IP Library › Granted Patent US 12,492,392
Granted Patent B2
US 12,492,392 · App. 17/344,154 · Granted Dec 9, 2025

Histidyl-tRNA synthetase-Fc conjugates and therapeutics using the same

Inventors: Chi-Fang Wu (San Diego, CA); Darin Lee (San Diego, CA); Jeffry D. Watkins (Encinitas, CA); Kristi Piehl (San Diego, CA); Kyle Chiang (Cardiff, CA); Marc Thomas (Vista, CA); Minh-Ha Do (San Diego, CA); Ying Buechler (Carlsbad, CA); John D. Mendlein (Encinitas, CA)
Assignee: aTyr Pharma, Inc.
C12N9/93A61P11/00A61P29/00A61P37/00C12N9/96C12Y601/01021C07K2319/30
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Quick Facts
Patent No.
US 12,492,392
App. No.
17/344,154
Granted
Dec 9, 2025
Kind
B2
Abstract

The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.

Claims (5)

1 . A histidyl-tRNA synthetase (HRS)-Fc fusion polypeptide, comprising an amino acid sequence at least 95% identical to SEQ ID NO: 337, wherein the HRS-Fc fusion polypeptide has an anti-inflammatory activity, and has increased serum half-life relative to an unmodified HRS polypeptide having an amino acid sequence according to SEQ ID NO: 6.

2 . The HRS-Fc fusion polypeptide of claim 1 , wherein the HRS-Fc fusion polypeptide comprises an amino acid sequence at least 98% identical to SEQ ID NO: 337.

3 . A therapeutic composition, comprising the HRS-Fc fusion polypeptide of claim 1 or 2 and a pharmaceutically acceptable carrier or excipient.

4 . A method for treating interstitial lung disease (ILD) in a subject in need thereof, comprising administering to the subject the therapeutic composition of claim 3 .

5 . The method of claim 4 , wherein the ILD is sarcoidosis or scleroderma/progressive systemic sclerosis.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 10, 2021
From: BUECHLER, YING; CHIANG, KYLE; DO, MINH-HA; LEE, DARIN; PIEHL, KRISTI; THOMAS, MARC; WATKINS, JEFFRY D.; WU, CHI-FANG; MENDLEIN, JOHN D.
To: ATYR PHARMA, INC.
Reel/Frame 056540/0870 →
Continuity (7)
Continuation 16842200 · Apr 7, 2020
Continuation 16577992 · Sep 20, 2019
Continuation 16122231 · Sep 5, 2018
Continuation 15415369 · Jan 25, 2017
Continuation 14214491 · Mar 14, 2014
Provisional Application 61789011 · Mar 15, 2013
Related Publication 20220098568A1 · Mar 31, 2022
References Cited (400)
US 5155214A · Baird et al. · 1992 [cited by applicant]
US 5370995A · Hennecke et al. · 1994 [cited by applicant]
US 5484703A · Raben et al. · 1996 [cited by applicant]
US 5556645A · Bockman et al. · 1996 [cited by applicant]
US 5641867A · Stern et al. · 1997 [cited by applicant]
US 5663066A · Raben et al. · 1997 [cited by applicant]
US 5665066A · Fisher · 1997 [cited by applicant]
US 5716632A · Margolin · 1998 [cited by examiner]
US 5750387A · Hodgson et al. · 1998 [cited by applicant]
US 5753480A · Lawlor · 1998 [cited by applicant]
US 5756327A · Sassanfar et al. · 1998 [cited by applicant]
US 5759833A · Shiba et al. · 1998 [cited by applicant]
US 5776749A · Hodgson et al. · 1998 [cited by applicant]
US 5795757A · Hodgson et al. · 1998 [cited by applicant]
US 5798240A · Martinis et al. · 1998 [cited by applicant]
US 5801013A · Tao et al. · 1998 [cited by applicant]
US 5817528A · Bohm et al. · 1998 [cited by applicant]
US 5866390A · Lawlor · 1999 [cited by applicant]
US 5885815A · Sassanfar et al. · 1999 [cited by applicant]
