IP Library › Granted Patent US 12,364,760
Granted Patent B2
US 12,364,760 · App. 18/417,268 · Granted Jul 22, 2025

Anaerobic blood storage and pathogen inactivation method

Inventors: Samuel O. Sowemimo-Coker (Dix Hills, NY); Jeffrey Sutton (Medway, MA); Tatsuro Yoshida (West Newton, MA)
Assignee: Hemanext Inc.
A61K41/17A61K35/18A61L2/0047A61L2/0076A61L2/0082A61L2202/22
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Quick Facts
Patent No.
US 12,364,760
App. No.
18/417,268
Granted
Jul 22, 2025
Kind
B2
Abstract

A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.

Claims (20)

1. Oxygen reduced and pathogen inactivated whole blood comprising whole blood collected in citrate phosphate dextrose (CPD), comprising between 40 to 60 micromolar (μM) riboflavin, having an oxygen saturation (SO2) of less than 25%, and having a partial pressure of carbon dioxide (pCO2) of 90 millimeters of mercury (mmHg) or less at 37° C., and having been irradiated with UV light between 265 to 400 nanometers (nm).

2. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the pCO2 is 5 to 90 mmHg at 37° C.

3. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the pCO2 is 70 mmHg at 37° C.

4. Oxygen and carbon dioxide reduced and pathogen inactivated whole blood comprising whole blood collected in citrate phosphate dextrose (CPD), comprising between 40 to 60 micromolar (μM) riboflavin, having an oxygen saturation (SO2) of less than 25%, having a partial pressure of carbon dioxide (pCO2) of 20 millimeters of mercury (mmHg) or less at 37° C., and having been irradiated with UV light between 265 to 400 nanometers (nm).

5. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the pCO2 is 5 to 20 mmHg at 37° C.

6. The oxygen reduced and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the pCO2 is 5 mmHg at 37° C.

7. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the irradiation comprises a UV dosage of between 3.2 to 7.0 Joules per square centimeter (J/cm 2 ).

8. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the oxygen reduced whole blood has reduced microparticles compared to non-oxygen reduced whole blood collected in CPD, comprising between 40 to 60 uM riboflavin, having a pCO2 of 90 mmHg or less at 37° C., and having been irradiated with UV light between 265 to 400 nm.

9. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the oxygen reduced whole blood has a reduced level of hemolysis compared to non-oxygen reduced whole blood collected in CPD, comprising between 40 to 60 uM riboflavin, having a pCO2 of 90 mmHg or less at 37° C., and having been irradiated with UV light between 265 to 400 nm.

10. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the oxygen reduced whole blood is oxygen reduced leukoreduced whole blood.

11. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the oxygen and carbon dioxide reduced whole blood has a reduced level of hemolysis compared to non-oxygen and carbon dioxide reduced whole blood collected in CPD, comprising between 40 to 60 uM riboflavin, having a pCO2 of 20 mmHg or less at 37° C., and having been irradiated with UV light between 265 to 400 nm.

12. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the oxygen and carbon dioxide reduced whole blood is oxygen and carbon dioxide reduced leukoreduced whole blood.

13. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the oxygen and carbon dioxide reduced whole blood has reduced microparticles compared to non-oxygen and carbon dioxide reduced whole blood collected in CPD, comprising between 40 to 60 uM riboflavin, having a pCO2 of 20 mmHg or less at 37° C., and having been irradiated with UV light between 265 to 400 nm.

14. The oxygen reduced and pathogen inactivated whole blood of claim 7 , wherein the irradiation comprises a dosage of between 5.0 to 7.0 J/cm 2 .

15. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the SO2 is less than 20%.

16. The oxygen reduced and pathogen inactivated whole blood of claim 15 , wherein the SO2 is less than 10%.

17. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 4 , wherein the SO2 is less than 20%.

18. The oxygen and carbon dioxide reduced and pathogen inactivated whole blood of claim 17 , wherein the SO2 is less than 10%.

19. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the oxygen reduced whole blood has an extended shelf life compared to non-oxygen reduced whole blood collected in CPD, comprising between 40 to 60 uM riboflavin, having a pCO2 of 90 mmHg or less at 37° C., and having been irradiated with UV light between 265 to 400 nm.

20. The oxygen reduced and pathogen inactivated whole blood of claim 1 , wherein the oxygen reduced whole blood is stored for a storage period of up to 6 weeks under anaerobic conditions.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2024
From: SUTTON, JEFFREY; YOSHIDA, TATSURO
To: NEW HEALTH SCIENCES, INC.
Reel/Frame 066187/0323 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2024
From: SOWEMIMO-COKER, SAMUEL O.; SUTTON, JEFFREY; YOSHIDA, TATSURO
To: NEW HEALTH SCIENCES, INC.
Reel/Frame 066187/0327 →
CHANGE OF NAME Recorded Jan 19, 2024
From: NEW HEALTH SCIENCES, INC.
To: HEMANEXT INC.
Reel/Frame 066356/0467 →
Continuity (5)
Division 17482846 · Sep 23, 2021
Division 16304611
Provisional Application 62445081 · Jan 11, 2017
Provisional Application 62342756 · May 27, 2016
Related Publication 20240148872A1 · May 9, 2024
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