IP Library › Granted Patent US 12,491,061
Granted Patent B2
US 12,491,061 · App. 17/383,958 · Granted Dec 9, 2025

Biomedical patches with aligned fibers

Inventors: Matthew R. MacEwan (St. Louis, MO); Jingwei Xie (Chesapeake, OH); Zack Ray (St. Louis, MO); Younan Xia (Atlanta, GA)
Assignee: Washington University
A61F2/02A61F2/0063A61F2/105A61L15/22A61L15/42A61L27/14A61L27/50B29C48/05B29C48/142D01D5/0076D01D5/0092D04H1/728D04H3/016D04H3/073C12M25/14
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Quick Facts
Patent No.
US 12,491,061
App. No.
17/383,958
Granted
Dec 9, 2025
Kind
B2
Abstract

A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

Claims (36)

1 . A fiber structure for repairing a void in a biological tissue, the fiber structure comprising a set of one or more inner point(s), a set of one or more inner area(s) extending from the one or more inner point(s) to a set of one or more inner perimeter(s), and a set of one or more outer area(s) extending from the one or more inner perimeter(s) to a set of one or more outer perimeter(s), wherein the one or more inner area(s) and the one or more outer area(s) at least partially overlap, the fiber structure comprising a first set of one or more substantially straight polymeric fiber sections extending from the inner point(s) to the inner perimeter(s), and a second set of one or more substantially straight polymeric fiber sections extending from the inner perimeter(s) to the outer perimeter(s),

wherein a spatial fiber density of the one or more inner area(s) is substantially the same as a spatial fiber density of the one or more outer area(s),

wherein each of the first set of one or more of substantially straight polymeric fiber sections and the second set of one or more of substantially straight polymeric fiber sections comprise one or more fiber sections generated by depositing via electrospinning a first polymer composition and one or more fiber sections generated by depositing via electrospinning a second polymer composition, and

wherein the first set of one or more substantially straight polymeric fiber sections transitions into a randomly oriented fiber section.

2 . The fiber structure of claim 1 , wherein the first polymer composition comprises glycolic acid.

3 . The fiber structure of claim 1 , wherein the first polymer composition comprises caprolactone, and wherein the second polymer composition comprises polyglycolic acid.

4 . The fiber structure of claim 1 , wherein the one or more inner area(s) further comprises a plurality of randomly oriented polymeric fiber sections.

5 . The fiber structure of claim 1 , wherein the one or more outer area(s) further comprises a plurality of randomly oriented polymeric fiber sections.

6 . The fiber structure of claim 1 , wherein the one or more inner area(s) further comprises a plurality of non-radially aligned polymeric fiber sections.

7 . The fiber structure of claim 1 , wherein the one or more outer area(s) further comprises a plurality of non-radially aligned polymeric fiber sections.

8 . The fiber structure of claim 1 , wherein the fiber structure comprises a single layer comprising the first set of one or more of substantially straight polymeric fiber sections, the second set of one or more of substantially straight polymeric fiber sections, and a plurality of non-radially aligned polymeric fiber sections.

9 . The fiber structure of claim 8 , wherein the plurality of non-radially aligned polymeric fiber sections comprises a plurality of randomly oriented polymeric fiber sections.

10 . The fiber structure of claim 1 , wherein the fiber structure comprises a first layer comprising the first set of one or more of substantially straight polymeric fiber sections and the second set of one or more of substantially straight polymeric fiber sections, the fiber structure further comprising a second layer comprising a plurality of non-radially aligned polymeric fiber sections.

11 . The fiber structure of claim 10 , wherein the plurality of non-radially aligned polymeric fiber sections comprises a plurality of randomly oriented polymeric fiber sections.

12 . The fiber structure of claim 10 wherein the first layer further comprises a plurality of randomly oriented polymeric fiber sections.

13 . The fiber structure of claim 1 , further comprising a surface pattern.

14 . The fiber structure of claim 13 , wherein the surface pattern comprises a plurality of depressions arranged in an ordered configuration.

