method of claim 1 , wherein said compound has the structure:
wherein:
each of R B and R D is independently —OH or —O—C 1-6 alkyl; and
R E is —O—C(O)-Me.
4. The method of claim 3 , wherein each of R B and R D is —OH.
5. The method of claim 3 , wherein each of R B and R D is independently —O—C 1-6 alkyl.
6. The method of claim 3 , wherein each of R B and R D is independently —O—C 1-3 alkyl.
7. The method of claim 3 , wherein each of R B and R D is —O-Me.
8. The method of claim 1 , wherein said compound has the structure:
wherein:
R A is —OH;
R C is —H or —OH; and
R E is —O—C 1-6 acyl.
9. The method of claim 8 , wherein R C is —OH and R E is —O—C(O)Me.
10. The method of claim 1 , wherein said compound has the structure:
11. A method of treating lung cancer in a subject in need thereof, comprising:
administering to said subject a therapeutically effective amount of a compound having the following structure:
or a pharmaceutically acceptable salt or prodrug thereof,
wherein:
E is —O—;
each of R A and R C is independently —H or —OH;
each of R D and R B is independently —H, —OH or —O—C 1-6 alkyl; and
R E is —O—C 1-6 acyl.
12. The method of claim 11 , wherein R A is —OH.
13. The method of claim 11 , wherein said compound has the structure:
wherein:
each of R B and R D is independently —OH or —O—C 1-6 alkyl; and
R E is —O—C(O)-Me.
14. The method of claim 13 , wherein each of R B and R D is —OH.
15. The method of claim 13 , wherein each of R B and R D is independently —O—C 1-6 alkyl.
16. The method of claim 13 , wherein each of R B and R D is independently —O—C 1-3 alkyl.
17. The method of claim 13 , wherein each of R B and R D is —O-Me.
18. The method of claim 11 , wherein said compound has the structure:
wherein:
R A is —OH;
R C is —H or —OH; and
R E is —O—C 1-6 acyl.
19. The method of claim 18 , wherein R C is —OH and R E is —O—C(O)Me.
20. The method of claim 11 , wherein said compound has the structure: