IP Library › Granted Patent US 12,203,741
Granted Patent B2
US 12,203,741 · App. 18/486,815 · Granted Jan 21, 2025

Method and device for superresolution optical measurement using singular optics

Inventor: Gabriel Y Sirat (Paris, FR)
Assignee: Bioaxial SAS
G01B11/14G01N21/64G01N21/6428G01N21/6458G02B21/0056G02B21/0072G02B21/0076G02B21/16G01B11/25G01N2201/06113G01N2201/12
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Quick Facts
Patent No.
US 12,203,741
App. No.
18/486,815
Granted
Jan 21, 2025
Kind
B2
Abstract

A method of optical measurement for determining a spatial position of at least one luminous object in a sample includes: projecting onto the sample a dynamically optimized sequence of compact luminous distributions of different topological families; wherein the dynamically optimized sequence is determined based on data selected from the group consisting of a positioning hypothesis and a first set of measures; for each compact luminous distribution in the optimized sequence, generating an image of the at least one luminous object as illuminated thereby; and algorithmically analyzing the generated images to obtain spatial position information of the at least one luminous object.

Claims (10)

1. A method of optical measurement for determining a spatial position of at least one luminous object in a sample, the method comprising:

projecting onto the sample a dynamically optimized sequence of compact luminous distributions of different topological families;

wherein the dynamically optimized sequence is determined based on data selected from the group consisting of a positioning hypothesis and a first set of measures;

for each compact luminous distribution in the optimized sequence, generating an image of the at least one luminous object as illuminated thereby; and

algorithmically analyzing the generated images to obtain spatial position information of the at least one luminous object.

2. A method according to claim 1 , further comprising causing moving, in space, in an optimized manner, the sequence of compact luminous distributions, wherein the optimized manner is determined based on data selected from the group consisting of the positioning hypothesis and the first set of measures.

3. A method according to claim 1 , wherein projecting the dynamically optimized sequence of compact luminous distributions is performed by conical diffraction and modified by a variation of polarization states at an input and output of at least one conical crystal performing the conical diffraction.

4. A method according to claim 1 , wherein the luminous object is a luminous nanoemitter.

5. A method according to claim 4 , further comprising retrieving at least one of a longitudinal position and a lateral position of the luminous nano-emitter.

6. A method according to claim 1 , wherein each luminous distribution of the dynamically optimized sequence is characterized by a distinct longitudinal dependency and algorithmically analyzing the generated images includes analyzing the images to obtain a spatial position of the at least one luminous object in a longitudinal dimension.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 15, 2023
From: SIRAT, GABRIEL
To: BIOAXIAL SAS
Reel/Frame 065566/0366 →
Priority Claims (1)
FR 1004067 · Oct 15, 2010 · national
Continuity (8)
Continuation 18179062 · Mar 6, 2023
Continuation 17589265 · Jan 31, 2022
Continuation 17087238 · Nov 2, 2020
Continuation 16557030 · Aug 30, 2019
Continuation 15812016 · Nov 14, 2017
Continuation 14998051 · Dec 24, 2015
Continuation 13822355
Related Publication 20240053138A1 · Feb 15, 2024
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