IP Library › Granted Patent US 12,383,416
Granted Patent B2
US 12,383,416 · App. 17/810,168 · Granted Aug 12, 2025

Medical device for sensing and or stimulating tissue

Inventors: Sam Emmanuel John (Parkville, AU); Nicholas Lachlan Opie (Parkville, AU); Thomas James Oxley (New York, NY)
Assignee: The University of Melbourne
A61F2/68A61B5/293A61B5/4851A61B5/6862A61B5/6868A61B5/6876A61F2/72A61F2/86A61N1/36003B25J9/00G06F3/015A61B2562/227A61F2002/6827A61F2002/705A61F2250/0002A61N1/0531A61N1/0534A61N1/0536A61N1/36067A61N1/36078A61N1/36085A61N1/36089A61N1/36096A61N1/36178
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Quick Facts
Patent No.
US 12,383,416
App. No.
17/810,168
Granted
Aug 12, 2025
Kind
B2
Abstract

Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal for stimulating and/or sensing activity of media proximal to the devices. The media can include tissue and/or fluid. A method of controlling an apparatus in communication with a brain machine interface. The method can include measuring a first neural activity in a first neural area and measuring a second neural activity in a second neural area. The first neural activity can be associated with a first intent. The method can include creating and delivering, via the processor, one or more first control signals to the apparatus upon comparing the second neural activity with the first neural activity, and confirming, based on this comparison, that the second neural activity is associated with the first intent.

Claims (34)

1. A method of controlling an apparatus in communication with a brain machine interface, the method comprising:

measuring a first neural activity in a first neural area associated with a first intent to control the apparatus, where measuring the first neural activity comprises using a first sensor;

measuring a second neural activity in a second neural area using a second sensor; and

delivering, via a processor, one or more control signals to the apparatus upon confirming that the second neural activity is associated with the first intent,

where the first neural area is different than the second neural area.

2. The method of claim 1 , further comprising:

decoding, via the processor, the first intent from the measured first neural activity; and

decoding, via the processor, a second intent from the measured second neural activity, where the delivering comprises delivering the one or more control signals to the apparatus upon confirming that the second is associated with the first intent.

3. The method of claim 2 , where decoding the first and second intents comprises referencing previously measured neural activities stored in a memory.

4. The method of claim 1 , further comprising repeating the measuring until at least one of the one or more control signals is delivered to the apparatus.

5. The method of claim 1 , where the delivering comprises delivering the one or more control signals to the apparatus to control a first parameter and/or a second parameter of the apparatus.

6. The method of claim 1 , where the first sensor is proximate or in a first neural area and where the second sensor is proximate or in a second neural area.

7. The method of claim 6 , where the first and second neural areas are in a brain.

8. The method of claim 1 , further comprising:

determining a desired parameter of the apparatus;

calculating a control correlation between the measured first neural activity and the desired parameter; and

adjusting a user control percentage and a computer control percentage of the apparatus.

9. The method of claim 8 , where the adjusting comprises increasing the user control percentage and decreasing the computer control percentage and/or where the adjusting comprises decreasing the user control percentage and increasing the computer control percentage.

10. A method of positioning an electrode array device for detecting, measuring, recording, stimulating, decoding, and/or modulating brain activity of a brain, the method comprising:

providing a scaffold comprising one or more substrate members, the one or more substrate members embedded with conductive materials configured to be in electrical communication with an external device, the scaffold attached to a communication conduit that facilitates communication between conductive materials and a control unit; and

delivering a flexible hollow delivery instrument through a vessel, the flexible hollow delivery instrument configured to translate the scaffold and its one or more substrate members from the vessel to a target location within a deposition point of the brain;

wherein the scaffold the one or more substrate members are configured to be confined to a small volume for containment in the flexible hollow delivery instrument during translation to the deposition point;

deploying the one or more substrate members to the deposition point such that the one or more substrate members are further configured to expand over a selected area such that the conductive materials electrically couple with a neural tissue at the deposition point while the communication conduit remains within the vessel; and

where the external device and the conductive materials are configured for the transfer of electrical signals between the deposition point of the brain and the external device.

11. The method of claim 10 , the conductive materials are further configured to enable sensing and relaying of cortical activity neural activity.

12. The method of claim 10 , wherein the external device is a brain-computer interface.

13. The method of claim 10 , further comprising an implantable wireless receiver configured to enable wireless communication with the external device.

14. The method of claim 10 , wherein the flexible hollow delivery instrument comprises a catheter system.

15. The method of claim 14 , wherein the scaffold is configured to be compressed into the catheter system and can be expanded after deployment from the catheter system.

