IP Library › Granted Patent US 12,279,989
Granted Patent B2
US 12,279,989 · App. 17/738,771 · Granted Apr 22, 2025

Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity

Inventor: Joseph E. Kovarik (Englewood, CO)
Assignee: Seed Health, Inc.
A61F5/566
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,279,989
App. No.
17/738,771
Granted
Apr 22, 2025
Kind
B2
Abstract

A method and system for increasing beneficial bacteria populations in a subject's oral cavity and decreasing pathogenic bacteria to address a variety of diseases and conditions, thereby enhancing a person's oral and overall health, including through the use of oral strips that adhere to surfaces in the oral cavity and that include at least one of xylitol, Lachnospira, Veillonella, Faecalibacterium and/or Rothia bacteria, including bacteria transformed via a CRISPR system. Certain embodiments employ light to modify oral cavity bacterial populations, including the use of bioluminescent oral strips that promote the growth of beneficial bacteria and decrease pathogenic bacteria populations.

Claims (16)

1. A method for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity of a subject, comprising, facilitating the growth of desired bacteria in a human's mouth by using a bioadhesive strip, said strip having a first and second side, said first side having at least one encapsulated feature containing at least one beneficial bacteria, and the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person's mouth, said strip comprising bioluminescent material to facilitate a user's ability to view when viewing in a mirror the placement of the strip in one's mouth, wherein said strip has compounds residing thereon to facilitate the growth of desired bacteria beneficial to a person's health, and wherein said at least one bacteria has one of a pathogenic or toxic element excised using a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system.

2. The method as set forth in claim 1 , wherein said strip is dissolvable in a person's mouth.

3. The method as set forth in claim 1 , wherein the bioluminescent material comprises one of luciferin, luciferase and aequorin.

4. The method as set forth in claim 1 , wherein said strip includes xylitol.

5. The method of claim 1 , wherein said strip further comprises breath freshening components.

6. The method of claim 1 , wherein light emanating from the bioluminescent material decreases the growth of pathogenic bacteria populations and reduces biofilm formation.

7. The method of claim 1 , wherein light emanating from the bioluminescent material induces nitric oxide release from cellular sources.

8. The method of claim 1 , wherein the bioluminescent material provides light having a wavelength of 400-410 nm that reduces Porphyromonas gingivalis growth inside the subject's oral cavity.

9. A method to facilitate the growth of desired bacteria on a human's mucosal membrane by using a bioadhesive strip, comprising:

providing to an individual in need thereof a bioadhesive strip, said strip having a first and second side, said first side having at least one encapsulated feature containing at least one bacteria that has one of a pathogenic or toxic element excised using a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system and the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour.

