IP Library › Granted Patent US 12,285,271
Granted Patent B2
US 12,285,271 · App. 18/926,029 · Granted Apr 29, 2025

Continuous analyte monitoring system with microneedle array

Inventors: Alan Campbell (San Diego, CA); Sirilak Sattayasamitsathit (San Diego, CA); Jared Rylan Tangney (Encinitas, CA); Joshua Ray Windmiller (San Diego, CA); James Patrick McCanna (San Diego, CA)
Assignee: Biolinq Incorporated
A61B5/685A61B5/0022A61B5/14514A61B5/14532A61B5/14546A61B5/14865A61B5/6833A61B5/742G01N27/327
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Quick Facts
Patent No.
US 12,285,271
App. No.
18/926,029
Granted
Apr 29, 2025
Kind
B2
Abstract

Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Claims (29)

1. A microneedle array for use in sensing an analyte, comprising:

a semiconductor substrate; and

a plurality of microneedles formed from the semiconductor substrate, the plurality of microneedles comprising:

a first microneedle comprising a first working electrode comprising a first biorecognition element configured to react with the analyte;

a second microneedle comprising a second working electrode comprising a second biorecognition element configured to react with the analyte; and

a third microneedle comprising a counter electrode,

wherein each of the first microneedle, the second microneedle, and the third microneedle are insulated from the semiconductor substrate and electrically isolated from one another such that a first redox reaction between the first working electrode and the counter electrode and a second redox reaction between the second working electrode and the counter electrode are independent of one another.

2. The microneedle array of claim 1 , wherein the plurality of microneedles further comprises a fourth microneedle comprising a reference electrode.

3. The microneedle array of claim 1 , wherein the first microneedle and the second microneedle are solid microneedles.

4. The microneedle array of claim 1 , wherein the first microneedle and the second microneedle each comprise an insulated distal tip.

5. The microneedle array of claim 1 , wherein the first microneedle and the second microneedle each comprise an insulative sheath that electrically isolates a respective one of the first microneedle and the second microneedle from the semiconductor substrate.

6. The microneedle array of claim 5 , wherein respective insulative sheaths insulates the first microneedle and the second microneedle such that they are individually addressable and electrically isolated from one another.

7. The microneedle array of claim 1 , wherein one or more of the first working electrode and the second working electrode comprises a material selected from the group consisting of: platinum, palladium, iridium, rhodium, gold, ruthenium, titanium, nickel, carbon, and doped diamond.

8. The microneedle array of claim 1 , wherein the first biorecognition element is entrapped within a first biorecognition layer comprising a conducting polymer, and wherein the second biorecognition element is entrapped within a second biorecognition layer comprising a conducting polymer.

9. The microneedle array of claim 2 , wherein the reference electrode comprises a metal salt or a metal oxide selected from the group consisting of: silver-silver chloride and iridium oxide.

10. The microneedle array of claim 1 , wherein the first redox reaction and the second redox reaction correspond to independent measurements of the analyte from the first working electrode and the second working electrode.

11. The microneedle array of claim 1 , wherein the first biorecognition element and the second biorecognition element comprise glucose oxidase, lactate oxidase, alcohol oxidase, beta-hydroxybutyrate dehydrogenase, tyrosinase, catalase, ascorbate oxidase, cholesterol oxidase, choline oxidase, pyruvate oxidase, urate oxidase, urease, and xanthine oxidase.

12. A method for sensing an analyte via a microneedle array, comprising:

applying a first bias potential between a first working electrode on a first microneedle formed from a semiconductor substrate and a reference electrode, wherein the first working electrode comprises a first biorecognition element;

applying a second bias potential between a second working electrode on a second microneedle formed from the semiconductor substrate and the reference electrode, wherein the second working electrode comprises a second biorecognition element;

measuring a first current value between the first working electrode and a counter electrode, the first current value being proportional to a concentration of the analyte; and

measuring a second current value between the second working electrode and the counter electrode, the second current value being proportional to a concentration of the analyte,

wherein each of the first microneedle and the second microneedle are insulated from the semiconductor substrate and electrically isolated from one another such that the first current value and the second current value are independent of one another.

13. The method of claim 12 , wherein the first microneedle and the second microneedle each comprise an insulated distal tip.

14. The method of claim 12 , wherein the first microneedle and the second microneedle are solid microneedles.

15. The method of claim 12 , wherein the first current value and the second current value correspond to independent measurements of the analyte from the first working electrode and the second working electrode, respectively.

16. The method of claim 12 , wherein the first microneedle and the second microneedle are each insulated by an insulative sheath.

17. The method of claim 16 , wherein respective insulative sheaths insulate the first microneedle and the second microneedle such that the first microneedle and the second microneedle are individually addressable.

18. The method of claim 12 , wherein the reference electrode comprises a metal salt or a metal oxide selected from the group consisting of: silver-silver chloride and iridium oxide.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2025
From: CAMPBELL, ALAN; SATTAYASAMITSATHIT, SIRILAK; TANGNEY, JARED RYLAN; WINDMILLER, JOSHUA RAY; MCCANNA, JAMES PATRICK
To: BIOLINQ INCORPORATED
Reel/Frame 070602/0424 →
Continuity (5)
Continuation 18630936 · Apr 9, 2024
Continuation 18086543 · Dec 21, 2022
Continuation PCTUS2021043786 · Jul 29, 2021
Provisional Application 63058275 · Jul 29, 2020
Related Publication 20250049397A1 · Feb 13, 2025
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