IP Library › Granted Patent US 12,485,094
Granted Patent B2
US 12,485,094 · App. 18/063,229 · Granted Dec 2, 2025

Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Inventors: Joan M. Fallon (White Plains, NY); Matthew Heil (Sherman, CT); James J. Fallon (Armonk, NY); Janice Hughes (Boulder, CO)
Assignee: CUREMARK, LLC
A61K9/1271A61K9/0029A61K9/025A61K38/465A61K38/47A61K38/48
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Quick Facts
Patent No.
US 12,485,094
App. No.
18/063,229
Granted
Dec 2, 2025
Kind
B2
Abstract

Methods for prophylaxis, treatment, and reduction of infection, re-infection, and transmission rates of Coronaviruses and more particularly Coronavirus Disease 2019 (COVID-19) resulting from a SARS-CoV-2 viral infection with the use of a pharmaceutical preparation comprising one or more coated or uncoated digestive enzymes, such as pancreatic enzymes and porcine pancreatic enzymes are described herein.

Claims (19)

1 . A method for reducing a transmission rate of a Severe Acute Respiratory Syndrome (SARS-CoV-2) infection in a subject in need thereof, comprising administering to the subject a pharmaceutical composition that comprises digestive enzymes, wherein the digestive enzymes comprise a protease, an amylase, and a lipase, wherein the digestive enzymes are provided as pancreatin, and wherein the transmission rate of the SARS-CoV-2 infection is reduced.

2 . The method of claim 1 , wherein the digestive enzymes are coated.

3 . The method of claim 1 , wherein the subject has COVID-19.

4 . The method of claim 1 , wherein the pharmaceutical composition comprises a buffer, an excipient, or a combination thereof.

5 . The method of claim 1 , wherein the pharmaceutical composition is a dosage formulation selected from the group consisting of a pill, a solution, a tablet, a capsule, a mini-tab, a sprinkle, and a combination thereof.

6 . The method of claim 1 , wherein a total amount of protease in the pharmaceutical composition ranges from about 10,000 to about 1,500,000 United States Pharmacopeia (U.S.P.) units/dose.

7 . The method of claim 1 , wherein a total amount of lipase in the pharmaceutical composition ranges from about 1,500 to about 282,000 U.S.P. units/dose.

8 . The method of claim 1 , wherein a total amount of amylase in the pharmaceutical composition ranges from about 1,000 to about 15,000,000 U.S.P. units/dose.

9 . The method of claim 2 , wherein digestive enzymes comprise coated digestive enzyme particles, and wherein the coated digestive enzyme particles comprise (i) a core comprising the digestive enzymes and (ii) a coating.

10 . The method of claim 2 , wherein the digestive enzymes are coated with a lipid.

11 . The method of claim 10 , wherein the lipid comprises a pharmaceutical grade lipid or a food grade lipid.

12 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of from about 5% to about 99% by weight.

13 . The method of claim 9 , wherein the digestive enzymes are coated with a lipid.

14 . The method of claim 13 , wherein the lipid comprises a pharmaceutical grade lipid or a food grade lipid.

15 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of from about 70% to about 90% by weight.

16 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of about 75% by weight.

17 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of about 80% by weight.

18 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of about 85% by weight.

19 . The method of claim 9 , wherein the digestive enzymes are present in the coated digestive enzyme particles in an amount of about 90% by weight.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2022
From: FALLON, JOAN M.; HEIL, MATTHEW; FALLON, JAMES J.; HUGHES, JANICE
To: CUREMARK, LLC
Reel/Frame 062031/0141 →
Continuity (3)
Continuation 17410743 · Aug 24, 2021
Provisional Application 63076500 · Sep 10, 2020
Related Publication 20230111947A1 · Apr 13, 2023
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