10. The method as set forth in claim 9 , wherein the mucosal membrane is in a person's mouth.

11. The method as set forth in claim 9 , wherein said strip is dissolvable in a person's mouth.

12. The method as set forth in claim 9 , wherein the strip comprises one of luciferin, luciferase and aequorin.

13. The method as set forth in claim 9 , wherein said strip includes xylitol.

14. The method of claim 9 , wherein said strip further comprises breath freshening components.

15. The method of claim 9 , wherein the strip reduces Porphyromonas gingivalis growth inside the subject's oral cavity.

Assignments (2)
SECURITY INTEREST Recorded Jul 21, 2026
From: SEED HEALTH, INC.
To: JPMORGAN CHASE BANK, N.A., AS LENDER
Reel/Frame 076028/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2022
From: KOVARIK, JOSEPH E
To: SEED HEALTH, INC.
Reel/Frame 059908/0561 →
Continuity (27)
Continuation In Part 16904056 · Jun 17, 2020
Continuation In Part 15983250 · May 18, 2018
Continuation In Part 15384716 · Dec 20, 2016
Continuation In Part 15270034 · Sep 20, 2016
Continuation In Part 15228454 · Aug 4, 2016
Continuation In Part 14954074 · Nov 30, 2015
Continuation In Part 14752192 · Jun 26, 2015
Continuation In Part 14611458 · Feb 2, 2015
Continuation In Part 14574517 · Dec 18, 2014
Continuation 14502097 · Sep 30, 2014
Continuation 14307651 · Jun 18, 2014
Continuation In Part 14225503 · Mar 26, 2014
Continuation In Part 14079054 · Nov 13, 2013
Continuation 13425913 · Mar 21, 2012
Continuation 13367052 · Feb 6, 2012
Provisional Application 62275341 · Jan 6, 2016
Provisional Application 62274550 · Jan 4, 2016
Provisional Application 62387404 · Dec 24, 2015
Provisional Application 62387405 · Dec 24, 2015
Provisional Application 62072476 · Oct 30, 2014
Provisional Application 62053926 · Sep 23, 2014
Provisional Application 62014855 · Jun 20, 2014
Provisional Application 61919297 · Dec 20, 2013
Provisional Application 61556023 · Nov 4, 2011
Provisional Application 61467767 · Mar 25, 2011
Provisional Application 61439652 · Feb 4, 2011
Related Publication 20220257410A1 · Aug 18, 2022
References Cited (400)
US 1492600A · Laskey · 1924 [cited by applicant]
US 3178341A · Hamill et al. · 1965 [cited by applicant]
US 3640741A · Etes · 1972 [cited by applicant]
US 3832460A · Kosti · 1974 [cited by applicant]
US 3996934A · Zaffaroni · 1976 [cited by applicant]
US 4136145A · Fuchs et al. · 1979 [cited by applicant]
US 4136162A · Fuchs et al. · 1979 [cited by applicant]
US 4163777A · Mitra · 1979 [cited by applicant]
US 4226848A · Nagai et al. · 1980 [cited by applicant]
US 4250163A · Nagai et al. · 1981 [cited by applicant]
US 4285934A · Tinnell · 1981 [cited by applicant]
US 4286592A · Chandrasekaran · 1981 [cited by applicant]
US 4292299A · Suzuki et al. · 1981 [cited by applicant]
US 4381296A · Tinnell · 1983 [cited by applicant]
US 4517173A · Kizawa et al. · 1985 [cited by applicant]
US 4518721A · Dhabhar et al. · 1985 [cited by applicant]
US 4568639A · Lew · 1986 [cited by applicant]
US 4572832A · Kigasawa et al. · 1986 [cited by applicant]
US 4668232A · Cordes et al. · 1987 [cited by applicant]
US 4687841A · Spilburg et al. · 1987 [cited by applicant]
US 4713243A · Schiraldi et al. · 1987 [cited by applicant]
US 4715369A · Susuki et al. · 1987 [cited by applicant]
US 4720486A · Spilburg et al. · 1988 [cited by applicant]
US 4740365A · Yukimatsu et al. · 1988 [cited by applicant]
US 4765983A · Takayanagi et al. · 1988 [cited by applicant]
US 4830008A · Meer · 1989 [cited by applicant]
US 4849246A · Schmidt · 1989 [cited by applicant]
