Granted Patent
B2
US 12,558,323 · App. 18/659,740 · Granted Feb 24, 2026
Particle formation and morphology
Inventors:
Paul Brown (Boston, MA); Lyndon Fitzgerald Charles, Jr. (Medford, MA); Chase Spenser Coffman (Newton, MA); Daniel Benjamin Dadon (East Boston, MA); James W. Ivey (Reading, MA); Lisa Liu (Somerville, MA); Chaitanya Sudrik (Stoneham, MA)
Assignee:
Elektrofi, Inc.
View Patent ↗
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Abstract
The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.
Claims (10)
1 . A composition comprising particles, wherein a plurality of the particles: comprise an antibody or fragment thereof and one or more excipients, wherein the one or more excipients comprises a surfactant; have less than about 7% residual moisture by weight; have a loading of the antibody or fragment thereof from about 75 wt % to about 100 wt %; and comprise less than about 0.1% internal void spaces, and wherein the composition comprises less than 5% aggregation of the antibody or fragment thereof.
2 . The composition of claim 1 , wherein the antibody or fragment thereof is an amorphous antibody or fragment thereof.
3 . The composition of claim 1 , wherein the composition comprises less than 3% aggregation of the antibody or fragment thereof.
4 . The composition of claim 1 , wherein the composition further comprises a sugar or an antioxidant.
5 . The composition of claim 1 , wherein the plurality of particles, upon contact with an aqueous solution, dissolve in the aqueous solution.
6 . The composition of claim 1 , wherein the plurality of particles are suspended in the composition.
7 . The composition of claim 6 , wherein the plurality of particles are suspended in an organic solvent comprising esters.
8 . The composition of claim 6 , wherein the plurality of particles are suspended in an organic solvent comprising a C1-C20 ester containing compound.
9 . The composition of claim 1 , wherein the plurality of particles have diameters from about 1 μm to about 25 μm.
10 . The composition of claim 1 , wherein the composition includes about 20 to about 90% particles by volume.
Assignments (2)
CHANGE OF NAME
Recorded Feb 2, 2026
From: ELEKTROFI, INC.
To: HALOZYME HYPERCON, INC.
Reel/Frame 073662/0717 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 16, 2024
From: BROWN, PAUL; CHARLES, LYNDON FITZGERALD, JR.; COFFMAN, CHASE SPENSER; DADON, DANIEL BENJAMIN; IVEY, JAMES; LIU, LISA; SUDRIK, CHAITANYA
To: ELEKTROFI, INC.
Reel/Frame 069595/0942 →
Continuity (5)
Continuation
PCTUS2020015957
· Jan 30, 2020
Provisional Application
62799696
· Jan 31, 2019
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