IP Library › Granted Patent US 12,264,189
Granted Patent B2
US 12,264,189 · App. 17/287,164 · Granted Apr 1, 2025

Methods and materials for treating cancer

Inventors: Saad J. Kenderian (Rochester, MN); Stephen James Russell (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
C07K14/70503A61K39/4611A61K39/4631A61K39/464412A61P35/00C07K16/2809C12N7/00A61K38/00A61K2239/48
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,264,189
App. No.
17/287,164
Granted
Apr 1, 2025
Kind
B2
Abstract

This document provides methods and materials for generating T cells expressing a selected antigen receptor (e.g., a chimeric antigen receptor) in vivo. For example, viral particles containing nucleic acid encoding a selected antigen receptor, cells capable of producing such viral particles, and methods for administering such viral particles and/or cells to a mammal to generate T cells expressing that selected antigen receptor within the mammal are provided.

Claims (10)

1. A method for generating T cells expressing a selected antigen receptor in vivo within a mammal, wherein said method comprises administering a viral particle to said mammal, wherein said viral particle comprises (a) nucleic acid encoding said selected antigen receptor and (b) an exogenous polypeptide capable of being encoded by SEQ ID NO:2, wherein said viral particle infects T cells comprising an endogenous T cell receptor within said mammal to form infected T cells, and wherein said infected T cells express said selected antigen receptor and said endogenous T cell receptor.

2. The method of claim 1 , wherein said mammal is a human.

3. The method of claim 1 , wherein said viral particle is a lentiviral particle.

4. The method of claim 1 , wherein said selected antigen receptor is a chimeric antigen receptor.

5. The method of claim 1 , wherein said viral particle selected antigen receptor can target one or more cancer cells.

6. The method of claim 5 , wherein said one or more cancer cells express a tumor-specific antigen.

7. The method of claim 6 , wherein said selected antigen receptor targets said tumor-specific antigen.

8. The method of claim 6 , wherein said tumor-specific antigen is CD19.

9. The method of claim 8 , wherein said selected antigen receptor targeting said tumor-specific antigen is a CAR targeting CD19.

10. The method of claim 1 , wherein said administration is intravenous injection or intratumoral injection.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2022
From: KENDERIAN, SAAD J.; RUSSELL, STEPHEN JAMES
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 058826/0567 →
Continuity (2)
Provisional Application 62753732 · Oct 31, 2018
Related Publication 20210355190A1 · Nov 18, 2021
References Cited (400)
US 3687808A · Merigan, Jr. et al. · 1972 [cited by applicant]
US 4034074A · Miles · 1977 [cited by applicant]
US 4036945A · Haber · 1977 [cited by applicant]
US 4098876A · Piasio et al. · 1978 [cited by applicant]
US 4233402A · Maggio et al. · 1980 [cited by applicant]
US 4257774A · Richardson et al. · 1981 [cited by applicant]
US 4272398A · Jaffe · 1981 [cited by applicant]
US 4331647A · Goldenberg · 1982 [cited by applicant]
US 4376110A · David et al. · 1983 [cited by applicant]
US 4469863A · Ts'o et al. · 1984 [cited by applicant]
US 4650764A · Temin et al. · 1987 [cited by applicant]
