Granted Patent
B2
US 12,318,632 · App. 18/628,649 · Granted Jun 3, 2025
Heart arrhythmia non-invasive treatment device and method
Assignee:
EBAMed SA
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Abstract
The present invention relates to a heart tissue ablation device comprising a charged particle emitting system 1 , a control system 2 for instructing the accelerator and beamline when to create the beam and what its required properties should be, a patient positioning and verification system, an ultrasound cardiac imaging system 3 performed on the patient, able to track the target movement, a computer program to determine and record the safe motion margins, the treatment plans for one or more motion phases and a computer program to regulate the control system 2 to load the correct irradiation plan according to the motion phase and if the position of the target is inside of the position margin, the irradiation is enabled and if the position of the target is outside of the position margin, the irradiation is disabled.
Claims (27)
1. A system for use with a radiation therapy system that generates a charged particle beam to ablate targeted tissue of a heart of a patient for non-invasive treatment of heart arrhythmia, the system comprising:
an ultrasound cardiac imaging system configured to image a region of the heart to assess motion of the targeted tissue and corresponding cardiac and respiratory cycle phases of the patient; and
a control system configured to process an irradiation plan comprising positional information of the targeted tissue imaged during a planning stage, the control system further configured to, during a treatment stage, process ultrasound images acquired with the ultrasound cardiac imaging system and instruct the radiation therapy system to generate the charged particle beam in accordance with the irradiation plan to ablate the targeted tissue of the heart based on information of the cardiac and respiratory cycle phases provided by the ultrasound cardiac imaging system during the treatment stage.
2. The system of claim 1 , wherein the control system is configured to, during the treatment stage, determine the irradiation plan for a corresponding cardiac and respiratory cycle phase.
3. The system of claim 1 , wherein the control system is configured to determine the positional information of the targeted tissue imaged during the planning stage by a Computer Tomography (CT) system or a magnetic resonance imaging (MRI) system.
4. The system of claim 1 , wherein the control system is configured to identify positional differences between the acquired ultrasound images at the treatment stage and the images of the targeted tissue at the planning stage.
5. The system of claim 4 , wherein, if the positional differences are determined to be within established safety margins according to the irradiation plan, the control system is configured to permit irradiation of the targeted tissue with the charged particle beam to ablate the targeted tissue.
6. The system of claim 4 , wherein, at the planning stage, the control unit is configured to determine fiducials of the targeted tissue.
7. The system of claim 6 , wherein the control system is configured to determine a change in position of the targeted tissue based on differences in positions of the fiducials in the acquired ultrasound cardiac images.
8. The system of claim 1 , wherein the control system is configured to cause the radiation therapy system to deliver a Bragg peak of the charged particle beam to the targeted tissue.
9. The system of claim 1 , wherein the ultrasound cardiac imaging system comprises an ultrasound transducer having a marker coupled thereto.
10. The system of claim 9 , wherein the marker comprises an optical marker or a magnetic marker.
11. The system of claim 9 , further comprising a cardiac motion sensor or a respiratory motion sensor or both for use with the marker.
12. The system of claim 1 , further comprising a cardiac cycle monitor configured to work in combination with the ultrasound cardiac imaging system.
13. The system of claim 12 , wherein the cardiac cycle monitor comprises an electrocardiogram (ECG) monitoring device.
14. The system of claim 1 , further comprising a respiratory cycle monitor configured to work in combination with the ultrasound cardiac imaging system.
15. The system of claim 14 , wherein the respiratory cycle monitor is configured to monitor abdomen movement of the patient.
16. The system of claim 1 , further comprising a cardiac cycle monitor and a respiratory cycle monitor, both of which are configured to work in combination with the ultrasound cardiac imaging system.
17. The system of claim 1 , wherein the control system is configured to cause the radiation therapy system to generate the charged particle beam at a specified intensity, position, angle, and energy.
18. A method for non-invasive treatment of heart arrhythmia using a radiation therapy system that generates a charged particle beam to ablate targeted tissue of a heart of a patient, the method comprising:
imaging a region of the heart using an ultrasound cardiac imaging system to assess motion of the targeted tissue and corresponding cardiac and respiratory cycle phases of the patient;
processing an irradiation plan comprising positional information of the targeted tissue imaged during a planning stage;
processing ultrasound images acquired with the ultrasound cardiac imaging system during a treatment stage; and
instructing the radiation therapy system to generate the charged particle beam in accordance with the irradiation plan to ablate the targeted tissue of the heart based on information of the cardiac and respiratory cycle phases provided by the ultrasound cardiac imaging system during the treatment stage.
19. The method of claim 18 , wherein the targeted tissue is imaged during the planning stage by a Computer Tomography (CT) system.
20. The method of claim 18 , further comprising identifying positional differences between the acquired ultrasound images at the treatment stage and the images of the targeted tissue at the planning stage,
wherein, if the positional differences are determined to be within established safety margins according to the irradiation plan, instructing the radiation therapy system comprises permitting irradiation of the targeted tissue with the charged particle beam for ablating the targeted tissue.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 8, 2024
From: GARONNA, ADRIANO; LEO, GIOVANNI
To: EBAMED SA
Reel/Frame 067033/0542 →
Priority Claims (1)
EP 17202164
· Nov 16, 2017
· regional
Continuity (3)
Continuation
16764967
References Cited (400)
US 3399302A
· Carrell
· 1968
[cited by applicant]
US 3923060A
· Ellinwood, Jr.
· 1975
[cited by applicant]
US 5538494A
· Matsuda
· 1996
[cited by applicant]
US 5590657A
· Cain et al.
· 1997
[cited by applicant]
US 5718241A
· Ben-Haim et al.
· 1998
[cited by applicant]
US 5764723A
· Weinberger et al.
· 1998
[cited by applicant]
US 5909476A
· Cheng et al.
· 1999
[cited by applicant]
US 6144875A
· Schweikard et al.
· 2000
[cited by applicant]
US 6443896B1
· Detmer
· 2002
[cited by applicant]
US 6658285B2
· Potse et al.