US 4867970A · Newsham et al. · 1989 [cited by applicant]
US 4889720A · Konishi · 1989 [cited by applicant]
US 4894232A · Reul et al. · 1990 [cited by applicant]
US 4900554A · Yanagibashi et al. · 1990 [cited by applicant]
US 4906463A · Cleary et al. · 1990 [cited by applicant]
US 4915948A · Gallopo et al. · 1990 [cited by applicant]
US 4937078A · Mezei et al. · 1990 [cited by applicant]
US 4995555A · Woodruff · 1991 [cited by applicant]
US 5002970A · Eby, III · 1991 [cited by applicant]
US 5059189A · Cilento et al. · 1991 [cited by applicant]
US 5064654A · Berner et al. · 1991 [cited by applicant]
US 5081157A · Pomerantz · 1992 [cited by applicant]
US 5081158A · Pomerantz · 1992 [cited by applicant]
US 5116621A · Oji et al. · 1992 [cited by applicant]
US 5137729A · Kuroya et al. · 1992 [cited by applicant]
US 5158789A · DuRoss · 1992 [cited by applicant]
US 5166233A · Kuroya et al. · 1992 [cited by applicant]
US 5190053A · Meer · 1993 [cited by applicant]
US 5192802A · Rencher · 1993 [cited by applicant]
US 5196202A · Konishi · 1993 [cited by applicant]
US 5277877A · Jeffrey et al. · 1994 [cited by applicant]
US 5284161A · Karell · 1994 [cited by applicant]
US 5298258A · Akemi et al. · 1994 [cited by applicant]
US 5314915A · Rencher · 1994 [cited by applicant]
US 5332576A · Mantelle · 1994 [cited by applicant]
US 5462749A · Rencher · 1995 [cited by applicant]
US 5465734A · Alvarez et al. · 1995 [cited by applicant]
US 5466465A · Royds et al. · 1995 [cited by applicant]
US 5505956A · Kim et al. · 1996 [cited by applicant]
US 5518733A · Lamothe et al. · 1996 [cited by applicant]
US 5578315A · Chien et al. · 1996 [cited by applicant]
US 5585098A · Coleman · 1996 [cited by applicant]
US 5614501A · Richards · 1997 [cited by applicant]
US 5629003A · Horstmann et al. · 1997 [cited by applicant]
US 5643603A · Bottenberg et al. · 1997 [cited by applicant]
US 5700478A · Biegajski et al. · 1997 [cited by applicant]
US 5713852A · Anthony et al. · 1998 [cited by applicant]
US 5718702A · Edwards · 1998 [cited by applicant]
US 5719196A · Uhari · 1998 [cited by applicant]
US 5792067A · Karell · 1998 [cited by applicant]
US 5800832A · Tapolsky et al. · 1998 [cited by applicant]
US 5804211A · Robertson et al. · 1998 [cited by applicant]
US 5843021A · Edwards et al. · 1998 [cited by applicant]
US 5855872A · Libin · 1999 [cited by applicant]
US 5876995A · Bryan · 1999 [cited by applicant]
US 5895804A · Lee et al. · 1999 [cited by applicant]
US 5900245A · Sawhney et al. · 1999 [cited by applicant]
US 5948430A · Zerbe et al. · 1999 [cited by applicant]
US 5988171A · Sohn et al. · 1999 [cited by applicant]
US 6054143A · Jones · 2000 [cited by applicant]
US 6072100A · Mooney et al. · 2000 [cited by applicant]
US 6139861A · Friedman · 2000 [cited by applicant]
US 6161541A · Woodson · 2000 [cited by applicant]
US 6174546B1 · Therriault et al. · 2001 [cited by applicant]
US 6210699B1 · Acharya · 2001 [cited by applicant]
US 6250307B1 · Conrad et al. · 2001 [cited by applicant]
US 6284235B1 · Foreman et al. · 2001 [cited by applicant]
US 6287610B1 · Bowling et al. · 2001 [cited by applicant]
US 6352711B1 · Campbell · 2002 [cited by applicant]
US 6375963B1 · Repka et al. · 2002 [cited by applicant]
US 6390096B1 · Conrad et al. · 2002 [cited by applicant]
US 6431174B1 · Knudson et al. · 2002 [cited by applicant]
US 6432986B2 · Levin · 2002 [cited by applicant]
US 6439238B1 · Brenzel et al. · 2002 [cited by applicant]
US 6453905B1 · Conrad et al. · 2002 [cited by applicant]
