Compositions comprising peroxyacid and methods for producing and using the same
The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods, and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.
1. A composition consisting essentially of: a peroxyacid, a corresponding parent carboxylic acid of the peroxyacid, and an oxidizing agent,
wherein the ratio of oxidizing agent to carboxylic acid is from about 0.5:1 to about 6:1,
wherein the parent carboxylic acid is acetic acid in an amount of from 6.2 to about 120.4 mM, and the oxidizing agent is present in an amount of from about 7.2 to about 71.5 mM, and
wherein the composition is formulated for wound treatment as a topical gel, liquid, lotion, irrigation gel, spray, skin patch or application granules.
2. The composition of claim 1 , wherein the oxidizing agent is at least one agent selected from the group consisting of hydrogen peroxide, barium peroxide, sodium carbonate peroxide, calcium peroxide, sodium perborate, lithium peroxide, magnesium peroxide, strontium peroxide, zinc peroxide, potassium superoxide, and a combination thereof.
3. The composition of claim 2 , wherein the oxidizing agent is hydrogen peroxide.
4. The composition of claim 1 , wherein the ratio is 2:1.
5. A method of treating or healing a wound, comprising topically applying the composition of claim 1 to a wound on a subject.
6. The composition of claim 1 , further including peroxymaleic acid and maleic acid.
7. The composition according to claim 1 , wherein the composition further-includes at least one other peroxyacid.
8. The composition according to claim 7 , wherein the other peroxyacid is selected from the group consisting of peroxymaleic acid, peroxyformic acid and a combination thereof.
9. The composition according to claim 1 , wherein the composition is a wound healing composition.
10. The composition according to claim 1 , wherein the composition is deposited on or in the skin patch.
11. The composition according to claim 1 , wherein the wound is selected from the group consisting of a surgical wound, battle wound, accidental wound, thermal burn wound, chemical burn wound, chronic wound, decubitus ulcer, foot ulcer, venous ulcer, laser treatment wound, sunburn, an abrasion, and a combination thereof.