US 4769330A · Paoletti et al. · 1988 [cited by applicant]
US 4816567A · Cabilly et al. · 1989 [cited by applicant]
US 4861627A · Mathiowitz et al. · 1989 [cited by applicant]
US 4861719A · Miller · 1989 [cited by applicant]
US 4925673A · Steiner et al. · 1990 [cited by applicant]
US 4935496A · Kudo · 1990 [cited by applicant]
US 4946778A · Ladner et al. · 1990 [cited by applicant]
US 4980289A · Temin et al. · 1990 [cited by applicant]
US 4987071A · Cech et al. · 1991 [cited by applicant]
US 5013556A · Woodle et al. · 1991 [cited by applicant]
US 5124263A · Temin et al. · 1992 [cited by applicant]
US 5155020A · Paoletti · 1992 [cited by applicant]
US 5155027A · Sledziewski et al. · 1992 [cited by applicant]
US 5175099A · Wills · 1992 [cited by applicant]
US 5204243A · Paoletti · 1993 [cited by applicant]
US 5214136A · Lin et al. · 1993 [cited by applicant]
US 5218105A · Cook et al. · 1993 [cited by applicant]
US 5225336A · Paoletti · 1993 [cited by applicant]
US 5225538A · Capon et al. · 1993 [cited by applicant]
US 5235033A · Summerton et al. · 1993 [cited by applicant]
US 5240846A · Collins et al. · 1993 [cited by applicant]
US 5254678A · Haseloff et al. · 1993 [cited by applicant]
US 5278056A · Bank et al. · 1994 [cited by applicant]
US 5284656A · Platz et al. · 1994 [cited by applicant]
US 5296347A · LaMotte, III · 1994 [cited by applicant]
US 5391682A · Ogawa et al. · 1995 [cited by applicant]
US 5451569A · Wong et al. · 1995 [cited by applicant]
US 5502167A · Waldmann et al. · 1996 [cited by applicant]
US 5521288A · Linsley et al. · 1996 [cited by applicant]
US 5530101A · Queen et al. · 1996 [cited by applicant]
US 5558864A · Bendig et al. · 1996 [cited by applicant]
US 5565332A · Hoogenboom et al. · 1996 [cited by applicant]
US 5567584A · Sledziewski et al. · 1996 [cited by applicant]
US 5585089A · Queen et al. · 1996 [cited by applicant]
US 5596086A · Matteucci et al. · 1997 [cited by applicant]
US 5639641A · Pedersen et al. · 1997 [cited by applicant]
US 5674704A · Goodwin et al. · 1997 [cited by applicant]
US 5675848A · Kappel · 1997 [cited by applicant]
US 5693493A · Robinson et al. · 1997 [cited by applicant]
US 5693761A · Queen et al. · 1997 [cited by applicant]
US 5693762A · Queen et al. · 1997 [cited by applicant]
US 5698417A · Robinson et al. · 1997 [cited by applicant]
US 5705154A · Dalie et al. · 1998 [cited by applicant]
US 5714147A · Capon et al. · 1998 [cited by applicant]
US 5733743A · Johnson et al. · 1998 [cited by applicant]
US 5750078A · Shitara et al. · 1998 [cited by applicant]
US 5750375A · Sledziewski et al. · 1998 [cited by applicant]
US 5750666A · Caruthers et al. · 1998 [cited by applicant]
US 5770403A · Dalie et al. · 1998 [cited by applicant]
US 5843725A · Sledziewski et al. · 1998 [cited by applicant]
US 5861310A · Freeman et al. · 1999 [cited by applicant]
US 5874240A · Ni et al. · 1999 [cited by applicant]
US 5928893A · Kang et al. · 1999 [cited by applicant]
US 5942607A · Freeman et al. · 1999 [cited by applicant]
US 6018026A · Sledziewski et al. · 2000 [cited by applicant]
US 6210669B1 · Aruffo et al. · 2001 [cited by applicant]
US 6291212B1 · Sledziewski et al. · 2001 [cited by applicant]
US 6291646B1 · Sledziewski · 2001 [cited by applicant]
US 6297008B1 · Okamoto et al. · 2001 [cited by applicant]
