IP Library › Granted Patent US 12,410,409
Granted Patent B2
US 12,410,409 · App. 17/835,830 · Granted Sep 9, 2025

Influenza viruses with mutant PB2 gene segment as live attenuated vaccines

Inventors: Yoshihiro Kawaoka (Middleton, WI); Gabriele Neumann (Madison, WI); Makoto Ozawa (Kagoshima, JP)
Assignee: Wisconsin Alumni Research Foundation (WARF)
C12N7/00A61K35/76A61K39/092A61K39/12A61K39/145G01N33/56983A61K2039/5252A61K2039/5254A61K2039/5256A61K2039/543A61K2039/70C12N2760/16121C12N2760/16134C12N2760/16143C12N2760/16151C12N2760/16171G01N2333/11
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Quick Facts
Patent No.
US 12,410,409
App. No.
17/835,830
Granted
Sep 9, 2025
Kind
B2
Abstract

The invention provides a recombinant biologically contained influenza virus that is a PB2 knockout virus, e.g., one that is useful to generate a multivalent vaccine, and methods of making and using that virus.

Claims (15)

1. A vaccine comprising an effective amount of a biologically contained influenza A virus comprising: 8 different viral segments including a PA viral segment, a PB1 viral segment, a mutant PB2 viral segment, a HA viral segment, a NA viral segment, a NP viral segment, a M (M1 and M2) viral segment, and a NS (NS1 and NS2) viral segment, wherein the mutant PB2 viral segment includes 5′ and 3′ incorporation sequences including 3′ or 5′ coding and non-coding incorporation sequences flanking a heterologous nucleotide sequence comprising a therapeutic or prophylactic gene and does not include contiguous sequences corresponding to sequences encoding a functional PB2, and wherein the HA viral segment encodes one of subtypes H1 to H16.

2. The vaccine of claim 1 wherein the heterologous nucleotide sequence encodes a gene product that induces a prophylactic or therapeutic immune response to a pathogen.

3. The vaccine of claim 1 wherein the heterologous nucleotide sequence encodes a heterologous protein that with the influenza virus HA encoded by the HA viral segment provides for multivalency.

4. The vaccine of claim 1 wherein the heterologous nucleotide sequence encodes a glycoprotein.

5. The vaccine of claim 1 which comprises H1, H3, H5, H7, or H9 HA.

6. The vaccine of claim 1 wherein the viral segments for HA and NA are from a different isolate than the PA, PB1, PB2, NP, NS, and M viral segments.

7. The vaccine of claim 1 wherein the heterologous nucleotide sequence encodes a protein of a bacterium, yeast, fungus, or a virus that is not an influenza virus.

8. The vaccine of claim 1 wherein the heterologous nucleotide sequence encodes a cancer associated antigen.

9. The vaccine of claim 1 wherein the heterologous nucleotide sequence is flanked by about 3 to about 400 nucleotides of the 5′ and/or 3′ PB2 coding region adjacent to non-coding sequence.

10. A method to immunize a vertebrate, comprising:

contacting the vertebrate with the vaccine of claim 1 .