US 6458380B1 · Leaderman · 2002 [cited by applicant]
US 6458777B1 · Sonis et al. · 2002 [cited by applicant]
US 6467485B1 · Schmidt · 2002 [cited by applicant]
US 6502574B2 · Stevens et al. · 2003 [cited by applicant]
US 6509028B2 · Williams et al. · 2003 [cited by applicant]
US 6523542B2 · Knudson et al. · 2003 [cited by applicant]
US 6552024B1 · Chen et al. · 2003 [cited by applicant]
US 6555125B2 · Campbell · 2003 [cited by applicant]
US 6569474B2 · Clayton et al. · 2003 [cited by applicant]
US 6578580B2 · Conrad et al. · 2003 [cited by applicant]
US 6585997B2 · Moro et al. · 2003 [cited by applicant]
US 6599883B1 · Romeo · 2003 [cited by applicant]
US 6620846B1 · Jonn et al. · 2003 [cited by applicant]
US 6713463B2 · Sonis et al. · 2004 [cited by applicant]
US 6722577B2 · Dobyns, III · 2004 [cited by applicant]
US 6726920B1 · Theeuwes et al. · 2004 [cited by applicant]
US 6734157B2 · Radwanski et al. · 2004 [cited by applicant]
US 6748951B1 · Schmidt · 2004 [cited by applicant]
US 6794318B2 · Anderson et al. · 2004 [cited by applicant]
US 6803420B2 · Cleary et al. · 2004 [cited by applicant]
US 6916480B2 · Anderson et al. · 2005 [cited by applicant]
US 6919373B1 · Lam et al. · 2005 [cited by applicant]
US 6923981B2 · Leung et al. · 2005 [cited by applicant]
US 7001609B1 · Matson et al. · 2006 [cited by applicant]
US 7067116B1 · Bess et al. · 2006 [cited by applicant]
US 7087249B2 · Burrelll · 2006 [cited by applicant]
US 7097853B1 · Garbe et al. · 2006 [cited by applicant]
US 7122198B1 · Singh et al. · 2006 [cited by applicant]
US 7138135B2 · Chen et al. · 2006 [cited by applicant]
US 7143709B2 · Brennan et al. · 2006 [cited by applicant]
US 7146981B2 · Knudson et al. · 2006 [cited by applicant]
US 7267975B2 · Strobel et al. · 2007 [cited by applicant]
US 7276246B2 · Zhang · 2007 [cited by applicant]
US 7287646B2 · Gierskcky · 2007 [cited by applicant]
US 7306812B2 · Zhang · 2007 [cited by applicant]
US 7332230B1 · Krumme · 2008 [cited by applicant]
US 7353194B1 · Kerker et al. · 2008 [cited by applicant]
US 7357891B2 · Yang et al. · 2008 [cited by applicant]
US 7425292B2 · Yang et al. · 2008 [cited by applicant]
US 7441559B2 · Nelson et al. · 2008 [cited by applicant]
US 7470397B2 · Meathrel et al. · 2008 [cited by applicant]
US 7500484B2 · Nelson et al. · 2009 [cited by applicant]
US 7540432B2 · Majerowski et al. · 2009 [cited by applicant]
US 7566310B2 · Badr et al. · 2009 [cited by applicant]
US 7575739B2 · Tamarkin et al. · 2009 [cited by applicant]
US 7579019B2 · Tapolsky et al. · 2009 [cited by applicant]
US 7579078B2 · Hartmann et al. · 2009 [cited by applicant]
US 7615235B2 · Rademacher et al. · 2009 [cited by applicant]
US 7632525B2 · Dodds et al. · 2009 [cited by applicant]
US 7645803B2 · Tamarkin et al. · 2010 [cited by applicant]
US 7648712B2 · Bess et al. · 2010 [cited by applicant]
US 7650848B2 · Brennan · 2010 [cited by applicant]
US 7666502B2 · Magill et al. · 2010 [cited by applicant]
US 7669603B2 · Knudson et al. · 2010 [cited by applicant]
US 7686021B2 · Knudson et al. · 2010 [cited by applicant]
US 7704518B2 · Tamarkin et al. · 2010 [cited by applicant]
US 7727466B2 · Meathrel et al. · 2010 [cited by applicant]
US 7799337B2 · Levin · 2010 [cited by applicant]
US 7820145B2 · Tamarkin et al. · 2010 [cited by applicant]
US 7820420B2 · Whitlock · 2010 [cited by applicant]
US 7824588B2 · Yang et al. · 2010 [cited by applicant]
US 7824704B2 · Anderson et al. · 2010 [cited by applicant]
US 7845356B2 · Paraschac et al. · 2010 [cited by applicant]
US 7862808B2 · Isolauri et al. · 2011 [cited by applicant]