· 2003
[cited by applicant]
US 6710362B2
· Kraft et al.
· 2004
[cited by applicant]
US 6780152B2
· Üstüner et al.
· 2004
[cited by applicant]
US 6863653B1
· Zanelli et al.
· 2005
[cited by applicant]
US 6889695B2
· Pankratov et al.
· 2005
[cited by applicant]
US 7260426B2
· Schweikard et al.
· 2007
[cited by applicant]
US 7322929B2
· Lovoi
· 2008
[cited by applicant]
US 7346381B2
· Okerlund et al.
· 2008
[cited by applicant]
US 7565190B2
· Okerlund et al.
· 2009
[cited by applicant]
US 7645276B2
· Pankratov et al.
· 2010
[cited by applicant]
US 7853313B2
· Thomson
· 2010
[cited by applicant]
US 7953204B2
· Sumanaweera et al.
· 2011
[cited by applicant]
US 8278633B2
· Nord et al.
· 2012
[cited by applicant]
US 8295435B2
· Wang et al.
· 2012
[cited by applicant]
US 8295906B2
· Saunders et al.
· 2012
[cited by applicant]
US 8348846B2
· Günther et al.
· 2013
[cited by applicant]
US 8351571B2
· Brinks et al.
· 2013
[cited by applicant]
US 8422631B2
· Takahashi et al.
· 2013
[cited by applicant]
US 8488910B2
· Ruijters
· 2013
[cited by applicant]
US 8784290B2
· Sumanaweera et al.
· 2014
[cited by applicant]
US 8792613B2
· Gardner et al.
· 2014
[cited by applicant]
US 8805481B2
· Sumanaweera et al.
· 2014
[cited by applicant]
US 8824757B2
· Kolthammer et al.
· 2014
[cited by applicant]
US 9014424B2
· Berlinger et al.
· 2015
[cited by applicant]
US 9061144B2
· Fujii et al.
· 2015
[cited by applicant]
US 9108048B2
· Maurer, Jr. et al.
· 2015
[cited by applicant]
US 9205279B2
· Sumanaweera et al.
· 2015
[cited by applicant]
US 9289268B2
· Ramraj et al.
· 2016
[cited by applicant]
US 9320916B2
· Sumanaweera et al.
· 2016
[cited by applicant]
US 9326751B2
· Hastings
· 2016
[cited by applicant]
US 9504853B2
· Sumanaweera et al.
· 2016
[cited by applicant]
US 9526476B2
· Schwartz et al.
· 2016
[cited by applicant]
US 9750957B2
· Fujii et al.
· 2017
[cited by applicant]
US 9789339B2
· Moskvin et al.
· 2017
[cited by applicant]
US 9907978B2
· Pankratov et al.
· 2018
[cited by applicant]
US 9962562B2
· Fahrig et al.
· 2018
[cited by applicant]
US 9968801B2
· Sumanaweera et al.
· 2018
[cited by applicant]
US 20020072674A1
· Criton et al.
· 2002
[cited by applicant]
US 20020095197A1
· Lardo et al.
· 2002
[cited by applicant]
US 20040162596A1
· Altshuler et al.
· 2004
[cited by applicant]
US 20050171396A1
· Pankratov et al.
· 2005
[cited by applicant]
US 20060224053A1
· Black et al.
· 2006
[cited by applicant]
US 20060241443A1
· Whitmore et al.
· 2006
[cited by applicant]
US 20080021300A1
· Allison
· 2008
[cited by applicant]
US 20080177279A1
· Sumanaweera et al.
· 2008
[cited by applicant]
US 20080177280A1
· Adler et al.
· 2008
[cited by applicant]
US 20080221382A1
· Karshafian et al.
· 2008
[cited by applicant]
US 20080317204A1
· Sumanaweera et al.
· 2008
[cited by applicant]
US 20090074278A1
· Beaulieu et al.
· 2009
[cited by applicant]
US 20090076373A1
· Maschke
· 2009
[cited by applicant]
US 20090238404A1
· Orderud et al.
· 2009
[cited by applicant]
US 20100016744A1
· Brost et al.
· 2010
[cited by applicant]
US 20100016765A1
· Hall et al.
· 2010
[cited by applicant]
US 20100217139A1
· Pinter et al.
· 2010
[cited by applicant]
US 20100282983A1
· Wright et al.
· 2010
[cited by applicant]
US 20110160566A1
· Petropoulos et al.
· 2011
[cited by applicant]
US 20110185503A1
· Yan
· 2011
[cited by applicant]
US 20110218438A1
· Hsieh et al.
· 2011
[cited by applicant]
US 20120083645A1
· Sun et al.
· 2012
[cited by applicant]
US 20120181428A1
· Bert et al.
· 2012
[cited by applicant]
US 20120292534A1
· Geneser et al.
· 2012
[cited by applicant]
US 20120323233A1
· Maguire et al.
· 2012
[cited by applicant]
US 20130035682A1
· Weil
· 2013
[cited by applicant]
US 20130211482A1
· Piipponen
· 2013
[cited by applicant]
US 20130237822A1
· Gross et al.
· 2013
[cited by applicant]
US 20140005463A1
· Jongen
· 2014
[cited by applicant]
US 20140107390A1
· Brown et al.
· 2014
[cited by applicant]
US 20140107435A1
· Sharf et al.
· 2014
[cited by applicant]
US 20140316247A1
· Hwang et al.
· 2014
[cited by applicant]
US 20140343401A1
· Huber et al.
· 2014
[cited by applicant]
US 20150004561A1
· Koehler
· 2015
[cited by applicant]
US 20150080634A1
· Huber et al.
· 2015
[cited by applicant]
US 20150150643A1
· Trayanova et al.
· 2015
[cited by applicant]
US 20150290472A1
· Maguire et al.
· 2015
[cited by applicant]
US 20150371420A1
· Yerushalmy et al.
· 2015
[cited by applicant]
US 20160074674A1
· Kohli et al.
