IP Library › Granted Patent US 12,274,744
Granted Patent B2
US 12,274,744 · App. 16/263,098 · Granted Apr 15, 2025

Biomaterials for modulating immune responses

Inventors: David J. Mooney (Sudbury, MA); Aileen Weiwei Li (Norcross, GA); Omar Abdel-Rahman Ali (Oakland, CA); Ting-Yu Shih (Brookline, MA)
Assignee: President and Fellows of Harvard College
A61K39/39A61K9/0019A61K9/5031A61K39/0011A61K39/001106A61K39/00119A61K47/02A61K47/34A61P35/00A61K2039/5154A61K2039/54A61K2039/545A61K2039/55522A61K2039/55555A61K2039/55561A61K2039/572A61K2039/6056A61K2039/812A61K2039/876
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,274,744
App. No.
16/263,098
Granted
Apr 15, 2025
Kind
B2
Abstract

The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens.

Claims (26)

1. A device comprising:

a polymeric scaffold composition comprising mesoporous silica rods surface modified with a coating of polyethylenimine (PEI); and

a tumor antigen attached to the PEI,

wherein (i) the PEI does not interact with the tumor antigen to form a nanoparticle, and (ii) the PEI is not attached to CpG-ODN, poly(I:C), or poly(A:U), and

wherein the polymeric scaffold composition comprises open interconnected macropores having diameters of about 10 μm to about 600 μm.

2. The device of claim 1 , wherein said tumor antigen comprises a tumor neoantigen.

3. The device of claim 2 , wherein said PEI is attached to said tumor antigen via an electrostatic interaction.

4. The device of claim 2 , wherein said PEI is attached to said tumor antigen via a covalent bond.

5. The device of claim 1 , wherein

(i) said PEI is branched or linear;

(ii) the device comprises both branched PEI and linear PEI;

(iii) said PEI comprises branched dendrimeric PEI;

(iv) said PEI comprises at least about 2 primary, secondary, and/or tertiary amino groups;

(v) said PEI comprises a molecular weight of at least about 1 kilodaltons (kDa); and/or

(vi) said PEI comprises linear PEI having a molecular weight of about 25 kDa or branched PEI having a molecular weight of about 60 kDa.

6. The device of claim 1 , further comprising

(a) an immunostimulatory compound;

(b) a compound that attracts an immune cell to or into the delivery vehicle;

(c) a compound that induces immunogenic cell death of a tumor cell;

(d) a compound that inhibits T-cell or dendritic cell suppression;

(e) a compound that inhibits an immune-inhibitory protein,

or any combination thereof.

7. The device of claim 1 , wherein said tumor antigen comprises a tumor antigen peptide.

8. A method of treating cancer in a subject in need thereof, comprising administering the device of claim 1 to said subject.

9. The method of claim 8 , wherein said device stimulates activation of dendritic cells or elicits a cytotoxic T cell-mediated immune response against a tumor antigen.