US 7901925B2 · Bojrab · 2011 [cited by applicant]
US 7906140B2 · Bromley et al. · 2011 [cited by applicant]
US 7937159B2 · Lima et al. · 2011 [cited by applicant]
US 7984714B2 · Hausmann et al. · 2011 [cited by applicant]
US 7992566B2 · Pflueger et al. · 2011 [cited by applicant]
US 7997266B2 · Frazier et al. · 2011 [cited by applicant]
US 8030457B2 · Jackson et al. · 2011 [cited by applicant]
US 8034601B2 · Boileau et al. · 2011 [cited by applicant]
US 8034606B2 · Park et al. · 2011 [cited by applicant]
US 8104478B2 · Pflueger et al. · 2012 [cited by applicant]
US 8110215B2 · Koenig et al. · 2012 [cited by applicant]
US 8197872B2 · Mills et al. · 2012 [cited by applicant]
US 8349313B2 · Smith et al. · 2013 [cited by applicant]
US 8357368B2 · Dudek et al. · 2013 [cited by applicant]
US 8362206B2 · Wallach et al. · 2013 [cited by applicant]
US 8383201B2 · Berry et al. · 2013 [cited by applicant]
US 8420074B2 · Rehberger et al. · 2013 [cited by applicant]
US 8454729B2 · Mittelmark et al. · 2013 [cited by applicant]
US 8481299B2 · Gueniche · 2013 [cited by applicant]
US 8496914B2 · Bonfiglio · 2013 [cited by applicant]
US 8584685B2 · Kovarik et al. · 2013 [cited by applicant]
US 8585588B2 · Kovarik et al. · 2013 [cited by applicant]
US 8591412B2 · Kovarik et al. · 2013 [cited by applicant]
US 8657879B2 · Shalon et al. · 2014 [cited by applicant]
US 8685389B2 · Baur · 2014 [cited by applicant]
US 8701671B2 · Kovarik · 2014 [cited by applicant]
US 8716327B2 · Zhao · 2014 [cited by applicant]
US 8757173B2 · Kovarik et al. · 2014 [cited by applicant]
US 8758764B2 · Masignani et al. · 2014 [cited by applicant]
US 8815538B2 · Lanzalaco et al. · 2014 [cited by applicant]
US 8829165B2 · Jackson et al. · 2014 [cited by applicant]
US 8859741B2 · Jackson et al. · 2014 [cited by applicant]
US 8865211B2 · Tzannis · 2014 [cited by applicant]
US 8936030B2 · Kovarik et al. · 2015 [cited by applicant]
US 8945839B2 · Zhang et al. · 2015 [cited by applicant]
US 8951775B2 · Castiel · 2015 [cited by applicant]
US 8999372B2 · Davidson · 2015 [cited by applicant]
US 9010340B2 · Kovarik et al. · 2015 [cited by applicant]
US 9011834B1 · McKenzie et al. · 2015 [cited by applicant]
US 9016221B2 · Brennan et al. · 2015 [cited by applicant]
US 9017718B2 · Tan · 2015 [cited by applicant]
US 9028841B2 · Henn et al. · 2015 [cited by applicant]
US 9044420B2 · Dubensky, Jr · 2015 [cited by applicant]
US 9045547B2 · Jackson et al. · 2015 [cited by applicant]
US 9056912B2 · Grandi et al. · 2015 [cited by applicant]
US 9095704B2 · McGuire et al. · 2015 [cited by applicant]
US 9131884B2 · Holmes · 2015 [cited by applicant]
US 9149429B2 · Kovacs et al. · 2015 [cited by applicant]
US 9234204B2 · Qvit-Raz et al. · 2016 [cited by applicant]
US 9254295B2 · Adams et al. · 2016 [cited by applicant]
US 9288981B2 · Gandhi et al. · 2016 [cited by applicant]
US 9295682B2 · Nunes et al. · 2016 [cited by applicant]
US 9314489B2 · Kelly et al. · 2016 [cited by applicant]
US 9457077B2 · Kovarik et al. · 2016 [cited by applicant]
US 9549842B2 · Kovarik · 2017 [cited by applicant]
US 9585920B2 · Kovarik et al. · 2017 [cited by applicant]
US 9730967B2 · Kovarik et al. · 2017 [cited by applicant]
US 9750802B2 · Kovarik et al. · 2017 [cited by applicant]
US 9795641B2 · Nardelli et al. · 2017 [cited by applicant]
US 9987224B2 · Kovarik · 2018 [cited by applicant]
US 10085938B2 · Kovarik et al. · 2018 [cited by applicant]
US 10086018B2 · Kovarik · 2018 [cited by applicant]
US 10111913B2 · Kovarik · 2018 [cited by applicant]