11. The method of claim 10 wherein the vertebrate is a mammal.

12. The method of claim 11 wherein the mammal is a human.

13. The method of claim 10 wherein the contacting is by injection.

14. The method of claim 10 wherein the contacting is by intranasal administration.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2022
From: KAWAOKA, YOSHIHIRO; NEUMANN, GABRIELE; OZAWA, MAKOTO
To: WISCONSIN ALUMNI RESEARCH FOUNDATION
Reel/Frame 060371/0856 →
Continuity (5)
Division 16694748 · Nov 25, 2019
Continuation 14699213 · Apr 29, 2015
Continuation 13594611 · Aug 24, 2012
Provisional Application 61527935 · Aug 26, 2011
Related Publication 20230348864A1 · Nov 2, 2023
References Cited (400)
US 4071618A · Konobe et al. · 1978 [cited by applicant]
US 4659569A · Mitsuhashi et al. · 1987 [cited by applicant]
US 5166057A · Palese et al. · 1992 [cited by applicant]
US 5578473A · Palese et al. · 1996 [cited by applicant]
US 5716821A · Wertz et al. · 1998 [cited by applicant]
US 5750394A · Palese et al. · 1998 [cited by applicant]
US 5786199A · Palese · 1998 [cited by applicant]
US 5789229A · Wertz et al. · 1998 [cited by applicant]
US 5820871A · Palese et al. · 1998 [cited by applicant]
US 5840520A · Clarke et al. · 1998 [cited by applicant]
US 5854037A · Palese et al. · 1998 [cited by applicant]
US 5948410A · Van Scharrenburg et al. · 1999 [cited by applicant]
US 5994526A · Meulewaeter et al. · 1999 [cited by applicant]
US 6001634A · Palese et al. · 1999 [cited by applicant]
US 6033886A · Conzelmann · 2000 [cited by applicant]
US 6037348A · Colacino et al. · 2000 [cited by applicant]
US 6146642A · Garcia-Sastre et al. · 2000 [cited by applicant]
US 6169175B1 · Frace et al. · 2001 [cited by applicant]
US 6194546B1 · Newton et al. · 2001 [cited by applicant]
US 6270958B1 · Olivo et al. · 2001 [cited by applicant]
US 6271011B1 · Lee et al. · 2001 [cited by applicant]
US 6358733B1 · Motwani et al. · 2002 [cited by applicant]
US 6455298B1 · Groner et al. · 2002 [cited by applicant]
US 6544785B1 · Palese et al. · 2003 [cited by applicant]
US 6656720B2 · Groner et al. · 2003 [cited by applicant]
US 6825036B2 · Makizumi et al. · 2004 [cited by applicant]
US 6843996B1 · Parkin et al. · 2005 [cited by applicant]
US 6872395B2 · Kawaoka · 2005 [cited by applicant]
US 6890710B1 · Palese et al. · 2005 [cited by applicant]
US 6951752B2 · Reiter et al. · 2005 [cited by applicant]
US 6951754B2 · Hoffmann · 2005 [cited by applicant]
US 6974695B2 · Vogels et al. · 2005 [cited by applicant]
US 7037707B2 · Webster et al. · 2006 [cited by applicant]
US 7176021B2 · Kawaoka · 2007 [cited by applicant]
US 7211378B2 · Kawaoka et al. · 2007 [cited by applicant]
US 7226774B2 · Kawaoka · 2007 [cited by applicant]
US 7312064B2 · Hoffmann · 2007 [cited by applicant]
US 7335356B2 · Hart et al. · 2008 [cited by applicant]
US 7507411B2 · Zhou et al. · 2009 [cited by applicant]
US 7566458B2 · Yang et al. · 2009 [cited by applicant]
US 7585657B2 · Kawaoka · 2009 [cited by applicant]
US 7588769B2 · Kawaoka · 2009 [cited by applicant]
US 7601356B2 · Jin et al. · 2009 [cited by applicant]