US 6300099B1 · Sledziewski et al. · 2001 [cited by applicant]
US 6303121B1 · Kwon · 2001 [cited by applicant]
US 6323323B1 · Sledziewski et al. · 2001 [cited by applicant]
US 6355779B1 · Goodwin et al. · 2002 [cited by applicant]
US 6423885B1 · Waterhouse et al. · 2002 [cited by applicant]
US 6458934B1 · Hong et al. · 2002 [cited by applicant]
US 6630575B2 · Coyle et al. · 2003 [cited by applicant]
US 6635750B1 · Coyle et al. · 2003 [cited by applicant]
US 6740493B1 · Long et al. · 2004 [cited by applicant]
US 6743619B1 · Tang et al. · 2004 [cited by applicant]
US 6803192B1 · Chen · 2004 [cited by applicant]
US 6891030B2 · Chen · 2005 [cited by applicant]
US 6919193B2 · Tang et al. · 2005 [cited by applicant]
US 6943150B1 · Altieri · 2005 [cited by applicant]
US 6965018B2 · Mikesell et al. · 2005 [cited by applicant]
US 7029674B2 · Carreno et al. · 2006 [cited by applicant]
US 7030219B2 · Pardoll et al. · 2006 [cited by applicant]
US 7122351B2 · Moore et al. · 2006 [cited by applicant]
US 7279567B2 · Mikesell et al. · 2007 [cited by applicant]
US 7358354B2 · Mikesell et al. · 2008 [cited by applicant]
US 7368531B2 · Rosen et al. · 2008 [cited by applicant]
US 7381794B2 · Moore et al. · 2008 [cited by applicant]
US 7414122B2 · Fox et al. · 2008 [cited by applicant]
US 7432059B2 · Freeman et al. · 2008 [cited by applicant]
US 7432062B2 · Coyle · 2008 [cited by applicant]
US 7432351B1 · Chen · 2008 [cited by applicant]
US 7449300B2 · Chen et al. · 2008 [cited by applicant]
US 7560540B2 · Pardoll et al. · 2009 [cited by applicant]
US 7563869B2 · Honjo et al. · 2009 [cited by applicant]
US 7582439B2 · Cory et al. · 2009 [cited by applicant]
US 7595048B2 · Honjo et al. · 2009 [cited by applicant]
US 7651686B2 · Chen et al. · 2010 [cited by applicant]
US 7709214B2 · Freeman et al. · 2010 [cited by applicant]
US 7723479B2 · Mikesell et al. · 2010 [cited by applicant]
US 7794710B2 · Chen et al. · 2010 [cited by applicant]
US 7892540B2 · Chen et al. · 2011 [cited by applicant]
US 8008449B2 · Korman et al. · 2011 [cited by applicant]
US 8039589B1 · Chen · 2011 [cited by applicant]
US 8053414B2 · Pardoll et al. · 2011 [cited by applicant]
US 8053558B2 · Pardoll et al. · 2011 [cited by applicant]
US 8163550B2 · Chen et al. · 2012 [cited by applicant]
US 8268635B2 · Ferrante et al. · 2012 [cited by applicant]
US 8273861B2 · Chen · 2012 [cited by applicant]
US 8383405B2 · Orme · 2013 [cited by applicant]
US 8460927B2 · Chen · 2013 [cited by applicant]
US 8518409B2 · Orme · 2013 [cited by applicant]
US 8772026B2 · Chen et al. · 2014 [cited by applicant]
US 8901120B2 · Bearss et al. · 2014 [cited by applicant]
US 8981063B2 · Chen · 2015 [cited by applicant]
US 9302005B2 · Dong et al. · 2016 [cited by applicant]
US 9534058B2 · Stull et al. · 2017 [cited by applicant]
US 9598491B2 · Ahmed et al. · 2017 [cited by applicant]
US 9730988B2 · Ince et al. · 2017 [cited by applicant]
US 11246890B2 · Lin et al. · 2022 [cited by applicant]
US 11419898B2 · Lu et al. · 2022 [cited by applicant]
US 20020076409A1 · March et al. · 2002 [cited by applicant]
US 20020091246A1 · Pardoll et al. · 2002 [cited by applicant]
US 20020095024A1 · Mikesell et al. · 2002 [cited by applicant]
US 20020106730A1 · Coyle et al. · 2002 [cited by applicant]
US 20020107363A1 · Fox et al. · 2002 [cited by applicant]
US 20020110836A1 · Freeman et al. · 2002 [cited by applicant]
