IP Library › Granted Patent US 12,291,494
Granted Patent B2
US 12,291,494 · App. 18/355,790 · Granted May 6, 2025

Methods of treating fibrosis

Inventors: Sergio Baroni (Villa d'Adda, IT); Salvatore Bellinvia (Mendrisio, CH); Francesca Viti (Salorino, CH)
Assignee: Nogra Pharma Limited
C07C229/44A61K31/196A61K31/343A61K31/357A61P1/04
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Quick Facts
Patent No.
US 12,291,494
App. No.
18/355,790
Granted
May 6, 2025
Kind
B2
Abstract

The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.

Claims (10)

1. A method of treating alpha 1-antitrypsin deficiency in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound, wherein the compound is 2-methoxy-3-(4′-aminophenyl) propionic acid, represented by the formula:

or a pharmaceutically acceptable salt or a stereoisomer thereof.

2. The method of claim 1 , wherein the compound is (S)-2-methoxy-3-(4′-aminophenyl) propionic acid, or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein the compound is (R)-2-methoxy-3-(4′-aminophenyl) propionic acid, or a pharmaceutically acceptable salt thereof.

4. A method of treating alpha 1-antitrypsin deficiency in a subject in need thereof, comprising administering to the subject a pharmaceutical preparation comprising a therapeutically effective amount of 2-methoxy-3-(4′-aminophenyl) propionic acid (compound 34), or a pharmaceutically acceptable salt or a stereoisomer thereof, and one or more pharmaceutically acceptable carriers.

5. The method of claim 4 , wherein the pharmaceutical preparation comprises a therapeutically effective amount of (S)-2-methoxy-3-(4′-aminophenyl) propionic acid, or a pharmaceutically acceptable salt thereof.

6. The method of claim 4 , wherein the pharmaceutical preparation comprises a therapeutically effective amount of (R)-2-methoxy-3-(4′-aminophenyl) propionic acid, or a pharmaceutically acceptable salt thereof.

7. The method of claim 4 , wherein the pharmaceutical preparation is for oral administration.

8. The method of claim 4 , wherein the subject is human.

9. The method of claim 4 , wherein the subject is currently suffering or has suffered from hepatitis B or hepatitis C, or wherein the subject has cirrhosis.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2024
From: BARONI, SERGIO; BELLINVIA, SALVATORE; VITI, FRANCESCA
To: NOGRA PHARMA LIMITED
Reel/Frame 069497/0467 →
Priority Claims (1)
EP 12425027 · Feb 9, 2012 · regional
Continuity (5)
Continuation 17199860 · Mar 12, 2021
Continuation 15593864 · May 12, 2017
Division 14377362
Provisional Application 61644544 · May 9, 2012
Related Publication 20240279157A1 · Aug 22, 2024
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