US 7670837B2 · Schwartz · 2010 [cited by applicant]
US 7682618B2 · Bavari et al. · 2010 [cited by applicant]
US 7723094B2 · Kawaoka et al. · 2010 [cited by applicant]
US 7833788B2 · Pau et al. · 2010 [cited by applicant]
US 7883844B2 · Nouchi et al. · 2011 [cited by applicant]
US 7955833B2 · Reiter et al. · 2011 [cited by applicant]
US 7959930B2 · De Wit et al. · 2011 [cited by applicant]
US 7968101B2 · Kawaoka et al. · 2011 [cited by applicant]
US 7972843B2 · Hoffmann · 2011 [cited by applicant]
US 7993924B2 · Billeter et al. · 2011 [cited by applicant]
US 8012736B2 · Hoffman et al. · 2011 [cited by applicant]
US 8043856B2 · Kawaoka et al. · 2011 [cited by applicant]
US 8048430B2 · Yang et al. · 2011 [cited by applicant]
US 8057806B2 · Kawaoka et al. · 2011 [cited by applicant]
US 8093033B2 · Kemble et al. · 2012 [cited by applicant]
US 8114415B2 · Hoffmann et al. · 2012 [cited by applicant]
US 8119337B2 · Gregersen · 2012 [cited by applicant]
US 8119388B2 · Schwartz et al. · 2012 [cited by applicant]
US 8298805B2 · Kawaoka · 2012 [cited by applicant]
US 8309099B2 · Hoffmann · 2012 [cited by applicant]
US 8354114B2 · Lu et al. · 2013 [cited by applicant]
US 8357376B2 · Liu et al. · 2013 [cited by applicant]
US 8409843B2 · Kemble et al. · 2013 [cited by applicant]
US 8460914B2 · Gregersen · 2013 [cited by applicant]
US 8465960B2 · Kawaoka et al. · 2013 [cited by applicant]
US 8475806B2 · Kawaoka · 2013 [cited by applicant]
US 8507247B2 · Kawaoka et al. · 2013 [cited by applicant]
US 8524497B2 · Reiter et al. · 2013 [cited by applicant]
US 8546123B2 · Lewis · 2013 [cited by applicant]
US 8574591B2 · Hoffmann et al. · 2013 [cited by applicant]
US 8574593B2 · Yang et al. · 2013 [cited by applicant]
US 8580277B2 · Yang et al. · 2013 [cited by applicant]
US 8591914B2 · Yang et al. · 2013 [cited by applicant]
US 8597661B2 · Kawaoka et al. · 2013 [cited by applicant]
US 8679819B2 · Kawaoka · 2014 [cited by applicant]
US 8877209B2 · Kawaoka et al. · 2014 [cited by applicant]
US 8900595B2 · Kawaoka et al. · 2014 [cited by applicant]
US 9101653B2 · Kawaoka et al. · 2015 [cited by applicant]
US 9109013B2 · Kawaoka et al. · 2015 [cited by applicant]
US 9222118B2 · Kawaoka et al. · 2015 [cited by applicant]
US 9254318B2 · Kawaoka et al. · 2016 [cited by applicant]
US 9284533B2 · Bilsel et al. · 2016 [cited by applicant]
US 9474798B2 · Watanabe et al. · 2016 [cited by applicant]
US 9757446B2 · LeFebvre et al. · 2017 [cited by applicant]
US 9890363B2 · Kawaoka · 2018 [cited by applicant]
US 9926535B2 · Kawaoka et al. · 2018 [cited by applicant]
US 9950057B2 · Kawaoka et al. · 2018 [cited by applicant]
US 10053671B2 · Kawaoka et al. · 2018 [cited by applicant]
US 10059925B2 · Kawaoka et al. · 2018 [cited by applicant]
US 10119124B2 · Watanabe et al. · 2018 [cited by applicant]
US 10130697B2 · Watanabe · 2018 [cited by applicant]
US 10172934B2 · Kawaoka et al. · 2019 [cited by applicant]
US 10246686B2 · Kawaoka et al. · 2019 [cited by applicant]
US 10358630B2 · Kawaoka et al. · 2019 [cited by applicant]
US 10494613B2 · Kawaoka et al. · 2019 [cited by applicant]
US 10513692B2 · Kawaoka et al. · 2019 [cited by applicant]