US 20020119121A1 · Vitiello et al. · 2002 [cited by applicant]
US 20020160395A1 · Altieri et al. · 2002 [cited by applicant]
US 20020160973A1 · Pero et al. · 2002 [cited by applicant]
US 20020164600A1 · Freeman et al. · 2002 [cited by applicant]
US 20020168719A1 · Kwon · 2002 [cited by applicant]
US 20020177551A1 · Terman · 2002 [cited by applicant]
US 20030039653A1 · Chen et al. · 2003 [cited by applicant]
US 20030142359A1 · Bean et al. · 2003 [cited by applicant]
US 20030171551A1 · Rosenblatt et al. · 2003 [cited by applicant]
US 20030208058A1 · Fiscella et al. · 2003 [cited by applicant]
US 20030223989A1 · Pluenneke · 2003 [cited by applicant]
US 20030232323A1 · Freeman et al. · 2003 [cited by applicant]
US 20040010134A1 · Rosen et al. · 2004 [cited by applicant]
US 20040109847A1 · Chen et al. · 2004 [cited by applicant]
US 20040180047A1 · Chen · 2004 [cited by applicant]
US 20040247563A1 · Lynch et al. · 2004 [cited by applicant]
US 20050013811A1 · Chen et al. · 2005 [cited by applicant]
US 20050228170A1 · Fox et al. · 2005 [cited by applicant]
US 20050260716A1 · Moore et al. · 2005 [cited by applicant]
US 20060034826A1 · Carreno et al. · 2006 [cited by applicant]
US 20060068386A1 · Slesarev et al. · 2006 [cited by applicant]
US 20060084794A1 · Rosen et al. · 2006 [cited by applicant]
US 20060110383A1 · Honjo et al. · 2006 [cited by applicant]
US 20060159685A1 · Mikesell et al. · 2006 [cited by applicant]
US 20060223088A1 · Rosen et al. · 2006 [cited by applicant]
US 20060276422A1 · Usman et al. · 2006 [cited by applicant]
US 20070037206A1 · Rosen et al. · 2007 [cited by applicant]
US 20070041963A1 · Rosen et al. · 2007 [cited by applicant]
US 20070065427A1 · Freeman et al. · 2007 [cited by applicant]
US 20070092504A1 · Carreno et al. · 2007 [cited by applicant]
US 20070099833A1 · Rosen et al. · 2007 [cited by applicant]
US 20070122378A1 · Freeman et al. · 2007 [cited by applicant]
US 20070224663A1 · Rosen et al. · 2007 [cited by applicant]
US 20070231344A1 · Leadbetter et al. · 2007 [cited by applicant]
US 20080025979A1 · Honjo et al. · 2008 [cited by applicant]
US 20080118511A1 · Freeman et al. · 2008 [cited by applicant]
US 20080226662A1 · Pardoll et al. · 2008 [cited by applicant]
US 20080241175A1 · Pardoll et al. · 2008 [cited by applicant]
US 20090012292A1 · Chen · 2009 [cited by applicant]
US 20090068193A1 · Chen et al. · 2009 [cited by applicant]
US 20090075338A1 · Moore et al. · 2009 [cited by applicant]
US 20090176317A1 · Kwon et al. · 2009 [cited by applicant]
US 20090215084A1 · Kwon et al. · 2009 [cited by applicant]
US 20090269783A1 · Coyle et al. · 2009 [cited by applicant]
US 20090304711A1 · Pardoll et al. · 2009 [cited by applicant]
US 20100015642A1 · Kwon et al. · 2010 [cited by applicant]
US 20100092470A1 · Bhatt et al. · 2010 [cited by applicant]
US 20100285039A1 · Chen · 2010 [cited by applicant]
US 20110020325A1 · Kwon et al. · 2011 [cited by applicant]
US 20110010409A1 · Strome et al. · 2011 [cited by applicant]
US 20120065374A1 · Pardoll et al. · 2012 [cited by applicant]
US 20120065385A1 · Pardoll et al. · 2012 [cited by applicant]
US 20120225043A1 · Chen et al. · 2012 [cited by applicant]
US 20130058936A1 · Bruenker et al. · 2013 [cited by applicant]
US 20130123566A1 · Lupold et al. · 2013 [cited by applicant]