10. The device of claim 1 , wherein said polymeric scaffold composition is anionic or cationic.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 25, 2019
From: ALI, OMAR ABDEL-RAHMAN; LI, AILEEN; MOONEY, DAVID J.; SHIH, TING-YU
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 048423/0531 →
Continuity (5)
Continuation PCTUS2017045022 · Aug 2, 2017
Provisional Application 62473699 · Mar 20, 2017
Provisional Application 62460652 · Feb 17, 2017
Provisional Application 62370211 · Aug 2, 2016
Related Publication 20190216910A1 · Jul 18, 2019
References Cited (400)
US 3773919A · Boswell et al. · 1973 [cited by applicant]
US 4465827A · Kawasaki et al. · 1984 [cited by applicant]
US 4522811A · Eppstein et al. · 1985 [cited by applicant]
US 4946778A · Ladner et al. · 1990 [cited by applicant]
US 5073627A · Curtis et al. · 1991 [cited by applicant]
US 5091513A · Huston et al. · 1992 [cited by applicant]
US 5132405A · Huston et al. · 1992 [cited by applicant]
US 5885829A · Mooney et al. · 1999 [cited by applicant]
US 5888987A · Haynes et al. · 1999 [cited by applicant]
US 5906826A · Emery et al. · 1999 [cited by applicant]
US 5951976A · Segal · 1999 [cited by applicant]
US 6129716A · Steer · 2000 [cited by applicant]
US 6160084A · Langer et al. · 2000 [cited by applicant]
US 6187762B1 · Mandeville, III et al. · 2001 [cited by applicant]
US 6193970B1 · Pardoll et al. · 2001 [cited by applicant]
US 6251396B1 · Gaur et al. · 2001 [cited by applicant]
US 6281256B1 · Harris et al. · 2001 [cited by applicant]
US 6334968B1 · Shapiro et al. · 2002 [cited by applicant]
US 6352694B1 · June et al. · 2002 [cited by applicant]
US 6403374B1 · Tsien et al. · 2002 [cited by applicant]
US 6429199B1 · Krieg et al. · 2002 [cited by applicant]
US 6511511B1 · Slivka et al. · 2003 [cited by applicant]
US 6511650B1 · Eiselt et al. · 2003 [cited by applicant]
US 6541022B1 · Murphy et al. · 2003 [cited by applicant]
US 6642363B1 · Mooney et al. · 2003 [cited by applicant]
US 6685963B1 · Taupin et al. · 2004 [cited by applicant]
US 6748954B2 · Lee et al. · 2004 [cited by applicant]
US 6767928B1 · Murphy et al. · 2004 [cited by applicant]
US 6783712B2 · Slivka et al. · 2004 [cited by applicant]
US 6790840B1 · Lee et al. · 2004 [cited by applicant]
US 6797738B2 · Harris et al. · 2004 [cited by applicant]
US 6800733B2 · Tsien et al. · 2004 [cited by applicant]
US 6858222B2 · Nelson et al. · 2005 [cited by applicant]
US 6974698B1 · Miller et al. · 2005 [cited by applicant]
US 7015205B1 · Wallack et al. · 2006 [cited by applicant]
US 7157566B2 · Tsien et al. · 2007 [cited by applicant]
US 7186413B2 · Bouhadir et al. · 2007 [cited by applicant]
US 7192693B2 · Bryant et al. · 2007 [cited by applicant]
US 7244714B1 · Gonda et al. · 2007 [cited by applicant]
US 7357936B1 · Garcon · 2008 [cited by applicant]
US 7410953B2 · Kawasaki · 2008 [cited by applicant]
US 7427602B1 · Shea et al. · 2008 [cited by applicant]
US 7569850B2 · Noy et al. · 2009 [cited by applicant]
US 7575759B2 · Murphy et al. · 2009 [cited by applicant]
US 7592326B2 · Karaolis · 2009 [cited by applicant]
US 7687241B2 · Chen · 2010 [cited by applicant]
