IP Library › Granted Patent US 12,600,789
Granted Patent B2
US 12,600,789 · App. 17/720,937 · Granted Apr 14, 2026

Modified antibody constant region

Inventors: Tomoyuki Igawa (Shizuoka, JP); Hirotake Shiraiwa (Shizuoka, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha
C07K16/2866C07K16/00C07K2317/52C07K2317/53C07K2317/71
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Quick Facts
Patent No.
US 12,600,789
App. No.
17/720,937
Granted
Apr 14, 2026
Kind
B2
Abstract

The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated from disulfide bonds in the hinge region, reduced heterogeneity originated from the H chain C terminus, and increased stability at high concentrations as well as in discovering novel constant region sequences having reduced Fcγ receptor-binding, while minimizing the generation of novel T-cell epitope peptides. As a result, the present inventors successfully discovered antibody constant regions with improved physicochemical properties (stability and homogeneity), immunogenicity, safety, and pharmacokinetics.

Claims (8)

1 . An antibody heavy chain constant region comprising the amino acid sequence of SEQ ID NO: 5.

2 . An antibody comprising the antibody heavy chain constant region of claim 1 .

3 . The antibody of claim 2 , wherein the antibody is an anti-IL-6 receptor antibody, anti-IL-31 receptor antibody, or anti-RANKL antibody.

4 . A pharmaceutical composition comprising the antibody heavy chain constant region of claim 1 .

5 . An antibody heavy chain constant region comprising the amino acid sequence of SEQ ID NO: 7.

6 . An antibody comprising the antibody heavy chain constant region of claim 5 .

7 . The antibody of claim 6 , wherein the antibody is an anti-IL-6 receptor antibody, anti-IL-31 receptor antibody, or anti-RANKL antibody.

8 . A pharmaceutical composition comprising the antibody heavy chain constant region of claim 5 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2022
From: IGAWA, TOMOYUKI; SHIRAIWA, HIROTAKE
To: CHUGAI SEIYAKU KABUSHIKI KAISHA
Reel/Frame 059646/0737 →
Priority Claims (1)
JP 2007-250147 · Sep 26, 2007 · national
Continuity (3)
Division 15614842 · Jun 6, 2017
Division 12680082
Related Publication 20220251225A1 · Aug 11, 2022
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