US 20130251736A1 · Kwon et al. · 2013 [cited by applicant]
US 20130273656A1 · Hendrickson · 2013 [cited by applicant]
US 20140031260A1 · O'Donnell et al. · 2014 [cited by applicant]
US 20140242080A1 · Roche · 2014 [cited by applicant]
US 20140271674A1 · Dong · 2014 [cited by applicant]
US 20140329248A1 · Kwon et al. · 2014 [cited by applicant]
US 20140335541A1 · Kwon et al. · 2014 [cited by applicant]
US 20150111232A1 · Kwon et al. · 2015 [cited by applicant]
US 20150203580A1 · Papadopoulos et al. · 2015 [cited by applicant]
US 20150273033A1 · Bosch et al. · 2015 [cited by applicant]
US 20150337048A1 · Stull et al. · 2015 [cited by applicant]
US 20160045581A1 · Ince et al. · 2016 [cited by applicant]
US 20160051651A1 · Brogdon et al. · 2016 [cited by applicant]
US 20160068601A1 · Brogdon et al. · 2016 [cited by applicant]
US 20160153996A1 · Kwon et al. · 2016 [cited by applicant]
US 20160154000A1 · Kwon · 2016 [cited by applicant]
US 20160176967A1 · Dong et al. · 2016 [cited by applicant]
US 20160237407A1 · Wagner et al. · 2016 [cited by applicant]
US 20160251437A1 · Dong et al. · 2016 [cited by applicant]
US 20170089918A1 · Dong · 2017 [cited by applicant]
US 20170121416A1 · Stull et al. · 2017 [cited by applicant]
US 20170173030A1 · Dong · 2017 [cited by applicant]
US 20170274095A1 · Meyer et al. · 2017 [cited by applicant]
US 20170275375A1 · Rossi et al. · 2017 [cited by applicant]
US 20170327590A1 · Lowy et al. · 2017 [cited by applicant]
US 20170363634A1 · Kwon · 2017 [cited by applicant]
US 20180139940A1 · Macdonald et al. · 2018 [cited by applicant]
US 20180154183A1 · Sahadevan · 2018 [cited by applicant]
US 20190038671A1 · Fan et al. · 2019 [cited by applicant]
US 20190292539A1 · Fulga et al. · 2019 [cited by applicant]
US 20190298774A1 · Lin et al. · 2019 [cited by applicant]
US 20190315869A1 · Dong · 2019 [cited by applicant]
US 20190361033A1 · Dong · 2019 [cited by applicant]
US 20200054673A1 · Ports et al. · 2020 [cited by applicant]
US 20200061077A1 · Dong · 2020 [cited by applicant]
US 20200147117A1 · Ben Yakar et al. · 2020 [cited by applicant]
US 20200190196A1 · Dong · 2020 [cited by applicant]
US 20200270355A1 · Faustman · 2020 [cited by applicant]
US 20200271656A1 · Cumba-Garcia et al. · 2020 [cited by applicant]
US 20200338112A1 · Lou et al. · 2020 [cited by applicant]
US 20210003556A1 · Dong · 2021 [cited by applicant]
US 20210145830A1 · Kenderian et al. · 2021 [cited by applicant]
US 20210145881A1 · Kenderian et al. · 2021 [cited by applicant]
US 20210401886A1 · Kenderian et al. · 2021 [cited by applicant]
US 20220041686A1 · Mackall et al. · 2022 [cited by applicant]
US 20220401488A1 · Kenderian et al. · 2022 [cited by applicant]
US 20230045174A1 · Rezvani et al. · 2023 [cited by applicant]
CN 103641917 · 2014 [cited by applicant]
CN 105814074 · 2016 [cited by applicant]
CN 107406517 · 2017 [cited by applicant]
CN 107849112 · 2018 [cited by applicant]
EP 1074617 · 2001 [cited by applicant]
EP 1537878 · 2005 [cited by applicant]
EP 2997141 · 2016 [cited by applicant]
EP 3130350 · 2017 [cited by applicant]
EP 2968415 · 2019 [cited by applicant]
EP 3964265 · 2022 [cited by applicant]
WO WO1990007861 · 1990 [cited by applicant]
WO WO1991010741 · 1991 [cited by applicant]
WO WO1991011465 · 1991 [cited by applicant]
WO WO1991017271 · 1991 [cited by applicant]