16. The method of claim 10 , wherein the deposition point is a motor cortex.

17. The method of claim 10 , wherein the deposition point is a sensory cortex.

18. The method of claim 10 , wherein the deposition point is a brain structure.

19. The method of claim 10 , wherein the vessel comprises a jugular vein.

20. The method of claim 10 , wherein the scaffold comprises a supporting substrate comprising a super-elastic material.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2022
From: JOHN, SAM EMMANUEL; OPIE, NICHOLAS LACHLAN; OXLEY, THOMAS JAMES
To: THE UNIVERSITY OF MELBOURNE
Reel/Frame 060557/0359 →
Continuity (5)
Continuation 16683077 · Nov 13, 2019
Continuation 16054657 · Aug 3, 2018
Provisional Application 62545875 · Aug 15, 2017
Provisional Application 62540997 · Aug 3, 2017
Related Publication 20220323241A1 · Oct 13, 2022
References Cited (173)
US 5522836A · Palermo · 1996 [cited by applicant]
US 6360122B1 · Fischell et al. · 2002 [cited by applicant]
US 6895280B2 · Meadows et al. · 2005 [cited by applicant]
US 7483747B2 · Gliner et al. · 2009 [cited by applicant]
US 7676263B2 · Harris et al. · 2010 [cited by applicant]
US 7826894B2 · Musallam et al. · 2010 [cited by applicant]
US 8038674B2 · Schmaltz · 2011 [cited by applicant]
US 8328860B2 · Strauss et al. · 2012 [cited by applicant]
US 8460332B2 · Tieu et al. · 2013 [cited by applicant]
US 8805494B2 · Libbus et al. · 2014 [cited by applicant]
US 9445739B1 · Payton et al. · 2016 [cited by applicant]
US 9833252B2 · Sepetka et al. · 2017 [cited by applicant]
US 9867978B1 · Rapoport · 2018 [cited by applicant]
US 10028782B2 · Orion · 2018 [cited by applicant]
US 10512555B2 · John et al. · 2019 [cited by applicant]
US 10709463B2 · Girdhar et al. · 2020 [cited by applicant]
US 10729530B2 · Opie et al. · 2020 [cited by applicant]
US 10758732B1 · Heldman · 2020 [cited by applicant]
US 11093038B2 · Yoo · 2021 [cited by applicant]
US 11376138B2 · John et al. · 2022 [cited by applicant]
US 11402909B2 · Forsland et al. · 2022 [cited by applicant]
US 11625014B2 · Oxley et al. · 2023 [cited by applicant]
US 11755110B2 · Yoo · 2023 [cited by applicant]
US 12032345B2 · Oxley et al. · 2024 [cited by applicant]
US 12223106B2 · Oxley et al. · 2025 [cited by applicant]
US 20030073917A1 · Echauz et al. · 2003 [cited by applicant]
US 20040199235A1 · Younis · 2004 [cited by applicant]
US 20050228515A1 · Musallam et al. · 2005 [cited by applicant]
US 20060005845A1 · Karr et al. · 2006 [cited by applicant]
US 20060167371A1 · Flaherty et al. · 2006 [cited by applicant]
US 20060189900A1 · Flaherty · 2006 [cited by applicant]
US 20070150006A1 · Libbus et al. · 2007 [cited by applicant]
US 20070255379A1 · Williams et al. · 2007 [cited by applicant]
US 20070276461A1 · Andreas et al. · 2007 [cited by applicant]
US 20080045881A1 · Teitelbaum et al. · 2008 [cited by applicant]
US 20080071314A1 · John · 2008 [cited by applicant]
US 20090092298A1 · Xu et al. · 2009 [cited by applicant]
US 20090105786A1 · Fetz et al. · 2009 [cited by applicant]
US 20100211126A1 · Cazares · 2010 [cited by applicant]
US 20100271051A1 · Sankai et al. · 2010 [cited by applicant]
US 20100298657A1 · McCombie et al. · 2010 [cited by applicant]
US 20110040546A1 · Gerber et al. · 2011 [cited by applicant]
US 20110137212A1 · Hahn et al. · 2011 [cited by applicant]
US 20110193688A1 · Forsell et al. · 2011 [cited by applicant]
US 20110307029A1 · Hargrove · 2011 [cited by applicant]
US 20120035765A1 · Sato et al. · 2012 [cited by applicant]
US 20120071780A1 · Barachant et al. · 2012 [cited by applicant]
