IP Library › Granted Patent US 12,291,778
Granted Patent B2
US 12,291,778 · App. 18/743,370 · Granted May 6, 2025

Liquid chromatography system and component

Inventor: Gary A. Barone (State College, PA)
Assignee: Silcotek Corp.
C23C16/45523C23C16/24C23C16/045
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Quick Facts
Patent No.
US 12,291,778
App. No.
18/743,370
Granted
May 6, 2025
Kind
B2
Abstract

Liquid chromatography systems and liquid chromatography components are disclosed. In an embodiment, a liquid chromatography system includes a liquid chromatography component. The liquid chromatography component includes a substrate and an amorphous coating on the substrate. The amorphous coating has a base layer and a surface layer. The base layer includes carboxysilane.

Claims (24)

1. A tube, comprising:

a substrate; and

an amorphous coating on the substrate;

wherein the amorphous coating includes silicon;

wherein the amorphous coating is devoid of particles of silicon dust formed from gas phase nucleation that are greater than 3 micrometers.

2. The tube of claim 1 , wherein the amorphous coating has an interior deposition thickness of greater than 100 nm.

3. The tube of claim 1 , wherein the amorphous coating has an interior deposition thickness of greater than 1,000 nm.

4. The tube of claim 1 , wherein the amorphous coating is chemically and physically adsorbed to the substrate.

5. The tube of claim 1 , wherein the tubing is ¼-inch-tubing.

6. The tube of claim 1 , wherein the amorphous coating is on the inside and the outside.

7. The tube of claim 1 , wherein the amorphous coating is on the inside and not the outside.

8. The tube of claim 1 , wherein the amorphous coating is on the outside and not the inside.

9. The tube of claim 1 , wherein the amorphous coating has homogenous nucleation.

10. The tube of claim 1 , wherein the amorphous coating has uniform color after the beginning of the tube.

11. The tube of claim 1 , wherein the tube is a portion of a component.

12. The component of claim 11 , comprising the tube and further comprising a block end.

13. The component of claim 12 , wherein the block end is coated.

14. The component of claim 11 , comprising the tube and further comprising bellows.

15. The bellows of claim 14 , wherein the bellows are coated.

16. The component of claim 11 , comprising the tube and further comprising bellows and a block end.

17. The component of claim 16 , wherein the bellows and the block end are coated.

18. A component comprising the tube of claim 1 , further comprising a needle connected to the tube.

19. A component comprising the tube of claim 1 , further comprising an aperture connected to the tube.

20. A component comprising the tube of claim 1 , further comprising another coating barrier.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2024
From: BARONE, GARY A.
To: SILCOTEK CORP
Reel/Frame 067730/0784 →
Continuity (5)
Continuation 17411545 · Aug 25, 2021
Continuation 16870034 · May 8, 2020
Continuation 15755962
Provisional Application 62212868 · Sep 1, 2015
Related Publication 20240327981A1 · Oct 3, 2024
References Cited (150)
US 4173661A · Bourdon · 1979 [cited by applicant]
US 4402997A · Hogan et al. · 1983 [cited by applicant]
US 4560589A · Endou et al. · 1985 [cited by applicant]
US 4579752A · Dubois et al. · 1986 [cited by applicant]
US 4671997A · Galasso et al. · 1987 [cited by applicant]
US 4684542A · Jasinski et al. · 1987 [cited by applicant]
US 4714632A · Cabrera et al. · 1987 [cited by applicant]
US 4720395A · Foster · 1988 [cited by applicant]
US 4741964A · Haller · 1988 [cited by applicant]
US 4749631A · Haluska et al. · 1988 [cited by applicant]
US 4753856A · Haluska et al. · 1988 [cited by applicant]