· 2016
[cited by applicant]
US 20160184610A1
· Porikli
· 2016
[cited by applicant]
US 20160324499A1
· Sen Sharma et al.
· 2016
[cited by applicant]
US 20160331262A1
· Kuck et al.
· 2016
[cited by applicant]
US 20160338676A1
· Berger et al.
· 2016
[cited by applicant]
US 20170042515A1
· Schwartz et al.
· 2017
[cited by applicant]
US 20170128744A1
· Adler et al.
· 2017
[cited by applicant]
US 20180153467A1
· Lichtenstein et al.
· 2018
[cited by applicant]
US 20200151921A1
· Schildkraut
· 2020
[cited by applicant]
US 20210065414A1
· Do
· 2021
[cited by applicant]
US 20210093897A1
· Zadicario
· 2021
[cited by examiner]
BE 1024702A1
· 2018
[cited by applicant]
CA 2781536A1
· 2012
[cited by applicant]
CN 1672651A
· 2005
[cited by applicant]
CN 101268467A
· 2008
[cited by applicant]
CN 101600473A
· 2009
[cited by applicant]
CN 102119586A
· 2011
[cited by applicant]
CN 102196768A
· 2011
[cited by applicant]
CN 102510735A
· 2012
[cited by applicant]
CN 102781359A
· 2012
[cited by applicant]
CN 103180015A
· 2013
[cited by applicant]
CN 103279929A
· 2013
[cited by applicant]
CN 104349817A
· 2015
[cited by applicant]
CN 105813691A
· 2016
[cited by applicant]
CN 106291656A
· 2017
[cited by applicant]
CN 107730455A
· 2018
[cited by applicant]
CN 108022272A
· 2018
[cited by applicant]
CN 111223156A
· 2020
[cited by applicant]
DE 102013102920A1
· 2014
[cited by applicant]
DE 102013112573A1
· 2015
[cited by applicant]
DE 102014217966A1
· 2016
[cited by applicant]
EP 0327459B1
· 1992
[cited by applicant]
EP 2140913A1
· 2010
[cited by applicant]
EP 2290406A2
· 2011
[cited by applicant]
EP 2523623A1
· 2012
[cited by applicant]
EP 2942081A1
· 2015
[cited by applicant]
EP 2950119A1
· 2015
[cited by applicant]
EP 3036978A1
· 2016
[cited by applicant]
FR 2930995A1
· 2009
[cited by applicant]
FR 3058249A3
· 2018
[cited by applicant]
JP 2005095640A
· 2005
[cited by applicant]
JP 2006113061A
· 2006
[cited by applicant]
JP 2007047066A
· 2007
[cited by applicant]
JP 2007526010A
· 2007
[cited by applicant]
JP 2010540050A
· 2010
[cited by applicant]
JP 2012533364A
· 2012
[cited by applicant]
JP 2016214438A
· 2016
[cited by applicant]
KR 20110040164A
· 2011
[cited by applicant]
WO WO0126569A1
· 2001
[cited by applicant]
WO WO2008086434A2
· 2008
[cited by applicant]
WO WO2009111783A2
· 2009
[cited by applicant]
WO WO2011012154A1
· 2011
[cited by applicant]
WO WO2011021410A1
· 2011
[cited by applicant]
WO WO2012104416A1
· 2012
[cited by applicant]
WO WO2012152938A2
· 2012
[cited by applicant]
WO WO2012154219A2
· 2012
[cited by applicant]
WO WO2013034709A1
· 2013
[cited by applicant]
WO WO2013129811A1
· 2013
[cited by applicant]
WO WO2013179221A1
· 2013
[cited by applicant]
WO WO2015025203A1
· 2015
[cited by applicant]
WO WO2015040225A1
· 2015
[cited by applicant]
WO WO2015053737A1
· 2015
[cited by applicant]
WO WO2016193929A2
· 2016
[cited by applicant]
WO WO2017066358A1
· 2017
[cited by applicant]
WO WO2017078757A1
· 2017
[cited by applicant]
WO WO2017156113A1
· 2017
[cited by applicant]
WO WO2019017752A1
· 2019
[cited by applicant]
WO WO2019096943A1
· 2019
[cited by applicant]
WO WO2020033355A1
· 2020
[cited by applicant]
WO WO2020075106A2
· 2020
[cited by applicant]
WO WO2020142397A1
· 2020
[cited by applicant]
WO WO2020212573A1
· 2020
[cited by applicant]
WO WO2021094824A1
· 2021
[cited by applicant]
WO WO2022136925A1
· 2022
[cited by applicant]
U.S. Appl. No. 16/641,917 / U.S. Pat. No. 11,857,808, filed Feb. 25, 2020 / Jan. 2, 2024.
[cited by applicant]
U.S. Appl. No. 16/764,967 / U.S. Pat. No. 11,298,565, filed May 18, 2020 / Apr. 12, 2022.
[cited by applicant]
U.S. Appl. No. 17/284,101 / U.S. Pat. No. 11,506,801, filed Apr. 9, 2021 / Nov. 22, 2022.
[cited by applicant]
U.S. Appl. No. 17/717,310 / U.S. Pat. No. 11,951,327, filed Apr. 11, 2022 / Apr. 9, 2024.
[cited by applicant]
U.S. Appl. No. 17/776,004, filed May 11, 2022.
[cited by applicant]
U.S. Appl. No. 17/897,771, filed Aug. 29, 2022.
[cited by applicant]
U.S. Appl. No. 17/992,042, filed Nov. 22, 2022.
[cited by applicant]
U.S. Appl. No. 18/269,351, filed Jun. 23, 2023.
[cited by applicant]
U.S. Appl. No. 18/542,354, filed Dec. 15, 2023.
[cited by applicant]
U.S. Appl. No. 29/927,660, filed Feb. 5, 2024.
[cited by applicant]
U.S. Appl. No. 18/597,839, filed Mar. 6, 2024.
[cited by applicant]
Achenbach S., et al., “Noninvasive Coronary Angiography by Retrospectively ECG-Gated Multislice Spiral CT,” Circulation, 102(23):2823-2828 (Dec. 2000).