US 10633422B2 · Kawaoka et al. · 2020 [cited by applicant]
US 10808229B2 · Kawaoka et al. · 2020 [cited by applicant]
US 11007262B2 · Watanabe et al. · 2021 [cited by applicant]
US 11046934B2 · Kawaoka et al. · 2021 [cited by applicant]
US 11180737B2 · Kawaoka et al. · 2021 [cited by applicant]
US 11197925B2 · Kawaoka et al. · 2021 [cited by applicant]
US 11197926B2 · Kawaoka et al. · 2021 [cited by applicant]
US 11241492B2 · Kawaoka et al. · 2022 [cited by applicant]
US 11384339B2 · Kawaoka et al. · 2022 [cited by applicant]
US 11389523B2 · Kawaoka et al. · 2022 [cited by applicant]
US 11390649B2 · Kawaoka et al. · 2022 [cited by applicant]
US 11739303B2 · Kawaoka et al. · 2023 [cited by applicant]
US 11807872B2 · Kawaoka et al. · 2023 [cited by applicant]
US 11851648B2 · Kawaoka et al. · 2023 [cited by applicant]
US 12258557B2 · Kawaoka et al. · 2025 [cited by applicant]
US 20020010143A1 · Barbosa et al. · 2002 [cited by applicant]
US 20020164770A1 · Hoffmann · 2002 [cited by applicant]
US 20020197705A1 · Kawaoka · 2002 [cited by applicant]
US 20030035814A1 · Kawaoka et al. · 2003 [cited by applicant]
US 20030044962A1 · Makizumi et al. · 2003 [cited by applicant]
US 20030073223A1 · Groner et al. · 2003 [cited by applicant]
US 20030119183A1 · Groner · 2003 [cited by applicant]
US 20030194694A1 · Kawaoka · 2003 [cited by applicant]
US 20030215794A1 · Kawaoka et al. · 2003 [cited by applicant]
US 20040002061A1 · Kawaoka · 2004 [cited by applicant]
US 20040029251A1 · Hoffman et al. · 2004 [cited by applicant]
US 20040057967A1 · Bavari et al. · 2004 [cited by applicant]
US 20040063141A1 · Lok · 2004 [cited by applicant]
US 20040077086A1 · Reiter et al. · 2004 [cited by applicant]
US 20040132164A1 · Doyle et al. · 2004 [cited by applicant]
US 20040142322A1 · Malcolm et al. · 2004 [cited by applicant]
US 20040219170A1 · Kawaoka · 2004 [cited by applicant]
US 20040241139A1 · Hobom et al. · 2004 [cited by applicant]
US 20040242518A1 · Chen et al. · 2004 [cited by applicant]
US 20050003349A1 · Kawaoka · 2005 [cited by applicant]
US 20050037487A1 · Kawaoka et al. · 2005 [cited by applicant]
US 20050095583A1 · Pekosz et al. · 2005 [cited by applicant]
US 20050118140A1 · Vorlop et al. · 2005 [cited by applicant]
US 20050158342A1 · Kemble et al. · 2005 [cited by applicant]
US 20050186563A1 · Hoffmann · 2005 [cited by applicant]
US 20050202553A1 · Groner et al. · 2005 [cited by applicant]
US 20050232950A1 · Kawaoka · 2005 [cited by applicant]
US 20050266023A1 · Bavari et al. · 2005 [cited by applicant]
US 20050266026A1 · Hoffmann et al. · 2005 [cited by applicant]
US 20060057116A1 · Kawaoka et al. · 2006 [cited by applicant]
US 20060088909A1 · Compans · 2006 [cited by applicant]
US 20060099609A1 · Bavari et al. · 2006 [cited by applicant]
US 20060134138A1 · Kawaoka et al. · 2006 [cited by applicant]
US 20060166321A1 · Kawaoka et al. · 2006 [cited by applicant]
US 20060188977A1 · Schwartz et al. · 2006 [cited by applicant]
US 20060216702A1 · Compans et al. · 2006 [cited by applicant]
US 20060240515A1 · Dimitrov et al. · 2006 [cited by applicant]
