Absorbable adhesives and their formulation for use in medical applications
Described are medical products including an adhesive containing a polypeptide component such as gelatin and a tackiness-providing polyhydroxy compound, such as at least one compound selected from the group consisting of glycerin and fructose. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Other medical applications utilizing a medical product of the invention include tissue repair and pharmaceutical delivery to a desired location. Related methods of manufacture and use are also described.
1. A medical product, comprising:
a medical graft material; and
a dried, reversible adhesive coating on at least a portion of a surface of said material, wherein said adhesive coating comprises a mixture of gelatin and fructose, wherein said fructose is present in the adhesive coating in an amount greater than that of said gelatin by dry weight ratio and in an amount of 1 to 10 mg/cm 2 , wherein said adhesive coating has a dry weight ratio of gelatin to fructose of 30:70 to 50:50, wherein said adhesive coating comprises a layer present at a level of 2 mg/cm 2 to 100 mg/cm 2 ; and wherein said reversible adhesive coating is suitable when wetted to attach said medical graft material to a surgical device while allowing for the release of the medical graft material from the surgical device upon implantation.
2. The medical product of claim 1 , wherein said reversible adhesive coating is non-tacky when dried, and wherein said reversible adhesive coating becomes tacky when moistened.
3. The medical product of claim 1 , wherein said medical graft material is comprised of a biological material.
4. The medical product of claim 3 , wherein said medical graft material is remodelable.
5. The medical product of claim 4 , wherein said medical graft material comprises an extracellular matrix (ECM) material.
6. The medical product of claim 5 , wherein said ECM comprises submucosa.
7. The medical product of claim 6 , wherein said submucosa is intestinal, urinary bladder or stomach submucosa.
8. The medical product of claim 7 , wherein said submucosa is small intestinal submucosa (SIS).
9. The medical product of claim 1 , wherein said medical product is useful as a bolster material.
10. The medical product of claim 9 , wherein said bolster material is configured for application to an arm of a surgical fastening device.
11. The medical product of claim 1 , wherein said medical product is useful as a hernia repair graft.
12. The medical product of claim 1 , wherein said adhesive is dried to form a porous open-cell foam.
13. The medical product of claim 1 , wherein said adhesive further comprises a bioactive component and/or pharmaceutical agent.
14. The medical product of claim 1 , wherein said adhesive is coated onto a substantial portion of the medical material.
15. The medical product of claim 1 , wherein said adhesive is air dried.
16. The medical product of claim 1 , wherein said adhesive is vacuum dried.
17. A medical product for use with a surgical device, said medical product comprising:
a layer of dried, collagenous extracellular matrix material; and
a dried, reversible adhesive coating on at least a portion of a surface of said layer, wherein said adhesive comprises a mixture of gelatin and fructose, wherein said mixture contains a greater amount of fructose than gelatin on a dry weight basis, wherein said adhesive coating has a dry weight ratio of gelatin to fructose of 30:70 to 50:50, and wherein said reversible adhesive coating is suitable when wetted to attach said medical graft material to the surgical device while allowing for the release of the medical graft material from the surgical device upon implantation.
18. The medical product of claim 17 , wherein said layer and said coating are lyophilized.
19. The medical product of claim 17 , wherein said layer comprises submucosa of a warm-blooded vertebrate.
20. The medical product of claim 19 , wherein said layer comprises small intestinal submucosa.
21. The medical product of claim 17 , wherein said adhesive is air dried.
22. The medical product of claim 17 , wherein said adhesive is vacuum dried.
23. A bolster material, comprising:
bolster material configured for application to an arm of a surgical fastening device; and
a dried, reversible adhesive coating on at least a portion of a surface of said bolster material, wherein said adhesive comprises a mixture of gelatin and fructose, and wherein said gelatin is present in the adhesive in an amount of 1 to 5 mg/cm 2 , wherein said fructose is present in the adhesive in an amount greater than that of said gelatin by dry weight, wherein said adhesive comprises at least 30% but less than 50% gelatin on a dry weight basis, and wherein said reversible adhesive coating is suitable when wetted to attach said bolster material to the arm of the surgical fastening device while allowing for the release of the bolster material from the arm of the surgical fastening device upon implantation.
24. The bolster material of claim 23 , wherein said adhesive coating has a dry weight ratio of gelatin to fructose of 30:70 to 50:50.