US 7709458B2 · Karaolis et al. · 2010 [cited by applicant]
US 7790699B2 · Melvik et al. · 2010 [cited by applicant]
US 8067237B2 · Mooney et al. · 2011 [cited by applicant]
US 8188058B2 · Hackam et al. · 2012 [cited by applicant]
US 8273373B2 · Alsberg et al. · 2012 [cited by applicant]
US 8354119B2 · Geistlich et al. · 2013 [cited by applicant]
US 8367628B2 · Goodwin et al. · 2013 [cited by applicant]
US 8535719B2 · Badylak et al. · 2013 [cited by applicant]
US 8709464B2 · Ma et al. · 2014 [cited by applicant]
US 8728456B2 · Sands et al. · 2014 [cited by applicant]
US 8883308B2 · Polshettiwar et al. · 2014 [cited by applicant]
US 8932583B2 · Mooney et al. · 2015 [cited by applicant]
US 9012399B2 · Cao et al. · 2015 [cited by applicant]
US 9132210B2 · Mooney et al. · 2015 [cited by applicant]
US 9139809B2 · Porcelli et al. · 2015 [cited by applicant]
US 9150631B2 · Super et al. · 2015 [cited by applicant]
US 9370558B2 · Ali et al. · 2016 [cited by applicant]
US 9381235B2 · Sands et al. · 2016 [cited by applicant]
US 9446107B2 · Mooney et al. · 2016 [cited by applicant]
US 9486512B2 · Kim et al. · 2016 [cited by applicant]
US 9591360B2 · Jennings et al. · 2017 [cited by applicant]
US 9610328B2 · Mooney et al. · 2017 [cited by applicant]
US 9675561B2 · Bencherif et al. · 2017 [cited by applicant]
US 9770535B2 · Mooney et al. · 2017 [cited by applicant]
US 9821045B2 · Ali et al. · 2017 [cited by applicant]
US 9937249B2 · Kim et al. · 2018 [cited by applicant]
US 10045947B2 · Bencherif et al. · 2018 [cited by applicant]
US 10080789B2 · Sands et al. · 2018 [cited by applicant]
US 10137184B2 · Mooney et al. · 2018 [cited by applicant]
US 10149897B2 · Mooney et al. · 2018 [cited by applicant]
US 10258677B2 · Mooney et al. · 2019 [cited by applicant]
US 11059050B2 · Kang et al. · 2021 [cited by applicant]
US 11684638B2 · Prabha et al. · 2023 [cited by applicant]
US 20020045672A1 · Harris et al. · 2002 [cited by applicant]
US 20020131853A1 · Nagasawa · 2002 [cited by applicant]
US 20020131953A1 · Takashima et al. · 2002 [cited by applicant]
US 20020150604A1 · Yi et al. · 2002 [cited by applicant]
US 20030075822A1 · Slivka et al. · 2003 [cited by applicant]
US 20030082806A1 · Berenson et al. · 2003 [cited by applicant]
US 20030095994A1 · Geistlich et al. · 2003 [cited by applicant]
US 20030100527A1 · Krieg et al. · 2003 [cited by applicant]
US 20030194397A1 · Mishra · 2003 [cited by applicant]
US 20030232895A1 · Omidian et al. · 2003 [cited by applicant]
US 20030235557A1 · Gaiger et al. · 2003 [cited by applicant]
US 20040028745A1 · Bouhadir et al. · 2004 [cited by applicant]
US 20040043034A1 · Jensenius et al. · 2004 [cited by applicant]
US 20040058883A1 · Phillips et al. · 2004 [cited by applicant]
US 20040063206A1 · Rowley et al. · 2004 [cited by applicant]
US 20040136968A1 · Zheng et al. · 2004 [cited by applicant]
US 20040151764A1 · Zamora · 2004 [cited by applicant]
US 20040213795A1 · Collins et al. · 2004 [cited by applicant]
US 20040220111A1 · Kleinman et al. · 2004 [cited by applicant]
US 20040228858A1 · Hanson et al. · 2004 [cited by applicant]
US 20040242469A1 · Lee et al. · 2004 [cited by applicant]