US 10195273B2 · Clube · 2019 [cited by applicant]
US 10245288B2 · Kovarik · 2019 [cited by applicant]
US 10314865B2 · Kovarik · 2019 [cited by applicant]
US 10314866B2 · Kovarik · 2019 [cited by applicant]
US 10512661B2 · Kovarik · 2019 [cited by applicant]
US 10548761B2 · Kovarik · 2020 [cited by applicant]
US 10555976B2 · Kovarik · 2020 [cited by applicant]
US 10668014B2 · Kovarik et al. · 2020 [cited by applicant]
US 10683323B2 · Prakash et al. · 2020 [cited by applicant]
US 10687975B2 · Kovarik et al. · 2020 [cited by applicant]
US 10716815B2 · Kovarik et al. · 2020 [cited by applicant]
US 10730827B2 · Wortmann et al. · 2020 [cited by applicant]
US 10760075B2 · Sommer et al. · 2020 [cited by applicant]
US 10835560B2 · Kovarik · 2020 [cited by applicant]
US 10940169B2 · Kovarik et al. · 2021 [cited by applicant]
US 11026982B2 · Kovarik · 2021 [cited by applicant]
US 11083760B2 · Han · 2021 [cited by applicant]
US 11213552B2 · Kovarik · 2022 [cited by applicant]
US 11357722B2 · Kovarik et al. · 2022 [cited by applicant]
US 11529379B2 · Kovarik · 2022 [cited by applicant]
US 11833177B2 · Simmons et al. · 2023 [cited by applicant]
US 11839632B2 · Tye et al. · 2023 [cited by applicant]
US 11844720B2 · Tye et al. · 2023 [cited by applicant]
US 11951140B2 · Kovarik · 2024 [cited by applicant]
US 11969445B2 · Kovarik · 2024 [cited by applicant]
US 11980643B2 · Simmons et al. · 2024 [cited by applicant]
US 11998479B2 · Simmons et al. · 2024 [cited by applicant]
US 11998574B2 · Simmons et al. · 2024 [cited by applicant]
US 12005085B2 · Simmons et al. · 2024 [cited by applicant]
US 20020009429A1 · Bostwick · 2002 [cited by applicant]
US 20020009520A1 · Clayton et al. · 2002 [cited by applicant]
US 20020022057A1 · Battey et al. · 2002 [cited by applicant]
US 20020037310A1 · Jonn et al. · 2002 [cited by applicant]
US 20020044988A1 · Fuchs et al. · 2002 [cited by applicant]
US 20030031737A1 · Rosenbloom · 2003 [cited by applicant]
US 20030062050A1 · Schmidt · 2003 [cited by applicant]
US 20030083287A1 · Burgess et al. · 2003 [cited by applicant]
US 20030104041A1 · Hsu et al. · 2003 [cited by applicant]
US 20030106243A1 · Tucker · 2003 [cited by applicant]
US 20030124178A1 · Haley · 2003 [cited by applicant]
US 20030140930A1 · Knudson et al. · 2003 [cited by applicant]
US 20030149387A1 · Barakat et al. · 2003 [cited by applicant]
US 20030149445A1 · Knudson et al. · 2003 [cited by applicant]
US 20030206995A1 · Bowling et al. · 2003 [cited by applicant]
US 20040053352A1 · Ouyang et al. · 2004 [cited by applicant]
US 20040057962A1 · Timmerman · 2004 [cited by applicant]
US 20040062757A1 · Finegold · 2004 [cited by applicant]
US 20040096569A1 · Barkalow et al. · 2004 [cited by applicant]
US 20040110111A1 · Wasylucha · 2004 [cited by applicant]
US 20040115223A1 · Follansbee · 2004 [cited by applicant]
US 20040120991A1 · Schobel · 2004 [cited by applicant]
US 20040136923A1 · Davidson et al. · 2004 [cited by applicant]
US 20040142463A1 · Walker et al. · 2004 [cited by applicant]
US 20040166501A1 · Azimzai et al. · 2004 [cited by applicant]
US 20040170617A1 · Finegold · 2004 [cited by applicant]
US 20040180080A1 · Furasawa et al. · 2004 [cited by applicant]
US 20040224007A1 · Zhang · 2004 [cited by applicant]
US 20040228804A1 · Jones et al. · 2004 [cited by applicant]
US 20050004417A1 · Nelson et al. · 2005 [cited by applicant]
US 20050159637A9 · Nelson et al. · 2005 [cited by applicant]
US 20050118655A1 · Weinstock et al. · 2005 [cited by applicant]
US 20050137109A1 · Quan et al. · 2005 [cited by applicant]