US 20060246092A1 · Neirynck et al. · 2006 [cited by applicant]
US 20070141699A1 · Kawaoka · 2007 [cited by applicant]
US 20070231348A1 · Kawaoka et al. · 2007 [cited by applicant]
US 20080009031A1 · Kawaoka · 2008 [cited by applicant]
US 20080187557A1 · Sambhara · 2008 [cited by applicant]
US 20080233560A1 · Hoffmann · 2008 [cited by applicant]
US 20080254067A1 · Trepanier et al. · 2008 [cited by applicant]
US 20080274141A1 · Groner et al. · 2008 [cited by applicant]
US 20080292658A1 · De Wit et al. · 2008 [cited by applicant]
US 20080293040A1 · Kawaoka et al. · 2008 [cited by applicant]
US 20080311148A1 · Hoffmann · 2008 [cited by applicant]
US 20080311149A1 · Hoffmann · 2008 [cited by applicant]
US 20090017444A1 · Kawaoka et al. · 2009 [cited by applicant]
US 20090047728A1 · Kawaoka et al. · 2009 [cited by applicant]
US 20090074812A1 · Watanabe et al. · 2009 [cited by applicant]
US 20090081252A1 · Gregersen · 2009 [cited by applicant]
US 20090181446A1 · Nouchi et al. · 2009 [cited by applicant]
US 20090311669A1 · Kawaoka · 2009 [cited by applicant]
US 20090324640A1 · Kawaoka et al. · 2009 [cited by applicant]
US 20100080825A1 · Kawaoka et al. · 2010 [cited by applicant]
US 20100112000A1 · Schwartz · 2010 [cited by applicant]
US 20100183671A1 · Gregersen et al. · 2010 [cited by applicant]
US 20100247572A1 · Kawaoka · 2010 [cited by applicant]
US 20100267116A1 · Kawaoka et al. · 2010 [cited by applicant]
US 20110020374A1 · Frazer · 2011 [cited by applicant]
US 20110027314A1 · Broeker · 2011 [cited by applicant]
US 20110045022A1 · Tsai · 2011 [cited by applicant]
US 20110081373A1 · Kawaoka et al. · 2011 [cited by applicant]
US 20110110978A1 · Kawaoka et al. · 2011 [cited by applicant]
US 20110159031A1 · Falkner et al. · 2011 [cited by applicant]
US 20110236417A1 · Watanabe et al. · 2011 [cited by applicant]
US 20110263554A1 · Kawaoka et al. · 2011 [cited by applicant]
US 20110300604A1 · Kawaoka et al. · 2011 [cited by applicant]
US 20120020997A1 · Hoffman et al. · 2012 [cited by applicant]
US 20120034600A1 · Gregersen · 2012 [cited by applicant]
US 20120058124A1 · Kurosawa et al. · 2012 [cited by applicant]
US 20120115206A1 · Schwartz et al. · 2012 [cited by applicant]
US 20120156241A1 · De Wit et al. · 2012 [cited by applicant]
US 20120207785A1 · Fabry et al. · 2012 [cited by applicant]
US 20120251568A1 · Garcia-Sastre et al. · 2012 [cited by applicant]
US 20130095135A1 · Collignon et al. · 2013 [cited by applicant]
US 20130183741A1 · Park et al. · 2013 [cited by applicant]
US 20130230552A1 · Kawaoka et al. · 2013 [cited by applicant]
US 20130243744A1 · Betenbaugh · 2013 [cited by applicant]
US 20130316434A1 · Reiter et al. · 2013 [cited by applicant]
US 20140227310A1 · Li et al. · 2014 [cited by applicant]
US 20150017205A1 · Kawaoka et al. · 2015 [cited by applicant]
US 20150166967A1 · Kawaoka et al. · 2015 [cited by applicant]
US 20150307851A1 · Kawaoka et al. · 2015 [cited by applicant]
US 20150368621A1 · Kawaoka et al. · 2015 [cited by applicant]
US 20160024193A1 · Ayalon et al. · 2016 [cited by applicant]
US 20160024479A1 · Kawaoka et al. · 2016 [cited by applicant]