US 20040242482A1 · Gehring et al. · 2004 [cited by applicant]
US 20050002915A1 · Atala et al. · 2005 [cited by applicant]
US 20050037330A1 · Fischer et al. · 2005 [cited by applicant]
US 20050053667A1 · Irvine et al. · 2005 [cited by applicant]
US 20050079159A1 · Shastri et al. · 2005 [cited by applicant]
US 20050090008A1 · Segura et al. · 2005 [cited by applicant]
US 20050106211A1 · Nelson et al. · 2005 [cited by applicant]
US 20050154376A1 · Riviere et al. · 2005 [cited by applicant]
US 20050177249A1 · Kladakis et al. · 2005 [cited by applicant]
US 20050202394A1 · Dobson · 2005 [cited by applicant]
US 20060083712A1 · Anversa · 2006 [cited by applicant]
US 20060141018A1 · Cochrum et al. · 2006 [cited by applicant]
US 20060264380A1 · Hellstrom et al. · 2006 [cited by applicant]
US 20060292134A1 · Stohs · 2006 [cited by applicant]
US 20070003595A1 · Wang et al. · 2007 [cited by applicant]
US 20070020232A1 · Rossignol et al. · 2007 [cited by applicant]
US 20070026518A1 · Healy et al. · 2007 [cited by applicant]
US 20070081972A1 · Sandler et al. · 2007 [cited by applicant]
US 20070116680A1 · Stegemann et al. · 2007 [cited by applicant]
US 20070178159A1 · Chen et al. · 2007 [cited by applicant]
US 20070190646A1 · Engler et al. · 2007 [cited by applicant]
US 20080044900A1 · Mooney et al. · 2008 [cited by applicant]
US 20080044990A1 · Lee · 2008 [cited by applicant]
US 20080051490A1 · Williams et al. · 2008 [cited by applicant]
US 20080113929A1 · Lipford et al. · 2008 [cited by applicant]
US 20080138416A1 · Rauh et al. · 2008 [cited by applicant]
US 20080152624A1 · Paludan et al. · 2008 [cited by applicant]
US 20080159993A1 · Stauss et al. · 2008 [cited by applicant]
US 20080206308A1 · Jabbari et al. · 2008 [cited by applicant]
US 20080233181A1 · Nagy et al. · 2008 [cited by applicant]
US 20080268019A1 · Badylak et al. · 2008 [cited by applicant]
US 20080268052A1 · Voytik-Harbin et al. · 2008 [cited by applicant]
US 20080279812A1 · Boyd et al. · 2008 [cited by applicant]
US 20090017096A1 · Lowman et al. · 2009 [cited by applicant]
US 20090041825A1 · Kotov et al. · 2009 [cited by applicant]
US 20090061014A1 · Messersmith et al. · 2009 [cited by applicant]
US 20090192079A1 · Santos et al. · 2009 [cited by applicant]
US 20090238853A1 · Liu et al. · 2009 [cited by applicant]
US 20090252752A1 · Tahara et al. · 2009 [cited by applicant]
US 20090297551A1 · Sattentau et al. · 2009 [cited by applicant]
US 20090297579A1 · Semino et al. · 2009 [cited by applicant]
US 20090305983A1 · Ying et al. · 2009 [cited by applicant]
US 20100015709A1 · Rehfeldt et al. · 2010 [cited by applicant]
US 20100055102A1 · Langermann · 2010 [cited by applicant]
US 20100055186A1 · Dadsetan et al. · 2010 [cited by applicant]
US 20100080816A1 · Hadeiba et al. · 2010 [cited by applicant]
US 20100129422A1 · Han et al. · 2010 [cited by applicant]
US 20100159008A1 · Barron et al. · 2010 [cited by applicant]
US 20100174346A1 · Boyden et al. · 2010 [cited by applicant]
US 20100189760A1 · Schaffer et al. · 2010 [cited by applicant]
US 20100190741A1 · Cohen et al. · 2010 [cited by applicant]
US 20100272771A1 · Harlow et al. · 2010 [cited by applicant]