US 5928920A · Hodgson et al. · 1999 [cited by applicant]
US 5939298A · Brown et al. · 1999 [cited by applicant]
US 5977079A · Good et al. · 1999 [cited by applicant]
US 5981606A · Martin · 1999 [cited by applicant]
US 6013483A · Coleman et al. · 2000 [cited by applicant]
US 6225060B1 · Clark et al. · 2001 [cited by applicant]
US 6228837B1 · Stern et al. · 2001 [cited by applicant]
US 6428960B1 · Clark et al. · 2002 [cited by applicant]
US 6548060B1 · Kim · 2003 [cited by applicant]
US 6696619B1 · Famodu et al. · 2004 [cited by applicant]
US 6712978B2 · Leinenbach et al. · 2004 [cited by applicant]
US 6723318B1 · Sandberg et al. · 2004 [cited by applicant]
US 6743619B1 · Tang et al. · 2004 [cited by applicant]
US 6800286B1 · Olwin et al. · 2004 [cited by applicant]
US 6812339B1 · Venter et al. · 2004 [cited by applicant]
US 6864226B1 · Coleman et al. · 2005 [cited by applicant]
US 6875749B2 · Schwarz et al. · 2005 [cited by applicant]
US 6903189B2 · Schimmel et al. · 2005 [cited by applicant]
US 6916648B2 · Goddard et al. · 2005 [cited by applicant]
US 7037505B2 · Kim et al. · 2006 [cited by applicant]
US 7045301B2 · Coleman et al. · 2006 [cited by applicant]
US 7067126B2 · Schimmel et al. · 2006 [cited by applicant]
US 7144984B2 · Schimmel et al. · 2006 [cited by applicant]
US 7196068B2 · Kim et al. · 2007 [cited by applicant]
US 7273844B2 · Schimmel et al. · 2007 [cited by applicant]
US 7282208B2 · Kim · 2007 [cited by applicant]
US 7413885B2 · Schimmel et al. · 2008 [cited by applicant]
US 7459529B2 · Kim · 2008 [cited by applicant]
US 7476651B2 · Schimmel et al. · 2009 [cited by applicant]
US 7482326B2 · Coleman et al. · 2009 [cited by applicant]
US 7521215B2 · Schimmel et al. · 2009 [cited by applicant]
US 7528106B2 · Friedlander et al. · 2009 [cited by applicant]
US 7572452B2 · Kim · 2009 [cited by applicant]
US 7842467B1 · Heidbrink et al. · 2010 [cited by applicant]
US 7901917B2 · Schimmel et al. · 2011 [cited by applicant]
US 7902165B2 · Kim · 2011 [cited by applicant]
US 7981426B2 · Kim · 2011 [cited by applicant]
US 8003780B2 · Kim et al. · 2011 [cited by applicant]
US 8014957B2 · Radich et al. · 2011 [cited by applicant]
US 8017593B2 · Schimmel et al. · 2011 [cited by applicant]
US 8026088B2 · Yang · 2011 [cited by applicant]
US 8101566B2 · Schimmel et al. · 2012 [cited by applicant]
US 8148125B2 · Schimmel et al. · 2012 [cited by applicant]
US 8182686B2 · Witthaus et al. · 2012 [cited by applicant]
US 8318163B2 · Appleton et al. · 2012 [cited by applicant]
US 8404242B2 · Zhou et al. · 2013 [cited by applicant]
US 8404471B2 · Greene et al. · 2013 [cited by applicant]
US 8466264B2 · Appleton et al. · 2013 [cited by applicant]
US 8481296B2 · Yang · 2013 [cited by applicant]
US 8648173B2 · Wu et al. · 2014 [cited by applicant]
US 8722043B2 · Borg et al. · 2014 [cited by applicant]
US 8753638B2 · Zhou et al. · 2014 [cited by applicant]
US 8828395B2 · Watkins et al. · 2014 [cited by applicant]
US 8835387B2 · Chiang et al. · 2014 [cited by applicant]
US 8920805B2 · Wu et al. · 2014 [cited by applicant]
US 9127268B2 · Watkins et al. · 2015 [cited by applicant]
US 9273302B2 · Chiang et al. · 2016 [cited by applicant]
US 9296803B2 · Kozbar · 2016 [cited by applicant]
US 9328340B2 · Watkins et al. · 2016 [cited by applicant]