[cited by applicant]
Asirvatham S.J., “Advances in Catheter Ablation: A Burning Trail!,” Indian Heart Journal, 2011, pp. 379-385.
[cited by applicant]
Bai S., et al., “An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling,” arXiv Prepr.arXiv:1803.01271v2, Apr. 19, 2018, 14 Pages.
[cited by applicant]
Baker, et al., “Prostate Displacement During Transabdominal Ultrasound Image-Guided Radiotherapy Assessed by Real-Time Four-dimensional Transperineal Monitoring,” Acta Oncologica, 2015, vol. 54, No. 9, pp. 1508-1514.
[cited by applicant]
Beddar A.S., et al., “Correlation Between Internal Fiducial Tumor Motion and External Marker Motion for Liver Tumors Imaged With 4D-CT,” International Journal of Radiation Oncology, Biology, Physics, vol. 67(2):630-638 …
[cited by applicant]
Beltrame P., et al., “Construction and Tests of Demonstrator Modules for a 3-D Axial PET System for Brain or Small Animal Imaging,” Nuclear Instruments and Methods in Physics Research A, 2011, vol. 636, pp. S226-S230, A…
[cited by applicant]
Bert C., et al., “Motion in Radiotherapy: Particle Therapy,” Physics in Medicine and Biology, 2011, vol. 56, pp. R113-R44.
[cited by applicant]
Bertholet, et al., “Real-Time Intrafraction Motion Monitoring in External Beam Radiotherapy,” Physics in Medicine, 2019, vol. 64, No. 15.
[cited by applicant]
Blanck O., et al., “Dose-Escalation Study for Cardiac Radiosurgery in a Porcine Model,” Int J Radiat Oncol Biol Phys., vol. 89:590-598 (Dec. 2014).
[cited by applicant]
Blanck, “Radiosurgery for Ventricular Tachycardia: Preclinical and Clinical Evidence and Study Design for a German Multi-Center Multi-Platform Feasibility Trial (Raventa),” Clinical Research in Cardiology, 09:1319-1332 …
[cited by applicant]
Boas F.E., et al., “Evaluation of Two Iterative Techniques for Reducing Metal Artifacts in Computed Tomography,” Radiology, Jun. 2011, vol. 259, No. 3, pp. 894-902.
[cited by applicant]
Bode F., et al., “Pulmonary Vein Isolation by Radiosurgery: Implications for Non-Invasive Treatment of Atrial Fibrillation,” Europace, vol. 17:1868-1874 (Mar. 2015).
[cited by applicant]
Braem A., et al., “AX-PET: A Novel PET Detector Concept with Full 3D Reconstruction,” Nuclear Instruments and Methods in Physics Research A, 2009, vol. 610, pp. 192-195, Available Online May 29, 2009.
[cited by applicant]
Calkins H., et al., “2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection Procedural Techniques, Patient Management and Follow-Up,…
[cited by applicant]
Cappato R., et al., “Updated Worldwide Survey on the Methods, Efficacy, and Safety of Catheter Ablation for Human Atrial Fibrillation,” Circulation: Arrhythmia and Electrophysiology, 2010, vol. 3, pp. 32-38, DOI: 10.116…
[cited by applicant]
Casella C., et al., “A High Resolution TOF-PET Concept With Axial Geometry and Digital SiPM Readout,” Nuclear Instruments and Methods in Physics Research A, 2014, vol. 736, pp. 161-168.
[cited by applicant]
Chaudhri, et al., “SU-E-T-334: Clinical Implementation of Gating and Dose Verification with Scanned Ion Beams at HIT,” Medical Physics, The American Association of Physicists in Medicine, 39(Issue 6—Part 15):3780-3781 (…
[cited by applicant]
Che, et al., “Ultrasound Registration: A Review,” Methods, 115:128-143 (Feb. 2017).
[cited by applicant]
Constantinescu A., et al., “Catheter-Free Ablation of Atrial Fibrillation: Further Planning Studies in Patient Data Using a Scanned Carbon Ion Beam for Pulmonary Vein Isolation, MP04-02,” Hearth Rhythm, May 2014, vol. 1…
[cited by applicant]
Constantinescu A., et al., “Planning Studies for Non-Invasive Isolation of the Pulmonary Veins with a Scanned Carbon Ion Beam,” Heart Rhythm, 2013, vol. 10, p. S33.
[cited by applicant]
Constantinescu A., et al., “Treatment Planning Studies in Patient Data with Scanned Carbon Ion Beams for Catheter-Free Ablation of Atrial Fibrillation,” Journal of Cardiovascular Electrophysiology, 2016, vol. 27, No. 3,…
[cited by applicant]
De Luca, et al., “The 2014 Liver Ultrasound Tracking Benchmark,” Physics in Medicine & Biology, 60(14):5571 (Jul. 2015).
[cited by applicant]
De Vries T., et al. “Improved Regularization of Convolutional Neural Networks with Cutout,” University of Guelph, Canadian Institute for Advanced Research and Vector Institute, Nov. 29, 2017, 08 Pages.
[cited by applicant]
Degiovanni A., et al., “Design of a Fast-Cycling High-Gradient Rotating Linac for Protontherapy,” Proceedings of IPAC, Shanghai, China THPWA008, 2013, pp. 3642-3644.
[cited by applicant]
Deisher A., et al., “Catheter-Free Ablation With External Photon Radiation: Treatment Planning, Delivery Considerations, and Correlation of Effects With Delivered Dose,” Heart Rhythm, May 2015, vol. 12, No. 5, Supplemen…
[cited by applicant]
Del Carpio Munoz F., et al., “Three-Dimensional Mapping of Cardiac Arrhythmias: What do the Colors Really Mean?,” Circulation Arrhythmia and Electrophysiology, Dec. 2010, vol. 3, No. 6, pp. e6-e11.
[cited by applicant]
Deneke T., et al., “Silent Cerebral Events/Lesions Related to Atrial Fibrillation Ablation: A Clinical Review,” Journal of Cardiovascular Electrophysiology, 2015, vol. 26, pp. 455-463, DOI: 10.1111/jce.12608.
