IP Library › Granted Patent US 12,329,783
Granted Patent B2
US 12,329,783 · App. 17/567,295 · Granted Jun 17, 2025

Method and system to improve the health of a person's skin microbiome

Inventor: Joseph E. Kovarik (Englewood, CO)
Assignee: Seed Health, Inc.
A61K35/74A61K31/58A61K31/715A61K38/1709A61K38/1758A61K2035/11
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Quick Facts
Patent No.
US 12,329,783
App. No.
17/567,295
Granted
Jun 17, 2025
Kind
B2
Abstract

Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. Certain embodiments include methods of treatment for acne and other skin disorders involving the use of probiotics, as well as the use of bacteria engineered via CRISPR systems for the treatment of specific skin disorders.

Claims (20)

1. A method of treating a skin disorder or condition in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a topical composition comprising a bacterial formulation comprising ammonia oxidizing bacteria selected from the group consisting of Nitrosomonas, Nitrosococcus, Nitrosospira , Nitrosocystis, Nitrosolobus , Nitrosovibrio and Propionibacterium bacteria, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual's skin; administering to the individual's skin a prebiotic that comprises a nutrient source for the ammonia oxidizing bacteria.

2. The method as set forth in claim 1 , wherein the region of the skin is the scalp.

3. The method as set forth in claim 1 , wherein the ammonia oxidizing bacteria is adapted to produce p53.

4. The method as set forth in claim 1 , further comprising administering to the skin an extract derived from a helminth selected from the group consisting of Capillaria hepatica, Dicrocoelium dendriticum, Ascaris lumbricoides, Enterobius vermicularis, Trichuris trichiura, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Haemonchus contortus , and Trichinella spiralis.

5. The method as set forth in claim 1 , wherein the bacterial formulation includes at least one arabinogalactan.

6. The method as set forth in claim 1 , wherein the bacterial formulation includes L. johnsonii.

7. The method as set forth in claim 1 , wherein the bacterial formulation comprises a topical lotion that further comprises a mixture of Lactobacillus johnsonii , and Bifidobacterium lognum bacteria.

8. The method as set forth in claim 1 , wherein the topical composition is administered to an individual's skin as a probiotic bacteriotherapy to treat skin diseases selected from the group consisting of eczema, atopic dermatitis, acne, allergic inflammation, and skin hypersensitivity.

9. The method as set forth in claim 1 , wherein the topical composition is administered to an individual's skin as a probiotic bacteriotherapy to treat UV-induced skin damage.

10. The method as set forth in claim 1 , wherein at least some bacteria in the bacterial formulation have been modified by using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system.

11. The method as set forth in claim 1 , wherein the topical composition further comprises a population of pre-selected bacteria comprising non-pathogenic bacteria.

12. The method as set forth in claim 1 , wherein the topical composition is administered to an individual's skin to establish a resident bacterial population on the individual's skin in order to enhance the overall health of the individual's skin.

13. The method as set forth in claim 1 , wherein the bacterial formulation further comprises UV protectant chemicals.

14. The method as set forth in claim 1 , wherein the bacterial formulation comprises proteins produced by said bacterial formulation.

15. The method as set forth in claim 1 , wherein the bacterial formulation enhances one of skin hydration, reduction of epidermal thickening, transepidermal water loss and protection of skin from harmful UV radiation.

16. The method as set forth in claim 1 , wherein the bacterial formulation further comprises a bifidobacterium strain.

17. The method as set forth in claim 1 , wherein the bacterial formulation further comprises one or more of Lactobacillus, Staphylococcus, Bifidobacterium , and Streptococcus.

18. A method of treating a skin disorder or condition in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a topical composition comprising a bacterial formulation comprising Nitrosomonas eutropha and Propionibacterium bacteria, said bacterial formulation including a bifidobacterium strain and UV protectant chemicals, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual's skin.

19. A method of treating a skin disorder or condition in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a topical composition comprising a bacterial formulation comprising Nitrosomonas eutropha and Propionibacterium bacteria, and administering a prebiotic that comprises a nutrient source in the bacterial formulation that is assimilated by the bacteria.

20. The method as set forth in claim 19 , wherein the bacterial formulation further includes Propionibacterium bacteria modified by using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to remove a virulence factor of at least some bacteria in the bacterial formulation.

Assignments (2)
SECURITY INTEREST Recorded Jul 21, 2026
From: SEED HEALTH, INC.
To: JPMORGAN CHASE BANK, N.A., AS LENDER
Reel/Frame 076028/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2022
From: KOVARIK, JOE
To: SEED HEALTH, INC.
Reel/Frame 059690/0210 →
Continuity (43)
Continuation In Part 17543992 · Dec 7, 2021
Continuation In Part 17337600 · Jun 3, 2021
Continuation In Part 17027953 · Sep 22, 2020
Continuation In Part 17023736 · Sep 17, 2020
Continuation In Part 17011175 · Sep 3, 2020
Continuation In Part 16917096 · Jun 30, 2020
Continuation In Part 16904056 · Jun 17, 2020
Continuation In Part 16884772 · May 27, 2020
Continuation In Part 16804361 · Feb 28, 2020
Continuation In Part 16782364 · Feb 5, 2020
Continuation In Part 16776861 · Jan 30, 2020
Continuation In Part 16722117 · Dec 20, 2019
Continuation In Part 16426346 · May 30, 2019
Continuation In Part 16423375 · May 28, 2019
Continuation In Part 16229252 · Dec 21, 2018
Continuation 16160336 · Oct 15, 2018
Continuation 16142171 · Sep 26, 2018
Continuation In Part 16037053 · Jul 17, 2018
Continuation In Part 16020433 · Jun 27, 2018
Continuation In Part 15983250 · May 18, 2018
Continuation 15639767 · Jun 30, 2017
Continuation In Part 15437976 · Feb 21, 2017
Continuation 15403823 · Jan 11, 2017
Continuation In Part 15395419 · Dec 30, 2016
Continuation In Part 15392173 · Dec 28, 2016
Continuation In Part 15384716 · Dec 20, 2016
Continuation In Part 15342642 · Nov 3, 2016
Continuation In Part 15270034 · Sep 20, 2016
Continuation In Part 15228454 · Aug 4, 2016
Continuation In Part 14954074 · Nov 30, 2015
Continuation In Part 14954074 · Nov 30, 2015
Continuation In Part 14752192 · Jun 26, 2015
Continuation In Part 14574517 · Dec 18, 2014
Provisional Application 62296186 · Feb 17, 2016
Provisional Application 62275341 · Jan 6, 2016
Provisional Application 62274550 · Jan 4, 2016
Provisional Application 62387405 · Dec 24, 2015
Provisional Application 62260906 · Nov 30, 2015
Provisional Application 62072476 · Oct 30, 2014
Provisional Application 62053926 · Sep 23, 2014
Provisional Application 62014855 · Jun 20, 2014
Provisional Application 61919297 · Dec 20, 2013
Related Publication 20220118031A1 · Apr 21, 2022
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