IP Library › Granted Patent US 12,686,009
Granted Patent B2
US 12,686,009 · App. 18/642,774 · Granted Jul 21, 2026

Control of evaporation in digital microfluidics

Inventors: Mais Jehan Jebrail (Toronto, CA); Mathieu Gabriel-Emmanuel Chauleau (San Francisco, CA); Poornasree Kumar (San Francisco, CA); Eduardo Cervantes (San Francisco, CA); Foteini Christodoulou (San Francisco, CA); Nikolay Sergeev (San Francisco, CA); Spencer Seiler (San Francisco, CA); Alejandro Tocigl Domeyko (San Francisco, CA); Ana Eugenia Carvajal (San Francisco, CA)
Assignee: INTEGRA Biosciences AG
B01L3/502792C12M23/16G01N27/44791B01L2200/027B01L2200/142B01L2300/042B01L2300/0874B01L2300/1822B01L2400/0415
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Quick Facts
Patent No.
US 12,686,009
App. No.
18/642,774
Filed
Apr 22, 2024
Granted
Jul 21, 2026
Kind
B2
Examiner
BALL, JOHN C
Art Unit
1795
USPC
204/450
Abstract

Air-matrix digital microfluidics (DMF) apparatuses and methods of using them. These methods and apparatuses may include the use of a liquid wax coating material and/or pinning the encapsulated reaction droplet within the air gap using pinning features. Any of these methods may also include separating the liquid wax from an encapsulated aqueous droplet, e.g., using an oil absorbent wick to selectively separate the liquid oil or wax from the aqueous droplet by adsorbing and/or absorbing the liquid wax into the absorbent wick while leaving the aqueous droplet behind.

Claims (28)

1 . A microfluidic apparatus configured to separate a liquid oil or wax from an encapsulated aqueous droplet, the apparatus comprising:

an air gap between a first and second layer;

an oil absorbent wick disposed within the air gap, the oil absorbent wick configured to selectively separate the liquid oil or wax from the encapsulated aqueous droplet; and

a controller programmed to:

actuate a driver to transport the encapsulated aqueous droplet through the air gap to make contact with the oil absorbent wick; and

transport the aqueous droplet away from the oil absorbent wick after the liquid oil or wax has been separated from the aqueous droplet.

2 . The apparatus of claim 1 , wherein the oil absorbent wick is hydrophobic.

3 . The apparatus of claim 1 , wherein the oil absorbent wick comprises a tip.

4 . The apparatus of claim 1 , wherein a tip of the oil absorbent wick tapers into a point.

5 . The apparatus of claim 4 , wherein the tip has a width less than a diameter of the encapsulated aqueous droplet.

6 . The apparatus of claim 1 , wherein the controller is programmed to actuate a first subset of a plurality of actuation electrodes to transport the encapsulated aqueous droplet through the air gap to make contact with a tip of the oil absorbent wick.

7 . The apparatus of claim 6 , wherein the plurality of actuation electrodes form a portion of the first layer.

8 . The apparatus of claim 6 , wherein the plurality of actuation electrodes are disposed on a film that is removably attached to the first layer.

9 . The apparatus of claim 1 , wherein the first layer and/or the second layer are part of a removable cartridge.

10 . The apparatus of claim 1 , wherein the apparatus comprises a digital microfluidics (DMF) apparatus.

11 . A method of separating a liquid oil or wax from an encapsulated aqueous droplet within an air gap of a microfluidic apparatus, the method comprising:

transporting the encapsulated aqueous droplet to an oil absorbent wick by actuating a driver to transport the encapsulated aqueous droplet through the air gap to make contact with the oil absorbent wick;

transferring the liquid oil or wax surrounding the aqueous droplet to the oil absorbent wick; and

transporting the aqueous droplet away from the oil absorbent wick after the liquid oil or wax has been transferred to the oil absorbent wick.

12 . The method of claim 11 , wherein transporting the encapsulated aqueous droplet to the oil absorbent wick comprises actuating a first subset of electrodes of the microfluidics apparatus.

13 . The method of claim 11 , wherein the oil absorbent wick has a tapered tip and the encapsulated aqueous droplet is transported to the tapered tip of the oil absorbent wick.

14 . The method of claim 11 , wherein the aqueous droplet is not substantially transferred to the oil absorbent wick.

15 . The method of claim 11 , wherein the oil absorbent wick is hydrophobic.

16 . The method of claim 11 , wherein a tip of the oil absorbent wick has a width less than a diameter of the encapsulated aqueous droplet.

17 . The method of claim 11 , wherein transporting the encapsulated aqueous droplet to the oil absorbent wick comprises operating a first subset of a plurality of actuation electrodes to transport the encapsulated aqueous droplet through the air gap to make contact with a tip of the oil absorbent wick.

18 . The method of claim 17 , wherein the plurality of actuation electrodes form a bottom of the air gap.

19 . The method of claim 17 , wherein the plurality of actuation electrodes are disposed on a film that is removably attached to a first layer, wherein the air gap is disposed between the first layer and a second layer.

20 . The method of claim 11 , further comprising inserting a cartridge including the air gap into the microfluidic apparatus.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2024
From: JEBRAIL, MAIS JEHAN; CHAULEAU, MATHIEU GABRIEL-EMMANUEL; KUMAR, POORNASREE; CERVANTES, EDUARDO; CHRISTODOULOU, FOTEINI; SERGEEV, NIKOLAY; SEILER, SPENCER; DOMEYKO, ALEJANDRO TOCIGL; CARVAJAL, ANA EUGENIA
To: MIROCULUS INC.
Reel/Frame 069146/0676 →
Continuity (4)
Continuation 17088572 · Nov 3, 2020
Continuation PCTUS2019033794 · May 23, 2019
Provisional Application 62675749 · May 23, 2018
Related Publication 20240416349A1 · Dec 19, 2024
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