[cited by applicant]
Depuydt, et al., “Treating Patients With Real-Time Tumor Tracking Using the Vero Gimbaled Linac System: Implementation and First Review,” Radiotherapy and Oncology, 2014, vol. 112, No. 3, pp. 343-351.
[cited by applicant]
Dickfeld T., et al., “MRI-Guided Ventricular Tachycardia Ablation: Integration of Late Gadolinium-Enhanced 3D Scar in Patients with Implantable Cardioverter-Defibrillators,” Circulation Arrhythmia and Electrophysiology,…
[cited by applicant]
Dieterich S., et al., “Respiratory Motion Management for External Beam Radiotherapy,” Practical Radiation Oncology Physics, Elsevier Inc., 2016, pp. 252-263.
[cited by applicant]
Dinov B., et al., “Early Referral for Ablation of Scar-Related Ventricular Tachycardia is Associated with Improved Acute and Long-Term Outcomes: Results from the Heart Center of Leipzig Ventricular Tachycardia Registry,…
[cited by applicant]
Extended European Search Report for European Application No. 18851934.2, mailed Sep. 15, 2021, 13 Pages.
[cited by applicant]
Fayad, et al., “Technical Note: Correlation of Respiratory Motion Between External Patient Surface and Internal Anatomical Landmarks,” Medical Physics, 38(6):3157-3164 (Jun. 2011).
[cited by applicant]
Fiorito A.M., et al., “Detection of Cardiac Events in Echocardiography Using 3D Convolutional Recurrent Neural Networks”, 2018 IEEE International Ultrasonics Symposium (IUS), Oct. 22, 2018, 04 Pages, Doi:10.1109/ULTSYM.…
[cited by applicant]
Fishbein M.C., et al., Early Phase Acute Myocardial Infarct Size Quantification: Validation of the Triphenyl Tetrazolium Chloride Tissue Enzyme Staining Technique, American Heart Journal, 1981, vol. 101, pp. 593-600.
[cited by applicant]
Fontanarosa, et al., “Review of Ultrasound Image Guidance in External Beam Radiotherapy: I. Treatment Planning and Inter-Fraction Motion Management,” Physics in Medicine & Biology, 60(3):R77-R114 (Jan. 2015).
[cited by applicant]
Franceschi F., et al., “Histopathological Effects and Evolution of Transvenous β-Radiation Applications in Right and Left Atria: An Animal Study,” Europace, 2012, vol. 14, pp. 745-751, DOI: 10.1093/europace/eur351.
[cited by applicant]
Ge J., et al., “Planning 4-Dimensional Computed Tomography (4DCT) Cannot Adequately Represent Daily Intrafractional Motion of Abdominal Tumors,” International Journal of Radiation Oncology, Biology, Physics, vol. 85(4):…
[cited by applicant]
Gerstenfeld E.P., “Recurrent Ventricular Tachycardia after Catheter Ablation in Post-Infarct Cardiomyopathy: “Failure” of Ablation or Progression of the Substrate?,” Journal of the American College of Cardiology, 2013, …
[cited by applicant]
Graeff C., et al., “A 4D-Optimization Concept for Scanned Ion Beam Therapy,” Radiotherapy and Oncology, Available Online Oct. 31, 2013, vol. 109, pp. 419-424.
[cited by applicant]
Graeff C., et al., “Motion Mitigation in Intensity Modulated Particle Therapy by Internal Target Volumes Covering Range Changes,” Medical Physics, 2012, vol. 39, pp. 6004-6013.
[cited by applicant]
Graeff, et al., “Noninvasive Cardiac Arrhythmia Ablation With Particle Beams,” Medical Physics, vol. 45, No. 11 (Nov. 2018).
[cited by applicant]
Grimm J., et al., “Dose Tolerance Limits and Dose Volume Histogram Evaluation for Stereotactic Body Radiotherapy,” Journal of Applied Clinical Medical Physics, vol. 12(2): 267-292 (Jan. 2011).
[cited by applicant]
Guerra P.G., et al., “Beta-Radiation for the Creation of Linear Lesions in the Canine Atrium,” Circulation, 2004, vol. 110, pp. 911-914, DOI: 10.1161/01.CIR.0000139865.39885.03.
[cited by applicant]
Haberer T., et al., “Magnetic Scanning System for Heavy ion Therapy,” Nuclear Instruments and Methods A, 1993, vol. 330, pp. 296-305.
[cited by applicant]
Hartman J., et al., “Dosimetric Feasibility of Intensity Modulated Proton Therapy in a Transverse Magnetic Field of 1.5 T,” Physics in Medicine and Biology, 2015, vol. 60, pp. 5955-5969.
[cited by applicant]
Hoogeman, et al., “Clinical Accuracy of the Respiratory Tumor Tracking System of the Cyberknife: Assessment by Analysis of Log Files,” International Journal of Radiation Oncology, Biology, Physics, 2009, vol. 74, No. 1,…
[cited by applicant]
Iguchi T., et al., “Development of Compact Compton Gamma Camera for Non-Destructive Detection and Location of Hidden Explosives with Neutron Induced Prompt Gamma-Ray Imaging,” Nuclear Science Symposium Conference Record…
[cited by applicant]
International Search Report & Written Opinion dated Dec. 11, 2023 in Int'l PCT Patent Appl. Serial No. PCT/IB2023/058539 (0710).
[cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/EP2018/081455, mailed Feb. 12, 2019, 13 Pages.
[cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/IB2019/058638, mailed Jun. 25, 2020, 17 Pages.
[cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/IB2020/000930, mailed Apr. 9, 2021, 11 Pages.
[cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/IB2021/000922, mailed Apr. 19, 2022, 15 Pages.
[cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/US2018/049114, mailed Nov. 21, 2018, 09 Pages.