US 9422539B2 · Greene et al. · 2016 [cited by applicant]
US 9453214B2 · Greene · 2016 [cited by applicant]
US 9540628B2 · Watkins et al. · 2017 [cited by applicant]
US 9587235B2 · Buechler et al. · 2017 [cited by applicant]
US 9605265B2 · Zhou et al. · 2017 [cited by applicant]
US 9637730B2 · Greene et al. · 2017 [cited by applicant]
US 9943577B2 · Watkins et al. · 2018 [cited by applicant]
US 10017582B2 · Zhou et al. · 2018 [cited by applicant]
US 10093915B2 · Wu et al. · 2018 [cited by applicant]
US 10196628B2 · Greene et al. · 2019 [cited by applicant]
US 10472618B2 · Wu et al. · 2019 [cited by applicant]
US 10526419B2 · Zhou et al. · 2020 [cited by applicant]
US 10669533B2 · Greene et al. · 2020 [cited by applicant]
US 10711260B2 · Wu et al. · 2020 [cited by applicant]
US 10941214B2 · Zhou et al. · 2021 [cited by applicant]
US 11072787B2 · Wu et al. · 2021 [cited by applicant]
US 11078299B2 · Zhou et al. · 2021 [cited by applicant]
US 11767520B2 · Mendlein et al. · 2023 [cited by applicant]
US 20020128187A1 · Tang et al. · 2002 [cited by applicant]
US 20020160957A1 · Stern et al. · 2002 [cited by applicant]
US 20020182666A1 · Schimmel et al. · 2002 [cited by applicant]
US 20030004309A1 · Kim et al. · 2003 [cited by applicant]
US 20030017564A1 · Schimmel et al. · 2003 [cited by applicant]
US 20030018985A1 · Falco et al. · 2003 [cited by applicant]
US 20030158400A1 · Tang et al. · 2003 [cited by applicant]
US 20030165921A1 · Tang et al. · 2003 [cited by applicant]
US 20030215827A1 · Yue et al. · 2003 [cited by applicant]
US 20040009163A1 · Schimmel et al. · 2004 [cited by applicant]
US 20040018505A1 · Lee et al. · 2004 [cited by applicant]
US 20040048290A1 · Lee et al. · 2004 [cited by applicant]
US 20040101879A1 · Seidel-Dugan et al. · 2004 [cited by applicant]
US 20040152079A1 · Schimmel et al. · 2004 [cited by applicant]
US 20040203094A1 · Martinis et al. · 2004 [cited by applicant]
US 20040214216A1 · Famodu et al. · 2004 [cited by applicant]
US 20040224981A1 · Janjic et al. · 2004 [cited by applicant]
US 20050119175A1 · Kim · 2005 [cited by applicant]
US 20050136513A1 · Zhang · 2005 [cited by applicant]
US 20050181375A1 · Aziz et al. · 2005 [cited by applicant]
US 20050196754A1 · Drmanac et al. · 2005 [cited by applicant]
US 20050208536A1 · Schultz et al. · 2005 [cited by applicant]
US 20060024288A1 · Glidden · 2006 [cited by applicant]
US 20060035232A1 · McGregor et al. · 2006 [cited by applicant]
US 20060046250A1 · Kim · 2006 [cited by applicant]
US 20060078553A1 · Glidden · 2006 [cited by applicant]
US 20060134663A1 · Harkin et al. · 2006 [cited by applicant]
US 20060160175A1 · Anderson et al. · 2006 [cited by applicant]
US 20060204508A1 · Champion et al. · 2006 [cited by applicant]
US 20060228715A1 · Shiffman et al. · 2006 [cited by applicant]
US 20060248617A1 · Imanaka et al. · 2006 [cited by applicant]
US 20060275794A1 · Carrino et al. · 2006 [cited by applicant]
US 20070037165A1 · Venter et al. · 2007 [cited by applicant]
US 20070042392A1 · Tang et al. · 2007 [cited by applicant]
US 20070048322A1 · Schimmel et al. · 2007 [cited by applicant]
US 20070054278A1 · Cargill · 2007 [cited by applicant]
US 20070061916A1 · Kovalic et al. · 2007 [cited by applicant]
US 20070072175A1 · Cooper et al. · 2007 [cited by applicant]
