IP Library › Granted Patent US 12,655,408
Granted Patent B2
US 12,655,408 · App. 17/770,591 · Granted Jun 16, 2026

Recombinant neuraminidase and uses thereof

Inventors: Peter Palese (New York, NY); Adolfo Garcia-Sastre (New York, NY); Florian Krammer (New York, NY)
Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
C12N9/2402C07K14/005C12Y302/01018C07K2319/02C07K2319/03C07K2319/21C07K2319/43C12N2760/16122
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Quick Facts
Patent No.
US 12,655,408
App. No.
17/770,591
Granted
Jun 16, 2026
Kind
B2
Abstract

In one aspect, provided herein are recombinant neuraminidases comprising an ectodomain of influenza virus neuraminidase with amino acid substitutions or insertions of cysteines in the stalk domain to generate a more stable, tetrameric influenza virus neuraminidase. In specific embodiments, the influenza virus neuraminidase further comprises influenza virus neuraminidase transmembrane and cytoplasmic domains. In another aspect, provided herein are recombinant neuraminidase comprising a globular head domain of influenza virus neuraminidase and a tetramerization domain, wherein the recombinant neuraminidase lacks influenza virus neuraminidase stalk, transmembrane and cytoplasmic domains. In another aspect, provided herein are methods of immunizing against influenza virus using such recombinant neuraminidases or compositions thereof.

Claims (21)

1 . A recombinant neuraminidase comprising

the amino acid sequence of SEQ ID NO: 56, 58, 27, 60, or 62.

2 . A recombinant neuraminidase comprising:

(a) an influenza virus neuraminidase globular head domain and a tetramerization domain, wherein the recombinant neuraminidase lacks an influenza virus neuraminidase stalk domain, transmembrane domain and cytoplasmic domain, wherein the tetramerization domain comprises a paramyxovirus phosphoprotein tetramerization domain, and wherein the paramyxovirus phosphoprotein tetramerization domain is a Sendai virus phosphoprotein tetramerization domain that comprises the amino acid sequence of SEQ ID NO: 2; or

(b) the amino acid sequence of SEQ ID NO: 25.

3 . The recombinant neuraminidase of claim 1 , wherein the recombinant neuraminidase comprises the amino acid sequence of SEQ ID NO: 27.

4 . The recombinant neuraminidase of claim 1 , wherein the recombinant neuraminidase comprises the amino acid sequence of SEQ ID NO: 56.

5 . The recombinant neuraminidase of claim 1 , wherein the recombinant neuraminidase comprises the amino acid sequence of SEQ ID NO: 58.

6 . The recombinant neuraminidase of claim 1 , wherein the recombinant neuraminidase comprises the amino acid sequence of SEQ ID NO: 60.

7 . A recombinant influenza virus comprising: (a) the recombinant neuraminidase of claim 1 ; and (b) a genome, wherein the genome comprises a gene segment comprising a nucleic acid sequence encoding the recombinant neuraminidase of claim 1 , such that the recombinant neuraminidase is expressed by a cell infected by the recombinant influenza virus.

8 . An immunogenic composition comprising the recombinant neuraminidase of claim 1 .

9 . The immunogenic composition of claim 8 , wherein the composition further comprises a trivalent inactivated influenza vaccine (TIV), quadrivalent inactivated influenza virus vaccine (QIV), or recombinant influenza virus vaccine.

10 . An immunogenic composition comprising the recombinant influenza virus of claim 7 .

11 . The recombinant neuraminidase of claim 1 , wherein the recombinant neuraminidase comprises the amino acid sequence of SEQ ID NO: 62.

12 . The recombinant neuraminidase of claim 1 , wherein the amino acid sequence of the recombinant neuraminidase consists of the amino acid sequence of SEQ ID NO: 56, 58, or 27.

13 . The recombinant neuraminidase of claim 1 , wherein the amino acid sequence of the recombinant neuraminidase consists of the amino acid sequence of SEQ ID NO: 60.

14 . The recombinant neuraminidase of claim 1 , wherein the amino acid sequence of the recombinant neuraminidase consists of the amino acid sequence of SEQ ID NO: 62.

15 . An immunogenic composition comprising the recombinant neuraminidase of claim 11 .

16 . An immunogenic composition comprising the recombinant neuraminidase of claim 12 .

17 . An immunogenic composition comprising the recombinant neuraminidase of claim 13 .

18 . An immunogenic composition comprising the recombinant neuraminidase of claim 14 .

Assignments (1)
LICENSE Recorded Aug 12, 2024
From: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
To: NATIONAL INSTITUTES OF HEALTH
Reel/Frame 068563/0352 →
Continuity (2)
Provisional Application 62924511 · Oct 22, 2019
Related Publication 20220403358A1 · Dec 22, 2022
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