US 20110008443A1 · Alsberg et al. · 2011 [cited by applicant]
US 20110020216A1 · Mooney et al. · 2011 [cited by applicant]
US 20110117170A1 · Cao et al. · 2011 [cited by applicant]
US 20110159023A1 · Langermann · 2011 [cited by applicant]
US 20110207166A1 · Vaiselbuh · 2011 [cited by applicant]
US 20110223255A1 · Thiesen et al. · 2011 [cited by applicant]
US 20110253643A1 · Polshettiwar et al. · 2011 [cited by applicant]
US 20110256184A1 · Lei et al. · 2011 [cited by applicant]
US 20110300186A1 · Hellstrom et al. · 2011 [cited by applicant]
US 20120040011A9 · Boons et al. · 2012 [cited by applicant]
US 20120100182A1 · Mooney et al. · 2012 [cited by applicant]
US 20120121539A1 · Sands et al. · 2012 [cited by applicant]
US 20120122218A1 · Huebsch et al. · 2012 [cited by applicant]
US 20120134967A1 · Mooney et al. · 2012 [cited by applicant]
US 20120207795A1 · Zink · 2012 [cited by examiner]
US 20120256336A1 · Yano · 2012 [cited by examiner]
US 20120264599A1 · Komatsu et al. · 2012 [cited by applicant]
US 20120294888A1 · Kishimoto et al. · 2012 [cited by applicant]
US 20120329791A1 · Ashwell et al. · 2012 [cited by applicant]
US 20130029030A1 · Larsen · 2013 [cited by applicant]
US 20130035283A1 · Super et al. · 2013 [cited by applicant]
US 20130045246A1 · Edwards et al. · 2013 [cited by applicant]
US 20130052117A1 · Imai et al. · 2013 [cited by applicant]
US 20130072547A1 · Hackam et al. · 2013 [cited by applicant]
US 20130145488A1 · Wang et al. · 2013 [cited by applicant]
US 20130177536A1 · Mooney et al. · 2013 [cited by applicant]
US 20130202707A1 · Ali et al. · 2013 [cited by applicant]
US 20130225502A1 · Sugiyama et al. · 2013 [cited by applicant]
US 20130251784A1 · Kim et al. · 2013 [cited by applicant]
US 20130302396A1 · Mooney et al. · 2013 [cited by applicant]
US 20130331343A1 · Cao et al. · 2013 [cited by applicant]
US 20140072510A1 · Shea et al. · 2014 [cited by applicant]
US 20140079752A1 · Huebsch et al. · 2014 [cited by applicant]
US 20140112990A1 · Bencherif et al. · 2014 [cited by applicant]
US 20140178964A1 · Mooney et al. · 2014 [cited by applicant]
US 20140193488A1 · Kim et al. · 2014 [cited by applicant]
US 20140205653A1 · Dubensky, Jr. et al. · 2014 [cited by applicant]
US 20140227327A1 · Bencherif et al. · 2014 [cited by applicant]
US 20140227723A1 · Ingber et al. · 2014 [cited by applicant]
US 20140234423A1 · Sands et al. · 2014 [cited by applicant]
US 20150024026A1 · Mooney et al. · 2015 [cited by applicant]
US 20150030669A1 · Platscher et al. · 2015 [cited by applicant]
US 20150072009A1 · Kim et al. · 2015 [cited by applicant]
US 20150080321A1 · Li et al. · 2015 [cited by applicant]
US 20150094518A1 · Wu et al. · 2015 [cited by applicant]
US 20150202291A1 · Bosch et al. · 2015 [cited by applicant]
US 20150352201A1 · Scheinberg et al. · 2015 [cited by applicant]
US 20150359928A1 · Gu et al. · 2015 [cited by applicant]
US 20150366956A1 · Mooney et al. · 2015 [cited by applicant]
US 20160033511A1 · Pannell et al. · 2016 [cited by applicant]
US 20160060360A1 · Moore et al. · 2016 [cited by applicant]
US 20160120984A1 · Navale et al. · 2016 [cited by applicant]