US 20070083334A1 · Mintz et al. · 2007 [cited by applicant]
US 20070093440A1 · Champion et al. · 2007 [cited by applicant]
US 20070111238A1 · Jamieson et al. · 2007 [cited by applicant]
US 20070154931A1 · Radich et al. · 2007 [cited by applicant]
US 20080044854A1 · Wang et al. · 2008 [cited by applicant]
US 20080113914A1 · Hays et al. · 2008 [cited by applicant]
US 20080153745A1 · Tian · 2008 [cited by applicant]
US 20090123971A1 · Paulsel et al. · 2009 [cited by applicant]
US 20090202539A1 · You et al. · 2009 [cited by applicant]
US 20090221437A1 · Harkin et al. · 2009 [cited by applicant]
US 20090221794A1 · Kim et al. · 2009 [cited by applicant]
US 20090226966A1 · Yokoyama et al. · 2009 [cited by applicant]
US 20090227002A1 · Schultz et al. · 2009 [cited by applicant]
US 20090227662A1 · Schimmel et al. · 2009 [cited by applicant]
US 20090264453A1 · Shiffman et al. · 2009 [cited by applicant]
US 20090285792A1 · Friedlander et al. · 2009 [cited by applicant]
US 20090305973A1 · Kim et al. · 2009 [cited by applicant]
US 20100003230A1 · Glidden · 2010 [cited by applicant]
US 20100028352A1 · Greene et al. · 2010 [cited by applicant]
US 20100041608A1 · Kim · 2010 [cited by applicant]
US 20100048413A1 · Arcus et al. · 2010 [cited by applicant]
US 20100092434A1 · Belani et al. · 2010 [cited by applicant]
US 20100093082A1 · Tian et al. · 2010 [cited by applicant]
US 20100130904A1 · Kirber · 2010 [cited by applicant]
US 20100138941A1 · Kim et al. · 2010 [cited by applicant]
US 20100167997A1 · Kim · 2010 [cited by applicant]
US 20100172921A1 · Wu et al. · 2010 [cited by applicant]
US 20100209445A1 · Jahns et al. · 2010 [cited by applicant]
US 20100297149A1 · Zhou et al. · 2010 [cited by applicant]
US 20100310576A1 · Adams et al. · 2010 [cited by applicant]
US 20110086058A1 · Jiang et al. · 2011 [cited by applicant]
US 20110091377A1 · Alani et al. · 2011 [cited by applicant]
US 20110104139A1 · Faber · 2011 [cited by applicant]
US 20110110917A1 · Schimmel et al. · 2011 [cited by applicant]
US 20110117572A1 · Kim et al. · 2011 [cited by applicant]
US 20110124582A1 · Kim et al. · 2011 [cited by applicant]
US 20110129486A1 · Meiron · 2011 [cited by applicant]
US 20110136119A1 · Kim et al. · 2011 [cited by applicant]
US 20110150885A1 · Watkins et al. · 2011 [cited by applicant]
US 20110183924A1 · Beck et al. · 2011 [cited by applicant]
US 20110189195A1 · Kim et al. · 2011 [cited by applicant]
US 20110250701A1 · Kim et al. · 2011 [cited by applicant]
US 20110256119A1 · Kim et al. · 2011 [cited by applicant]
US 20120004185A1 · Greene · 2012 [cited by applicant]
US 20120015383A1 · Park et al. · 2012 [cited by applicant]
US 20120058133A1 · Whitman et al. · 2012 [cited by applicant]
US 20120064082A1 · Watkins et al. · 2012 [cited by applicant]
US 20130052177A1 · Schimmel et al. · 2013 [cited by applicant]
US 20130108630A1 · Watkins et al. · 2013 [cited by applicant]
US 20130129703A1 · Chiang et al. · 2013 [cited by applicant]
US 20130129704A1 · Greene et al. · 2013 [cited by applicant]
US 20130129705A1 · Greene et al. · 2013 [cited by applicant]
US 20130142774A1 · Greene et al. · 2013 [cited by applicant]
US 20130165484A1 · Radhakrishnan et al. · 2013 [cited by applicant]
US 20130195832A1 · Greene et al. · 2013 [cited by applicant]
US 20130202574A1 · Greene et al. · 2013 [cited by applicant]