US 20160115518A1 · Kawaoka et al. · 2016 [cited by applicant]
US 20160208223A1 · Kawaoka et al. · 2016 [cited by applicant]
US 20160215040A1 · Kyratsous et al. · 2016 [cited by applicant]
US 20160355790A1 · Kawaoka et al. · 2016 [cited by applicant]
US 20170058265A1 · Kawaoka et al. · 2017 [cited by applicant]
US 20170067029A1 · Kawaoka et al. · 2017 [cited by applicant]
US 20170096645A1 · Watanabe et al. · 2017 [cited by applicant]
US 20170097334A1 · Kawaoka et al. · 2017 [cited by applicant]
US 20170121391A1 · Kawaoka et al. · 2017 [cited by applicant]
US 20170258888A1 · Kawaoka · 2017 [cited by applicant]
US 20170298120A1 · Sasisekharan · 2017 [cited by applicant]
US 20170354730A1 · Kawaoka et al. · 2017 [cited by applicant]
US 20180245054A1 · Kawaoka et al. · 2018 [cited by applicant]
US 20180273588A1 · Kawaoka et al. · 2018 [cited by applicant]
US 20180340152A1 · Kawaoka et al. · 2018 [cited by applicant]
US 20190032023A1 · Kawaoka et al. · 2019 [cited by applicant]
US 20190048324A1 · Kawaoka et al. · 2019 [cited by applicant]
US 20190117759A1 · Wantanabe et al. · 2019 [cited by applicant]
US 20190167781A1 · Kawaoka et al. · 2019 [cited by applicant]
US 20200188506A1 · Kawaoka et al. · 2020 [cited by applicant]
US 20200237899A1 · Kawaoka et al. · 2020 [cited by applicant]
US 20200263142A1 · Kawaoka et al. · 2020 [cited by applicant]
US 20200263143A1 · Kawaoka et al. · 2020 [cited by applicant]
US 20200291384A1 · Kawaoka et al. · 2020 [cited by applicant]
US 20210061862A1 · Kawaoka et al. · 2021 [cited by applicant]
US 20210102178A1 · Kawaoka et al. · 2021 [cited by applicant]
US 20210121545A1 · Knoll et al. · 2021 [cited by applicant]
US 20210228708A1 · Smith et al. · 2021 [cited by applicant]
US 20210246432A1 · Kawaoka et al. · 2021 [cited by applicant]
US 20210252130A1 · Watanabe et al. · 2021 [cited by applicant]
US 20210290754A1 · Kawaoka et al. · 2021 [cited by applicant]
US 20210299249A1 · Kawaoka et al. · 2021 [cited by applicant]
US 20220025339A1 · Kawaoka et al. · 2022 [cited by applicant]
US 20220202926A1 · Kawaoka et al. · 2022 [cited by applicant]
US 20220202927A1 · Kawaoka et al. · 2022 [cited by applicant]
US 20220241396A1 · Kawaoka et al. · 2022 [cited by applicant]
US 20230321217A1 · Kawaoka et al. · 2023 [cited by applicant]
US 20230346911A1 · Kawaoka et al. · 2023 [cited by applicant]
US 20240010995A1 · Kawaoka et al. · 2024 [cited by applicant]
US 20240076632A1 · Kawaoka et al. · 2024 [cited by applicant]
US 20240238403A1 · Kawaoka et al. · 2024 [cited by applicant]
US 20240318167A1 · Kawaoka et al. · 2024 [cited by applicant]
AU 2012204138B2 · 2014 [cited by applicant]
AU 2014202470 · 2016 [cited by applicant]
AU 2014290203B2 · 2020 [cited by applicant]
AU 2017221444B2 · 2021 [cited by applicant]
BR PI0410702B1 · 2022 [cited by applicant]
CA 2379012A1 · 2001 [cited by applicant]
CA 2816242C · 2019 [cited by applicant]
CN 1826407A · 2006 [cited by applicant]
CN 101472941A · 2009 [cited by applicant]
CN 1826407B · 2013 [cited by applicant]
CN 105296356A · 2016 [cited by applicant]
CN 103540614B · 2018 [cited by applicant]
