IP Library › Granted Patent US 12,364,501
Granted Patent B2
US 12,364,501 · App. 18/235,904 · Granted Jul 22, 2025

Ultrasound transducer and uses thereof

Inventors: Ariel Sverdlik (Tel-Aviv, IL); Or Shabtay (Kibbutz Farod, IL)
Assignee: Sonivie Ltd.
A61B17/320068A61B17/2202A61M37/0092A61N7/02A61N7/022A61B2017/00106A61B2017/22008A61B2017/22051A61B2017/22081A61B2090/378A61N2007/0078
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Quick Facts
Patent No.
US 12,364,501
App. No.
18/235,904
Granted
Jul 22, 2025
Kind
B2
Abstract

According to some embodiments there is provided a method for controlling a treatment effect on blood vessel tissue during an ultrasonic treatment, the method comprising positioning an ultrasonic transducer device in the blood vessel lumen; controlling a treatment effect by controlling fluid flow, wherein controlling comprises deploying a fluid restrictor at a location relative to the transducer effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. According to some embodiments there is provided an ultrasonic transducer device sized for placement in a body lumen, and comprising a fluid restrictor effective to block at least a portion of fluid flowing upstream, downstream or adjacent the transducer. In some embodiments, the fluid is blood.

Claims (34)

1. A method for online testing of efficiency or treatment efficacy of an ultrasound transducer to detect changes in said efficiency while said ultrasound transducer is positioned within a liquid filled body lumen during a treatment of tissue, said method comprising:

applying an electrical impulse to said ultrasound transducer;

measuring an electrical response of said ultrasound transducer to said electrical impulse;

inferring changes in said efficiency of said ultrasound transducer or changes in an efficacy of a treatment provided by said ultrasound transducer from said measured electrical response; and

modifying an operation of said transducer during said treatment based on the results of said inferring.

2. The method of claim 1 , wherein said applying comprises applying said electrical impulse while said transducer is positioned within a blood filled blood vessel.

3. The method of claim 1 , wherein said ultrasound transducer is positioned on a catheter for said treatment of tissue by emitting ultrasonic waves from said ultrasound transducer.

4. The method of claim 3 , wherein said emitted ultrasonic waves are focused ultrasonic waves.

5. The method of claim 3 , wherein said emitted ultrasonic waves are unfocused ultrasonic waves.

6. The method of claim 3 , comprising positioning said catheter inside a blood vessel or blood cavity, prior to said applying.

7. The method of claim 3 , comprising positioning said catheter inside said body lumen filled with said liquid, prior to said applying.

8. The method of claim 1 , wherein said efficiency is a ratio between ultrasound energy and heat generated in said transducer.

9. The method of claim 1 , wherein said inferring said changes in efficiency comprises inferring said changes in efficiency from at least one member of the group comprising: a shape of said measured electrical response; an envelope of said measured electrical response, a duration of said measured electrical response, and a damping factor of said measured electrical response.

10. The method of claim 1 , wherein said inferring said changes in efficiency comprises inferring said changes in efficiency from amplitudes of said measured electrical response.

11. The method of claim 1 , wherein said transducer has a resonance and an anti-resonance and wherein said inferring comprises inferring from a change in at least one of said resonance and said anti-resonance.

12. The method of claim 1 , wherein said measuring comprises measuring an impedance of said transducer at a current working frequency, and wherein said inferring comprises inferring said changes in said efficiency from changes in said measured impedance.

13. The method of claim 1 , comprising:

placing said transducer in said body lumen and in a flow of said liquid;

wherein said measuring comprises measuring temperature of said flowing liquid, and wherein said inferring comprises inferring a decrease in said efficiency or a change in said efficacy from an increase in said measured temperature.

14. The method of claim 13 , wherein said measuring temperature comprises measuring temperature of said flowing liquid downstream of said transducer.

15. The method of claim 1 , comprising placing said ultrasound transducer in a body lumen at a distance from a lumen wall and in a liquid flow, wherein said measuring comprises measuring liquid flow between the device and the wall, and wherein said inferring comprises inferring said changes in said efficiency or said efficacy based on changes in said flow measurements.

16. The method of claim 1 , wherein said inferring comprises inferring a danger of overheating from said measured electrical response.

17. The method of claim 1 , wherein said modifying comprises stopping the activity of said transducer based on the results of said inferring.

18. The method of claim 1 , wherein said modifying comprises changing an applied duty cycle when activating said transducer based on the results of said inferring.

19. The method of claim 1 , wherein said modifying comprises changing working power when activating said transducer based on the results of said inferring.

20. The method of claim 1 , wherein said modifying comprises modifying the working frequency of said transducer based on the results of said inferring.

21. The method of claim 1 , comprising repeating said applying, said measuring and said inferring during said treatment.

22. The method of claim 1 , wherein said modifying comprises introducing a delay during said method for online testing.

23. The method of claim 1 , comprising providing an indication based on said inferred changes.

24. The method of claim 1 , wherein said treatment of tissue comprises heating the tissue of said body lumen using ultrasonic waves generated by said ultrasound transducer and cooling the tissue by said liquid in said body lumen.

25. The method of claim 1 , wherein said measuring comprises measuring an impedance of said ultrasound transducer in response to said applied electrical impulse, and wherein said inferring comprises inferring changes in an efficiency of said ultrasound transducer from said measured changes in said impedance, and inferring changes in said treatment efficacy from said inferred changes in efficiency.

26. The method of claim 1 , wherein said inferring comprises inferring changes in an efficiency of said ultrasound transducer from said measured changes in said electrical response, and inferring changes in said treatment efficacy from said inferred changes in efficiency.

27. The method of claim 26 , wherein said modifying comprises modifying an operation of said transducer during said treatment to control said treatment efficacy based on the results of said inferring.

28. The method of claim 1 , wherein said measuring comprises measuring changes in said electrical response of said ultrasound transducer to said electrical impulse.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 30, 2023
From: CARDIOSONIC LTD.
To: SONIVIE LTD.
Reel/Frame 064747/0570 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2023
From: SVERDLIK, ARIEL; SHABTAY, OR
To: CARDIOSONIC LTD.
Reel/Frame 064728/0975 →
Continuity (5)
Continuation 16451087 · Jun 25, 2019
Continuation 14190113 · Feb 26, 2014
Division 13049013 · Mar 16, 2011
Provisional Application 61393947 · Oct 18, 2010
Related Publication 20230389954A1 · Dec 7, 2023
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