US 20130202575A1 · Greene et al. · 2013 [cited by applicant]
US 20130202576A1 · Greene et al. · 2013 [cited by applicant]
US 20130209434A1 · Greene et al. · 2013 [cited by applicant]
US 20130209472A1 · Greene et al. · 2013 [cited by applicant]
US 20130224173A1 · Greene et al. · 2013 [cited by applicant]
US 20130224174A1 · Greene et al. · 2013 [cited by applicant]
US 20130230505A1 · Greene et al. · 2013 [cited by applicant]
US 20130230507A1 · Greene et al. · 2013 [cited by applicant]
US 20130230508A1 · Greene et al. · 2013 [cited by applicant]
US 20130236440A1 · Greene et al. · 2013 [cited by applicant]
US 20130236455A1 · Greene et al. · 2013 [cited by applicant]
US 20130243745A1 · Greene et al. · 2013 [cited by applicant]
US 20130243766A1 · Zhou et al. · 2013 [cited by applicant]
US 20130273045A1 · Watkins et al. · 2013 [cited by applicant]
US 20130280230A1 · Greene et al. · 2013 [cited by applicant]
US 20130287755A1 · Greene et al. · 2013 [cited by applicant]
US 20130315887A1 · Greene et al. · 2013 [cited by applicant]
US 20130330312A1 · Greene et al. · 2013 [cited by applicant]
US 20130344096A1 · Chiang et al. · 2013 [cited by applicant]
US 20140066321A1 · Xu et al. · 2014 [cited by applicant]
US 20140141994A1 · Wu et al. · 2014 [cited by applicant]
US 20140349369A1 · Buechler et al. · 2014 [cited by applicant]
US 20140371294A1 · Zhou et al. · 2014 [cited by applicant]
US 20150064188A1 · Greene · 2015 [cited by applicant]
US 20150093799A1 · Chiang et al. · 2015 [cited by applicant]
US 20150140072A1 · Watkins et al. · 2015 [cited by applicant]
US 20150344866A1 · Greene et al. · 2015 [cited by applicant]
US 20160175458A1 · Alvarez et al. · 2016 [cited by applicant]
US 20160369259A1 · Chiang et al. · 2016 [cited by applicant]
US 20170100456A1 · Briscoe et al. · 2017 [cited by applicant]
US 20170114148A1 · Zhou et al. · 2017 [cited by applicant]
US 20170202933A1 · Watkins et al. · 2017 [cited by applicant]
US 20170267990A1 · Wu et al. · 2017 [cited by applicant]
US 20170321206A1 · Greene et al. · 2017 [cited by applicant]
US 20180282402A1 · Adams et al. · 2018 [cited by applicant]
US 20190031775A1 · Zhou et al. · 2019 [cited by applicant]
US 20190062720A1 · Wu et al. · 2019 [cited by applicant]
US 20190264190A1 · Greene et al. · 2019 [cited by applicant]
US 20190309076A1 · Burman et al. · 2019 [cited by applicant]
US 20200085925A1 · Burkart et al. · 2020 [cited by applicant]
US 20200149028A1 · Wu et al. · 2020 [cited by applicant]
US 20200216564A1 · Zhou et al. · 2020 [cited by applicant]
US 20200231704A1 · Zhou et al. · 2020 [cited by applicant]
US 20200283751A1 · Wu et al. · 2020 [cited by applicant]
US 20200377874A1 · Mendlein et al. · 2020 [cited by applicant]
US 20220098327A1 · Zhou et al. · 2022 [cited by applicant]
US 20220098568A1 · Wu · 2022 [cited by examiner]
US 20230039401A1 · Burkart et al. · 2023 [cited by applicant]
CA 2531146 · 2005 [cited by applicant]
CN 1314486A · 2001 [cited by applicant]
CN 1331293 · 2002 [cited by applicant]
CN 1341725 · 2002 [cited by applicant]
CN 1341727 · 2002 [cited by applicant]
CN 1352242 · 2002 [cited by applicant]
CN 1352252 · 2002 [cited by applicant]
CN 1519315A · 2004 [cited by applicant]
CN 1871252A · 2006 [cited by applicant]
CN 101258164A · 2008 [cited by applicant]