US 20120172743A1 · Aguilar et al. · 2012 [cited by applicant]
US 20120290024A1 · Zhang et al. · 2012 [cited by applicant]
US 20120296476A1 · Cale et al. · 2012 [cited by applicant]
US 20130184558A1 · Gallant et al. · 2013 [cited by applicant]
US 20140005531A1 · Taylor · 2014 [cited by applicant]
US 20140046407A1 · Ben-Ezra et al. · 2014 [cited by applicant]
US 20140058528A1 · Contreras-Vidal · 2014 [cited by examiner]
US 20140066949A1 · Eskuri · 2014 [cited by applicant]
US 20140277253A1 · Jaax · 2014 [cited by applicant]
US 20140277256A1 · Osorio · 2014 [cited by applicant]
US 20140288667A1 · Oxley · 2014 [cited by applicant]
US 20140309538A1 · More et al. · 2014 [cited by applicant]
US 20140330404A1 · Abdelghani · 2014 [cited by applicant]
US 20150012111A1 · Contreras-Vidal et al. · 2015 [cited by applicant]
US 20150038869A1 · Simon et al. · 2015 [cited by applicant]
US 20150091791A1 · Segal · 2015 [cited by applicant]
US 20150157862A1 · Greenberg et al. · 2015 [cited by applicant]
US 20150272465A1 · Ishii · 2015 [cited by applicant]
US 20150289892A1 · Lam et al. · 2015 [cited by applicant]
US 20150313496A1 · Connor · 2015 [cited by applicant]
US 20150317817A1 · Ryu · 2015 [cited by applicant]
US 20150327805A1 · Ben-Haim · 2015 [cited by applicant]
US 20150338917A1 · Steiner et al. · 2015 [cited by applicant]
US 20150351655A1 · Coleman · 2015 [cited by applicant]
US 20160015316A1 · Borsook et al. · 2016 [cited by applicant]
US 20160048753A1 · Sussillo et al. · 2016 [cited by applicant]
US 20160128767A1 · Azamian et al. · 2016 [cited by applicant]
US 20160136427A1 · De Ridder · 2016 [cited by applicant]
US 20160144186A1 · Kaemmerer et al. · 2016 [cited by applicant]
US 20160242690A1 · Principe et al. · 2016 [cited by applicant]
US 20160346164A1 · Ward et al. · 2016 [cited by applicant]
US 20170108926A1 · Moon et al. · 2017 [cited by applicant]
US 20170172497A1 · Marquez · 2017 [cited by applicant]
US 20170239486A1 · Suryavanshi · 2017 [cited by applicant]
US 20170281086A1 · Donaldson · 2017 [cited by applicant]
US 20180036533A1 · Yoo · 2018 [cited by applicant]
US 20180116717A1 · Taff et al. · 2018 [cited by applicant]
US 20180116723A1 · Hettrick et al. · 2018 [cited by applicant]
US 20180140354A1 · Lam et al. · 2018 [cited by applicant]
US 20180178009A1 · Lee et al. · 2018 [cited by applicant]
US 20180199840A1 · Loureiro et al. · 2018 [cited by applicant]
US 20180229046A1 · Parker · 2018 [cited by applicant]
US 20180236221A1 · Opie et al. · 2018 [cited by applicant]
US 20180292902A1 · Min · 2018 [cited by applicant]
US 20190025917A1 · Francis et al. · 2019 [cited by applicant]
US 20190038438A1 · John et al. · 2019 [cited by applicant]
US 20190046119A1 · Oxley · 2019 [cited by applicant]
US 20190058703A1 · Zhu · 2019 [cited by applicant]
US 20190091475A1 · Pachon-Mateos et al. · 2019 [cited by applicant]
US 20190104968A1 · Fedele · 2019 [cited by applicant]
US 20190113973A1 · Coleman et al. · 2019 [cited by applicant]
US 20190134401A1 · Schouenborg et al. · 2019 [cited by applicant]
US 20190166434A1 · Petley et al. · 2019 [cited by applicant]
US 20190183590A1 · Hladio et al. · 2019 [cited by applicant]
US 20190192125A1 · Coakley et al. · 2019 [cited by applicant]
US 20190201691A1 · Poltorak · 2019 [cited by applicant]
US 20190232061A1 · Ganguly et al. · 2019 [cited by applicant]
US 20190274855A1 · Pate et al. · 2019 [cited by applicant]
US 20190336748A1 · Oxley · 2019 [cited by applicant]
US 20190388097A1 · Girdhar et al. · 2019 [cited by applicant]
US 20200016396A1 · Yoo · 2020 [cited by applicant]
US 20200061378A1 · Ganguly et al. · 2020 [cited by applicant]