WO WO1992000092 · 1992 [cited by applicant]
WO WO1992001047 · 1992 [cited by applicant]
WO WO1992020791 · 1992 [cited by applicant]
WO WO1993001222 · 1993 [cited by applicant]
WO WO1995005464 · 1995 [cited by applicant]
WO WO1995007707 · 1995 [cited by applicant]
WO WO1996029348 · 1996 [cited by applicant]
WO WO1997017613 · 1997 [cited by applicant]
WO WO1997017614 · 1997 [cited by applicant]
WO WO1997024447 · 1997 [cited by applicant]
WO WO1998016249 · 1998 [cited by applicant]
WO WO1998023635 · 1998 [cited by applicant]
WO WO1998033914 · 1998 [cited by applicant]
WO WO1998036096 · 1998 [cited by applicant]
WO WO1999036093 · 1999 [cited by applicant]
WO WO1999064597 · 1999 [cited by applicant]
WO WO2000026342 · 2000 [cited by applicant]
WO WO2000029445 · 2000 [cited by applicant]
WO WO2000029582 · 2000 [cited by applicant]
WO WO2000041508 · 2000 [cited by applicant]
WO WO2000055375 · 2000 [cited by applicant]
WO WO2000061612 · 2000 [cited by applicant]
WO WO2001034629 · 2001 [cited by applicant]
WO WO2001062905 · 2001 [cited by applicant]
WO WO2001070979 · 2001 [cited by applicant]
WO WO2001083750 · 2001 [cited by applicant]
WO WO2001094413 · 2001 [cited by applicant]
WO WO2002000692 · 2002 [cited by applicant]
WO WO2002000730 · 2002 [cited by applicant]
WO WO2002002587 · 2002 [cited by applicant]
WO WO2002002891 · 2002 [cited by applicant]
WO WO2002008279 · 2002 [cited by applicant]
WO WO2002078731 · 2002 [cited by applicant]
WO WO2002024891 · 2002 [cited by applicant]
WO WO2002046449 · 2002 [cited by applicant]
WO WO2002057453 · 2002 [cited by applicant]
WO WO2002079474 · 2002 [cited by applicant]
WO WO2002081731 · 2002 [cited by applicant]
WO WO2002086083 · 2002 [cited by applicant]
WO WO2003006632 · 2003 [cited by applicant]
WO WO2003008583 · 2003 [cited by applicant]
WO WO2003049755 · 2003 [cited by applicant]
WO WO2004085418 · 2004 [cited by applicant]
WO WO2006042237 · 2006 [cited by applicant]
WO WO2006050172 · 2006 [cited by applicant]
WO WO2006133396 · 2006 [cited by applicant]
WO WO2008037080 · 2008 [cited by applicant]
WO WO2008083174 · 2008 [cited by applicant]
WO WO2009023566 · 2009 [cited by applicant]
WO WO2009029342 · 2009 [cited by applicant]
WO WO2009114110 · 2009 [cited by applicant]
WO WO2010027423 · 2010 [cited by applicant]
WO WO2010027827 · 2010 [cited by applicant]
WO WO2010027828 · 2010 [cited by applicant]
WO WO2010098788 · 2010 [cited by applicant]
WO WO2011066342 · 2011 [cited by applicant]
WO WO2011066389 · 2011 [cited by applicant]
WO WO2011072246 · 2011 [cited by applicant]
WO WO2013003112 · 2013 [cited by applicant]
WO WO2013019906 · 2013 [cited by applicant]
WO WO2013090552 · 2013 [cited by applicant]
WO WO2013132044 · 2013 [cited by applicant]
WO WO2014110045 · 2014 [cited by applicant]
WO WO2014144666 · 2014 [cited by applicant]
WO WO2014163684 · 2014 [cited by applicant]
WO WO2014184143 · 2014 [cited by applicant]
WO WO2015049280 · 2015 [cited by applicant]
WO WO2015050663 · 2015 [cited by applicant]
WO WO2015061668 · 2015 [cited by applicant]
WO WO2015066262 · 2015 [cited by applicant]
WO WO2015142314 · 2015 [cited by applicant]
WO WO2015157252 · 2015 [cited by applicant]
WO WO2015179654 · 2015 [cited by applicant]
WO WO2016014148 · 2016 [cited by applicant]
WO WO2016014576 · 2016 [cited by applicant]
WO WO2016018920 · 2016 [cited by applicant]