CN 101267810A · 2008 [cited by applicant]
CN 101528914 · 2009 [cited by applicant]
CN 101616929A · 2009 [cited by applicant]
CN 102821784A · 2012 [cited by applicant]
CN 104334196A · 2015 [cited by applicant]
CN 105378075A · 2016 [cited by applicant]
EP 0313378 · 1988 [cited by applicant]
EP 0307247 · 1989 [cited by applicant]
EP 0893494 · 1999 [cited by applicant]
EP 0893496 · 1999 [cited by applicant]
EP 0897004 · 1999 [cited by applicant]
EP 0575484 · 2000 [cited by applicant]
EP 1275720 · 2003 [cited by applicant]
EP 1300468 · 2003 [cited by applicant]
EP 1384486 · 2004 [cited by applicant]
EP 1748063 · 2007 [cited by applicant]
EP 1377305 · 2009 [cited by applicant]
EP 1776138 · 2009 [cited by applicant]
EP 2177610 · 2010 [cited by applicant]
EP 1274834 · 2010 [cited by applicant]
EP 2084190 · 2011 [cited by applicant]
EP 2509625A1 · 2012 [cited by applicant]
JP 2003514510A · 2003 [cited by applicant]
JP 2012520681 · 2012 [cited by applicant]
JP 2013513390 · 2013 [cited by applicant]
JP 5590540 · 2014 [cited by applicant]
KR 1020020092596 · 2002 [cited by applicant]
KR 101067816 · 2011 [cited by applicant]
KR 20150077770A · 2015 [cited by applicant]
WO WO1991008291 · 1991 [cited by applicant]
WO WO1996039506 · 1996 [cited by applicant]
WO WO1997025426 · 1997 [cited by applicant]
WO WO1997026351 · 1997 [cited by applicant]
WO WO1997039017 · 1997 [cited by applicant]
WO WO1998014591 · 1998 [cited by applicant]
WO WO1998050554 · 1998 [cited by applicant]
WO WO1999029729 · 1999 [cited by applicant]
WO WO1999029858 · 1999 [cited by applicant]
WO WO1999045130 · 1999 [cited by applicant]
WO WO2000055320 · 2000 [cited by applicant]
WO WO2000073801 · 2000 [cited by applicant]
WO WO2001007628 · 2001 [cited by applicant]
WO WO2001019999 · 2001 [cited by applicant]
WO WO2001057190 · 2001 [cited by applicant]
WO WO2001064892 · 2001 [cited by applicant]
WO WO2001074841 · 2001 [cited by applicant]
WO WO2001075067 · 2001 [cited by applicant]
WO WO2001075078 · 2001 [cited by applicant]
WO WO2001088188 · 2001 [cited by applicant]
WO WO2001090330 · 2001 [cited by applicant]
WO WO2001094568 · 2001 [cited by applicant]
WO WO2001095927 · 2001 [cited by applicant]
WO WO2002044349 · 2002 [cited by applicant]
WO WO2002055663 · 2002 [cited by applicant]
WO WO2002059323 · 2002 [cited by applicant]
WO WO2002067970 · 2002 [cited by applicant]
WO WO2002068579 · 2002 [cited by applicant]
WO WO2003009813 · 2003 [cited by applicant]
WO WO2003051388 · 2003 [cited by applicant]
WO WO2003080648 · 2003 [cited by applicant]
WO WO2003094848 · 2003 [cited by applicant]
WO WO2003094862 · 2003 [cited by applicant]
WO WO2004023973 · 2004 [cited by applicant]
WO WO2004030615 · 2004 [cited by applicant]
WO WO2004060262 · 2004 [cited by applicant]
WO WO2004063355 · 2004 [cited by applicant]
WO WO2004064863 · 2004 [cited by applicant]
WO WO2004087875 · 2004 [cited by applicant]
WO WO2005019258 · 2005 [cited by applicant]
WO WO2005019415 · 2005 [cited by applicant]
WO WO2005073250 · 2005 [cited by applicant]
WO WO2005087953 · 2005 [cited by applicant]
WO WO2005102395 · 2005 [cited by applicant]
WO WO2005113812 · 2005 [cited by applicant]
WO WO2005117954 · 2005 [cited by applicant]
WO WO2006016217 · 2006 [cited by applicant]
WO WO2006048219 · 2006 [cited by applicant]