[cited by applicant]
Ipsen, et al., “Radiotherapy Beyond Cancer: Target Localization in Real-time MRI and Treatment Planning for Cardiac Radiosurgery,” Medical Physics, vol. 41(12):120702_1-120702_8 (Dec. 2014).
[cited by applicant]
Ipsen, et al., “Target Tracking Accuracy and Latency With Different 4D Ultrasound Systems—A Robotic Phantom Study,” Current Directions in Biomedical Engineering, 6(1):20200038 (Sep. 2020).
[cited by applicant]
Ipsen, S., “See What You Treat: 4d Ultrasound Imaging for Real Time Motion Compensation in the Liver,” PhD Thesis University of Luebeck, pp. 1-142 (Nov. 2019).
[cited by applicant]
Kachelriess M., et al., “ECG-Correlated Image Reconstruction from Subsecond Multi-Slice Spiral CT Scans of the Heart,” Medical Physics, 2000, vol. 27, pp. 1881-1902.
[cited by applicant]
Keall et al., “The Management of respiratory motion in radiation on oncology report of AAPM Task Group 76
[cited by applicant]
Keall P.J, et al., “The First Clinical Implementation of Electromagnetic Transponder-Guided MLC Tracking,” Medical Physics, 2014, vol. 41: 020702.
[cited by applicant]
Keall P.J., et al., “The First Clinical Treatment with Kilovoltage Intrafraction Monitoring (KIM): A Real-Time Image Guidance Method,” Medical Physics, 2015, vol. 42, pp. 354-358.
[cited by applicant]
Khalil, et al., “An Overview on Image Registration Techniques for Cardiac Diagnosis and Treatment,” Cardiology Research and Practice, 2018, Article ID 1437125, 15 pages, https://doi.org/10.1155/2018/1437125.
[cited by applicant]
Kincaid, et al., “Investigation of Gated Cone-Beam CT to Reduce Respiratory Motion Blurring,” Medical Physics, 40(4):041717 (Apr. 2013).
[cited by applicant]
Kingma D.P., et al., “Adam: A Method for Stochastic Optimization,” Published as a Conference Paper at ICLR, arXiv: 1412.6980v8, Jul. 23, 2015, pp. 1-15.
[cited by applicant]
Klein E.E., et al., “Task Group 142 report: Quality assurance of medical accelerators,” Medical Physics, The American Association of Physicists in Medicine, Sep. 2009, vol. 36, No. 9, pp. 4197-4212, Published on Aug. 17…
[cited by applicant]
Koike Y., et al., “Deep Learning-Based Metal Artifact Reduction Using Cycle-Consistent Adversarial Network for Intensity-Modulated Head and Neck Radiation Therapy Treatment Planning,” Physica Medica, Sep. 7, 2020, vol. …
[cited by applicant]
Krimmer J., et al., “Prompt-Gamma Monitoring in Hadrontherapy: A Review,” Nuclear Instruments and Methods in Physics Research A, 2018, vol. 878, pp. 58-73, Available online Aug. 12, 2017.
[cited by applicant]
Kumar S., et al., “Effect of Respiration on Catheter-Tissue Contact Force during Ablation of Atrial Arrhythmias,” Heart Rhythm, vol. 9(7):1041-1047e1 (Jul. 2012).
[cited by applicant]
Kuntz J., et al., “Fully Automated Intrinsic Respiratory and Cardiac Gating for Small Animal CT,” Physics in Medicine and Biology, vol. 55:2069-2085 (Apr. 2010).
[cited by applicant]
Lachaine, et al., “Intrafractional Prostate Motion Management With the Clarity Autoscan System,” Medical Physics International Journal, 1(1):72-80 (2013).
[cited by applicant]
Lehmann H.I., et al., “Atrioventricular Node Ablation in Langendorffperfused Porcine Hearts using Carbon Ion Particle Therapy: Methods and an in Vivo Feasibility Investigation for Catheter-Free Ablation of Cardiac Arrhy…
[cited by applicant]
Lehmann H.I., et al., “Biophysics of Tissue Ablation in Catheter-Free Ablation With Carbon Ion Beams,” vol. 13:(5):AB29-05 S67 (May 1016).
[cited by applicant]
Lehmann H.I., et al., “Delineation of Target Locations and Organs at Risk for Particle Beam Therapy: Atlas for Extracorporeal CT-Based Ablation of Cardiac Tissue,” Heart Rhythm, May 2017 vol. 11, No. 5, Supplement.
[cited by applicant]
Lehmann H.I., et al., “External Arrhythmia Ablation using Photon Beams: Ablation of the Atrioventricular Junction in an Intact Animal Model,” Circulation: Arrhythmia and Electrophysiology, Apr. 2017, vol. 10, No. 4 (e00…
[cited by applicant]
Lehmann H.I., et al., “Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams,” Nature, Scientific Reports, Dec. 20, 2016, vol. 6, No. 38895, 13 Pages, DOI: 10.1038/srep38895.
[cited by applicant]
Lehmann H.I., et al., “In-Beam PET Verification of Catheter-Free Arrhythmia Ablation by Scanned Carbon-12 Ion Beam Irradiation,” Circulation, 2015, vol. 132, Supplement. 3, p. A12443.
[cited by applicant]
Li, et al., Comparative Quantitative Analysis of Robotic Ultrasound Image Calibration Methods, 2021 20th International Conference on Advanced Robotics (ICAR), IEEE, pp. 511-516.
[cited by applicant]
Lin M.H., et al., “4D Patient Dose Reconstruction using Online Measured EPID Cine Images for Lung SBRT Treatment Validation,” Medical Physics, 2012, vol. 39, pp. 5949-5958.
[cited by applicant]
Lis M., et al., “A Modular Dose Delivery System for Treating Moving Targets With Scanned Ion Beams: Performance and Safety Characteristics, and Preliminary Tests,” Physica Medica, 2020, vol. 76, pp. 307-316.
[cited by applicant]
Luzhbin D., et al., “Model Image-Based Metal Artifact Reduction for Computed Tomography,” Journal of Digital Imaging, 2020, vol. 33, pp. 71-82.