15 . The fiber structure of claim 1 , wherein the first set of one or more of substantially straight polymeric sections and the second set of one or more of substantially straight polymeric fiber sections are degradable.

16 . The fiber structure of claim 1 , wherein the first set of one or more of substantially straight polymeric fiber sections and the second set of one or more of substantially straight polymeric fiber sections are configured to degrade within three months from application to tissue.

17 . A fiber structure for repairing a wound in a biological tissue, the fiber structure comprising a non-peripheral point, an inner area extending between the non-peripheral point and an inner perimeter, and an outer area extending between the inner perimeter and an outer perimeter, wherein the inner area and the outer area at least partially overlap, the fiber structure comprising a first set of one or more of substantially straight polymeric fiber segments extending between the non-peripheral point and the inner perimeter, and a second set of one or more of substantially straight polymeric fiber segments extending between the inner perimeter and the outer perimeter,

wherein the fiber structure comprises a substantially consistent spatial fiber density,

wherein each of the first set of one or more of substantially straight polymeric fiber segments and the second set of one or more of substantially straight polymeric fiber segments comprises a first set of fiber segments comprising a first polymer composition and a second set of fiber segments comprising a second polymer composition, and

wherein the first set of one or more substantially straight polymeric fiber sections transitions into a randomly oriented fiber section.

18 . The fiber structure of claim 17 , wherein the first polymer composition comprises glycolic acid.

19 . The fiber structure of claim 17 , wherein the first polymer composition comprises caprolactone, and wherein the second polymer composition comprises polyglycolic acid.

20 . The fiber structure of claim 17 , wherein the inner area further comprises a plurality of randomly oriented polymeric fiber segments.

21 . The fiber structure of claim 17 , wherein the outer area further comprises a plurality of randomly oriented polymeric fiber segments.

22 . The fiber structure of claim 17 , wherein the inner area further comprises a plurality of non-radially aligned polymeric fiber segments.

23 . The fiber structure of claim 17 , wherein the outer area further comprises a plurality of non-radially aligned polymeric fiber segments.

24 . The fiber structure of claim 17 , wherein the fiber structure comprises a single layer comprising the first set of one or more of substantially straight polymeric fiber segments, the second set of one or more of substantially straight polymeric fiber segments, and a plurality of non-radially aligned polymeric fiber segments.

25 . The fiber structure of claim 24 , wherein the plurality of non-radially aligned polymeric fiber segments comprises a plurality of randomly oriented polymeric fiber segments.

26 . The fiber structure of claim 17 , wherein the fiber structure comprises a first layer comprising the first set of one or more of substantially straight polymeric fiber segments and the second set of one or more of substantially straight polymeric fiber segments, the fiber structure further comprising a second layer comprising a plurality of non-radially aligned polymeric fiber segments.

27 . The fiber structure of claim 26 , wherein the plurality of non-radially aligned polymeric fiber segments comprises a plurality of randomly oriented polymeric fiber sections.

28 . The fiber structure of claim 26 , wherein the first layer further comprises a plurality of randomly oriented polymeric fiber sections.

29 . The fiber structure of claim 17 , wherein the first set of one or more of substantially straight polymeric fiber segments and the second set of one or more of substantially straight polymeric fiber segments are configured to degrade within three months from application to tissue.

30 . The fiber structure of claim 17 , further comprising a surface, the surface comprising a plurality of wells.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 6, 2023
From: WASHINGTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065789/0825 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2021
From: MACEWAN, MATTHEW; XIA, YOUNAN; XIE, JINGWEI; RAY, ZACK
To: WASHINGTON UNIVERSITY
Reel/Frame 057428/0441 →
Continuity (5)
Continuation 17229171 · Apr 13, 2021
Continuation 16130005 · Sep 13, 2018
Division 13703210
Provisional Application 61355712 · Jun 17, 2010
Related Publication 20220175510A1 · Jun 9, 2022
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