Granted Patent B2

US 12,453,681 · App. 18/761,235 · Granted Oct 28, 2025

Inventor: Laura C. Singleton (Inglewood, CA)

Assignee: LCS Advanced Solutions, LLC

A61K8/25A61K8/064A61K8/27A61K8/29A61Q17/04A61K2800/31A61K2800/412

Abstract

Claims (19)

1. A composition suitable for topical administration comprising a matrix composition of a mixture of structurally diverse matrix particles that are formed from at least three different types of primary particles comprising (a) a first primary particle population, (b) a second primary particle population, and (c) a third primary particle population, wherein (i) the first primary particle population has an average particle size from 1000 nm to 8500 nm, makes up 4-9% of the composition by weight, and 20-70% of the first primary particle population comprises a glass composition, (ii) the second particle population has an average particle size from 250 nm to 500 nm, makes up 5-15% of the composition by weight and comprises UV-protective particles, (iii) the third particle population has an average particle size from 500 nm to 1000 nm, makes up 6.75-22% of the composition by weight, and at least 75% of the third particle population comprises UV-protective metal oxide particles, and (iv) the composition exhibits a sun protection factor (SPF) of at least 30, a critical wavelength of at least 370 nm, a UVA/UVB ratio of at least 0.333, and a UVA1 to UV ratio of at least 0.7.

2. The composition according to claim 1 , wherein the glass composition comprises a borosilicate component.

3. The composition according to claim 2 , wherein the borosilicate component comprises non-porous, spherical particles.

4. The composition according to claim 3 , wherein a salt of the borosilicate component comprises calcium or sodium.

5. The composition according to claim 4 , wherein the UV-protective particles are mostly composed of a styrene acrylate copolymer.

6. The composition according to claim 5 , wherein the third particle population comprising at least 75% UV-protective metal oxide particles consist of particles having an average particle size (a) from 500 nm to less than 750 nm making up 5%-15% of the composition by weight and (b) from 750 nm to 1000 nm and making up 1.75%-7% of the composition by weight.

7. The composition according to claim 6 , wherein the UV-protective metal oxide particles mostly comprise mesoporous metal oxide particles.

8. The composition according to claim 7 , wherein the mesoporous metal oxide particles comprise pores with a maximum dimension of about 2 nm to about 100 nm.

9. The composition according to claim 7 , wherein at least 80% by weight of the mesoporous metal oxide particles comprise mesoporous zinc oxide particles.

10. The composition according to claim 9 , wherein the mesoporous zinc oxide particles comprise aggregates of greater than one of the mesoporous zinc oxide particles.

11. The composition according to claim 10 , wherein the composition comprises a fourth particle population having a maximum particle size of 250 nm and makes up less than 2% of the composition by weight.

12. The composition according to claim 11 , wherein the fourth particle population comprises less than 5% by weight of metal oxide particles.

13. The composition according to claim 12 , wherein the fourth particle population comprises clay particles, synthetic mica particles, or natural mica particles.

14. The composition according to claim 13 , wherein the composition comprises a fifth particle population having an average particle size of greater than 8500 nm and makes up less than 3.5% of the composition by weight.

15. The composition according to claim 14 , wherein the fifth particle composition is mostly comprised of amorphous, spherical, porous silica particles.

16. The composition according to claim 15 , wherein the amorphous, spherical, porous silica particles comprise silicon oxide hydrate.

17. The composition according to claim 16 , wherein the composition comprise one or more types of particle agglomerates.

18. The composition according to claim 17 , wherein at least 33% of the weight concentration of the mixture of structurally diverse matrix particles is composed of UV-protectant metal oxide particles having a minimum particle size of greater than 100 nm, wherein scanning electron microscope analysis of the composition fails to identify a significant number of discrete matrix particles having a size of 100 nm or less.

19. The composition according to claim 9 , wherein the weight ratio of the mesoporous zinc oxide particles to a calcium sodium borosilicate component is about 6:1 to about 12:1.

Assignments (1)

Continuity (3)

References Cited (385)