[cited by applicant]
Maguire., et al., “First-In-Man Cardiac Radiosurgery for Atrial Arrhythmia,” International Journal of Radiation Oncology, Biology, Physics, 96(2):E504-5 (Oct. 2016).
[cited by applicant]
Maguire P., et al., “Cardiac Radiosurgery (CyberHeart) for Treatment of Arrhythmia: Physiologic and Histopathologic Correlation in the Porcine Model,” Cureus, 3(8):(e32) (Aug. 2011).
[cited by applicant]
Nakao M., et al., “Regularized Three-Dimensional Generative Adversarial Nets for Unsupervised Metal Artifact Reduction in Head and Neck CT Images,” IEEE Access, Digital Object Identifier, Jun. 12, 2020, vol. 8, pp. 1094…
[cited by applicant]
Nankali, et al., “Geometric and Dosimetric Comparison of Four Intrafraction Motion Adaptation Strategies for Stereotactic Liver Radiotherapy,” Physics in Medicine & Biology, 63(14):145010 (Jul. 2018).
[cited by applicant]
Ng J., et al., “Mapping of Dominant Activation Directions in a Canine Rapid Atrial Pacing Model of Atrial Fibrillation,” Heart Rhythm Session, May 12, 2017.
[cited by applicant]
O'Shea, et al., “Review of Ultrasound Image Guidance in External Beam Radiotherapy Part II: Intra-Fraction Motion Management and Novel Applications,” Physics in Medicine & Biology, 2016, vol. 61, No. 8, DOI: 10.1088/003…
[cited by applicant]
Okumura Y., et al., “Three-Dimensional Ultrasound for Image-Guided Mapping and Intervention: Methods, Quantitative Validation, and Clinical Feasibility of a Novel Multimodality Image Mapping System,” Circulation Arrhyth…
[cited by applicant]
Ortega P.G., et al., “Noise Evaluation of Compton Camera Imaging for Proton Therapy,” Physics in Medicine and Biology, Institute of Physics Publishing and Engineering in Medicine, Bristol, GB, Feb. 6, 2015, vol. 60, No.…
[cited by applicant]
Ortmaier T., et al., “Motion Estimation in Beating Heart Surgery,” IEEE Transactions on Biomedical Engineering, 2005, vol. 52, pp. 1729-1740.
[cited by applicant]
Pan J., et al., “A Real-Time QRS Detection Algorithm,” IEEE Transactions on Biomedical Engineering, Mar. 1985, vol. BME-32, No. 3, pp. 230-236.
[cited by applicant]
Partial Supplementary European Search Report for European Application No. 18851934.2, mailed Apr. 22, 2021, 11 Pages.
[cited by applicant]
Perali I., et al., “Prompt Gamma Imaging of Proton Pencil Beams at Clinical Dose Rate,” Institute of Physics and Engineering in Medicine, Physics in Medicine and Biology, Sep. 10, 2014, vol. 59, pp. 5849-5871.
[cited by applicant]
Peulen H., et al., “Mid-Ventilation Based PTV Margins in Stereotactic Body Radiotherapy (SBRT): A Clinical Evaluation,” Radiotherapy and Oncology, vol. 110:(3):511-516, DOI: 10.1016/j.radonc.2014.01.010 (Mar. 2014).
[cited by applicant]
Pfanner F., et al. “Monitoring Cardiac Motion in CT using a Continuous Wave Radar Embedded in the Patient Table,” Medical Physics, 2014, vol. 41: 081908.
[cited by applicant]
Pfanner F., et al., “Monitoring internal organ motion with continuous wave radar in CT,” Medical Physics, 2013, vol. 40: 091915.
[cited by applicant]
Piersanti L., et al., Measurement of Charged Particle Yields from PMMA Irradiated by a 220 MeV/u (12)C Beam, Physics in Medicine and Biology, 2014, vol. 59, pp. 1857-1872.
[cited by applicant]
Poon, et al., “Technical Note: Cardiac Synchronized Volumetric Modulated Arc Therapy for Stereotactic Arrhythmia Radioablation—Proof of Principle,” Medical Physics, vol. 47(8):3567-3572 (Aug. 2020).
[cited by applicant]
Poulsen P.R., et al., “A Method of Dose Reconstruction for Moving Targets Compatible with Dynamic Treatments,” Medical Physics, vol. 39(10):6237-6246 (Oct. 2012).
[cited by applicant]
Poulsen P.R., et al., “Kilovoltage Intrafraction Motion Monitoring and Target Dose Reconstruction for Stereotactic Volumetric Modulated Arc Therapy of Tumors in the Liver,” Radiotherapy and Oncology, 2014, vol. 111, pp.…
[cited by applicant]
Prall M., et al., “Ion Beam Tracking Using Ultrasound Motion Detection,” Medical Physics, 41(4):041708-1-041708-5 (Apr. 2014).
[cited by applicant]
Prall M., et al., “Treatment of Arrhythmias by External Charged Particle Beams: A Langendorff Feasibility Study,” Biomedical Engineering-Biomedical Technology, Published Online on Feb. 19, 2015, vol. 60, No. 2, pp. 147-…
[cited by applicant]
Pérez-Castellano N., et al., “Pathological Effects of Pulmonary Vein Beta-Radiation in a Swine Model,” Journal of Cardiovascular Electrophysiology, 2006, vol. 17, pp. 662-669, DOI: 10.1111/j.1540-8167.2006.00462.x.
[cited by applicant]
Queiros, et al., “Fast Left Ventricle Tracking Using Localized Anatomical Affine Optical Flow,” International Journal for Numerical Methods in Biomedical Engineering, 33(11):e2871 (Nov. 2017).
[cited by applicant]
Raaymakers B.W., et al., “Integrating a 1.5 T MRI Scanner With A 6 MV Accelerator: Proof of Concept,” Physics in Medicine and Biology, 54(12):N229-N37 (May 2009).
[cited by applicant]
Ravkilde T., et al., “Time-Resolved Dose Distributions to Moving Targets During Volumetric Modulated Arc Therapy With and Without Dynamic MLC Tracking,” Medical Physics, 2013, 40(11):111723-1-111723-8 (Nov. 2013).