US 4792460A · Chu et al. · 1988 [cited by applicant]
US 4842888A · Haluska et al. · 1989 [cited by applicant]
US 4956204A · Amazawa et al. · 1990 [cited by applicant]
US 5128515A · Tanaka · 1992 [cited by applicant]
US 5141567A · Tahara · 1992 [cited by applicant]
US 5160544A · Garg et al. · 1992 [cited by applicant]
US 5208069A · Clark et al. · 1993 [cited by applicant]
US 5249554A · Tamor et al. · 1993 [cited by applicant]
US 5250451A · Chouan · 1993 [cited by applicant]
US 5270082A · Lin et al. · 1993 [cited by applicant]
US 5299731A · Liyanage et al. · 1994 [cited by applicant]
US 5413813A · Cruse et al. · 1995 [cited by applicant]
US 5474613A · Pickering et al. · 1995 [cited by applicant]
US 5480677A · Li et al. · 1996 [cited by applicant]
US 5481135A · Chandra et al. · 1996 [cited by applicant]
US 5510146A · Miyasaki · 1996 [cited by applicant]
US 5562952A · Nakahigashi et al. · 1996 [cited by applicant]
US 5563102A · Michael · 1996 [cited by applicant]
US 5756404A · Friedenreich et al. · 1998 [cited by applicant]
US 5818071A · Loboda et al. · 1998 [cited by applicant]
US 5825078A · Michael · 1998 [cited by applicant]
US 5874368A · Laxman et al. · 1999 [cited by applicant]
US 5939333A · Hurley et al. · 1999 [cited by applicant]
US 5981403A · Ma et al. · 1999 [cited by applicant]
US 5994675A · Bethune et al. · 1999 [cited by applicant]
US 5997742A · Gjerde et al. · 1999 [cited by applicant]
US 6157003A · Drimer · 2000 [cited by applicant]
US 6159871A · Loboda et al. · 2000 [cited by applicant]
US 6312808B1 · Veerasamy et al. · 2001 [cited by applicant]
US 6319556B1 · Olsen et al. · 2001 [cited by applicant]
US 6337459B1 · Terwijn et al. · 2002 [cited by applicant]
US 6416577B1 · Suntoloa et al. · 2002 [cited by applicant]
US 6416816B2 · Veerasamy et al. · 2002 [cited by applicant]
US 6444268B2 · Lefcowitz et al. · 2002 [cited by applicant]
US 6444326B1 · Smith · 2002 [cited by examiner]
US 6472076B1 · Hacker · 2002 [cited by applicant]
US 6511760B1 · Barone et al. · 2003 [cited by applicant]
US 6531182B2 · Veerasamy et al. · 2003 [cited by applicant]
US 6531398B1 · Gaillard et al. · 2003 [cited by applicant]
US 6531415B1 · Yang et al. · 2003 [cited by applicant]
US 6566281B1 · Buchanan et al. · 2003 [cited by applicant]
US 6592993B2 · Veerasamy et al. · 2003 [cited by applicant]
US 6593655B1 · Loboda et al. · 2003 [cited by applicant]
US 6630413B2 · Todd · 2003 [cited by applicant]
US 6765178B2 · Shang et al. · 2004 [cited by applicant]
US 6998579B2 · Inagawa et al. · 2006 [cited by applicant]
US 7022948B2 · Shang et al. · 2006 [cited by applicant]
US 7070833B2 · Smith et al. · 2006 [cited by applicant]
US 7192626B2 · Dussarrat et al. · 2007 [cited by applicant]
US 7429717B2 · Yudovsky · 2008 [cited by applicant]
US 7510935B2 · Lee et al. · 2009 [cited by applicant]
US 7860379B2 · Hunter et al. · 2010 [cited by applicant]
US 7867627B2 · Smith et al. · 2011 [cited by applicant]
US 7875556B2 · Xiao et al. · 2011 [cited by applicant]
US 8092770B2 · Betz et al. · 2012 [cited by applicant]
US 8286571B2 · Driver et al. · 2012 [cited by applicant]
US 8357430B2 · Dussarrat et al. · 2013 [cited by applicant]
US D689107S · Grove · 2013 [cited by applicant]
US 8552346B2 · Ambal et al. · 2013 [cited by applicant]
US 8563445B2 · Liang et al. · 2013 [cited by applicant]
US D713024S · Grove et al. · 2014 [cited by applicant]
US 8822018B2 · Thoumazet et al. · 2014 [cited by applicant]
US 8980382B2 · Ingle et al. · 2015 [cited by applicant]
US 9296616B2 · Hertlein · 2016 [cited by examiner]
US 9340880B2 · Mattzela · 2016 [cited by applicant]
US 9777368B2 · Smith et al. · 2017 [cited by applicant]
US 9915001B2 · Yuan et al. · 2018 [cited by applicant]
US 9975143B2 · Smith et al. · 2018 [cited by applicant]