US 20200078195A1 · John et al. · 2020 [cited by applicant]
US 20200121335A1 · Aboytes · 2020 [cited by applicant]
US 20200147387A1 · Osorio · 2020 [cited by applicant]
US 20200268296A1 · Alcaide et al. · 2020 [cited by applicant]
US 20200289012A1 · Rapoport et al. · 2020 [cited by applicant]
US 20200298100A1 · Ambinder et al. · 2020 [cited by applicant]
US 20200363869A1 · Yoo · 2020 [cited by applicant]
US 20210137542A1 · Oxley et al. · 2021 [cited by applicant]
US 20210257078A1 · Marquez Chin · 2021 [cited by examiner]
US 20210342004A1 · Yoo · 2021 [cited by applicant]
US 20210361222A1 · Elbogen et al. · 2021 [cited by applicant]
US 20210361950A1 · Opie et al. · 2021 [cited by applicant]
US 20210365117A1 · Yoo et al. · 2021 [cited by applicant]
US 20210369394A1 · Braido · 2021 [cited by applicant]
US 20210373665A1 · Yoo · 2021 [cited by applicant]
US 20220159932A1 · Takada Neff · 2022 [cited by applicant]
US 20220240833A1 · Oxley · 2022 [cited by applicant]
US 20220241596A1 · Opie et al. · 2022 [cited by applicant]
US 20220253024A1 · Oxley et al. · 2022 [cited by applicant]
US 20220273907A1 · Poltorak · 2022 [cited by applicant]
US 20230152961A1 · Perea-Ochoa · 2023 [cited by applicant]
US 20230244314A1 · Oxley et al. · 2023 [cited by applicant]
US 20230350360A1 · Oxley et al. · 2023 [cited by applicant]
US 20240019933A1 · Yoo · 2024 [cited by applicant]
US 20240319692A1 · Oxley et al. · 2024 [cited by applicant]
US 20240370089A1 · Yoo · 2024 [cited by applicant]
US 20240419248A1 · Oxley et al. · 2024 [cited by applicant]
AU 2012321050 · 2014 [cited by applicant]
AU 2017276276 · 2018 [cited by applicant]
AU 2019283829 · 2020 [cited by applicant]
CN 101464729 · 2009 [cited by applicant]
CN 104023787 · 2014 [cited by applicant]
CN 106922125 · 2017 [cited by applicant]
CN 107374623 · 2017 [cited by applicant]
CN 101300045 · 2018 [cited by applicant]
EP 2763745 · 2014 [cited by applicant]
EP 3536375 · 2019 [cited by applicant]
IL 267547 · 2019 [cited by applicant]
JP 2005018167 · 2005 [cited by applicant]
JP 2014528800 · 2014 [cited by applicant]
JP 6149269 · 2017 [cited by applicant]
JP 2017159079 · 2017 [cited by applicant]
JP 2019506691 · 2019 [cited by applicant]
JP 2020526357 · 2020 [cited by applicant]
KR 20140008022 · 2014 [cited by applicant]
WO WO2006078432 · 2006 [cited by applicant]
WO WO2010121300 · 2010 [cited by applicant]
WO WO2011105000 · 2011 [cited by applicant]
WO WO2013049887 · 2013 [cited by applicant]
WO WO2014102722 · 2014 [cited by applicant]
WO WO2016196797 · 2016 [cited by applicant]
WO WO2017009787 · 2017 [cited by applicant]
WO WO2017070252 · 2017 [cited by applicant]
WO WO2017172020 · 2017 [cited by applicant]
WO WO2019028394 · 2019 [cited by applicant]
WO WO2019243992 · 2019 [cited by applicant]
WO WO2021092462 · 2021 [cited by applicant]
WO WO2021097448 · 2021 [cited by applicant]
WO WO2021202915 · 2021 [cited by applicant]
WO WO2022170342 · 2022 [cited by applicant]
WO WO2023137427 · 2023 [cited by applicant]
Brunner et al. “Online Control of a Brain-Computer Interface Using Phase Synchronization,” IEEE Transactions on Biomedical Engineering, vol. 53, No. 12, pp. 2501-2506, Dec. 2006. [cited by applicant]
Kremen, V. et al. “Integrating brain implants with local and distributed computing devices: a next generation epilepsy management system,” IEEE Journal of Translational Engineering in Health and Medicine, vol. 6, 12 pag… [cited by applicant]
Nicolas-Alonso, L. et al. “Brain Computer Interfaces, a Review”, Sensors, vol. 12, No. 12, pp. 1211-1279, Jan. 31, 2012. [cited by applicant]