[cited by applicant]
Rettmann M.E., et al., “Analysis of Left Atrial Respiratory and Cardiac Motion for Cardiac Ablation Therapy,” Medical Imaging 2015: Image-Guided Procedures, Robotic Interventions, and Modeling, 9415:651-656 ) Mar. 2015.
[cited by applicant]
Rettmann M.E., et al., “Centerline Tracking for Quantification of Reverse Structural Remodeling of the Pulmonary Veins Following Cardiac Ablation Therapy,” Academic Radiology, 19(11):1332-1344 (Nov. 2012).
[cited by applicant]
Richter C., et al., “First Clinical Application of a Prompt Gamma Based in Vivo Proton Range Verification System,” Radiotherapy and Oncology, vol. 118(2):232-237 (Feb. 2016).
[cited by applicant]
Richter D., et al., “ECG-Based 4d-Dose Reconstruction of Cardiac Arrhythmia Ablation With Carbon Ion Beams: Application in a Porcine Model,” Physics in Medicine and Biology, Aug. 4, 2017, vol. 62, No. 17, p. 6869.
[cited by applicant]
Richter D., et al., “Four-Dimensional Patient Dose Reconstruction for Scanned Ion Beam Therapy of Moving Liver Tumors,” International Journal of Radiation Oncology, Biology, Physics, 2014, vol. 89, pp. 175-181.
[cited by applicant]
Richter D., et al., “Residual Motion Mitigation in Scanned Carbon Ion Beam Therapy of Liver Tumors Using Enlarged Pencil Beam Overlap,” Radiotherapy and Oncology, vol. 113, pp. 290-295 (Nov. 2014).
[cited by applicant]
Richter D., et al., “Upgrade and Benchmarking of A 4D Treatment Planning System for Scanned Ion Beam Therapy,” Medical Physics, vol. 40:051722 (May 2013).
[cited by applicant]
Robinson, et al., “An Evaluation of the Clarity 3D Ultrasound System for Prostate Localization,” Journal of Applied Clinical Medical Physics, 13(4):100-112 (Jul. 2012).
[cited by applicant]
Roujol, et al., “Characterization of Respiratory and Cardiac Motion From Electro-Anatomical Mapping Data for Improved Fusion of MRI to Left Ventricular Electrograms,” PloS One, 2013, vol. 8, No. 11, p. e78852.
[cited by applicant]
Saint-Gobain Ceramics & Plastics Inc: “Scintillation Materials and Assemblies, About Saint-Gobain Crystals,” Saint-Gobain Crystals Handbook, 2004-2019, 12 Pages.
[cited by applicant]
Sauli F., “Radiation Imaging with Gaseous Detectors,” Nuclear Instruments and Methods in Physics Research A, 2018, vol. 878, pp. 1-9.
[cited by applicant]
Scandurra D., et al., “Assessing the Quality of Proton PBS Treatment Delivery Using Machine Log Files: Comprehensive Analysis of Clinical Treatments Delivered at PSI Gantry 2,” Physics in Medicine and Biology, vol. 61, …
[cited by applicant]
Schardt D., et al., “Heavy-Ion Tumor Therapy: Physical and Radiobiological Benefits,” Reviews of Modern Physics, vol. 82(1):383-425 (Mar. 2010).
[cited by applicant]
Schlosser J., et al., “Radiolucent 4D Ultrasound Imaging: System Design and Application to Radiotherapy Guidance,” IEEE Transactions on Medical Imaging, Oct. 2016, vol. 35, No. 10, pp. 2292-2300.
[cited by applicant]
Shackleford J.A., et al., “On Developing B-Spline Registration Algorithms for Multi-Core Processors,” Phys. Med. Biol., vol. 55, pp. 6329-6351 (Oct. 2010).
[cited by applicant]
Sharma A., et al., “New Non-Invasive Therapy for Cardiac Arrhythmias using Stereotactic Radiosurgery: Initial Feasibility Testing,” Heart Rythm, vol. 4(5):S68, Abstract (May 2007).
[cited by applicant]
Sharma A., et al., “Non-Invasive Ablation of the Left Superior Pulmonary Vein-Left Atrial Junction Using Stereotactic Focused Radiation,” Circulation, vol. 116:489, Abstract (Oct. 2007).
[cited by applicant]
Sharma A., et al., “Non-Invasive Approach to Myocardial Ablation: Pathology of Stereotactic Robot Targeted High Energy X-Ray Lesions at Potential Arrhythmia Sites,” Heart Rhythm, vol. 5(5): S67 (AB32-3), Abstract (May 2…
[cited by applicant]
Sharma A., et al., “Noninvasive Stereotactic Radiosurgery (CyberHeart) for Creation of Ablation Lesions in the Atrium,” Heart Rhythm, 2010, vol. 7, pp. 802-810, DOI: 10.1016/j.hrthm.2010.02.010.
[cited by applicant]
Smith, Scott, Ultrasound Miniaturization, 2011 Joint AAPM / COMP Meeting Jul. 31-Aug. 4, 2011, Vancouver, available at: https://www.aapm.org/meetings/amos2/pdf/59-17269-42515-909.pdf.
[cited by applicant]
Soejima K., et al., “Catheter Ablation in Patients With Multiple and Unstable Ventricular Tachycardias after Myocardial Infarction: Short Ablation Lines Guided by Reentry Circuit Isthmuses and Sinus Rhythm Mapping,” Cir…
[cited by applicant]
Soejima K., et al., “Endocardial and Epicardial Radiofrequency Ablation of Ventricular Tachycardia Associated With Dilated Cardiomyopathy: The Importance of Low-Voltage Scars,” Journal of American College of Cardiology,…
[cited by applicant]
Solevi P., “Study of an In-Beam PET System for CNAO, the National Centre for Oncological Hadrontherapy,” PHD Thesis, Milano University, 2007, pp. 1-142 (144 Pages).
[cited by applicant]