US 10087521B2 · Yuan et al. · 2018 [cited by applicant]
US 10316408B2 · Smith et al. · 2019 [cited by applicant]
US 10323321B1 · Yuan et al. · 2019 [cited by applicant]
US 10487402B2 · Yuan et al. · 2019 [cited by applicant]
US 10487403B2 · Smith · 2019 [cited by applicant]
US 10604660B2 · Smith et al. · 2020 [cited by applicant]
US 10767429B2 · McGuire · 2020 [cited by examiner]
US 10876206B2 · Vezza · 2020 [cited by examiner]
US 11131020B2 · Barone · 2021 [cited by examiner]
US 11261524B2 · Vezza · 2022 [cited by examiner]
US 11807777B2 · Smith · 2023 [cited by examiner]
US 12037685B2 · Barone · 2024 [cited by examiner]
US 20010049203A1 · Kim et al. · 2001 [cited by applicant]
US 20010055672A1 · Todd · 2001 [cited by applicant]
US 20020045009A1 · Tobaski et al. · 2002 [cited by applicant]
US 20030152701A1 · Kang et al. · 2003 [cited by applicant]
US 20030186000A1 · Li et al. · 2003 [cited by applicant]
US 20040037956A1 · Yang · 2004 [cited by applicant]
US 20040175579A1 · Smith et al. · 2004 [cited by applicant]
US 20050064684A1 · Todd et al. · 2005 [cited by applicant]
US 20050100670A1 · Dussarrat et al. · 2005 [cited by applicant]
US 20050183663A1 · Cheng et al. · 2005 [cited by applicant]
US 20050271893A1 · Kobrin et al. · 2005 [cited by applicant]
US 20060216952A1 · Bhanap et al. · 2006 [cited by applicant]
US 20070042118A1 · Yoo · 2007 [cited by applicant]
US 20070243317A1 · DuBois et al. · 2007 [cited by applicant]
US 20070281448A1 · Chen et al. · 2007 [cited by applicant]
US 20090078202A1 · Strikovski et al. · 2009 [cited by applicant]
US 20090173146A1 · Pursch · 2009 [cited by applicant]
US 20090230558A1 · Matsuoka · 2009 [cited by applicant]
US 20100248496A1 · Wei et al. · 2010 [cited by applicant]
US 20110259879A1 · Hanawa et al. · 2011 [cited by applicant]
US 20110305784A1 · Lee · 2011 [cited by applicant]
US 20120045954A1 · Bleecher et al. · 2012 [cited by applicant]
US 20120219727A1 · Gandhiraman et al. · 2012 [cited by applicant]
US 20120251797A1 · Smith et al. · 2012 [cited by applicant]
US 20130244025A1 · Smith et al. · 2013 [cited by applicant]
US 20140256156A1 · Harada et al. · 2014 [cited by applicant]
US 20140357091A1 · Mattzela · 2014 [cited by applicant]
US 20140370300A1 · Smith · 2014 [cited by applicant]
US 20150024152A1 · Carr et al. · 2015 [cited by applicant]
US 20150030885A1 · Smith · 2015 [cited by applicant]
US 20150206795A1 · Hasebe et al. · 2015 [cited by applicant]
US 20150283307A1 · Smith et al. · 2015 [cited by applicant]
US 20150371991A1 · Nobuto · 2015 [cited by applicant]
US 20160049309A1 · Tapily et al. · 2016 [cited by applicant]
US 20160354758A1 · Gorecki et al. · 2016 [cited by applicant]
US 20170167016A1 · Oh · 2017 [cited by examiner]
US 20180318742A1 · Bevis · 2018 [cited by applicant]
US 20190003044A1 · Yuan · 2019 [cited by applicant]
US 20190086371A1 · Lauber et al. · 2019 [cited by applicant]
CN 100347834 · 2007 [cited by applicant]
CN 104294236A · 2015 [cited by applicant]
DE 2523257 · 1976 [cited by applicant]
DE 2829568 · 1980 [cited by applicant]
EP 0911307A1 · 1999 [cited by applicant]
EP 1150345A2 · 2001 [cited by applicant]
EP 0996767B1 · 2003 [cited by applicant]
EP 1790757A1 · 2007 [cited by applicant]
EP 1988190A2 · 2008 [cited by applicant]
GB 2395492A · 2004 [cited by applicant]
JP 2012138627A · 2012 [cited by applicant]
JP 2013227628A · 2013 [cited by applicant]
WO 9902757A1 · 1999 [cited by applicant]
WO 0136190A1 · 2001 [cited by applicant]
WO 2009032488A1 · 2009 [cited by applicant]
WO 2009143618A1 · 2009 [cited by applicant]
WO 2010125926A1 · 2010 [cited by applicant]
WO 2010079299A1 · 2010 [cited by applicant]
WO 2011056550A1 · 2011 [cited by applicant]
WO 2012047945A2 · 2012 [cited by applicant]