WO WO2016120219 · 2016 [cited by applicant]
WO WO2016164731 · 2016 [cited by applicant]
WO WO2016201394 · 2016 [cited by applicant]
WO WO2017023803 · 2017 [cited by applicant]
WO WO2017066561 · 2017 [cited by applicant]
WO WO2017075389 · 2017 [cited by applicant]
WO WO2017091546 · 2017 [cited by applicant]
WO WO2017100587 · 2017 [cited by applicant]
WO WO2017143094 · 2017 [cited by applicant]
WO WO2017172981 · 2017 [cited by applicant]
WO WO2017173360 · 2017 [cited by applicant]
WO WO2017177179 · 2017 [cited by applicant]
WO WO2017220704 · 2017 [cited by applicant]
WO WO2017222593 · 2017 [cited by applicant]
WO WO2018005712 · 2018 [cited by applicant]
WO WO2018045069 · 2018 [cited by applicant]
WO WO2018073391 · 2018 [cited by applicant]
WO WO2018195339 · 2018 [cited by applicant]
WO WO2019036724 · 2019 [cited by applicant]
WO WO2019108756 · 2019 [cited by applicant]
WO WO2019133793 · 2019 [cited by applicant]
WO WO2019178334 · 2019 [cited by applicant]
WO WO2019195142 · 2019 [cited by applicant]
WO WO2019217423 · 2019 [cited by applicant]
WO WO2019232370 · 2019 [cited by applicant]
WO WO2020018620 · 2020 [cited by applicant]
WO WO2021092577 · 2021 [cited by applicant]
WO WO2022236049 · 2022 [cited by applicant]
WO WO2022236142 · 2022 [cited by applicant]
WO WO2022266396 · 2022 [cited by applicant]
Boyiadzis et al., “The emerging roles of tumor-derived exosomes in hematological malignancies,” Leukemia, Mar. 21, 2017, 31(6):1259-1268. [cited by applicant]
Corcoran et al., “Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes,” PLoS One, Dec. 10, 2012, 7(12):e50999, 12 pages. [cited by applicant]
Liu, “Differential Expression of Cell Surface Molecules in Prostate Cancer Cells,” Cancer Research, July 1, 200, 60:3429-3434. [cited by applicant]
Oksvold et al., “Expression of B-Cell Surface Antigens in Subpopulations of Exosomes Released From B-Cell Lymphoma Cells,” Clin. Therapeutics, Jun. 18, 2014, 36(6):847-862.e1. [cited by applicant]
Baek et al., “In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors,” Exp. Mol. Medicine, Oct. 2011, 43(10):596-603. [cited by applicant]
Barbarino et al., “Functional role of Bruton's tyrosine kinase inhibitor therapy in the tumor microenvironment of B-cell malignancies,” Oncol Res Treat, Oct. 2019, 42(suppl 4):220-221, 5 pages (Abstract Only). [cited by applicant]
Beyersdorf et al., “CD28 co-stimulation in T-cell homeostasis: a recent perspective,” Immunotargets Therapy, May 4, 2015:111-122. [cited by applicant]
Boardman et al., “Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection,” Am. J. Transplantation, Feb. 20… [cited by applicant]
Boroughs et al., “Chimeric antigen receptor costimulation domains modulate human regulatory T cell function,” JCI Insight, Mar. 2019, 5(8):e126194, 19 pages. [cited by applicant]
Charvet et al., “Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression,” J. Immunology, Oct. 2006, 177(8):5024-5031. [cited by applicant]
Cheng et al., “The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture,” Stem Cells Transl. Medicine, Dec. 2019, 9(4):518-530. [cited by applicant]
Cox et al., “GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity,” Leukemia, 36:1635-1645, Apr. 19, 2022. [cited by applicant]
Cox et al., “Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia,” Mol. Therapy, Jan. 2021, 29(4):1529-1540. [cited by applicant]