CN 109477074A · 2019 [cited by applicant]
CN 113874496A · 2021 [cited by applicant]
CN 114929269A · 2022 [cited by applicant]
EP 0687471A1 · 1995 [cited by applicant]
EP 0700991A1 · 1996 [cited by applicant]
EP 0702085A1 · 1996 [cited by applicant]
EP 0704533A1 · 1996 [cited by applicant]
EP 1201760A1 · 2002 [cited by applicant]
EP 2010557B1 · 2014 [cited by applicant]
EP 1572910B1 · 2015 [cited by applicant]
EP 1631663B1 · 2016 [cited by applicant]
EP 2747778B1 · 2017 [cited by applicant]
EP 3009507B1 · 2020 [cited by applicant]
EP 2493912B1 · 2020 [cited by applicant]
EP 3022296B1 · 2022 [cited by applicant]
IL 171831A · 2015 [cited by applicant]
JP 07203958 · 1995 [cited by applicant]
JP 2002536992A · 2002 [cited by applicant]
JP 2003528570A · 2003 [cited by applicant]
JP 2004500842A · 2004 [cited by applicant]
JP 2004531232A · 2004 [cited by applicant]
JP 2005523698A · 2005 [cited by applicant]
JP 2005245302A · 2005 [cited by applicant]
JP 2005535288A · 2005 [cited by applicant]
JP 2006525815A · 2006 [cited by applicant]
JP 2007518395A · 2007 [cited by applicant]
JP 2007525175A · 2007 [cited by applicant]
JP 2007529997A · 2007 [cited by applicant]
JP 2008520248A · 2008 [cited by applicant]
JP 2009511084A · 2009 [cited by applicant]
JP 2009523252A · 2009 [cited by applicant]
JP 2009532352A · 2009 [cited by applicant]
JP 2010530248A · 2010 [cited by applicant]
JP 2011530295A · 2011 [cited by applicant]
JP 4927290 · 2012 [cited by applicant]
JP 4927290B2 · 2012 [cited by applicant]
JP 2013507990A · 2013 [cited by applicant]
JP 2013511280A · 2013 [cited by applicant]
JP 2014131516A · 2014 [cited by applicant]
JP 2014039551A · 2015 [cited by applicant]
JP 2016500007A · 2016 [cited by applicant]
JP 2016521553A · 2016 [cited by applicant]
JP 2016144463A · 2016 [cited by applicant]
JP 2016524915A · 2016 [cited by applicant]
JP 2016169225A · 2016 [cited by applicant]
JP 2017527557A · 2017 [cited by applicant]
JP 2017197555A · 2017 [cited by applicant]
JP 2018064493A · 2018 [cited by applicant]
JP 6352974B2 · 2018 [cited by applicant]
JP 6375329B2 · 2018 [cited by applicant]
JP 2019510481A · 2019 [cited by applicant]
JP 2020010711A · 2020 [cited by applicant]
JP 2020114250 · 2020 [cited by applicant]
JP 2021500891A · 2021 [cited by applicant]
JP 2021036878A · 2021 [cited by applicant]
JP 2021184761A · 2021 [cited by applicant]
JP 2021533157A · 2021 [cited by applicant]
JP 2021536228A · 2021 [cited by applicant]
JP 2022066209A · 2022 [cited by applicant]
JP 2022522112A · 2022 [cited by applicant]
JP 2022527235A · 2022 [cited by applicant]
JP 2022172369A · 2022 [cited by applicant]
JP 2022551805A · 2022 [cited by applicant]
KR 101113432B1 · 2012 [cited by applicant]
MX 285206 · 2011 [cited by applicant]
NO 341506 · 2017 [cited by applicant]
WO WO9610631A1 · 1996 [cited by applicant]
WO WO9610632A1 · 1996 [cited by applicant]
WO WO9640955A1 · 1996 [cited by applicant]
WO WO9737000A1 · 1997 [cited by applicant]
WO WO9802530A1 · 1998 [cited by applicant]
WO WO9848834A1 · 1998 [cited by applicant]
WO WO9853078A1 · 1998 [cited by applicant]
WO WO9928445A1 · 1999 [cited by applicant]
