IP Library › Granted Patent US 12,252,532
Granted Patent B2
US 12,252,532 · App. 17/742,824 · Granted Mar 18, 2025

Anti-myostatin antibodies and methods of use

Inventors: Yoshinao Ruike (Singapore, SG); Taichi Kuramochi (Singapore, SG)
Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
C07K16/22A61P21/00A61K2039/505C07K2317/21C07K2317/24C07K2317/52C07K2317/56C07K2317/567C07K2317/76C07K2317/77C07K2317/92C07K2317/94
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Quick Facts
Patent No.
US 12,252,532
App. No.
17/742,824
Granted
Mar 18, 2025
Kind
B2
Abstract

The invention provides anti-myostatin antibodies and methods of using the same. In some embodiments, an isolated anti-myostatin antibody of the present invention binds to mature myostatin, and uptake of the antibody into cells is enhanced when complexed with the antigen. The invention also provides isolated nucleic acids encoding an anti-myostatin antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. Anti-myostatin antibodies of the present invention may be for use as a medicament. Anti-myostatin antibodies of the present invention may be for use in treating a muscle wasting disease, in increasing mass of muscle tissue or in increasing strength of muscle tissue.

Claims (10)

1. A method of producing an antibody, the method comprising:

preparing a nucleic acid encoding an antibody that binds to mature myostatin homodimer having the amino acid sequence of SEQ ID NO:2; and

culturing an isolated host cell comprising the nucleic acid so that the antibody is produced,

wherein the antibody has been determined to have at least 2.5-fold higher cellular uptake compared with a reference antibody which is identical to the antibody except that the Fc region of the reference antibody has no Fc gamma receptor-binding activity, and

wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence X 1 YVX 2 G, wherein X 1 is N or H, X 2 is M or K (SEQ ID NO: 84), (b) HVR-H2 comprising the amino acid sequence IINIX 1 GX 2 TYYASWAX 3 G, wherein X 1 is S or E, X 2 is S or E, X 3 is K or E (SEQ ID NO: 85), (c) HVR-H3 comprising the amino acid sequence GX 1 DNFGYSYX 2 DFNL, wherein X 1 is G or H, X 2 is I or H (SEQ ID NO: 86), (d) HVR-L1 comprising the amino acid sequence QASX 1 SIX 2 X 3 X 4 LS, wherein X 1 is Q or E, X 2 is S or H, X 3 is N or H, X 4 is E or D (SEQ ID NO: 87); (e) HVR-L2 comprising the amino acid sequence LASTLAS (SEQ ID NO: 81); and (f) HVR-L3 comprising the amino acid sequence QTYDGISX 1 YGVA, wherein X 1 is S or H (SEQ ID NO: 88).

2. The method of claim 1 , wherein the higher cellular uptake is caused by the interaction between the Fc region of the antibody and Fc gamma receptor on the cells.

3. The method of claim 1 , wherein the antibody has been determined to have a kd ratio of (kd at pH 5.8)/(kd at pH 7.4) of 17 or greater.

4. The method of claim 1 , wherein the antibody comprises a VH sequence of any one of SEQ ID NOs: 48-51 and a VL sequence of any one of SEQ ID NOs: 52-55.

5. The method of claim 1 , wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 71, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 74, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 76, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 79; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 81; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 83.

6. The method of claim 1 , wherein the antibody comprises a VH sequence of SEQ ID NO: 51 and a VL sequence of SEQ ID NO: 54.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2024
From: RUIKE, YOSHINAO; KURAMOCHI, TAICHI
To: CHUGAI SEIYAKU KABUSHIKI KAISHA
Reel/Frame 069699/0332 →
Priority Claims (1)
JP 2015-253346 · Dec 25, 2015 · national
Continuity (2)
Division 16065192
Related Publication 20220275076A1 · Sep 1, 2022
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