US 20160129053A1 · Brass et al. · 2016 [cited by applicant]
US 20160220668A1 · Mooney et al. · 2016 [cited by applicant]
US 20160228543A1 · Mooney et al. · 2016 [cited by applicant]
US 20160271298A1 · Mooney et al. · 2016 [cited by applicant]
US 20160279219A1 · Mooney et al. · 2016 [cited by applicant]
US 20160279220A1 · Mooney et al. · 2016 [cited by applicant]
US 20160296611A1 · Ali et al. · 2016 [cited by applicant]
US 20170042995A1 · Ali et al. · 2017 [cited by applicant]
US 20170182138A1 · Kim et al. · 2017 [cited by applicant]
US 20170246281A1 · Super et al. · 2017 [cited by applicant]
US 20170362307A1 · Ingber et al. · 2017 [cited by applicant]
US 20170368169A1 · Loew et al. · 2017 [cited by applicant]
US 20180021253A1 · Sandeep et al. · 2018 [cited by applicant]
US 20180117171A1 · Mooney et al. · 2018 [cited by applicant]
US 20180164298A1 · Ali et al. · 2018 [cited by applicant]
US 20180243231A1 · Bencherif et al. · 2018 [cited by applicant]
US 20180289789A1 · Ali et al. · 2018 [cited by applicant]
US 20180298047A1 · Cheng et al. · 2018 [cited by applicant]
US 20180320157A1 · Super et al. · 2018 [cited by applicant]
US 20180326073A1 · Mooney et al. · 2018 [cited by applicant]
US 20180344821A1 · Kim et al. · 2018 [cited by applicant]
US 20180371058A1 · Watters et al. · 2018 [cited by applicant]
US 20190060525A1 · Shah et al. · 2019 [cited by applicant]
US 20190076373A1 · Bencherif et al. · 2019 [cited by applicant]
US 20190125849A1 · Mooney et al. · 2019 [cited by applicant]
US 20190183992A1 · Sands et al. · 2019 [cited by applicant]
US 20190290696A1 · De Miroschedji · 2019 [cited by applicant]
US 20190292517A1 · Cheung et al. · 2019 [cited by applicant]
US 20190367550A1 · Cheng et al. · 2019 [cited by applicant]
US 20200024339A1 · Springer et al. · 2020 [cited by applicant]
US 20200206333A1 · Shah et al. · 2020 [cited by applicant]
US 20200276290A1 · Ali et al. · 2020 [cited by applicant]
US 20200297854A1 · Ingber et al. · 2020 [cited by applicant]
US 20210170007A1 · Super et al. · 2021 [cited by applicant]
US 20210205233A1 · Bencherif et al. · 2021 [cited by applicant]
US 20210284776A1 · Wang et al. · 2021 [cited by applicant]
US 20220047778A1 · Shah et al. · 2022 [cited by applicant]
US 20220107308A1 · Ali et al. · 2022 [cited by applicant]
US 20220192986A1 · Huebsch et al. · 2022 [cited by applicant]
US 20220339274A1 · Najibi et al. · 2022 [cited by applicant]
US 20230000961A1 · Kim et al. · 2023 [cited by applicant]
US 20230085214A1 · Wang et al. · 2023 [cited by applicant]
US 20230340404A1 · Cheung et al. · 2023 [cited by applicant]
US 20230404936A1 · Bencherif et al. · 2023 [cited by applicant]
AU 2014200405A1 · 2014 [cited by applicant]
AU 2018201930A1 · 2018 [cited by applicant]
CN 1487839A · 2004 [cited by applicant]
CN 1527697A · 2004 [cited by applicant]
CN 1757662A · 2006 [cited by applicant]
CN 101584612A · 2009 [cited by applicant]
CN 101655611A · 2010 [cited by applicant]
CN 101829361A · 2010 [cited by applicant]
CN 102000689A · 2011 [cited by applicant]
CN 102006891A · 2011 [cited by applicant]
CN 102170903A · 2011 [cited by applicant]
CN 102947341A · 2013 [cited by applicant]