WO WO2006057500 · 2006 [cited by applicant]
WO WO2006083087 · 2006 [cited by applicant]
WO WO2007020075 · 2007 [cited by applicant]
WO WO2007064941 · 2007 [cited by applicant]
WO WO2007083853 · 2007 [cited by applicant]
WO WO2007091106 · 2007 [cited by applicant]
WO WO2007139397 · 2007 [cited by applicant]
WO WO2008007818 · 2008 [cited by applicant]
WO WO2008016356 · 2008 [cited by applicant]
WO WO2008021290 · 2008 [cited by applicant]
WO WO2008030558 · 2008 [cited by applicant]
WO WO2008094012 · 2008 [cited by applicant]
WO WO2008133359 · 2008 [cited by applicant]
WO WO2009059056 · 2009 [cited by applicant]
WO WO2009114623 · 2009 [cited by applicant]
WO WO2009152247 · 2009 [cited by applicant]
WO WO2009158649 · 2009 [cited by applicant]
WO WO2010021415 · 2010 [cited by applicant]
WO WO2010041892 · 2010 [cited by applicant]
WO WO2010041913 · 2010 [cited by applicant]
WO WO2010090471 · 2010 [cited by applicant]
WO WO2010096170 · 2010 [cited by applicant]
WO WO2010099477 · 2010 [cited by applicant]
WO WO2010107825 · 2010 [cited by applicant]
WO WO2010120509 · 2010 [cited by applicant]
WO WO2011032013 · 2011 [cited by applicant]
WO WO2011035335 · 2011 [cited by applicant]
WO WO2011072265 · 2011 [cited by applicant]
WO WO2011072266 · 2011 [cited by applicant]
WO WO2011097031 · 2011 [cited by applicant]
WO WO2011139714 · 2011 [cited by applicant]
WO WO2011139799 · 2011 [cited by applicant]
WO WO2011139801 · 2011 [cited by applicant]
WO WO2011139853 · 2011 [cited by applicant]
WO WO2011139854 · 2011 [cited by applicant]
WO WO2011139907 · 2011 [cited by applicant]
WO WO2011139986 · 2011 [cited by applicant]
WO WO2011139988 · 2011 [cited by applicant]
WO WO2011140132 · 2011 [cited by applicant]
WO WO2011140135 · 2011 [cited by applicant]
WO WO2011140266 · 2011 [cited by applicant]
WO WO2011140267 · 2011 [cited by applicant]
WO WO2011143482 · 2011 [cited by applicant]
WO WO2011146410 · 2011 [cited by applicant]
WO WO2011150279 · 2011 [cited by applicant]
WO WO2011153277 · 2011 [cited by applicant]
WO WO2012009289 · 2012 [cited by applicant]
WO WO2012021247 · 2012 [cited by applicant]
WO WO2012021249 · 2012 [cited by applicant]
WO WO2012027611 · 2012 [cited by applicant]
WO WO2012048125 · 2012 [cited by applicant]
WO WO2012149247 · 2012 [cited by applicant]
WO WO2012149252 · 2012 [cited by applicant]
WO WO2012149259 · 2012 [cited by applicant]
WO WO2012149265 · 2012 [cited by applicant]
WO WO2012149282 · 2012 [cited by applicant]
WO WO2012149301 · 2012 [cited by applicant]
WO WO2012149405 · 2012 [cited by applicant]
WO WO2012149411 · 2012 [cited by applicant]
WO WO2012158945 · 2012 [cited by applicant]
WO WO2013022982 · 2013 [cited by applicant]
WO WO2013036293 · 2013 [cited by applicant]
WO WO2013036294 · 2013 [cited by applicant]
WO WO2013036295 · 2013 [cited by applicant]
WO WO2013036296 · 2013 [cited by applicant]
WO WO2013036299 · 2013 [cited by applicant]
WO WO2013036300 · 2013 [cited by applicant]
WO WO2013036301 · 2013 [cited by applicant]
WO WO2013036302 · 2013 [cited by applicant]
WO WO2013086216 · 2013 [cited by applicant]
WO WO2013086228 · 2013 [cited by applicant]
WO WO2013115926 · 2013 [cited by applicant]
WO WO2013123432 · 2013 [cited by applicant]
WO WO2014145050 · 2014 [cited by applicant]
WO WO2016172722 · 2016 [cited by applicant]