IP Library › Granted Patent US 12,503,503
Granted Patent B2
US 12,503,503 · App. 17/242,667 · Granted Dec 23, 2025

Bispecific anti-VEGF/ANG2 antibody formulation

Inventors: Christian Freichel (Basel, CH); Claudia Mueller (Basel, CH); Robert Mueller (Basel, CH); Piotr Jan Szczesny (Basel, CH); Martin Worgull (Basel, CH); Christine Wurth (Basel, CH)
Assignee: Hoffmann-La Roche Inc.
C07K16/22A61M5/178C07K2317/31C07K2317/526C07K2317/565C07K2317/94
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Quick Facts
Patent No.
US 12,503,503
App. No.
17/242,667
Granted
Dec 23, 2025
Kind
B2
Abstract

This invention relates to a pharmaceutical formulation of a bispecific anti-VEGF/ANG2 antibody, and a process for the preparation and uses of the formulation.

Claims (28)

1 . A liquid pharmaceutical formulation comprising:

120 mg/mL of faricimab,

25 mM of sodium chloride,

20 mM of a histidine acetate buffer,

7.0 mM methionine,

160 mM sucrose,

0.04% (w/v) polysorbate 20

at a pH of 5.5.

2 . The pharmaceutical formulation according to claim 1 which is formulated for intravitreal administration.

3 . The pharmaceutical formulation according to claim 1 , wherein the formulation is essentially free of visible particles.

4 . The pharmaceutical formulation according to claim 1 , wherein the high molecular weight species (HMW) content representing aggregates of the bispecific antibody in the pharmaceutical formulation is below 10% after 8 weeks at 25° C. or after 52 weeks at 25° C., as measured by size exclusion chromatography.

5 . A method of treating an ocular vascular disease comprising administering the pharmaceutical formulation according to claim 1 .

6 . The method according to claim 5 , wherein the ocular vascular disease is selected from the group consisting of diabetic retinopathy (DR), diabetic macular edema (DME), retinal vein occlusion (RVO), central retinal vein occlusion (CRVO), macular degeneration, wet age-related macular degeneration (wet AMD), retinopathy of prematurity (ROP), neovascular glaucoma, retinitis pigmentosa (RP), retinal angiomatous proliferation, macular telangiectasia, ischemic retinopathy, iris neovascularization, intraocular neovascularization, corneal neovascularization, retinal neovascularization, choroidal neovascularization, and retinal degeneration.

7 . The method according to claim 5 , wherein the ocular vascular disease is selected from the group consisting of diabetic retinopathy, diabetic macular edema, retinal vein occlusion, central retinal vein occlusion, wet age-related macular degeneration.

8 . A vial comprising the pharmaceutical formulation of claim 1 .

9 . A prefilled syringe comprising the pharmaceutical formulation of claim 1 .

10 . The pharmaceutical formulation according to claim 1 , wherein the formulation is essentially free of arginine and calcium chloride.

11 . A liquid pharmaceutical formulation comprising:

120 mg/mL of the bispecific anti-VEGF/ANG2 antibody,

25 mM of sodium chloride,

20 mM of a histidine acetate buffer,

7.0 mM methionine,

160 mM sucrose,

0.04% (w/v) polysorbate 20

at a pH of 5.5,

wherein the bispecific anti-VEGF/ANG2 antibody is bivalent and comprises a first antigen-binding site that specifically binds to human vascular endothelial growth factor (VEGF) and a second antigen-binding site that specifically binds to human Angiopoietin-2 (ANG-2), and wherein the bispecific anti-VEGF/ANG2 antibody comprises the amino acid sequences of SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, and SEQ ID NO: 20.

12 . A vial comprising the pharmaceutical formulation of claim 11 .

13 . A prefilled syringe comprising the pharmaceutical formulation of claim 11 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2022
From: FREICHEL, CHRISTIAN; MUELLER, CLAUDIA; MUELLER, ROBERT; SZCZESNY, PIOTR; WORGULL, MARTIN; WURTH, CHRISTINE
To: F. HOFFMANN-LA ROCHE AG
Reel/Frame 062167/0283 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2022
From: F. HOFFMANN-LA ROCHE AG
To: HOFFMANN-LA ROCHE INC.
Reel/Frame 062167/0626 →
Priority Claims (1)
EP 18203104 · Oct 29, 2018 · regional
Continuity (2)
Continuation PCTEP2019079137 · Oct 25, 2019
Related Publication 20210324062A1 · Oct 21, 2021
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