Granted Patent B2

US 12,667,617 · App. 18/529,658 · Granted Jun 30, 2026

Inventors: Evan Johnson (Spring, TX); Anthony G. Petrello (Houston, TX); Paul Yollin (Tomball, TX); Dylan Cook (Spring, TX)

Assignee: NABORS ENERGY TRANSITION SOLUTIONS LLC

A61K41/0028A61K47/52

Abstract

Claims (44)

1 . A cancer treatment delivery method comprising:

preparing a cancer treatment delivery component comprising a carbon-based nanomaterial composition and a cancer treatment composition attached to the carbon-based nanomaterial composition;

delivering the cancer treatment delivery component to a treatment location; and

applying a radio frequency to the cancer treatment delivery component at the treatment location, wherein the radio frequency is configured to heat the cancer treatment delivery component and cause the cancer treatment composition to detach from the carbon-based nanomaterial composition for delivery at the treatment location,

wherein the carbon-based nanomaterial composition comprises:

a carbon content of at least about 93 atomic percent (at. %) and not greater than about 97 at. % based on elemental analysis of the carbon-based nanomaterial composition conducted using x-ray photoelectron spectroscopy (XPS), and

an oxygen content of at least about 1.0 at. % and not greater than about 2.5 at. % based on elemental analysis of the carbon-based nanomaterial composition conducted using XPS.

2 . The cancer treatment delivery method of claim 1 , wherein the cancer treatment composition comprises a cancer treatment, medicine or other molecule designed for delivery at a location within or on the surface of a body for cancer treatment or treatment at a location within or on the surface of a body for cancer treatment.

3 . The cancer treatment delivery method of claim 1 , wherein the treatment location comprises a cancer treatment, medicine or other molecule designed for delivery at a location within or on the surface of a body for cancer treatment or treatment at a location within or on the surface of a body for cancer treatment.

4 . The cancer treatment delivery method of claim 1 , wherein the radio frequency applied to the treatment location is at least about 100 MHz and not greater than about 140 Mhz.

5 . The cancer treatment delivery method of claim 4 , wherein the radio frequency is transmitted at a power of at least about 1 watt and not greater than about 5000 watts.

6 . The cancer treatment delivery method of claim 4 , wherein the radio frequency heats the treatment location to a temperature of at least about 50° C. and not greater than about 400° C.

7 . The cancer treatment delivery method of claim 4 , wherein the radio frequency is applied for a time length of at least about 0.01 seconds and not greater than about 60 seconds.

8 . The cancer treatment delivery method of claim 1 ,

wherein the carbon-based nanomaterial composition comprises a D/G ratio of at least about 0.1 and not greater than about 2.0; and

wherein the carbon-based nanomaterial composition has a carbon hybridization ratio P sp3 /P sp2 of at least about 0.1 and not greater than about 5.0, where P sp3 is the percent of carbon within the carbon-based nanomaterial composition having a sp3 hybridization and P sp2 is the percent of carbon within the carbon-based nanomaterial composition having a sp2 hybridization.

9 . The cancer treatment delivery method of claim 1 ,

wherein the carbon-based nanomaterial composition comprises an aspect ratio at least about 1 and not greater than about 50.

10 . The cancer treatment delivery method of claim 1 , wherein the carbon-based nanomaterial composition comprises a carbon hybridization ratio P sp3 /P sp2 of at least about 0.1 and not greater than about 5.0, where P sp3 is the percent of carbon within the carbon-based nanomaterial composition having a sp3 hybridization and P sp2 is the percent of carbon within the carbon-based nanomaterial composition having a sp2 hybridization.

11 . The cancer treatment delivery method of claim 1 , wherein the carbon-based nanomaterial composition comprises a D/G ratio of not greater than about 0.1 and at least about 2.0.

12 . A cancer treatment delivery component comprising:

a carbon-based nanomaterial composition and a cancer treatment composition attached to the carbon-based nanomaterial composition;

wherein the cancer treatment delivery component is configured to be delivered to a treatment location and heated using a radio frequency at the treatment location,

wherein heating the cancer treatment delivery component causes the cancer treatment composition to detach from the carbon-based nanomaterial composition for delivery at the treatment location,

wherein the carbon-based nanomaterial composition comprises:

a carbon content of at least about 93 at. % and not greater than about 97 at. % based on elemental analysis of the carbon-based nanomaterial graphene-composition, and

an oxygen content of at least about 1.0 at. % and not greater than about 2.5 at. % based on elemental analysis of the carbon-based nanomaterial graphene-composition.

13 . The cancer treatment delivery component of claim 12 , wherein the cancer treatment composition comprises a cancer treatment, medicine or other molecule designed for delivery at a location within or on the surface of a body for cancer treatment or treatment at a location within or on the surface of a body for cancer treatment.

14 . The cancer treatment delivery component of claim 12 , wherein the treatment location comprises a cancer treatment, medicine or other molecule designed for delivery at a location within or on the surface of a body for cancer treatment or treatment at a location within or on the surface of a body for cancer treatment.

15 . The cancer treatment delivery component of claim 12 , wherein the radio frequency applied to the treatment location is at least about 100 MHz and not greater than about 140 Mhz.

16 . The cancer treatment delivery component of claim 15 , wherein the radio frequency is transmitted at a power of at least about 1 watt and not greater than about 5000 watts.

17 . The cancer treatment delivery component of claim 15 , wherein the radio frequency heats the treatment location to a temperature of at least about 50° C. and not greater than about 400° C.

18 . The cancer treatment delivery component of claim 15 , wherein the radio frequency is applied for a time length of at least about 0.01 seconds and not greater than about 60 seconds.

19 . The cancer treatment delivery component of claim 12 ,

wherein the carbon-based nanomaterial composition comprises a D/G ratio of at least about 0.1 and not greater than about 2.0; and

wherein the carbon-based nanomaterial composition has a carbon hybridization ratio P sp3 /P sp2 of at least about 0.1 and not greater than about 5.0, where P sp3 is the percent of carbon within the carbon-based nanomaterial composition having a sp3 hybridization and P sp2 is the percent of carbon within the carbon-based nanomaterial composition having a sp2 hybridization.

20 . A method of forming a cancer treatment delivery component, wherein the method comprises:

providing a carbon-based nanomaterial composition, and

attaching a cancer treatment composition to the carbon-based nanomaterial composition to form the cancer treatment delivery component,

wherein the cancer treatment delivery component is configured to be delivered to a treatment location and heated using a radio frequency at the treatment location,

wherein heating the cancer treatment delivery component causes the cancer treatment composition to detach from the carbon-based nanomaterial composition,

wherein the carbon-based nanomaterial composition comprises:

a carbon content of at least about 93 at. % and not greater than about 97 at. % based on elemental analysis of the carbon-based nanomaterial graphene-composition conducted using XPS, and

an oxygen content of at least about 1.0 at. % and not greater than about 2.5 at. % based on elemental analysis of the carbon-based nanomaterial graphene-composition conducted using XPS.

Continuity (2)

References Cited (400)