US 20050196358A1 · Georglades et al. · 2005 [cited by applicant]
US 20050197495A1 · Naidu · 2005 [cited by applicant]
US 20050260544A1 · Jones et al. · 2005 [cited by applicant]
US 20060018843A1 · Fine · 2006 [cited by applicant]
US 20060035008A1 · Virgalli et al. · 2006 [cited by applicant]
US 20060064903A1 · Tucker · 2006 [cited by applicant]
US 20060127330A1 · Tsuchida et al. · 2006 [cited by applicant]
US 20060188813A1 · Shimada · 2006 [cited by applicant]
US 20060204591A1 · Burrel et al. · 2006 [cited by applicant]
US 20060207721A1 · Slominski et al. · 2006 [cited by applicant]
US 20060252087A1 · Tang et al. · 2006 [cited by applicant]
US 20070054008A1 · Clayton et al. · 2007 [cited by applicant]
US 20070057086A1 · Van Kippersluis · 2007 [cited by applicant]
US 20070059718A1 · Toner et al. · 2007 [cited by applicant]
US 20070059774A1 · Grisham et al. · 2007 [cited by applicant]
US 20070063026A1 · Mamaropolos et al. · 2007 [cited by applicant]
US 20070087020A1 · O'Connor · 2007 [cited by applicant]
US 20070093420A1 · Yeomans · 2007 [cited by applicant]
US 20070098744A1 · Knorr et al. · 2007 [cited by applicant]
US 20070102010A1 · Lemperle et al. · 2007 [cited by applicant]
US 20070122455A1 · Myers et al. · 2007 [cited by applicant]
US 20070123448A1 · Kaplan et al. · 2007 [cited by applicant]
US 20070148136A1 · Whitlock · 2007 [cited by applicant]
US 20070202057A1 · Fankhauser et al. · 2007 [cited by applicant]
US 20070207955A1 · Tanihara et al. · 2007 [cited by applicant]
US 20070218114A1 · Sorousch · 2007 [cited by applicant]
US 20070227545A1 · Conrad et al. · 2007 [cited by applicant]
US 20070231923A1 · Cumberland et al. · 2007 [cited by applicant]
US 20070246052A1 · Hegde et al. · 2007 [cited by applicant]
US 20070261701A1 · Sanders · 2007 [cited by applicant]
US 20070280964A1 · Knorr et al. · 2007 [cited by applicant]
US 20070293587A1 · Haley · 2007 [cited by applicant]
US 20070295340A1 · Buscemi · 2007 [cited by applicant]
US 20080032253A1 · Montgomery et al. · 2008 [cited by applicant]
US 20080075825A1 · Fuisz et al. · 2008 [cited by applicant]
US 20080112983A1 · Bufe et al. · 2008 [cited by applicant]
US 20080242543A1 · Banerjee et al. · 2008 [cited by applicant]
US 20080267933A1 · Ohlson et al. · 2008 [cited by applicant]
US 20080286210A1 · He · 2008 [cited by applicant]
US 20080305089A1 · Bufe et al. · 2008 [cited by applicant]
US 20090004275A1 · Martyn · 2009 [cited by applicant]
US 20090098192A1 · Fuisz · 2009 [cited by applicant]
US 20090130199A1 · Kovacs · 2009 [cited by applicant]
US 20090148482A1 · Peters · 2009 [cited by applicant]
US 20090196907A1 · Bunick · 2009 [cited by applicant]
US 20090196908A1 · Lee · 2009 [cited by applicant]
US 20090205083A1 · Gupta et al. · 2009 [cited by applicant]
US 20100029832A1 · Pinnavaia et al. · 2010 [cited by applicant]
US 20100040593A1 · Hedman et al. · 2010 [cited by applicant]
US 20100040712A1 · Fisher · 2010 [cited by applicant]
US 20100081681A1 · Blagosklonny · 2010 [cited by applicant]
US 20100092406A1 · Perez-Davidi et al. · 2010 [cited by applicant]
US 20100124560A1 · Hugerth · 2010 [cited by examiner]
US 20100143447A1 · Hansen et al. · 2010 [cited by applicant]
US 20100229876A1 · Knudson et al. · 2010 [cited by applicant]
US 20100247644A1 · Domb et al. · 2010 [cited by applicant]
US 20100260720A1 · Sprenger · 2010 [cited by applicant]
US 20100285098A1 · Haley · 2010 [cited by applicant]
US 20110009834A1 · Asmussen et al. · 2011 [cited by applicant]
US 20110033542A1 · Myers et al. · 2011 [cited by applicant]