Dmitrieva et al., “Bone marrow- and subcutaneous adipose tissue-derived mesenchymal stem cells: differences and similarities,” Cell Cycle, Jan. 2012, 11(2):377-383. [cited by applicant]
Dominici et al., “Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement,” Cytotherapy, Feb. 2006, 8(4):315-317. [cited by applicant]
Dorronsoro et al., “Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB,” Eur. J. Immunology, Dec. 2013, 44(2):480-488. [cited by applicant]
Dorronsoro et al., “Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation,” Sci. Reports, Dec. 2020, 10(1):21853, 12 pages. [cited by applicant]
English et al., “IFN-γ and TNF-α differentially regulate immunomodulation by murine mesenchymal stem cells,” Immunol. Letters, Apr. 2007, 110(2):91-100. [cited by applicant]
Estrada-Capetillo et al., “CD28 is expressed by macrophages with anti-inflammatory potential and limits their T-cell activating capacity,” Eur. J. Immunology, Nov. 2020, 51(4):824-834. [cited by applicant]
Extended European Search Report in European Appln. No. 19780974.2, dated Nov. 30, 2021, 13 pages. [cited by applicant]
Extended European Search Report in European Appln. No. 19784411.1, dated Dec. 20, 2021, 11 pages. [cited by applicant]
Extended European Search Report in European Appln. No. 19880748.9, dated Jun. 29, 2022, 9 pages. [cited by applicant]
Fan et al., “Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9,” Stem Cell Res. Therapy, Sep. 2018, 9(1):237, 12 pages. [cited by applicant]
Fraietta et al., “Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia,” Blood, Mar. 2016, 127(9):1117-1127. [cited by applicant]
Gao et al., “Mesenchymal stem cells and immunomodulation: current status and future prospects,” Cell Death Disease, Jan. 2016, 7:e2062, 11 pages. [cited by applicant]
GenBank Accession No. AB032738.1, “ [cited by applicant]
GenBank Accession No. AC003959.1, “ [cited by applicant]
GenBank Accession No. AC011377.6, “ [cited by applicant]
GenBank Accession No. AF363458.1, “ [cited by applicant]
GenBank Accession No. AL136985.11, “Human DNA sequence from clone RP11-63G10 on chromosome 1p32.1-32.3, complete sequence,” dated Jan. 24, 2013, 33 pages. [cited by applicant]
GenBank Accession No. CH471059.2, “ [cited by applicant]
GenBank Accession No. CH471062.2, “ [cited by applicant]
GenBank Accession No. CQ834184.1, “Sequence 55 from Patent WO2004058805,” dated Jul. 29, 2004, 2 pages. [cited by applicant]
GenBank Accession No. DQ789232.1, “ [cited by applicant]
GenBank Accession No. EF064716.1, “ [cited by applicant]
GenBank Accession No. NM_000572.2, “ [cited by applicant]
GenBank Accession No. NM 000594.3, “ [cited by applicant]
GenBank Accession No. NM_000758.3, “ [cited by applicant]
GenBank Accession No. NM_000759.3, “ [cited by applicant]
GenBank Accession No. NM_001008540.2, “ [cited by applicant]
GenBank Accession No. NM_001142797.1, “ [cited by applicant]
GenBank Accession No. NM_001165412.1, “ [cited by applicant]
GenBank Accession No. NM_001319226.1, “ [cited by applicant]
GenBank Accession No. NM_001330163.1, “ [cited by applicant]
GenBank Accession No. NM_001348056.1, “ [cited by applicant]
GenBank Accession No. NM_001348059.1, “ [cited by applicant]
GenBank Accession No. NM_001354924.1, “ [cited by applicant]