CN 103237885A · 2013 [cited by applicant]
CN 104244929A · 2014 [cited by applicant]
CN 104411331A · 2015 [cited by applicant]
EP 0562862A1 · 1993 [cited by applicant]
EP 1452191A2 · 2004 [cited by applicant]
EP 1561481A2 · 2005 [cited by applicant]
EP 1712238A1 · 2006 [cited by applicant]
EP 1975230A1 · 2008 [cited by applicant]
EP 2254602A2 · 2010 [cited by applicant]
JP 2000503884A · 2000 [cited by applicant]
JP 2001049018A · 2001 [cited by applicant]
JP 2001524136A · 2001 [cited by applicant]
JP 2003506401A · 2003 [cited by applicant]
JP 2003180815A · 2003 [cited by applicant]
JP 2004159849A · 2004 [cited by applicant]
JP 2004520043A · 2004 [cited by applicant]
JP 2005160669A · 2005 [cited by applicant]
JP 2005168760A · 2005 [cited by applicant]
JP 2005170816A · 2005 [cited by applicant]
JP 2005528401A · 2005 [cited by applicant]
JP 2007500673A · 2007 [cited by applicant]
JP 2007503881A · 2007 [cited by applicant]
JP 2007505827A · 2007 [cited by applicant]
JP 2007528848A · 2007 [cited by applicant]
JP 2008515503A · 2008 [cited by applicant]
JP 2008528114A · 2008 [cited by applicant]
JP 2009519042A · 2009 [cited by applicant]
JP 2009521406A · 2009 [cited by applicant]
JP 2009540921A · 2009 [cited by applicant]
JP 2010502824A · 2010 [cited by applicant]
JP 2010508976A · 2010 [cited by applicant]
JP 2010227012A · 2010 [cited by applicant]
JP 2010228961A · 2010 [cited by applicant]
JP 2011511684A · 2011 [cited by applicant]
JP 2011511834A · 2011 [cited by applicant]
JP 2012062236A · 2012 [cited by applicant]
JP 2013531043A · 2013 [cited by applicant]
JP 2015503626A · 2015 [cited by applicant]
JP 2015516398A · 2015 [cited by applicant]
JP 2015134766A · 2015 [cited by applicant]
JP 2018117680A · 2018 [cited by applicant]
JP 2019522486A · 2019 [cited by applicant]
WO WO199602555A1 · 1996 [cited by applicant]
WO WO199616086A1 · 1996 [cited by applicant]
WO WO199812228A1 · 1998 [cited by applicant]
WO WO199816266A1 · 1998 [cited by applicant]
WO WO199944583A2 · 1999 [cited by applicant]
WO WO199951259A2 · 1999 [cited by applicant]
WO WO199952356A1 · 1999 [cited by applicant]
WO WO200050006A2 · 2000 [cited by applicant]
WO WO2007150020A1 · 2000 [cited by applicant]
WO WO200110421A1 · 2001 [cited by applicant]
WO WO200135932A2 · 2001 [cited by applicant]
WO WO200137810A2 · 2001 [cited by applicant]
WO WO200216557A2 · 2002 [cited by applicant]
WO WO200240071A1 · 2002 [cited by applicant]
WO WO2002058723A2 · 2002 [cited by applicant]
WO WO2002092054A2 · 2002 [cited by applicant]
WO WO2003020161A2 · 2003 [cited by applicant]
WO WO2003020884A2 · 2003 [cited by applicant]
WO WO2003070291A1 · 2003 [cited by applicant]
WO WO2003088905A2 · 2003 [cited by applicant]
WO WO2004006990A2 · 2004 [cited by applicant]
WO WO2004029230A2 · 2004 [cited by applicant]
WO WO2004030706A2 · 2004 [cited by applicant]
WO WO2004031371A2 · 2004 [cited by applicant]
WO WO2004089413A1 · 2004 [cited by applicant]
WO WO2005013896A2 · 2005 [cited by applicant]
WO WO2005013933A1 · 2005 [cited by applicant]
WO WO2005020849A2 · 2005 [cited by applicant]
WO WO2005025614A2 · 2005 [cited by applicant]
WO WO2005026318A2 · 2005 [cited by applicant]