US 20110088701A1 · Thornton · 2011 [cited by applicant]
US 20110100378A1 · Rousseau · 2011 [cited by applicant]
US 20110142942A1 · Gardner et al. · 2011 [cited by applicant]
US 20110217368A1 · Prakash et al. · 2011 [cited by applicant]
US 20110230587A1 · Macinnis et al. · 2011 [cited by applicant]
US 20110230727A1 · Sanders et al. · 2011 [cited by applicant]
US 20110250626A1 · Williams et al. · 2011 [cited by applicant]
US 20110274795A1 · Bogue et al. · 2011 [cited by applicant]
US 20110290694A1 · Fuisz et al. · 2011 [cited by applicant]
US 20120027786A1 · Gupta · 2012 [cited by applicant]
US 20120029832A1 · Dodgson · 2012 [cited by applicant]
US 20120039806A1 · Lahoud et al. · 2012 [cited by applicant]
US 20120058094A1 · Blasser et al. · 2012 [cited by applicant]
US 20120128597A1 · Peters et al. · 2012 [cited by applicant]
US 20120142548A1 · Corsi et al. · 2012 [cited by applicant]
US 20120148629A1 · Holvoet et al. · 2012 [cited by applicant]
US 20120222685A1 · Kovarik · 2012 [cited by applicant]
US 20120276143A1 · O'Mahony et al. · 2012 [cited by applicant]
US 20120276149A1 · Littman et al. · 2012 [cited by applicant]
US 20120276525A1 · Kovarik et al. · 2012 [cited by applicant]
US 20120283269A1 · Blagosklonny et al. · 2012 [cited by applicant]
US 20120294822A1 · Russo et al. · 2012 [cited by applicant]
US 20120301452A1 · Gueniche et al. · 2012 [cited by applicant]
US 20130059815A1 · Fournell et al. · 2013 [cited by applicant]
US 20130087155A1 · Hedman et al. · 2013 [cited by applicant]
US 20130157876A1 · Lynch et al. · 2013 [cited by applicant]
US 20130225440A1 · Friedman et al. · 2013 [cited by applicant]
US 20130236488A1 · Dashper et al. · 2013 [cited by applicant]
US 20130252983A1 · Cerione et al. · 2013 [cited by applicant]
US 20130259834A1 · Klaenhammer et al. · 2013 [cited by applicant]
US 20130310416A1 · Blagosklonny · 2013 [cited by applicant]
US 20130315869A1 · Qimron et al. · 2013 [cited by applicant]
US 20130323025A1 · Crawford et al. · 2013 [cited by applicant]
US 20130323100A1 · Poulton et al. · 2013 [cited by applicant]
US 20130326645A1 · Cost et al. · 2013 [cited by applicant]
US 20130330215A1 · Li · 2013 [cited by applicant]
US 20140030332A1 · Baron et al. · 2014 [cited by applicant]
US 20140044677A1 · Qvit-Raz et al. · 2014 [cited by applicant]
US 20140045744A1 · Gordon · 2014 [cited by applicant]
US 20140065209A1 · Putaala et al. · 2014 [cited by applicant]
US 20140065218A1 · Lang et al. · 2014 [cited by applicant]
US 20140066817A1 · Kovarik et al. · 2014 [cited by applicant]
US 20140068797A1 · Doudna et al. · 2014 [cited by applicant]
US 20140125550A1 · Kaneko et al. · 2014 [cited by applicant]
US 20140154290A1 · Peters et al. · 2014 [cited by applicant]
US 20140199266A1 · Park · 2014 [cited by applicant]
US 20140238411A1 · Kovarik · 2014 [cited by applicant]
US 20140255351A1 · Berstad et al. · 2014 [cited by applicant]
US 20140271867A1 · Myers · 2014 [cited by applicant]
US 20140294915A1 · Barreca et al. · 2014 [cited by applicant]
US 20140296139A1 · Cohen et al. · 2014 [cited by applicant]
US 20140333003A1 · Allen · 2014 [cited by applicant]
US 20140349405A1 · Sontheimer et al. · 2014 [cited by applicant]
US 20140356460A1 · Lutin · 2014 [cited by applicant]
US 20140363441A1 · Grandea, III et al. · 2014 [cited by applicant]
US 20140364460A1 · Freed-Pastor et al. · 2014 [cited by applicant]
US 20140377278A1 · Elinav et al. · 2014 [cited by applicant]
US 20150004130A1 · Faber et al. · 2015 [cited by applicant]
US 20150017143A1 · Holvoet et al. · 2015 [cited by applicant]