Granted Patent
B2
US 12,228,579 · App. 17/841,704 · Granted Feb 18, 2025
Methods of prognosis and treatment
Inventors:
Eran Eden (Haifa, IL); Kfir Oved (Hof HaCarmel, IL); Assaf Cohen-Dotan (Natania, IL); Roy Navon (Tel-Aviv, IL); Olga Boico (Atlit, IL); Meital Paz (Haifa, IL)
Assignee:
MeMed Diagnostics Ltd.
G01N33/6893G01N33/50G01N33/52G01N33/53G01N33/582G01N33/60G01N33/6863G01N33/6869G16H50/20G16H50/30G16H50/70C07K14/4716C07K14/4737C07K14/522C07K14/525C07K14/5412G01N2333/52G01N2333/525G01N2333/5412G01N2800/26
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Abstract
A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.
Claims (8)
1. A method for triaging subjects who are suspected of having a viral infection, comprising measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below 30 pg/ml, the subject is subjected to a management selected from the group consisting of hospitalization, mechanical ventilation, invasive monitoring, sedation, intensive care admission and surgical intervention.
2. The method of claim 1 , wherein said blood sample is a fraction of whole blood.
3. The method of claim 2 , wherein said fraction is serum or plasma.
4. The method of claim 1 , wherein said blood sample comprises cells selected from the group consisting of lymphocytes, monocytes and granulocytes.
5. The method of claim 1 , wherein said measuring is determined electrophoretically or immunochemically.
6. The method of claim 5 , wherein said immunochemical determination is measured by lateral flow immunoassay, flow cytometry, radioimmunoassay, immunofluorescence or by an enzyme-linked immunosorbent assay.
7. The method of claim 1 , wherein the triaging further comprises measuring the level of at least one additional determinant selected from the group consisting of IP10, CRP, PCT, IL1RA and IL-6.
8. The method of claim 1 , wherein when the TRAIL level is below 25 pg/ml, the subject is subjected to the management.
Assignments (2)
SECURITY INTEREST
Recorded Mar 11, 2026
From: MEMED DIAGNOSTICS LTD.
To: WTI FUND X, INC.; WTI FUND XI, INC.
Reel/Frame 074048/0278 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 13, 2022
From: EDEN, ERAN; OVED, KFIR; COHEN-DOTAN, ASSAF; NAVON, ROY; BOICO, OLGA; PAZ, MEITAL
To: MEMED DIAGNOSTICS LTD.
Reel/Frame 061932/0541 →
Continuity (3)
Division
16334033
Provisional Application
62401296
· Sep 29, 2016
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