WO WO2005037190A2 · 2005 [cited by applicant]
WO WO2005037293A1 · 2005 [cited by applicant]
WO WO2005046748A1 · 2005 [cited by applicant]
WO WO2005072088A2 · 2005 [cited by applicant]
WO WO2005104755A2 · 2005 [cited by applicant]
WO WO2006039045A2 · 2006 [cited by applicant]
WO WO2006040128A1 · 2006 [cited by applicant]
WO WO2006078987A2 · 2006 [cited by applicant]
WO WO2006113407A2 · 2006 [cited by applicant]
WO WO2006119619A1 · 2006 [cited by applicant]
WO WO2006136905A2 · 2006 [cited by applicant]
WO WO2007001332A2 · 2007 [cited by applicant]
WO WO2007030901A1 · 2007 [cited by applicant]
WO WO2007039150A2 · 2007 [cited by applicant]
WO WO2007042554A2 · 2007 [cited by applicant]
WO WO2007051120A2 · 2007 [cited by applicant]
WO WO2007063075A1 · 2007 [cited by applicant]
WO WO2007064152A1 · 2007 [cited by applicant]
WO WO2007068489A2 · 2007 [cited by applicant]
WO WO2007070660A2 · 2007 [cited by applicant]
WO WO2007078196A1 · 2007 [cited by applicant]
WO WO2007087585A1 · 2007 [cited by applicant]
WO WO2007089870A2 · 2007 [cited by applicant]
WO WO2007107739A1 · 2007 [cited by applicant]
WO WO2007149161A2 · 2007 [cited by applicant]
WO WO2008008266A2 · 2008 [cited by applicant]
WO WO2008018707A1 · 2008 [cited by applicant]
WO WO2008031525A1 · 2008 [cited by applicant]
WO WO2008043157A1 · 2008 [cited by applicant]
WO WO2008057600A2 · 2008 [cited by applicant]
WO WO2008109852A2 · 2008 [cited by applicant]
WO WO2008114149A2 · 2008 [cited by applicant]
WO WO2008148761A1 · 2008 [cited by applicant]
WO WO2008157394A2 · 2008 [cited by applicant]
WO WO2009002401A2 · 2008 [cited by applicant]
WO WO2009005769A2 · 2009 [cited by applicant]
WO WO2009018500A1 · 2009 [cited by applicant]
WO WO2009024775A1 · 2009 [cited by applicant]
WO WO2009072767A2 · 2009 [cited by applicant]
WO WO2009074341A1 · 2009 [cited by applicant]
WO WO2009100716A2 · 2009 [cited by applicant]
WO WO2009102465A2 · 2009 [cited by applicant]
WO WO2009146456A1 · 2009 [cited by applicant]
WO WO2009155583A1 · 2009 [cited by applicant]
WO WO2010078209A2 · 2010 [cited by applicant]
WO WO2010120749A2 · 2010 [cited by applicant]
WO WO2011014871A1 · 2011 [cited by applicant]
WO WO2011043834A1 · 2011 [cited by applicant]
WO WO2011043835A1 · 2011 [cited by applicant]
WO WO2011063336A2 · 2011 [cited by applicant]
WO WO2011109834A2 · 2011 [cited by applicant]
WO WO2011130753A2 · 2011 [cited by applicant]
WO WO2011150240A1 · 2011 [cited by applicant]
WO WO2011151431A1 · 2011 [cited by applicant]
WO WO2011163669A2 · 2011 [cited by applicant]
WO WO2012009611A2 · 2012 [cited by applicant]
WO WO2012019049A1 · 2012 [cited by applicant]
WO WO2012048165A2 · 2012 [cited by applicant]
WO WO2012064697A2 · 2012 [cited by applicant]
WO WO2012148684A1 · 2012 [cited by applicant]
WO WO2012149358A1 · 2012 [cited by applicant]
WO WO2012167230A1 · 2012 [cited by applicant]
WO WO2013012924A2 · 2013 [cited by applicant]
WO WO2013106852A1 · 2013 [cited by applicant]
WO WO2013158673A1 · 2013 [cited by applicant]
WO WO2013172967A1 · 2013 [cited by applicant]
WO WO2013190555A1 · 2013 [cited by applicant]
WO WO2014063128A1 · 2014 [cited by applicant]