Methods for tissue analysis, location determination and therapy thereof using optical radiation
A tissue detection and location identification apparatus can include, a first electrically conductive layer surrounding a lumen, an insulating layer surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can surround the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for determination/detection of a tissue type, and/or determination of a location of insertion device/apparatus.
1. A method of determining information associated with at least one target tissue of a patient using a needle comprising at least one lumen extending along a length thereof, a cladding layer applied to and circumferentially surrounding an exterior of the needle and an optically-transmissive coating applied to and circumferentially surrounding an exterior of the cladding layer, the method comprising:
inserting the needle into the patient to access the target tissue by puncturing with the needle an outer tissue structure overlaying the target tissue;
after the outer tissue structure is punctured, transmitting, to the target tissue, a first optical radiation using the optically-transmissive coating or the cladding layer;
receiving, from the target tissue, at a processor, a second optical radiation via the other of the optically-transmissive coating or the cladding layer based on the first optical radiation; and
determining, by the processor, based on the second optical radiation, data characterizing at least one of (i) at least one characteristic of the target tissue, (ii) at least one location of the target tissue, and (iii) a location of a tip of the needle with respect to the target tissue,
wherein the optically-transmissive coating is provided at least at a distal end of the needle.
2. The method of claim 1 , further comprising at least one of (i) administering a pharmacological agent to the at least one patient through the at least one lumen, (ii) exposing the pharmacological agent to the first optical radiation, and (iii) obtaining a biopsy sample from the at least one patient through the at least one lumen.
3. The method of claim 1 , further comprising, based on the data, ablating an area of the target tissue by applying a further optical radiation to the target tissue.
4. The method of claim 1 , further comprising determining a three-dimensional location of at least one portion of the insertion apparatus at or in a body based on the data.
5. The method of claim 1 , further comprising generating an image on a display of at least one portion of the insertion apparatus at or in a body in a three-dimensional space based on the data.
6. The method of claim 1 , wherein a second optically-transmissive coating circumferentially surrounds the optically-transmissive coating, the lumen and the cladding layer.
7. The method of claim 6 , wherein the optically-transmissive coating circumferentially comprises a plurality of outer core sections which are (a) provided on an outer surface of the cladding layer over and away from the lumen, and (b) optically separated from one another.
8. A method of determining information associated with at least one target tissue of a patient using a needle comprising at least one lumen extending along a length thereof, a cladding layer formed on an external surface of the needle and an optically-transmissive coating circumferentially surrounding an exterior of the cladding layer, the method comprising:
inserting the needle into the patient to access the target tissue by puncturing with the needle an outer tissue structure overlaying the target tissue;
after the outer tissue structure is punctured, transmitting, to the target tissue, a first optical radiation using the optically-transmissive coating or the cladding layer;
receiving, from the target tissue, at a processor, a second optical radiation via the other of the optically-transmissive coating or the cladding layer based on the first optical radiation; and
determining, by the processor, based on the second optical radiation, data characterizing at least one of (i) at least one characteristic of the target tissue, (ii) at least one location of the target tissue, and (iii) a location of a tip of the needle with respect to the target tissue,
wherein the optically-transmissive coating is provided at least at a distal end of the needle.
9. The method of claim 8 , further comprising providing the data to a user via at least one of an optical display, an auditory device and a haptic device communicatively coupled to the processor.
10. The method of claim 8 , further comprising providing an audible, tactile and/or visual alert to the needle based on the at least one characteristic of the target tissue.
11. The method of claim 8 , further comprising at least one of (i) administering a material and/or substance to the at least one patient through the at least one lumen, (ii) exposing the material and/or substance to the first optical radiation, and (iii) obtaining a biopsy sample from the at least one patient through the at least one lumen.
12. The method of claim 11 , wherein the at least one characteristic of the target tissue is indicative of cellulite in fat and the material and/or substance administered is an enzyme configured to break down fibrous cords in the fat.
13. The method of claim 12 , further comprising determining a three-dimensional location of at least one portion of the insertion apparatus within the fat before enzyme.
14. The method of claim 11 , wherein the at least one characteristic of the target tissue is indicative of an epidural fluid and the material and/or substance administered is a steroid.
15. The method of claim 11 , wherein the material and/or substance administered is a gel or cross-linkable monomer and the first optical radiation exposed to the gel or cross-linkable monomer is configured to polymerize the gel or cross-linkable monomer.
16. The method of claim 11 , wherein the material and/or substance administered is a photosensitizing agent.
17. The method of claim 11 , wherein the material and/or substance administered are stem cells or genetic materials.