WO WO0053786A1 · 2000 [cited by applicant]
WO WO0060050A2 · 2000 [cited by applicant]
WO WO2000060050A2 · 2000 [cited by applicant]
WO WO0060050A3 · 2001 [cited by applicant]
WO WO2001004333A1 · 2001 [cited by applicant]
WO WO2001025462A1 · 2001 [cited by applicant]
WO WO0179273A2 · 2001 [cited by applicant]
WO WO2001079273A2 · 2001 [cited by applicant]
WO WO0183794A2 · 2001 [cited by applicant]
WO WO2001083794A2 · 2001 [cited by applicant]
WO WO0210143A1 · 2002 [cited by applicant]
WO WO02064757A2 · 2002 [cited by applicant]
WO WO02074795A2 · 2002 [cited by applicant]
WO WO03068923A2 · 2003 [cited by applicant]
WO WO2003068923A2 · 2003 [cited by applicant]
WO WO03076462A1 · 2003 [cited by applicant]
WO WO2003080846A1 · 2003 [cited by applicant]
WO WO03091401A2 · 2003 [cited by applicant]
WO WO2003091401A2 · 2003 [cited by applicant]
WO WO2004142322A1 · 2004 [cited by applicant]
WO WO2004094466A2 · 2004 [cited by applicant]
WO WO04112831A2 · 2004 [cited by applicant]
WO WO2004112831A2 · 2004 [cited by applicant]
WO WO2004112831A3 · 2004 [cited by applicant]
WO WO05028658A2 · 2005 [cited by applicant]
WO WO05028658A3 · 2005 [cited by applicant]
WO WO2005028658A2 · 2005 [cited by applicant]
WO Wo2005062820A2 · 2005 [cited by applicant]
WO WO2006051069A2 · 2006 [cited by applicant]
WO WO2007044024A2 · 2007 [cited by applicant]
WO WO2007044024A3 · 2007 [cited by applicant]
WO WO2007126810A2 · 2007 [cited by applicant]
WO WO2007126810A3 · 2007 [cited by applicant]
WO WO2007146057A2 · 2007 [cited by applicant]
WO WO2007146057A3 · 2007 [cited by applicant]
WO WO08156681A3 · 2008 [cited by applicant]
WO WO2008147496A2 · 2008 [cited by applicant]
WO WO2008147496A3 · 2008 [cited by applicant]
WO WO2008156681A2 · 2008 [cited by applicant]
WO WO2008156778A2 · 2008 [cited by applicant]
WO WO2008156778A3 · 2008 [cited by applicant]
WO WO2008157583A1 · 2008 [cited by applicant]
WO WO09008921A3 · 2009 [cited by applicant]
WO WO09008921A9 · 2009 [cited by applicant]
WO WO2009007244A2 · 2009 [cited by applicant]
WO WO2009008921A2 · 2009 [cited by applicant]
WO WO2009014919A2 · 2009 [cited by applicant]
WO WO2008156778A9 · 2009 [cited by applicant]
WO WO09128867A2 · 2009 [cited by applicant]
WO WO2009152181A1 · 2009 [cited by applicant]
WO WO2009128867A3 · 2010 [cited by applicant]
WO WO2010053573A2 · 2010 [cited by applicant]
WO WO2010053573A3 · 2010 [cited by applicant]
WO WO2011014645A1 · 2011 [cited by applicant]
WO WO2011056591A1 · 2011 [cited by applicant]
WO WO2011087839A1 · 2011 [cited by applicant]
WO WO2011126370A1 · 2011 [cited by applicant]
WO WO2011130627A2 · 2011 [cited by applicant]
WO WO2012045882A2 · 2012 [cited by applicant]
WO WO2012177924A2 · 2012 [cited by applicant]
WO WO2013032942A1 · 2013 [cited by applicant]
WO WO2013032942A9 · 2013 [cited by applicant]
WO WO2013034069A1 · 2013 [cited by applicant]
WO WO2013087945A2 · 2013 [cited by applicant]
WO WO2013148302A1 · 2013 [cited by applicant]
WO WO2014195920A2 · 2014 [cited by applicant]
WO WO2015009743A1 · 2015 [cited by applicant]
WO WO2015031166A1 · 2015 [cited by applicant]
WO WO2015134488A1 · 2015 [cited by applicant]